-
1
-
-
0035892597
-
-
For selected recent reviews in this area, see: Sohail M. Drug Disc. Today. 6:2001;1260 Dean N.M. Curr. Opin. Biotechnol. 12:2001;622 Crooke S.T. Oncogene. 19:2000;6651 Green D.W., Roh H., Pippin J., Drebin J.A. J. Am. Coll. Surg. 191:2000;93 Koller E., Gaarde W.A., Monia B.P. Trends Pharmacol. Sci. 21:2000;142 Sanghvi, Y. S. Comprehensive Natural Products Chemistry. Editor-in-chief: Barton, D. H. R.; Nakanishi, K. In DNA and Aspects of Molecular Biology; Kool, E. T., Ed.; Academic: 1999; Vol.7, p 258.
-
(2001)
Drug Disc. Today
, vol.6
, pp. 1260
-
-
Sohail, M.1
-
2
-
-
0035709416
-
-
For selected recent reviews in this area, see: Sohail M. Drug Disc. Today. 6:2001;1260 Dean N.M. Curr. Opin. Biotechnol. 12:2001;622 Crooke S.T. Oncogene. 19:2000;6651 Green D.W., Roh H., Pippin J., Drebin J.A. J. Am. Coll. Surg. 191:2000;93 Koller E., Gaarde W.A., Monia B.P. Trends Pharmacol. Sci. 21:2000;142 Sanghvi, Y. S. Comprehensive Natural Products Chemistry. Editor-in-chief: Barton, D. H. R.; Nakanishi, K. In DNA and Aspects of Molecular Biology; Kool, E. T., Ed.; Academic: 1999; Vol.7, p 258.
-
(2001)
Curr. Opin. Biotechnol.
, vol.12
, pp. 622
-
-
Dean, N.M.1
-
3
-
-
0034722899
-
-
For selected recent reviews in this area, see: Sohail M. Drug Disc. Today. 6:2001;1260 Dean N.M. Curr. Opin. Biotechnol. 12:2001;622 Crooke S.T. Oncogene. 19:2000;6651 Green D.W., Roh H., Pippin J., Drebin J.A. J. Am. Coll. Surg. 191:2000;93 Koller E., Gaarde W.A., Monia B.P. Trends Pharmacol. Sci. 21:2000;142 Sanghvi, Y. S. Comprehensive Natural Products Chemistry. Editor-in-chief: Barton, D. H. R.; Nakanishi, K. In DNA and Aspects of Molecular Biology; Kool, E. T., Ed.; Academic: 1999; Vol.7, p 258.
-
(2000)
Oncogene
, vol.19
, pp. 6651
-
-
Crooke, S.T.1
-
4
-
-
0033919203
-
-
For selected recent reviews in this area, see: Sohail M. Drug Disc. Today. 6:2001;1260 Dean N.M. Curr. Opin. Biotechnol. 12:2001;622 Crooke S.T. Oncogene. 19:2000;6651 Green D.W., Roh H., Pippin J., Drebin J.A. J. Am. Coll. Surg. 191:2000;93 Koller E., Gaarde W.A., Monia B.P. Trends Pharmacol. Sci. 21:2000;142 Sanghvi, Y. S. Comprehensive Natural Products Chemistry. Editor-in-chief: Barton, D. H. R.; Nakanishi, K. In DNA and Aspects of Molecular Biology; Kool, E. T., Ed.; Academic: 1999; Vol.7, p 258.
-
(2000)
J. Am. Coll. Surg.
, vol.191
, pp. 93
-
-
Green, D.W.1
Roh, H.2
Pippin, J.3
Drebin, J.A.4
-
5
-
-
0034176085
-
-
For selected recent reviews in this area, see: Sohail M. Drug Disc. Today. 6:2001;1260 Dean N.M. Curr. Opin. Biotechnol. 12:2001;622 Crooke S.T. Oncogene. 19:2000;6651 Green D.W., Roh H., Pippin J., Drebin J.A. J. Am. Coll. Surg. 191:2000;93 Koller E., Gaarde W.A., Monia B.P. Trends Pharmacol. Sci. 21:2000;142 Sanghvi, Y. S. Comprehensive Natural Products Chemistry. Editor-in-chief: Barton, D. H. R.; Nakanishi, K. In DNA and Aspects of Molecular Biology; Kool, E. T., Ed.; Academic: 1999; Vol.7, p 258.
