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Volumn 17, Issue 4, 2003, Pages 457-463

Induction of cytotoxicity and ssDNA breaks by 9-bromo-5-morpholino-tetrazolo[1,5-c]quinazoline in tumor cells cultured in vitro

Author keywords

Apoptosis; Cytotoxicity; DNA single strand breaks; Quinazolines

Indexed keywords

9 BROMO 5 MORPHOLINOTETRAZOLO[1,5 C]QUINAZOLINE; DNA FRAGMENT; QUINAZOLINE DERIVATIVE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

EID: 0038771104     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(03)00066-3     Document Type: Article
Times cited : (14)

References (39)
  • 2
    • 0000695308 scopus 로고
    • Measurement of strand breaks by alkaline denaturation and hydroxylapatite chromatography
    • E.C. Friedberg, & P.C. Hanawalt. Marcel Dekker: New York
    • Ahnstrom G., Erixon K. Measurement of strand breaks by alkaline denaturation and hydroxylapatite chromatography. Friedberg E.C., Hanawalt P.C. DNA Repair. A Laboratory Manual of Research Procedures. 1981;403-418 New York, Marcel Dekker.
    • (1981) DNA Repair. A Laboratory Manual of Research Procedures , pp. 403-418
    • Ahnstrom, G.1    Erixon, K.2
  • 3
    • 0034779584 scopus 로고    scopus 로고
    • Synthesis and antimicrobial evaluation of chalcone and syndrome derivatives of 4(3H)-quinazolinone
    • Bekhit A.A., Habib N.S., el-Din A., Bekhit A. Synthesis and antimicrobial evaluation of chalcone and syndrome derivatives of 4(3H)-quinazolinone. Bollettino Chimico Farmaceutico. 140:2001;297-301.
    • (2001) Bollettino Chimico Farmaceutico , vol.140 , pp. 297-301
    • Bekhit, A.A.1    Habib, N.S.2    El-Din, A.3    Bekhit, A.4
  • 4
    • 0037079614 scopus 로고
    • Quinazoline-derived alpha1-adrenoceptor antagonists induce prostrate cancer cell apoptosis via an alpha1-adenoceptor-independent action
    • Benning C.M., Kyprianou N. Quinazoline-derived alpha1-adrenoceptor antagonists induce prostrate cancer cell apoptosis via an alpha1-adenoceptor-independent action. Cancer Res. 2:1992;597-602.
    • (1992) Cancer Res. , vol.2 , pp. 597-602
    • Benning, C.M.1    Kyprianou, N.2
  • 5
    • 0033763084 scopus 로고    scopus 로고
    • ZD1839 ('Iressa') as an anticancer agent
    • Baselga J., Averbuch S.D. ZD1839 ('Iressa') as an anticancer agent. Drugs. 60:2000;33-42.
    • (2000) Drugs , vol.60 , pp. 33-42
    • Baselga, J.1    Averbuch, S.D.2
  • 6
    • 0025832386 scopus 로고
    • Structure-activity relationships of a series of antitumoral 5,8-quinazolinediones in mutagenicity studies
    • Callais F., Min S., Giorgi-Renault S., Festy B. Structure-activity relationships of a series of antitumoral 5,8-quinazolinediones in mutagenicity studies. Mutation Research. 261:1991;51-56.
    • (1991) Mutation Research , vol.261 , pp. 51-56
    • Callais, F.1    Min, S.2    Giorgi-Renault, S.3    Festy, B.4
  • 7
    • 0034068319 scopus 로고    scopus 로고
    • Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
    • Ciardiello F., Caputo R., Bianco R., Damiano V., Pomatico G., De Placido S., Bianco A.R., Tortora G. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clinical Cancer Research. 6:2000;2053-2063.
    • (2000) Clinical Cancer Research , vol.6 , pp. 2053-2063
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3    Damiano, V.4    Pomatico, G.5    De Placido, S.6    Bianco, A.R.7    Tortora, G.8
  • 8
    • 0033598323 scopus 로고    scopus 로고
    • Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha
    • Chao Q., Deng L., Shih H., Leoni L.M., Genini D., Carson D.A., Cottam H.B. Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. Journal of Medicinal Chemistry. 42:1999;3860-3873.
    • (1999) Journal of Medicinal Chemistry , vol.42 , pp. 3860-3873
