Extracts of various species of Epilobium inhibit proliferation of human prostate cells

Journal of Pharmacy and Pharmacology

Volumn 55, Issue 5, 2003, Pages 683-690

  Vitalone, Annabella ^a   Guizzetti, Marina ^b   Costa, Lucio G ^a,b   Tita, Beatrice ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CHELERYTHRINE; DNA FRAGMENT; EPILOBIUM ROSMARINIFOLIUM EXTRACT; EPILOBIUM SPICATUM EXTRACT; EPILOBIUM TETRAGONUM EXTRACT; PLANT EXTRACT; STAUROSPORINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN CONDENSATION; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS INHIBITION; DRUG EFFECT; EPILOBIUM ROSMARINIFOLIUM; EPILOBIUM SPICATUM; EPILOBIUM TETRAGONUM; EPITHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; NICK END LABELING; PHYTOTHERAPY; PLANT; PROSTATE EPITHELIUM; PROSTATE HYPERTROPHY; STAINING; TRADITIONAL MEDICINE;

CELL DIVISION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILOBIUM; GROWTH INHIBITORS; HUMANS; MALE; PLANT EXTRACTS; PROSTATE; TUMOR CELLS, CULTURED;

EID: 0038719649     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/002235703765344603     Document Type: Article

References (45)