-
(2000)
Trends Pharmacol. Sci.
, vol.21
, pp. 142
-
-
Koller, E.1
Gaarde, W.A.2
Monia, B.P.3
-
6
-
-
0000926938
-
Comprehensive Natural Products Chemistry
-
Editor-in-chief: Barton, D. H. R.; Nakanishi, K. Kool, E. T., Ed.; Academic
-
For selected recent reviews in this area, see: Sohail M. Drug Disc. Today. 6:2001;1260 Dean N.M. Curr. Opin. Biotechnol. 12:2001;622 Crooke S.T. Oncogene. 19:2000;6651 Green D.W., Roh H., Pippin J., Drebin J.A. J. Am. Coll. Surg. 191:2000;93 Koller E., Gaarde W.A., Monia B.P. Trends Pharmacol. Sci. 21:2000;142 Sanghvi, Y. S. Comprehensive Natural Products Chemistry. Editor-in-chief: Barton, D. H. R.; Nakanishi, K. In DNA and Aspects of Molecular Biology; Kool, E. T., Ed.; Academic: 1999; Vol.7, p 258.
-
(1999)
DNA and Aspects of Molecular Biology
, vol.7
, pp. 258
-
-
Sanghvi, Y.S.1
-
8
-
-
85031184636
-
-
The first generation of antisense nucleosides refers to modifications of the phosphodiester backbone by replacing the equatorial oxygen with a sulfur, whereas second generation refers to the modification of sugar in addition to the backbone.
-
-
-
-
9
-
-
0028858581
-
-
Beigelman L., McSwiggen J.A., Draper K.G., Gonzalez C., Jensen K., Karpeisky A.M., Modak A.S., Matulic-Admic J., DiRenzo A.B., Haeberli P., Sweedler D., Tracz D., Grimm S., Wincott F.E., Thackray V.G., Usman N. J. Biol. Chem. 270:1995;25702.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 25702
-
-
Beigelman, L.1
McSwiggen, J.A.2
Draper, K.G.3
Gonzalez, C.4
Jensen, K.5
Karpeisky, A.M.6
Modak, A.S.7
Matulic-Admic, J.8
DiRenzo, A.B.9
Haeberli, P.10
Sweedler, D.11
Tracz, D.12
Grimm, S.13
Wincott, F.E.14
Thackray, V.G.15
Usman, N.16
-
10
-
-
0034681342
-
-
For a recent account on 2′-O-methylation of guanosine and adenosine, see:
-
For a recent account on 2′-O-methylation of guanosine and adenosine, see: Beigelman L., Haeberli P., Sweedler D., Karpeisky A. Tetrahedron. 56:2000;1047.
-
(2000)
Tetrahedron
, vol.56
, pp. 1047
-
-
Beigelman, L.1
Haeberli, P.2
Sweedler, D.3
Karpeisky, A.4
-
11
-
-
37049091070
-
-
Direct methylation of purine nucleosides has been considered but its synthetic use is limited, due to the low regioselectivity of alkylation. For selected references on this topic, see: Yamauchi K., Nakagima T., Kinoshita M. J. Chem. Soc., Perkin Trans 1. 1980;2787 Yamauchi K., Nakagima T., Kinoshita M. J. Org. Chem. 45:1980;3865 Pettit G.R., Yamauchi K., Einck J.L. Synth. Commun. 10:1980;25. For a comprehensive analysis of this issue, see ref 5.
-
(1980)
J. Chem. Soc., Perkin Trans 1
, pp. 2787
-
-
Yamauchi, K.1
Nakagima, T.2
Kinoshita, M.3
-
12
-
-
0010615689
-
-
Direct methylation of purine nucleosides has been considered but its synthetic use is limited, due to the low regioselectivity of alkylation. For selected references on this topic, see: Yamauchi K., Nakagima T., Kinoshita M. J. Chem. Soc., Perkin Trans 1. 1980;2787 Yamauchi K., Nakagima T., Kinoshita M. J. Org. Chem. 45:1980;3865 Pettit G.R., Yamauchi K., Einck J.L. Synth. Commun. 10:1980;25. For a comprehensive analysis of this issue, see ref 5.
