The effect of combined rapamycin/cyclosporine on the changes in pro-fibrotic gene expression that occur during the development of allograft vasculopathy in rats, compared with cyclosporine or rapamycin in isolation

Transplant International

Volumn 16, Issue 5, 2003, Pages 347-353

  Murphy, Gavin J ^a,b   Bicknell, Gareth R ^b   Nicholson, Michael L ^b  

^a DERRIFORD HOSPITAL   (United Kingdom)

^b LEICESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

Allograft vasculopathy; Cyclosporine; Fibrosis; Metalloproteinases; Rapamycin; Vascular remodelling

Indexed keywords

BETA ACTIN; COLLAGEN TYPE 3; CYCLOSPORIN; CYCLOSPORIN A; GELATINASE B; MESSENGER RNA; RAPAMYCIN; TISSUE INHIBITOR OF METALLOPROTEINASE;

ABDOMINAL AORTA; ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY DIAMETER; ARTERY GRAFT; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; EXTRACELLULAR MATRIX; FIBROSIS; FROZEN SECTION; GENE EXPRESSION; GRAFT FAILURE; HOUSEKEEPING GENE; HYPERPLASIA; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY INFILTRATE; MONOTHERAPY; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR DISEASE;

ANIMALS; AORTA; AORTIC DISEASES; AZO COMPOUNDS; CYCLOSPORINE; DRUG THERAPY, COMBINATION; FIBROSIS; GENE EXPRESSION; GRAFT REJECTION; IMMUNOSUPPRESSIVE AGENTS; MATRIX METALLOPROTEINASE 9; RATS; RATS, INBRED F344; RATS, INBRED LEW; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIROLIMUS; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION, HOMOLOGOUS;

EID: 0038748039     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2003.tb00311.x     Document Type: Article

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