1. Anderson, J. B., Roehrborn, C. G., Schalken, J. A., Emberton, M. (2001) The progression of benign prostatic hyperplasia: Examining the evidence and determining the risk. Eur. Urol. 39: 390-399
2. Berry, S. J., Coffey, D. S., Walsh, P. C., Ewing, L. L. (1984) The development of human benign prostatic hyperplasia with age. J. Urol. 132: 474-479
3. Buck, A. C. (1996) Phytotherapy for the prostate. Br. J. Urol. 78: 235-336
4. Cooper, K. L., McKiernan, J. M., Kaplan, S. A. (1999) Alpha-adrenoceptor antagonists in the treatment of benign prostatic hyperplasia. Drugs 57: 9-17
5. Ducrey, B., Marston, A., Gohring, S., Hartmann, R. W., Hostettmann, K. (1997) Inhibition of 5 alpha-reductase and aromatase by the ellagitannins oenothein A and oenothein B from Epilobium species. Planta Med. 63: 111-114
6. Fizpatrick, J. M. (2000) Will laser replace TURP for the treatment of benign prostatic hyperplasia? Lancet 356: 357-358
7. Garraway, W. M., Kirby, R. S. (1994) Benign prostatic hyperplasia: Effects on quality of life and impact on treatment decisions. Urology 44: 629-636
8. Glassman, D. T., Chon, J. K., Borkowski, A., Jakobs, S. C. Kyprianou, N. (2001) Combined effect of terazosin and finasteride on apoptosis, cell proliferation, and transforming growth factor-β expression in benign prostatic hyperplasia. Prostate 46: 45-51
9. Guizzetti, M., Costa, L. G. (1996) Inhibition of muscarinic receptor-stimulated glial cell proliferation by ethanol. J. Neurochem. 67: 2236-2245
10. Guizzetti, M., Costa, P., Peters, J., Costa, L. G. (1996) Acetylcholine as a mitogen: Muscarinic receptor-mediated proliferation of rat astrocytes and human astrocytoma cells. Eur. J. Pharmacol. 297: 265-273
11. Gupta, S., Afaq, F., Muktar, H. (2001) Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. Biochem. Biophys. Res. Comm. 287: 914-920
12. Habib, F. K., Ross, M., Lewenstein, A., Zhang, X., Jaton, J. C. (1995) Identification of a prostate inhibitory substance in a pollen extract. Prostate 26: 133-139
13. Hiermann, A. (1999) Die Untersuchung potentieller Wirkstoffe in Epilobium-Arten. 1. Mitteilung: Aufklärung der Flavonoid-muster. Sci. Pharm. 51: 158-167
14. Hiermann, A., Bucar, F. (1997) Studies of Epilobium angustifolium extracts on growth of accessory sexual organs in rats. J. Ethnopharmacol. 55: 179-183
15. Hiermann, A., Juan, H., Sametz, W. (1986) Influence of Epilobium extracts on prostaglandin biosynthesis and carrageenin induced oedema of the rat paw. J. Ethnopharmacol. 17: 161-169
16. Hryb, D. J., Khan, M. S., Romas, N. A., Rosner, W. (1994) The effect of extracts of the roots of stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes. Planta Med. 61: 31-32
17. Iehle, C., Delos, S., Guirou, O., Tate, R., Raynaud, J. P., Martin, P. M. (1995) Human prostatic steroid 5α-reductase isoform - A comparative study of selective inhibitors. J. Steroid Biochem. Mol. Biol. 54: 273-279
18. Jonler, M., Riehmann, M., Brinkmann,. R., Bruskewitz, R. C. (1994) Benign prostatic hyperplasia. Endocrinol. Metab. Clin. North Am. 23: 795-807
19. Juan, H., Sametz, W., Hiermann, A. (1988) Anti-inflammatory effects of a substance extracted from Epilobium angustifolium. Agents Actions 23: 106-107
20. Kampa, M., Hatzoglou, A., Notas, G., Damianaki, A., Bakogeorgou, E., Gemetzi, C., Kouroumalis, E., Martin P. M., Castanas, E. (2000) Wine antioxidant polyphenols inhibit the proliferation of human prostate cancer cell lines. Nutr. Cancer 37: 223-233
21. Kirby, R. S. (1997) Medical therapy for benign prostatic hyperplasia: The road ahead. Br. J. Urol. 79: 92-96
22. Kirby, R. S. (2000) The natural history of benign prostatic hyperplasia: What have we learned in the last decade? Urology 56: 3-6
23. Knowles, L. M., Zigrossi, D. A., Taubert, R. A., Hightower, C., Milner, J. A. (2000) Flavonoids suppress androgen-independent human prostate tumor proliferation. Nutr. Cancer 38: 116-122
24. Konrad, L., Muller, H. H., Lenz, C., Laubinger, H., Aumuller, G., Lichius, J. J. (2000) Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Med. 66: 44-47
25. Lesuisse, D., Berjonneau, J., Ciot, C., Devaux, P., Doucet, B., Gourvest, J. F., Khemis, B., Lang, C., Legrand, R., Lowinski, M., Maquin, P., Parent, A., Schoot, B., Teutsch, G. (1996) Determination of Oenothein B as the active 5-α-reductase-inhibiting principle of the folk medicine Epilobium parviflorum. J. Nat. Prod. 59: 490-492
26. Lowe, F. C., Fagelman, E. (1999) Phytotherapy in the treatment of benign prostatic hyperplasia: An update. Urology 53: 671-678
27. Lowe, F. C., Fagelman, E. (2002) Phytotherapy in the treatment of benign prostatic hyperplasia. Curr. Opin. Urol. 12: 15-18
28. Medina, J., Parra, R. O., Moore, R. G. (1999) Benign prostatic hyperplasia (the aging prostate). Med. Clin. North Am. 83: 1213-1229
29. Miyamoto, K., Murayama, T., Nomura, M., Hatano, T., Yoshida, T., Furukawa, T., Koshiura, R., Okuda, T. (1993) Antitumor activity and interleukin-1 induction by tannins. Anticancer Res. 13: 37-42
30. Patterson, M. K. (1979) Measurement of growth and viability of cells in culture. In: Jacoby, W. J., Pastan, I. H. (eds) Methods in Enzymology. Vol. LVIII, Academic Press, New York, pp 141-152
31. Paubert-Braquet, M., Cave, A., Hocquemiller, R., Delacroix, D., Dupont Hedef, N., Borgeat, P. (1994) Effect of Pygeum africanum extract on A23187 stimulated production of lipoxygenase metabolites from human polymorphonuclear cells. J. Lipid Mediat. Cell Signal. 9: 285-290
32. Paubert-Braquet, M., Cousse, H., Raynaud, J. P., Mencia-Huerta, J. M., Braquet, P. (1998) Effect of the lipidosterolic extract of Serenoa repens (Permixon) and its major components on a basic fibroblast growth factor-induced proliferation of cultures of human prostate biopsies. Eur. Urol. 33: 340-347
33. Rabinovitch, P. S., Kubbies, M., Chen, Y. C., Schindler, D., Hoehn, H. (1988) BrdU-Hoechst flow cytometry: A unique tool for quantitative cell cycle analysis. Exp. Cell Res. 174: 309-318
34. Ravenna, L., Di Silverio, F., Russo, M. A., Salvatori, L., Morgante, E., Morrone, S., Cardillo, M. R., Russo, A., Frati, L., Gulino, A., Pietrangeli, E. (1996) Effects of the lipidosterolic extract of Serenoa repens (Permixon) on human prostatic cell lines. Prostate 29: 219-230
35. Romijn, J. C., Verkoelen, C. F., Schroeder, F. H. (1988) Application of the MTT assay to human prostate cancer cell lines in vitro: Establishment of test conditions and assessment of hormone-stimulated growth and drug-induced cytostatic and cytotoxic effects. Prostate 12: 99-110
36. Rosenberg Zand, R. S., Jenkins, D. J., Diamandis, E. P. (2001) Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin. Chim. Acta 312: 213-219
37. Slacanin, I., Marston, A., Hostettmann, K. (1991) Isolation and determination of flavonol glycosides from Epilobium species. J. Chromatogr. 557: 391-398
38. Tita, B., Abdel-Haq, H., Vitalone, A., Mazzanti, G., Saso, L. (2001) Analgesic properties of Epilobium angustifolium, evaluated by the hot plate test and the writhing test. Farmaco 56: 341-343
39. Vacherot, F., Azzouz, M., Gil-Diez-De-Medina, S., Colombel, M., De La Taille, A., Lefrere Belda, M. A., Abbou, C. C., Raynaud, J. P., Chopin, D. K. (2000) Induction of apoptosis and inhibition of proliferation by the lipido-sterolic extract of Serenoa Repens (LSESr, Permixon) in benign prostatic hyperplasia. Prostate 45: 259-266
40. Van Hellemont, J. (1986) Compendium de Phytothérapie. Association pharmaceutique Belge, Brussels, pp 143-144
41. Vitalone, A., Bordi, F., Baldazzi, C., Mazzanti, G., Saso, L., Tita, B. (2001) Anti-proliferative effect on a prostatic epithelial cell line (PZ-HPV-7) by Epilobium angustifolium L. Farmaco 56: 483-489
42. Wang, C. C., Chen, L. C., Yang, L. L. (1999) Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia. Cancer Lett. 140: 195-200
43. Weijerman, P. C., König, J. J., Wong, S. T., Niesters, H. G., Peehl, D. M. (1994) Lipofection-mediated immortalization of human prostatic epithelial cells of normal and malignant origin using human papillomavirus type 18. Cancer Res. 54: 5579-5583
44. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., Greenberg, M. E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331
45. Yablonsky, F., Nicolas, V., Riffaud, J. P., Bellamy, F. (1997) Antiproliferative effect of Pygeum africanum on rat prostatic fibroblasts. J. Urol. 157: 2381-2387