-
(1980)
J. Org. Chem.
, vol.45
, pp. 3865
-
-
Yamauchi, K.1
Nakagima, T.2
Kinoshita, M.3
-
13
-
-
0010542247
-
-
Direct methylation of purine nucleosides has been considered but its synthetic use is limited, due to the low regioselectivity of alkylation. For selected references on this topic, see: For a comprehensive analysis of this issue, see ref 5
-
Direct methylation of purine nucleosides has been considered but its synthetic use is limited, due to the low regioselectivity of alkylation. For selected references on this topic, see: Yamauchi K., Nakagima T., Kinoshita M. J. Chem. Soc., Perkin Trans 1. 1980;2787 Yamauchi K., Nakagima T., Kinoshita M. J. Org. Chem. 45:1980;3865 Pettit G.R., Yamauchi K., Einck J.L. Synth. Commun. 10:1980;25. For a comprehensive analysis of this issue, see ref 5.
-
(1980)
Synth. Commun.
, vol.10
, pp. 25
-
-
Pettit, G.R.1
Yamauchi, K.2
Einck, J.L.3
-
14
-
-
33748631069
-
-
Grotli M., Douglas M., Beijer B., Garcia R.G., Eritja R., Sproat B. J. Chem. Soc., Perkin Trans. 1. 1997;2779 Gundlach C. W., IV, Ryder T.R., Glick G.D. Tetrahedron Lett. 38:1997;4039.
-
(1997)
J. Chem. Soc., Perkin Trans. 1
, pp. 2779
-
-
Grotli, M.1
Douglas, M.2
Beijer, B.3
Garcia, R.G.4
Eritja, R.5
Sproat, B.6
-
15
-
-
0030920045
-
-
Grotli M., Douglas M., Beijer B., Garcia R.G., Eritja R., Sproat B. J. Chem. Soc., Perkin Trans. 1. 1997;2779 Gundlach C. W., IV, Ryder T.R., Glick G.D. Tetrahedron Lett. 38:1997;4039.
-
(1997)
Tetrahedron Lett.
, vol.38
, pp. 4039
-
-
Gundlach C.W. IV1
Ryder, T.R.2
Glick, G.D.3
-
16
-
-
0016403838
-
-
Robins M.J., Naik S.R., Lee A.S.K. J. Org. Chem. 39:1974;1891 Robins M.J., Hansske F., Bernier S.E. Can. J. Chem. 59:1981;3360 Cramer H., Pfeiderer W. Helv. Chim. Acta. 79:1996;2114 Leonard T.E., Bhan P., Miller P.S. Nucleosides Nucleotides. 11:1992;1201.
-
(1974)
J. Org. Chem.
, vol.39
, pp. 1891
-
-
Robins, M.J.1
Naik, S.R.2
Lee, A.S.K.3
-
17
-
-
0000427302
-
-
Robins M.J., Naik S.R., Lee A.S.K. J. Org. Chem. 39:1974;1891 Robins M.J., Hansske F., Bernier S.E. Can. J. Chem. 59:1981;3360 Cramer H., Pfeiderer W. Helv. Chim. Acta. 79:1996;2114 Leonard T.E., Bhan P., Miller P.S. Nucleosides Nucleotides. 11:1992;1201.
-
(1981)
Can. J. Chem.
, vol.59
, pp. 3360
-
-
Robins, M.J.1
Hansske, F.2
Bernier, S.E.3
-
18
-
-
0029856489
-
-
Robins M.J., Naik S.R., Lee A.S.K. J. Org. Chem. 39:1974;1891 Robins M.J., Hansske F., Bernier S.E. Can. J. Chem. 59:1981;3360 Cramer H., Pfeiderer W. Helv. Chim. Acta. 79:1996;2114 Leonard T.E., Bhan P., Miller P.S. Nucleosides Nucleotides. 11:1992;1201.
