Theophylline-induced respiratory recovery following cervical spinal cord hemisection is augmented by serotonin 2 receptor stimulation

Brain Research

Volumn 956, Issue 1, 2002, Pages 1-13

  Basura, Gregory J ^a   Nantwi, Kwaku D ^a   Goshgarian, Harry G ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cross phrenic phenomenon; Crossed phrenic nerve activity; Fluorogold; Immunoreactivity; Phrenic nucleus; Serotonin receptor

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; ADENOSINE A1 RECEPTOR; KETANSERIN; MESSENGER RNA; SEROTONIN 2 RECEPTOR; THEOPHYLLINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CERVICAL SPINAL CORD; CONTROLLED STUDY; DRUG EFFECT; ELECTROMYOGRAPHY; FEMALE; HEMIDIAPHRAGM; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; MOTONEURON; NONHUMAN; PARALYSIS; PHRENIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SPINAL CORD HEMISECTION; SPINAL CORD VENTRAL HORN;

ACTION POTENTIALS; AMPHETAMINES; ANIMALS; CERVICAL VERTEBRAE; DIAPHRAGM; DRUG SYNERGISM; FEMALE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KETANSERIN; PHRENIC NERVE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; RECEPTORS, SEROTONIN; RNA, MESSENGER; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SPINAL CORD; SPINAL CORD INJURIES; THEOPHYLLINE;

EID: 0037159610     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03097-4     Document Type: Article

References (53)

