Interactions between 3-(Trifluoromethyl)-3-(m[125I]iodophenyl)diazirine and tetracaine, phencyclidine, or histrionicotoxin in the Torpedo species nicotinic acetylcholine receptor ion channel

Molecular Pharmacology

Volumn 59, Issue 6, 2001, Pages 1514-1522

  Gallagher, M J ^a   Chiara, D C ^a   Cohen, J B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3 IODOPHENYL) 3 (TRIFLUOROMETHYL)DIAZIRINE I 125; AZIRINE DERIVATIVE; HISTRIONICOTOXIN; ION CHANNEL; LEUCINE; NICOTINIC RECEPTOR; PHENCYCLIDINE; TETRACAINE; UNCLASSIFIED DRUG; VALINE;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MOLECULAR INTERACTION; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; TORPEDO;

EID: 0034990317     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.6.1514     Document Type: Article

References (34)

1. Binding sites for exogenous and endogenous non-competitive inhibitors of the nicotinic acetylcholine receptor
2. Mapping the lipid exposed regions in the Torpedo species nicotinic acetylcholine receptor
3. Identifying the lipid-protein interface of the Torpedo nicotinic acetylcholine receptor: Secondary structure implications
4. 3H]diazofluorene
5. - ion fluxes
6. 125I]iodophenyl)diazirine, a carbene-generating reagent
7. An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor
8. Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis
9. Nicotinic receptors at the amino acid level
10. 3H]quinacrine azide in the active state of the nicotonic acetylcholine receptor
11. 3H]-meproadifen mustard with membrane-bound acetylcholine receptor
12. M2 Mutations of the nicotinic acetylcholine receptor increase the potency of the non-competitive inhibitor phencyclidine
13. 3H]tetracaine
14. 3H]chlorpromazine
15. 3H]chlorpromazine labels homologous residues in the β and γ chains
16. 3H]chlorpromazine labels segment M2 but not segment M1 of the nicotinic acetylcholine receptor α-subunit
17. Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from. Torpedo marmorata
18. The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits
19. The emerging three-dimensional structure of a receptor - The nicotinic acetylcholine receptor
20. Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
21. A ring of uncharged polar amino acids as a component of channel constriction in the nicotinic acetylcholine receptor
22. 3H]tetracaine, a nondesensitizing noncompetitive antagonist
23. Localization of azidophencyclidine-binding site on the nicotinic acetylcholine receptor α-subunit
24. Ultraviolet light-induced labeling by noncompetitive blockers of the acetylcholine receptor from Torpedo marmorata
25. Location of ligand binding sites on the nicotinic acetylcholine receptor α-subunit
26. 3H]meproadifen mustard reacts selectively with α-subunit Glu-262
27. 3H]chlorpromazine labels three amino acids of the acetylcholine receptor γ subunit: Implications for the α-helical organization of regions MII and for the structure of the ion channel
28. A conformational intermediate between the resting and desensitized states of the nicotinic acetylcholine receptor
29. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 KDa
30. Mutations in the M1 region of the nicotinic acetylcholine receptor alter the sensitivity to inhibition by quinacrine
31. 125I]iodophenyl)diazirine
32. Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic non-competitive antagonist
33. 125I]iodophenyl)diazirine is a novel noncompetitive antagonist of the nicotinic acetylcholine receptor
34. Identification of acetylcholine receptor channel-lining residues in the M1 segment of the beta-subunit