-
(1996)
Helv. Chim. Acta
, vol.79
, pp. 2114
-
-
Cramer, H.1
Pfeiderer, W.2
-
19
-
-
0026754425
-
-
Robins M.J., Naik S.R., Lee A.S.K. J. Org. Chem. 39:1974;1891 Robins M.J., Hansske F., Bernier S.E. Can. J. Chem. 59:1981;3360 Cramer H., Pfeiderer W. Helv. Chim. Acta. 79:1996;2114 Leonard T.E., Bhan P., Miller P.S. Nucleosides Nucleotides. 11:1992;1201.
-
(1992)
Nucleosides Nucleotides
, vol.11
, pp. 1201
-
-
Leonard, T.E.1
Bhan, P.2
Miller, P.S.3
-
20
-
-
0025943951
-
-
Wagner E., Oberhauser B., Holzner A., Brunar H., Issakides G., Schaffner G., Cotton M., Knollmueller M., Noe C.R. Nucleic Acids Res. 19:1991;5965 Yano J., Kan L.S., Ts'o P.O.P. Biochem. Biophys. Acta. 629:1980;178.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 5965
-
-
Wagner, E.1
Oberhauser, B.2
Holzner, A.3
Brunar, H.4
Issakides, G.5
Schaffner, G.6
Cotton, M.7
Knollmueller, M.8
Noe, C.R.9
-
21
-
-
0019327471
-
-
Wagner E., Oberhauser B., Holzner A., Brunar H., Issakides G., Schaffner G., Cotton M., Knollmueller M., Noe C.R. Nucleic Acids Res. 19:1991;5965 Yano J., Kan L.S., Ts'o P.O.P. Biochem. Biophys. Acta. 629:1980;178.
-
(1980)
Biochem. Biophys. Acta
, vol.629
, pp. 178
-
-
Yano, J.1
Kan, L.S.2
Ts'o, P.O.P.3
-
22
-
-
0023651145
-
-
Inoue H., Hayase Y., Imura A., Iwai S., Miura K., Ohtsuka E. Nucleic Acids Res. 15:1987;6131 Hodge R.P., Sinha N.D. Tetrahedron Lett. 36:1995;2933.
-
(1987)
Nucleic Acids Res.
, vol.15
, pp. 6131
-
-
Inoue, H.1
Hayase, Y.2
Imura, A.3
Iwai, S.4
Miura, K.5
Ohtsuka, E.6
-
23
-
-
0028960429
-
-
Inoue H., Hayase Y., Imura A., Iwai S., Miura K., Ohtsuka E. Nucleic Acids Res. 15:1987;6131 Hodge R.P., Sinha N.D. Tetrahedron Lett. 36:1995;2933.
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 2933
-
-
Hodge, R.P.1
Sinha, N.D.2
-
25
-
-
0028955750
-
-
Wada T., Tobe M., Nagayama T., Furusawa K., Sekine M. Tetrahedron Lett. 36:1995;1683.
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 1683
-
-
Wada, T.1
Tobe, M.2
Nagayama, T.3
Furusawa, K.4
Sekine, M.5
-
26
-
-
0025174080
-
-
Sproat B.S., Beijer B., Iribarren A. Nucleic Acids Res. 18:1990;41 Grotli M., Douglas M., Beijer B., Eritja R., Sproat B. Bioorg. Med. Chem. Lett. 7:1997;425.
-
(1990)
Nucleic Acids Res.
, vol.18
, pp. 41
-
-
Sproat, B.S.1
Beijer, B.2
Iribarren, A.3
-
27
-
-
0031576816
-
-
Sproat B.S., Beijer B., Iribarren A. Nucleic Acids Res. 18:1990;41 Grotli M., Douglas M., Beijer B., Eritja R., Sproat B. Bioorg. Med. Chem. Lett. 7:1997;425.
-
(1997)
Bioorg. Med. Chem. Lett.