    • Chao, Q.1    Deng, L.2    Shih, H.3    Leoni, L.M.4    Genini, D.5    Carson, D.A.6    Cottam, H.B.7
  • 9
    • 0028833163 scopus 로고
    • The kinetics of repair of oxidative DNA damage (strand breaks and oxidized pyrimidine dimmers) in human cells
    • Collins A.R., Ai-guo M., Duthir S.J. The kinetics of repair of oxidative DNA damage (strand breaks and oxidized pyrimidine dimmers) in human cells. Mutation Research. 336:1995;69-77.
    • (1995) Mutation Research , vol.336 , pp. 69-77
    • Collins, A.R.1    Ai-guo, M.2    Duthir, S.J.3
  • 10
    • 0030466603 scopus 로고    scopus 로고
    • Fused pyrimidines. Synthesis of new derivatives of potential diuretic activity
    • Eisa H.M. Fused pyrimidines. Synthesis of new derivatives of potential diuretic activity. Bollettino Chimico Farmaceutico. 135:1996;585-590.
    • (1996) Bollettino Chimico Farmaceutico , vol.135 , pp. 585-590
    • Eisa, H.M.1
  • 11
    • 0032978037 scopus 로고    scopus 로고
    • Apoptosis and growth inhibition of head and neck tumor cell line induced by epidermal growth factor receptor tyrosine kinase inhibitor
    • Faust R.A., Tawfic S., Davis A.T., Ahmed K. Apoptosis and growth inhibition of head and neck tumor cell line induced by epidermal growth factor receptor tyrosine kinase inhibitor. Oral Oncology. 35:1999;290-295.
    • (1999) Oral Oncology , vol.35 , pp. 290-295
    • Faust, R.A.1    Tawfic, S.2    Davis, A.T.3    Ahmed, K.4
  • 12
    • 0036570203 scopus 로고    scopus 로고
    • ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
    • Hirata A., Ogawa S., Kometani T., Kuwano T., Naito S., Kuwano M., Ono M. ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Research. 62:2002;2554-2560.
    • (2002) Cancer Research , vol.62 , pp. 2554-2560
    • Hirata, A.1    Ogawa, S.2    Kometani, T.3    Kuwano, T.4    Naito, S.5    Kuwano, M.6    Ono, M.7
  • 14
    • 0025997350 scopus 로고
    • ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent of L1210 tumor cell growth in vitro and in vivo: A new agent for clinical study
    • Jackman A.L., Taylor G.A., Girson W., Kimbeli R., Brown M., Calvert A.H., Judson I.R., Hughes L.R. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. Cancer Research. 51:1991;5579-5586.
    • (1991) Cancer Research , vol.51 , pp. 5579-5586
    • Jackman, A.L.1    Taylor, G.A.2    Girson, W.3    Kimbeli, R.4    Brown, M.5    Calvert, A.H.6    Judson, I.R.7    Hughes, L.R.8
  • 15
    • 0038160434 scopus 로고    scopus 로고
    • Cytotoxic effect of substituted tetrazolo[1,5-c]quinazolines on HeLa cells
    • Jantová S., Ružeková L'., Špirková K., Stankovský Š. Cytotoxic effect of substituted tetrazolo[1,5-c]quinazolines on HeLa cells. Biology. 52:1997;445-450.
    • (1997) Biology , vol.52 , pp. 445-450
    • Jantová, S.1    Ružeková, L'.2    Špirková, K.3    Stankovský, Š.4
  • 16
    • 0030765158 scopus 로고    scopus 로고
    • Antiproliferation activity and the mechanism of action of 9-bromo-5-morpholino-tetrazolo[1,5-c]quinazoline - Potentional anticancer drug
    • Jantová S., Ružeková L'., Stankovský Š., Špirková K. Antiproliferation activity and the mechanism of action of 9-bromo-5-morpholino-tetrazolo[1,5-c]quinazoline - potentional anticancer drug. Neoplasma. 44:1997;240-246.
    • (1997) Neoplasma , vol.44 , pp. 240-246
    • Jantová, S.1    Ružeková, L'.2    Stankovský, Š.3    Špirková, K.4
  • 17
    • 0031957897 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells
    • Karnes W.E. Jr., Weller S.G., Adjei P.N., Kottke T.J., Glenn K.S., Gores G.J., Kaufmann S.H. Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells. Gastroenterology. 114:1998;930-939.
    • (1998) Gastroenterology , vol.114 , pp. 930-939
    • Karnes W.E., Jr.1    Weller, S.G.2    Adjei, P.N.3    Kottke, T.J.4    Glenn, K.S.5    Gores, G.J.6    Kaufmann, S.H.7
