Lack of interaction of digoxin and P-glycoprotein inhibitors, quinidine and verapamil in human placenta in vitro

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 109, Issue 2, 2003, Pages 133-137

  Holcberg, Gershon ^a   Sapir, Olga ^a   Tsadkin, Marina ^a,b   Huleihel, Mahmoud ^a   Lazer, Simcha ^a   Katz, Miriam ^a   Mazor, Moshe ^a   Ben Zvi, Zvi ^b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Digoxin interaction; Human perfusion system; Human placenta

Indexed keywords

ALBUMIN; DIGOXIN; GLUCOSE; PHENAZONE; QUINIDINE; VERAPAMIL;

ARTICLE; BLOOD FLOW VELOCITY; CALCULATION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG TISSUE LEVEL; DRUG TRANSPORT; FEMALE; FETUS CIRCULATION; FLUORESCENCE POLARIZATION IMMUNOASSAY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MATERNAL BLOOD; PLACENTA; PLACENTAL TRANSFER; PRIORITY JOURNAL; TISSUE PERFUSION;

EID: 0038691604     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-2115(02)00513-4     Document Type: Article

References (29)

1. Harrigan J.T., Kangos J.I., Sikka A., Spisso K., Natarajan N., Rosenfeld D.et al. Successful treatment of fetal congestive heart failure secondary to tachycardia. New Engl. J. Med. 304:1981;1527-1529.
2. Wiggins J.W. Jr., Bowes W., Clewell W., Manco-Johnson M., Manchester D., Johnson R.et al. Echocardiographic diagnosis and intravenous digoxin management of fetal tachyarrhythmias and congestive heart failure. Am. J. Dis. Child. 140:1986;202-204.
3. Ito S., Magee L., Smallhorn J. Drug therapy for fetal arrhythmias. Clin. Perinatol. 21:1994;543-572.
4. Pacifici G.M., Nattoli R. Placental transfer of drugs administered to the mother. Clin. Pharmacokinet. 28:1995;235-269.
5. Nakamura Y., Ikeda S., Furukawa T., Sumizawa T., Tani A., Akiyama S.et al. Function of P-glycoprotein expressed in placenta and mole. Biochem. Biophys. Res. Commun. 235:1997;849-853.
6. Lankas G.R., Wise L.D., Cartwright M.E., Pippert T., Umbenhauer D.R. Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice. Reprod. Toxicol. 12:1998;457-463.
7. Ushigome F., Takanaga H., Matsuo H., Yanai S., Tsukimori K., Nakano H.et al. Human placental transport of vinblastine, vincristine, digoxin and progesterone: contribution of P-glycoprotein. Eur. J. Pharmacol. 408:2000;1-10.
8. Tanigawara Y., Okamura N., Hiray M., Yasuhara M., Ueda K., Kioka N.et al. Transport of digoxin by human P-glycoprotein expressed in porcine kidney epithelial cell line (LLC-PK1). J. Pharmacol. Exp. Ther. 263:1992;841-846.
9. Fromm M.F., Kim R.B., Stein M., Wilkinson G.R., Roden D.M. Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine. Circulation. 99:1999;552-557.
10. Su S.F., Huang J.D. Inhibition of the intestinal digoxin absorption and exsorption by quinidine. Drug Metab. Dispos. 24:1996;42-147.
11. Mungall D.R., Robichaux R.P., Perry W., Skott J.W., Robinson A., Burelle T.et al. Effects of quinidine on serum digoxin concentration: a prospective study. Ann. Int. Med. 93:1980;9-693.
12. Pedersen K.E., Dorf-Pedersen A., Hvidt S., Klitgaard N.A., Nielsen-Kudsk F. Digoxin-verapamil interaction. Clin. Pharmacol. Ther. 30:1981;311-316.
13. Hori R., Okamura N., Aiba T., Tanigawa Y. Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney. J. Pharmacol. Exp. Ther. 266:1993;1620-1625.
14. Yu D.S., Sun G.H., Ma C.P., Chang S.Y. Verapamil modulation of multidrug resistance in renal cell carcinoma. J. Formos. Med. Assoc. 99:2000;311-316.
15. Verschraagen M., Koks C.H.W., Schellens J.H.M., Beijnen J.H. P-glycoprotein system as a determinant of drug interactions: the case of digoxin-verapamil. Pharmacol. Res. 40:1999;301-306.
16. Holcberg G, Sapir O, Huleihel M, Katz M, Tsadkin M, Wiznizer A, et al. Transfer of quinidine, a P-glycoprotein inhibitor, across the isolated human placenta. Am J Obstet Gynecol 2000;182:S193 [abstract].
17. Schneider H., Huch A. Dual in vitro perfusion of an isolated lobe of human placenta: method and instrumentation. Contrib. Gynecol. Obstet. 13:1985;40-47.
18. Koren G. Clinical pharmacokinetic significance of the renal tubular secretion of digoxin. Clin. Pharmacokinet. 13:1987;334-343.
19. Schneider H., Panigel M., Dancis J. Transfer across the human placenta of antipyrine, sodium and leucine. Am. J. Obstet. Gynecol. 144:1972;822-828.
20. Di Grande A., Boura A.L., Read M.A., Malatino L.S., Walters W.A. Release of substance from the human placenta having digoxin-like immunoreactivity. Clin. Exp. Pharmacol. Physiol. 20:1993;603-607.
21. Audus K.L. Controlling drug delivery across the placenta. Eur. J. Pharm. Sci. 8:1999;161-165.
22. Woodland C., Ito S., Koren G. A model for prediction of digoxin-drug interactions at the renal tubular cell level. Ther. Drug Monit. 20:1998;134-138.
23. Derewlany L.O., Leeder J.S., Kumar R., Radde I.C., Knie B., Koren G. The transport of digoxin across the perfused human placental lobule. J. Pharmacol. Exp. Ther. 256:1991;1107-1111.
24. Paul T., Bertram H., Bokenkamp R., Hausdorf G. Supraventricular tachycardia in infants, children and adolescents: diagnosis, and pharmacological and interventional therapy. Pediat. Drugs. 2:2000;171-181.
25. Cordon-Cardo C., O'Brien P., Boccia J., Casals D., Bertino J.R., Melamed M.R. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J. Histochem. Cytochem. 38:1990;1277-1287.
26. MacFarland A., Abramovich D.R., Ewen S.W.B., Pearson C.K. Stage-specific distribution of P-glycoprotein in first trimester and full-term human placenta. Histochem. J. 26:1994;417-423.
27. Cormet-Boyaka E., Huneau J.F., Mordrelle A., Boyaka P.N., Carbon C., Rubinstein E.et al. Secretion of sparfloxacin from the human intestinal Caco-2 cell line is altered by P-glycoprotein inhibitors. Antimicrob. Agents Chemother. 42:1998;2607-2611.
28. Meynard P.V., Stein P.E., Symonds E.M. Umbilical cord plasma progesterone at term in relation to mode of delivery. Br. J. Obstet. Gynecol. 87:1980;864-868.
29. Cudeville R., Mondon F.M., Robert B., Rebourcet R., Mignot T., Benassayag C.et al. Evidence for progesterone receptors in human fetoplacental vascular tree. Biol. Reprod. 62:2000;759-765.