, vol.7
, pp. 425
-
-
Grotli, M.1
Douglas, M.2
Beijer, B.3
Eritja, R.4
Sproat, B.5
-
28
-
-
85031189210
-
-
2′-O-Alkyl purine nucleosides can be prepared by coupling a protected purine base to an alkylated sugar, but these procedures add to the number of steps in a synthesis and can result in undesirable isomers.
-
-
-
-
30
-
-
0002452792
-
-
For selected recent references in the area of reactivity of pentacoordinated silicon, see: Holmes R.R. Chem. Rev. 90:1990;17 Corriu R.J.P., Guerin C., Henner B.J.L., Wong Chi Man W.W.C. Organomet. 7:1988;237 Schinzer D. Org. Synth. Highlights II. 1995;123 Corriu R.J.P. Organosilicon Chem. 1994;157 Chuit C., Corriu R.J.P., Reye C., Young J.C. Chem. Rev. 93:1993;1371 Hosomi A. Rev. Heteroatom. Chem. 7:1992;214.
-
(1990)
Chem. Rev.
, vol.90
, pp. 17
-
-
Holmes, R.R.1
-
31
-
-
0001586928
-
-
For selected recent references in the area of reactivity of pentacoordinated silicon, see: Holmes R.R. Chem. Rev. 90:1990;17 Corriu R.J.P., Guerin C., Henner B.J.L., Wong Chi Man W.W.C. Organomet. 7:1988;237 Schinzer D. Org. Synth. Highlights II. 1995;123 Corriu R.J.P. Organosilicon Chem. 1994;157 Chuit C., Corriu R.J.P., Reye C., Young J.C. Chem. Rev. 93:1993;1371 Hosomi A. Rev. Heteroatom. Chem. 7:1992;214.
-
(1988)
Organomet.
, vol.7
, pp. 237
-
-
Corriu, R.J.P.1
Guerin, C.2
Henner, B.J.L.3
Wong Chi Man, W.W.C.4
-
32
-
-
0037527325
-
-
For selected recent references in the area of reactivity of pentacoordinated silicon, see: Holmes R.R. Chem. Rev. 90:1990;17 Corriu R.J.P., Guerin C., Henner B.J.L., Wong Chi Man W.W.C. Organomet. 7:1988;237 Schinzer D. Org. Synth. Highlights II. 1995;123 Corriu R.J.P. Organosilicon Chem. 1994;157 Chuit C., Corriu R.J.P., Reye C., Young J.C. Chem. Rev. 93:1993;1371 Hosomi A. Rev. Heteroatom. Chem. 7:1992;214.
-
(1995)
Org. Synth. Highlights II
, pp. 123
-
-
Schinzer, D.1
-
33
-
-
0037864961
-
-
For selected recent references in the area of reactivity of pentacoordinated silicon, see: Holmes R.R. Chem. Rev. 90:1990;17 Corriu R.J.P., Guerin C., Henner B.J.L., Wong Chi Man W.W.C. Organomet. 7:1988;237 Schinzer D. Org. Synth. Highlights II. 1995;123 Corriu R.J.P. Organosilicon Chem. 1994;157 Chuit C., Corriu R.J.P., Reye C., Young J.C. Chem. Rev. 93:1993;1371 Hosomi A. Rev. Heteroatom. Chem. 7:1992;214.
-
(1994)
Organosilicon Chem.
, pp. 157
-
-
Corriu, R.J.P.1
-
34
-
-
0001214450
-
-
For selected recent references in the area of reactivity of pentacoordinated silicon, see: Holmes R.R. Chem. Rev. 90:1990;17 Corriu R.J.P., Guerin C., Henner B.J.L., Wong Chi Man W.W.C. Organomet. 7:1988;237 Schinzer D. Org. Synth. Highlights II. 1995;123 Corriu R.J.P. Organosilicon Chem. 1994;157 Chuit C., Corriu R.J.P., Reye C., Young J.C. Chem. Rev. 93:1993;1371 Hosomi A. Rev. Heteroatom. Chem. 7:1992;214.
-
(1993)
Chem. Rev.