1. Aserinsky E. Effects of usage of a dormant respiratory nerve pathway upon its subsequent activity. Exp. Neurol. 3:1961;467-475.
2. Basura G.J., Zhou S.-Y., Walker P.D., Goshgarian H.G. Distribution of serotonin 2A and 2C receptor mRNA expression in the cervical ventral horn and phrenic motoneurons following spinal cord hemisection. Exp. Neurol. 169:2001;255-263.
3. Bianchi A.L., Denavit-Saubie M., Champagnat J. Central control of breathing in mammals: neuronal circuitry, membrane properties and neurotransmitters. Physiol. Rev. 75:1995;1-45.
4. Bowker R.M., Westlund K.N., Coulter J.D. Origins of serotonergic projections to the spinal cord in rat: an immunocytochemical-retrograde transport study. Brain Res. 226:1981;187-199.
5. Corradetti R., Lo Conte G., Moroni F., Passani M.B., Pepeu G. Adenosine decreases aspartate and glutamate release from rat hippocampal slices. Eur. J. Pharmacol. 104:1984;19-26.
6. DeVries K.L., Goshgarian H.G. Spinal cord localization and characterization of the neurons which give rise to the accessory phrenic nerve in the adult rat. Exp. Neurol. 104:1989;88-90.
7. Dolphin A.C., Archer E.R. An adenosine agonist inhibits and a cyclic AMP analogue enhances the release of glutamate but not GABA from slices of rat dentate gyrus. Neurosci. Lett. 43:1983;49-54.
8. Dolphin A.C., Prestwich S.A. Pertussis toxin reverses adenosine inhibition of neuronal glutamate release. Nature. 316:1985;148-150.
9. Dong X.-W., Feldman J.L. Modulation of inspiratory drive to phrenic motoneurons by presynaptic adenosine A1 receptors. J. Neurosci. 15:1995;3458-3467.
10. Eldridge F.L. Quantification of electrical activity in the phrenic nerve in the study of ventilatory control. Chest. 70:1976;154-157.
11. Eldridge F.L., Milhorn D.E., Killey J.P. Antagonism by theophylline of respiratory inhibition induced by adenosine. J. Appl. Physiol. 59:1985;1428-1433.
12. Ferguson G.T., Khanchandani N., Lattin C.D., Goshgarian H.G. Clinical effects of theophylline on inspiratory muscle drive in tetraplegia. Neurorehab. Neural Repair. 13:1999;191-197.
13. Gerber U., Greene R.W., Haas H.L., Stevens D.R. Characterization of inhibition mediated by adenosine in the hippocampus of the rat in vitro. J. Physiol. 417:1989;567-578.
14. Greene R.W., Haas H.L. Adenosine actions on CA1 pyramidal neurones in rat hippocampal slices. J. Physiol. 366:1985;119-127.
15. Goshgarian H.G., Rafols J.A. The phrenic nucleus of the albino rat: a correlative HRP and Golgi study. J. Comp. Neurol. 201:1981;441-456.
16. Gould D.J., Goshgarian H.G. Glial changes in the phrenic nucleus following superimposed cervical spinal cord hemisection and peripheral chronic phrenicotomy injuries in adult rats. Exp. Neurol. 148:1997;1-9.
17. Guth L. Functional plasticity in the respiratory pathway of the mammalian spinal cord. Exp. Neurol. 51:1976;414-420.
18. Hadley S.D., Walker P.D., Goshgarian H.G. Effects of the serotonin synthesis inhibitor p-CPA on the expression of the crossed phrenic phenomenon 4 h following C2 spinal cord hemisection. Exp. Neurol. 160:1998;446-453.
19. Hilaire G., Bou C., Monteau R. Serotonergic modulation of central respiratory activity in the neonatal mouse: an in vitro study. Eur. J. Pharmacol. 329:1997;115-120.
20. Holtman J.R., Norman W.P., Gillis R.A. Projections from the raphe nuclei to the phrenic motor nucleus in the cat. Neurosci. Lett. 44:1984;105-111.
21. Holtman J.R., Norman W.P., Skirboll L., Dretchen K.L., Cuello C., Visser T.J., Hokfelt T., Gillis R.A. Evidence for 5-hydroxytryptamine, substance P, and thyrotropin-releasing hormone in neurons innervating the phrenic motor nucleus. J. Neurosci. 4:1984;1064-1071.
22. Holtman J.R., Anastasi N.C., Norman W.P., Dretchen K.L. Effect of electrical and chemical stimulation of the raphe obscurus on phrenic nerve activity in the cat. Brain Res. 362:1986;214-220.
23. Holtman J.R., Dick T.E., Berger A.J. Involvement of serotonin in the excitation of phrenic motoneurons evoked by stimulation of the raphe obscurus. J. Neurosci. 6:1986;1185-1193.
24. Holtman J.R., Dick T.E., Berger A.J. Serotonin-mediated excitation of recurrent laryngeal and phrenic motoneurons evoked by stimulation of the raphe obscurus. Brain Res. 417:1987;12-20.
25. Jackson D.A., White S.R. Receptor subtypes mediating facilitation by serotonin of excitability of spinal motoneurons. Neuropharmacology. 29:1990;787-797.
26. Kinkead R., Mitchell G.S. Time-dependent hypoxic ventilatory responses in rats: effects of ketanserin 5-carboxamidotryptamine. Am. J. Physiol. 277:1999;R658-666.
