Murine local lymph node assay: An alternative test method for skin hypersensitivity testing

Lab Animal

Volumn 31, Issue 7, 2002, Pages 36-41

  Sailstad, Denise M ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCOMPATIBILITY; BIOSAFETY; CLINICAL PROTOCOL; COST; EVALUATION; LOCAL LYMPH NODE ASSAY; MEDICAL DOCUMENTATION; MOUSE; NONHUMAN; REGULATORY MECHANISM; REVIEW; SKIN ALLERGY; SKIN TEST; STATISTICAL ANALYSIS;

ANIMAL TESTING ALTERNATIVES; ANIMALS; BIOLOGICAL ASSAY; DERMATITIS, ALLERGIC CONTACT; DRUG HYPERSENSITIVITY; GUINEA PIGS; HUMANS; LYMPH NODES; MICE; SKIN TESTS;

MURINAE;

EID: 0038718452     PISSN: 00937355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (34)

1. Klecak, G. in Dermatotoxicology 5th edn (eds Marzulli, F.N. & Maibach, H.I.) 437-459 (Taylor & Francis, Washington, DC, 1996).
2. Organisation for Economic Cooperation and Development. Skin Sensitization. OECD Guidelines for Testing of Chemicals, No. 406 (OECD, Paris, 1993).
3. Stokes, W.S. & Hill, R.N. The role of ICCVAM in evaluating new and alternative test methods. Lab Anim. (NY) 31, 26-32 (2002).
4. Sailstad, D.M., Hattan, D., Hill, R.N. & Stokes, W.S. ICCVAM evaluation of the Murine Local Lymph Node Assay. The ICCVAM review process. Regul. Toxicol. Pharmacol. 34, 249-257 (2001).
5. Interagency Coordinating Committee on the Validation of Alternative Methods. The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds. NIH Publication 99-4494 (National Institute of Environmental Health Sciences, Research Triangle Park, NC, 1999).
6. Interagency Coordinating Committee on the Validation of Alternative Methods. Validation and Regulatory Acceptance of Toxicological Test Methods: A Report of the ad hoc Interagency Coordinating Committee on the Validation of Alternative Methods. NIH Publication 97-3981 (National Institute of Environmental Health Sciences, Research Triangle Park, NC, 1997)
7. Sailstad, D., Hattan, D., Hill, R. & Stokes, W. in Progress in the Reduction, Refinement and Replacement of Animal Experimentation (eds Balls, M., van Zeller, A.-M. & Halder, M.E.) 425-433 (Elsevier, Amsterdam, The Netherlands, 2000).
8. Selgrade, M.J.K., Germolec, D.R., Luebke, R.W., Smialowicz, R.J., Ward, M.D. & Sailstad, D.M. in Introduction to Biochemical Toxicology 3rd edn (eds Hodgson, E. & Smart, R.C.) 597-561 (Wiley, New York, NY, 2001).
9. Kimber, I. & Dearman, R.J. in Toxicology of Contact Hypersensitivity (eds Kimber I. & Maurer, T.) 4-25 (Taylor and Francis, London, UK, 1996).
10. Grabbe, S. & Schwarz, T. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol. Today 19, 37-44 (1998).
11. Klecak, G. in Dermatotoxicology 5th edn (eds Marzulli, F.N. & Maibach, H.I.) 437-459 (Taylor & Francis, Washington, DC, 1996).
12. Dean, J.H., Twerdok, L.E., Tice, R.R., Sailstad, D.M., Hattan, D.G. & Stokes, W.S. ICCVAM evaluation of the murine local lymph node assay. Conclusions and recommendations of an independent scientific peer review panel. Regul. Toxicol. Pharmacol. 34, 258-273 (2001).
13. ICCVAM website: http://iccvam.niehs.nih.gov.
14. Basketter, D.A, Evans P., Fielder, R.J., Dearman, R.J. & Kimber, I. Local lymph node assay- validation conduct and use in practice: a commentary. Food Chem. Toxicol. 40, 593-598 (2002).
15. Kimber, I. & Basketter, D.A. The murine local lymph node assay: a commentary on collaborative studies and new direction. Food Chem. Toxicol. 30, 165-169 (1992).