, vol.93
, pp. 1371
-
-
Chuit, C.1
Corriu, R.J.P.2
Reye, C.3
Young, J.C.4
-
35
-
-
0000053475
-
-
For selected recent references in the area of reactivity of pentacoordinated silicon, see:
-
For selected recent references in the area of reactivity of pentacoordinated silicon, see: Holmes R.R. Chem. Rev. 90:1990;17 Corriu R.J.P., Guerin C., Henner B.J.L., Wong Chi Man W.W.C. Organomet. 7:1988;237 Schinzer D. Org. Synth. Highlights II. 1995;123 Corriu R.J.P. Organosilicon Chem. 1994;157 Chuit C., Corriu R.J.P., Reye C., Young J.C. Chem. Rev. 93:1993;1371 Hosomi A. Rev. Heteroatom. Chem. 7:1992;214.
-
(1992)
Rev. Heteroatom. Chem.
, vol.7
, pp. 214
-
-
Hosomi, A.1
-
36
-
-
85031182912
-
-
The effects of different bases (pyridine, imidazole, triethylamine and lutidine) and temperature (0-70 °C) for the protection of 3 were investigated. Among them, imidazole was found to produce the best results.
-
-
-
-
37
-
-
85031187755
-
-
1-alkylated product 7.
-
-
-
-
38
-
-
85031191228
-
-
+) 560.2695, found 560.2688.
-
-
-
-
39
-
-
85031182317
-
-
6-TMS ether. The latter compound is known to be hydrolytically ustable and upon extraction gives rise to the free nucleobase. See also refs 7 and 13 on this topic.
-
-
-
-
40
-
-
0031880848
-
-
For relevant references on this topic, see: Zhang Z.-H., Li T.-S., Yang F., Fu C.-G. Synth. Commun. 28:1998;3105 Langer S.H., Connell S., Wender I. J. Org. Chem. 23:1958;50 Sweeley C.C., Bentley R., Makita M., Wells W.W. J. Am. Chem. Soc. 85:1963;2497 Bruynes C.A., Jurriens T.K. J. Org. Chem. 47:1982;3966.
-
(1998)
Synth. Commun.
, vol.28
, pp. 3105
-
-
Zhang, Z.-H.1
Li, T.-S.2
Yang, F.3
Fu, C.-G.4
-
41
-
-
33845310727
-
-
For relevant references on this topic, see: Zhang Z.-H., Li T.-S., Yang F., Fu C.-G. Synth. Commun. 28:1998;3105 Langer S.H., Connell S., Wender I. J. Org. Chem. 23:1958;50 Sweeley C.C., Bentley R., Makita M., Wells W.W. J. Am. Chem. Soc. 85:1963;2497 Bruynes C.A., Jurriens T.K. J. Org. Chem. 47:1982;3966.
-
(1958)
J. Org. Chem.
, vol.23
, pp. 50
-
-
Langer, S.H.1
Connell, S.2
Wender, I.3
-
42
-
-
33947487166
-
-
For relevant references on this topic, see: Zhang Z.-H., Li T.-S., Yang F., Fu C.-G. Synth. Commun. 28:1998;3105 Langer S.H., Connell S., Wender I. J. Org. Chem. 23:1958;50 Sweeley C.C., Bentley R., Makita M., Wells W.W. J. Am. Chem. Soc. 85:1963;2497 Bruynes C.A., Jurriens T.K. J. Org. Chem. 47:1982;3966.
-
(1963)
J. Am. Chem. Soc.
, vol.85
, pp. 2497
-
-
Sweeley, C.C.1
Bentley, R.2
Makita, M.3
Wells, W.W.4
-
43
-
-
33845553922
-
-
For relevant references on this topic, see:
-
For relevant references on this topic, see: Zhang Z.-H., Li T.-S., Yang F., Fu C.-G. Synth. Commun. 28:1998;3105 Langer S.H., Connell S., Wender I. J. Org. Chem. 23:1958;50 Sweeley C.C., Bentley R., Makita M., Wells W.W. J. Am. Chem. Soc. 85:1963;2497 Bruynes C.A., Jurriens T.K. J. Org. Chem. 47:1982;3966.
-
(1982)
J. Org. Chem.
, vol.47
, pp. 3966
-
-
Bruynes, C.A.1
Jurriens, T.K.2
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