27. Kocsis J.D., Eng D.L., Bhisitkul R.B. Adenosine selectively blocks parallel-fiber-mediated synaptic potentials in rat cerebellar cortex. Proc. Natl. Acad. Sci. USA. 81:1984;6531-6534.
28. Ling L., Bach K.B., Mitchell G.S. Serotonin reveals ineffective spinal pathways to contralateral phrenic motoneurons in spinally hemisected rats. Exp. Brain Res. 101:1994;35-43.
29. Lindsay A.D., Feldman J.L. Modulation of respiratory activity of neonatal rat phrenic motoneurons by serotonin. J. Physiol. 461:1993;213-233.
30. MacDonald R.L., Skerritt J.H., Werz M.A. Adenosine agonists reduce voltage-dependent calcium conductance of mouse sensory neurones in cell culture. J. Physiol. 370:1986;75-90.
31. Malenka R.C., Kocsis J.D. Presynaptic actions of carbachol and adenosine on corticostriatal synaptic transmission studied in vitro. J. Neurosci. 8:1988;3750-3757.
32. Miller J.F., Paul K.D., Lee R.H., Rymer W.Z., Heckman C.J. Restoration of extensor excitability in the acute spinal cat by the 5-HT2 agonist DOI. J. Neurophysiol. 75:1996;620-628.
33. 2+ current in hippocampal CA3 neurons. Neuron. 10:1993;327-334.
34. Moreno D.E., Yu X., Goshgarian H.G. Identification of the axon pathways which mediate functional recovery of a paralyzed hemidiaphragm following spinal cord hemisection in the adult rat. Exp. Neurol. 116:1992;219-228.
35. Morin D., Monteau R., Hilaire G. 5-Hydroxytryptamine modulates central respiratory activity in the newborn rat: an in vitro study. Eur. J. Pharmacol. 192:1991;89-95.
36. 1 receptor decreases N-type calcium current in mouse motoneurons. J. Neurosci. 14:1994;3628-3634.
37. Nantwi K.D., Goshgarian H.G. Theophylline-induced recovery in a hemidiaphragm paralyzed by hemisection in rats Contribution of adenosine receptors. Neuropharmacology. 37:1998;113-121.
38. Nantwi K.D., Goshgarian H.G. Effects of chronic systemic theophylline injections on recovery of hemidiaphragmatic function after cervical spinal cord injury in adult rats. Brain Res. 789:1998;126-129.
39. Nantwi K.D., Goshgarian H.G. Alkylxanthine-induced recovery of respiratory function following cervical spinal cord injury in adult rats. Exp. Neurol. 168:2001;123-134.
40. Pilowsky P.M., de Castro D., Llewellyn-Smith I., Lipski J., Voss M.D. Serotonin immunoreactive boutons make synapses with feline phrenic motoneurons. J. Neurosci. 10:1990;1091-1098.
41. Prince D.A., Stevens C.F. Adenosine decreases neurotransmitter release at central synapses. Proc. Natl. Acad. Sci. USA. 89:1992;8586-8590.
42. Proctor W.R., Dunwiddie T.V. Pre- and postsynaptic actions of adenosine in the in vitro rat hippocampus. Brain Res. 426:1987;187-190.
43. Reppert S.M., Weaver D.R., Stehle J.H., Rivkees S.A. Molecular cloning and characterization of a rat A1-adenosine receptor that is widely expressed in brain and spinal cord. Mol. Endocrinol. 5:1991;1037-1048.
44. Scanziani M., Capogna M., Gahwiler B.H., Thompson S.M. Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus. Neuron. 9:1992;919-927.
45. Schmid K., Bohmer G., Merkelbach S. Serotonergic control of phrenic motoneuronal activity at the level of the spinal cord of the rabbit. Neurosci. Lett. 116:1990;204-209.
46. 2+ currents and synaptic transmission in cultured rat hippocampal pyramidal neurones. J. Physiol. 435:1991;373-393.
47. Tai Q., Palazzolo K.L., Goshgarian H.G. Synaptic plasticity of 5-hydroxytryptamine-immunoreactive terminals in the phrenic nucleus following spinal cord injury. A quantitative electron microscopic analysis. J. Comp. Neurol. 386:1997;613-624.
48. Trussell L.O., Jackson M.B. Adenosine-activated potassium conductance in cultured striatal neurons. Proc. Natl. Acad. Sci. USA. 82:1985;4857-4861.
49. Woodcock A.A., Johnson M.A., Geddes D.M. Theophylline prescribing, serum concentrations, and toxicity. Lancet. ii:1983;610-613.
50. 1C receptor-mediated facilitatory action on unit activity of ventral horn cells in rat spinal cord slices. Eur. J. Pharmacol. 220:1992;237-242.
51. Zhan W.-Z., Ellenberger H.H., Feldman J.L. Monoaminergic and GABAergic terminations in phrenic nucleus of rat identified by immunohistochemical labeling. Neuroscience. 31:1989;105-113.
52. Zhou S.-Y., Goshgarian H.G. Effects of serotonin on crossed phrenic nerve activity in cervical spinal cord hemisected rats. Exp. Neurol. 160:1999;446-453.
53. Zhou S.-Y., Basura G.J., Goshgarian H.G. Involvement of serotonin 2 receptors in respiratory recovery following cervical spinal cord hemisection in adult rats. J. Appl. Phys. 91:2001;2665-2673.