16. Kimber, I., Dearman, R.J., Scholes, E.W. & Basketter, D.A. The local lymph node assay: developments and applications Toxicology 93, 13-31 (1994).
17. Kimber, I. et al. The murine local lymph node assay: results of an inter-laboratory trial. Toxicol. Lett. 55, 203-213 (1991).
18. Kimber, I. et al. An international evaluation of the murine local lymph node assay and comparison of modified procedures. Toxicology 103, 63-73 (1995).
19. Loveless, S.E. et al. Further evaluation of the local lymph node assay in the final phase of an international collaborative trial. Toxicology 108, 141-152 (1996).
20. Basketter, D.A. et al. Interlaboratory evaluation of the local lymph node assay with 25 chemicals and comparison with guinea pig test data. Toxicol. Methods 1, 30-43 (1991).
21. Stokes, W. & Hill, R. in Progress in the Reduction, Refinement and Replacement of Animal Experimentation (eds Balls, M., van Zeller, A.-M. & Halder, M.E.) 385-395 (Elsevier, Amsterdam, The Netherlands, 2000).
22. Haneke, K.E., Tice, R.R., Carson, B.L., Margolin, B.H. & Stokes, W.S. ICCVAM evaluation of the murine local lymph node assay. Data analyses completed by the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods. Regul. Toxicol. Pharmacol. 34, 274-286 (2001).
23. Organisation for Economic Cooperation and Development. Draft test Guidelines for the local lymph node assay. Guideline 429 Proposal (OECD, Paris, 2000).
24. Blaikie, L., Basketter, D.A., Warbrick, E.V., Dearman, R.J. & Kimber, I. Utility of the LLNA for investigation of impact of vehicle matrix on sensitization potency. Toxicol. Sci. 54, 121 (2000).
25. Lea, L.J., Warbrick, E.V., Dearman, R.J., Harvey, P., Kimber, I. & Basketter, D.A. The impact of vehicle on assessment of relative skin sensitization potency of 1,4-dihydroquinone in the local lymph node assay. Food Chem. Toxicol. 10, 213-218 (1999).
26. Warbrick, E.V., Dearman, R.J., Basketter, D.A., & Kimber, I. Failure of vehicle matrix to influence local lymph node assay responses in benzocaine. Contact Dermatitis 42, 164-165 (2000).
27. Basketter, D.A., Gerberick, G.F. & Kimber, I. Skin sensitization, vehicle effects and the local lymph node assay. Food Chem. Toxicol. 39, 621-627 (2001).
28. Dearman, R.J., Hilton, J., Evans, P., Harvey, P., Basketter, D.A. & Kimber, I. Temporal stability of local lymph node assay responses to hexyl cinnamic aldehyde. J. Appl. Toxicol. 18, 281-284 (1998).
29. Dearman, R.J., Wright, Z.M., Basketter, D.A., Ryan, C.A., Gerberick, G.F. & Kimber, I. The suitability of hexyl cinnamic aldehyde as a calibrant for the murine local lymph node assay. Contact Dermatitis 44, 357-361 (2001).
30. Woolhiser, M.R., Munson, A.E. & Meade, B.J. Comparison of mouse strains using the local lymph node assay. Toxicology 146, 221-227 (2000).
31. Takeyoshi, M., Yamasaki, K., Yakabe, Y., Takatsuki, M. & Kimber, I. Development of non-radioisotopic endpoint of murine local lymph node assay based on 5-bromo-2′-deoxyuridine (BrdU) incorporation. Toxicol. Lett. 119, 203-208 (2001).
32. Kimber, I. et al. Skin sensitization testing in potency and risk assessment. Toxicol. Sci. 59, 198-208 (2001).
33. Basketter, D.A. et al. Use of the local lymph node assay for the estimation of relative contact allergenic potency. Contact Dermatitis 43, 344-348 (2000).
34. Gerberick G.F. & Robinson, M.K. A skin sensitization risk assessment approach for evaluation of new ingredients and products, Am. J. Contact Dermat. 11, 65-73 (2000).