  • 18
    • 0031603399 scopus 로고    scopus 로고
    • New antimetabolites in cancer chemotherapy and their clinical impact
    • Kaye S.B. New antimetabolites in cancer chemotherapy and their clinical impact. British Journal of Cancer. 78:1998;1-7.
    • (1998) British Journal of Cancer , vol.78 , pp. 1-7
    • Kaye, S.B.1
  • 21
    • 0037017754 scopus 로고    scopus 로고
    • A glutamate receptor subtype antagonist inhibits seizures in rat hippocampal slices
    • Lasztoczi B., Kovacs R., Nyikos L., Kardos J. A glutamate receptor subtype antagonist inhibits seizures in rat hippocampal slices. Neuroreport. 13:2002;351-356.
    • (2002) Neuroreport , vol.13 , pp. 351-356
    • Lasztoczi, B.1    Kovacs, R.2    Nyikos, L.3    Kardos, J.4
  • 22
    • 0036492173 scopus 로고    scopus 로고
    • Reduction of the soluble cyclic GMP vasorelaxing system in the vascular wall of stroke-prone spontaneously hypertensive rats: Effect of the alpha1-receptor blocker doxazosin
    • Lopez-Farre A., Rodriguez-Feo J.A., Garcia-Colis E., Gomez J., Lopez-Blaya A., Fortes J., de Andres R., Rico L., Casado S. Reduction of the soluble cyclic GMP vasorelaxing system in the vascular wall of stroke-prone spontaneously hypertensive rats. effect of the alpha1-receptor blocker doxazosin Journal of Hypertension. 20:2002;463-470.
    • (2002) Journal of Hypertension , vol.20 , pp. 463-470
    • Lopez-Farre, A.1    Rodriguez-Feo, J.A.2    Garcia-Colis, E.3    Gomez, J.4    Lopez-Blaya, A.5    Fortes, J.6    De Andres, R.7    Rico, L.8    Casado, S.9
  • 24
    • 0028106383 scopus 로고
    • Quinazoline inhibitors of thymidylate synthase - Potent new anticancer agents
    • Marsham P.R. Quinazoline inhibitors of thymidylate synthase - potent new anticancer agents. Journal of Heterocyclic Chemistry. 31:1994;603-613.
    • (1994) Journal of Heterocyclic Chemistry , vol.31 , pp. 603-613
    • Marsham, P.R.1
  • 25
    • 0029841372 scopus 로고    scopus 로고
    • DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells
    • Matsui S.I., Arredondo M.A., Wrzosek C., Rustum Y.M. DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells. Cancer Research. 56:1996;4715-4723.
    • (1996) Cancer Research , vol.56 , pp. 4715-4723
    • Matsui, S.I.1    Arredondo, M.A.2    Wrzosek, C.3    Rustum, Y.M.4
  • 27
    • 0031801528 scopus 로고    scopus 로고
    • 4-(3α-Bromo-4′hydroxylphenyl)-amino-6,7- dimethoxyquinazoline: A novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells
    • Narla R.K., Liu X.P., Myers D.E., Uckun F.M. 4-(3α-Bromo-4′hydroxylphenyl)-amino-6,7-dimethoxyquinazoline. a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells Clinical Cancer Research. 4:1998;1405-1414.
    • (1998) Clinical Cancer Research , vol.4 , pp. 1405-1414
    • Narla, R.K.1    Liu, X.P.2    Myers, D.E.3    Uckun, F.M.4
  • 28
    • 0029026611 scopus 로고
    • Contrasting patterns of DNA fragmentation induced by thymidylate synthase inhibitors, ZD1694 and AG-331
    • Panadero A., Yin M.B., Voigt W., Rustum Y.M. Contrasting patterns of DNA fragmentation induced by thymidylate synthase inhibitors, ZD1694 and AG-331. Oncology Research. 7:1995;73-81.
    • (1995) Oncology Research , vol.7 , pp. 73-81
    • Panadero, A.1    Yin, M.B.2    Voigt, W.3    Rustum, Y.M.4
  • 29
    • 0033395476 scopus 로고    scopus 로고
    • Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methylmercapto quinazolin-4(3H)-one
    • Pandeya S.N., Sriram D., Nath G., De Clercq E. Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methylmercapto quinazolin-4(3H)-one. Pharmaceutica Acta Helvetiae. 74:1999;11-17.
    • (1999) Pharmaceutica Acta Helvetiae , vol.74 , pp. 11-17
    • Pandeya, S.N.1    Sriram, D.2    Nath, G.3    De Clercq, E.4
  • 30
