Cytotoxic effect of substituted tetrazolo-[1,5-c]quinazolines on HeLa cells

Biologia

Volumn 52, Issue 3, 1997, Pages 445-450

  Jantová, Soňa ^a   Ružeková, L'ubica ^b   Špirková, Katarína ^a   Stankovský, Štefan ^a  

^a SLOVAK UNIVERSITY OF TECHNOLOGY   (Slovakia)

^b CANCER RESEARCH INSTITUTE   (Slovakia)

Author keywords

Cytotoxicity; Damage of cytoplasmatic membrane; Proliferation; Quinazoline derivatives; Transformed cell culture; Unbalanced growth

Indexed keywords

EID: 0038160434     PISSN: 00063088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. CURTIN, N. J., HARRIS, A. L., JAMES, O. F. W., BASSENDINE, M. F., 1986: Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB 3717.- Br. J. Cancer 53: 361-368.
2. ELZOHRY, M. F., ELHAMED, A., AHMED, N., OMAR, F. A., ABDALLA, M. A., 1992: Synthesis and antibacterial activity of certain quinoline and quinazoline derivatives containing sulfide and sulfone moieties.- J. Chem. Technol. Biotechnol. 53: 329-336.
3. FARGHALY, A. M., CHAABAN, I., KHALIL, M. A., BEKHIT, A. A., 1990: Nonsteroidal antiinflammatory agents. Synthesis of novel 2-pyrazolyl-4(3H)-quinazolinones.- Arch. Pharm. 323: 833-836.
4. GABRIEL, S., 1903: Über das Chinazolin.- Ber. Deut. Chem. Ges. 36: 800-813.
5. GEORGOPOULOS, G., WELCH, W. J., 1993: Role of the major heat shock proteins as molecular chaperones.- Annu. Rev. Cell Biol. 9: 601-634.
6. HORÁKOVÁ, K., JANTOVÁ, S., STREĎANSKÝ, M., NOVOTNÁ, L'., 1993: Ethyl 4-iso-thiocyanatobutanoate - antiproliferative activity in vitro and in vivo.- Anti-Cancer Drugs 4: 828-832.
7. HORÁKOVÁ, K., KALAFUT, F., NAVAROVÁ, J., PATERSON, A. R. P., 1974: Delayed expression of 6-mercaptopurine cytotoxicity toward HeLa cells.-Neoplasma 21: 555-560.
8. HORÁKOVÁ, K., LUKÁČOVÁ, D., KOZÁNKOVÁ, Z., DŽURBA, A., ZlEGELHÖFFER, A., JANTOVÁ, S., 1988: The mechanism of cytolytic and cytostatic activity of benfluron.- Neoplasma 35: 177-183.
9. HUGHES, L. R., JACKMAN, A. L., OLDFIELD, J., SMITH, R. C., BURROWS, K. D., MARSHAM, P. R., BISHOP, J. A. M., JONES, T. R., O'CONNOR, B. M., CALVERT, A. H., 1990: Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl and aryl substituents in the C2 position.- J. Med. Chem. 33: 3060-3067.
10. JANTOVÁ, S., HORÁKOVÁ, K., 1993: 9-hydroxybenfluron induced inhibition of proliferation and metabolism in HeLa cells.- Cell Biochem. Funct. 11: 131-135.
11. JANTOVÁ, S., HORÁKOVÁ, K., NOVOTOVÁ, M., UHRÍK, B., 1995: Mechanism of cytostatic and cytolytic activity of 9-hydroxybenfluron in HMB-2 human melanom cells.- Biologia 50: 615-622.
12. JANTOVÁ S., HORÁKOVÁ, K., UHRÍK, B., NOVOTOVÁ, M., KŘEPELKA, J., 1992: Cytotoxic ac-tivity of benzo(c)fluorene derivatives in in vitro conditions.- Biologia 47: 725-736.
13. KORNET, M. J., 1992: Synthesis and anticonvulsant activity of 3-alkyl-3,4-dihydro-2(1H)-quinazolinones.- J. Heter. Chem. 29: 103-105.
14. LOWRY, O. H., ROSEBROUGH, N. J., FARR, A. L., RANDALL, R. J., 1951: Protein measurement with the folin phenol reagent.- J. Biol. Chem. 143: 265-275.
15. MARSHAM, P. R., 1994: Quinazoline inhibitors of thymidylate synthase - potent new anticancer agents.- J. Heterocyc. Chem. 31: 603-613.
16. NAITHANI, P. K., PALIT, G., SRIVASTAVA, V. K., SHANKER, K., 1989: 2,3-Disubstituted quinazolinones and their antiparkinsonian activity.- Ind. J. Chem. Sect. B Org. Chem. Incl. Med. Chem. 28: 745-750.
17. PEET, N. P., BAUGH, L. E., LEWIS, J. E., MATHEWS, E. H., OLBERDING, E. L., SHAH, D. N., SUNDER, S., 1986: Chemistry and antiallergic activity of 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone sodiumsalt (MDL-427).- Abstr. Paap. Amer. Chem. Soc. 192: 13.
18. PENDARGAS, W., DICKERSON, S. H., DEV, I. K., FERONE, R., DUCH, D. S., SMITH, G. K., 1994: Benzo(F)quinazoline inhibitors of thymidylate synthase - metyleneamino-linked aroylglutamate derivatives.- J. Med. Chem. 37: 838-844.
19. POMARNACKA, E., ANGIELSKI, S., HOPPE, A., 1984: Derivatives of 4-chloro-5-sulfanoyl-benzoic acid. 8. Synthesis and diuretic activity of pyrazole [3,2-b]quinazoline and 1-benzoylpyrazole derivatives.-Acta Polon. Pharm. 41: 141-151.
20. STANKOVSKÝ, Š., ŠPIRKOVÁ, K., 1991: Amidinoyl isothiocyanates in the synthesis of condensed heterocycles: Tetrazolo-azidoazomethine tautomerism in substituted tetrazolo[1,5-c]quinazolines.- Monatshefte für Chemie 122: 849-852.
21. SÜSSL, M., JOHNE, S., 1981: Chinazolinderivate mit phytoeffektorischen oder bioziden Eigenschaften.-Z. Chem. 21: 431-442.
22. TAYLOR, G. A., JACKMAN, A. L., BALMANNO, K., CALVERT, A. H., 1987: Thymidylate synthase activity in L1210 cells following in vitro or in vivo exposure to quinazoline antifolates.- Br. J. Cancer 56: 195.
23. TIDD, D. M., KIM, S. C., HORÁKOVÁ, K., MORIWAKI, A., PATERSON, A. R. P., 1972: A delayed cytotoxic reaction for 6-mercaptopurine.- Cancer Res. 32: 317-321.
24. WISELOGE, F. W., 1946: Survey of Antimalaric Drugs 1941-45 (E. Brothers, Ed.). Ann Arbor, Michigan.