    • 0027930648 scopus 로고
    • Quantification of 2,3-dihydro-7-methoxypyrrolo-[2,1-b]-quinazolin-9(1H)-one, a new antiallergic agent, by high-performance liquid chromatography in serum
    • Singh S.K., Paliwal J.K., Grover P.K., Gupta R.C. Quantification of 2,3-dihydro-7-methoxypyrrolo-[2,1-b]-quinazolin-9(1H)-one, a new antiallergic agent, by high-performance liquid chromatography in serum. Journal of Chromatography B: Biomedical Sciences and Applications. 658:1994;198-201.
    • (1994) Journal of Chromatography B: Biomedical Sciences and Applications , vol.658 , pp. 198-201
    • Singh, S.K.1    Paliwal, J.K.2    Grover, P.K.3    Gupta, R.C.4
  • 31
    • 0023919963 scopus 로고
    • A simple technique for quantification of low levels of DNA damage in individual cells
    • Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantification of low levels of DNA damage in individual cells. Exp. Cell Res. 175:1988;184-191.
    • (1988) Exp. Cell Res. , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 34
    • 0009556506 scopus 로고
    • Amidinoyl isothiocyanates in the synthesis of condensed heterocycles: Tetrazolo-azidoazodomethine tautomerism in substituted tetrazolo[1,5-c] quinazolines
    • Stankovský Š., Špirková K. Amidinoyl isothiocyanates in the synthesis of condensed heterocycles: tetrazolo-azidoazodomethine tautomerism in substituted tetrazolo[1,5-c] quinazolines. Monatschefte für Chemie. 122:1991;849-852.
    • (1991) Monatschefte für Chemie , vol.122 , pp. 849-852
    • Stankovský, Š.1    Špirková, K.2
  • 35
    • 13344284626 scopus 로고    scopus 로고
    • The role of acetylation in the mutagenicity of the antitumor agent, batracylin
    • Stevens G.J., LaVoie E.J., McQueen C.A. The role of acetylation in the mutagenicity of the antitumor agent, batracylin. Carcinogenesi. 17:1996;115-119.
    • (1996) Carcinogenesi , vol.17 , pp. 115-119
    • Stevens, G.J.1    LaVoie, E.J.2    McQueen, C.A.3
  • 36
    • 0032546269 scopus 로고    scopus 로고
    • EGF receptor signaling inhibits keratinocyte apoptosis: Evidence for mediation by Bcl-XL
    • Stoll S.W., Benedict M., Mitra R., Hiniker A., Elder J.T., Nunez G. EGF receptor signaling inhibits keratinocyte apoptosis. evidence for mediation by Bcl-XL Oncogene. 16:1998;1493-1499.
    • (1998) Oncogene , vol.16 , pp. 1493-1499
    • Stoll, S.W.1    Benedict, M.2    Mitra, R.3    Hiniker, A.4    Elder, J.T.5    Nunez, G.6
  • 37
    • 0036480889 scopus 로고    scopus 로고
    • Molecular target-based cancer therapy: Epidermal growth factor receptor inhibitors
    • Tamura T. Molecular target-based cancer therapy. epidermal growth factor receptor inhibitors Nippon Geka Gakkai Zasshi. 103:2002;233-236.
    • (2002) Nippon Geka Gakkai Zasshi , vol.103 , pp. 233-236
    • Tamura, T.1
  • 38
    • 0031444213 scopus 로고    scopus 로고
    • Antifolates in clinical development
    • Takimo C.H. Antifolates in clinical development. Seminars in Oncology. 24:1997;18-51.
    • (1997) Seminars in Oncology , vol.24 , pp. 18-51
    • Takimo, C.H.1
  • 39
    • 0030947994 scopus 로고    scopus 로고
    • P53 and WAF1 are induced and Rb protein is hypophosphorylated during cell growth inhibition by the thymidylate synthase inhibitor ZD1694 (Tomudex)
    • Yin M.B., Voigt W., Panadero A., Vanhoefer U., Frank C., Pajovic S., Azizkhan J., Rustum Y.M. p53 and WAF1 are induced and Rb protein is hypophosphorylated during cell growth inhibition by the thymidylate synthase inhibitor ZD1694 (Tomudex). Molecular Pharmacology. 51:1997;630-636.
    • (1997) Molecular Pharmacology , vol.51 , pp. 630-636
    • Yin, M.B.1    Voigt, W.2    Panadero, A.3    Vanhoefer, U.4    Frank, C.5    Pajovic, S.6    Azizkhan, J.7    Rustum, Y.M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.