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Volumn 28, Issue 1, 1998, Pages 1-13

Metabolism of Meloxicam in human liver involves cytochromes P4502C9 and 3A4

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME; CYTOCHROME P450; KETOCONAZOLE; MELOXICAM; NIFEDIPINE; OXIDOREDUCTASE; OXYGENASE; TOLBUTAMIDE;

EID: 0031985363     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982598239704     Document Type: Article
Times cited : (118)

References (29)
  • 1
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • BRADFORD, M., 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72, 248-254.
    • (1976) Analytical Biochemistry , vol.72 , pp. 248-254
    • Bradford, M.1
  • 3
    • 0022263133 scopus 로고
    • Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism
    • DISLERATH, L. M., REILLY, P. E., MARTIN, M. V., DAVIS, G. G., WILKINSON, G. R. and GUENGERICH, F. P., 1985, Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism. Journal of Biological Chemistry, 260, 9057-9067.
    • (1985) Journal of Biological Chemistry , vol.260 , pp. 9057-9067
    • Dislerath, L.M.1    Reilly, P.E.2    Martin, M.V.3    Davis, G.G.4    Wilkinson, G.R.5    Guengerich, F.P.6
  • 4
    • 0030061289 scopus 로고
    • Meloxican: Influence on arachidonic acid metabolism. Part II: In vivo findings
    • ENGELHARDT, G., BÖGEL, R., SCHNITZLER, C. and UTZMANN, R., 1995a, Meloxican: influence on arachidonic acid metabolism. Part II: In vivo findings. Biochemical Pharmacology, 51, 21-38.
    • (1995) Biochemical Pharmacology , vol.51 , pp. 21-38
    • Engelhardt, G.1    Bögel, R.2    Schnitzler, C.3    Utzmann, R.4
  • 5
    • 0028860983 scopus 로고
    • Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance
    • ENGELHARDT, G., HOMMA, D., SCHLEGEL, K., UTZMANN, R. and SCHNITZLER, C., 1995b, Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance. Inflammation Research, 44, 423-433.
    • (1995) Inflammation Research , vol.44 , pp. 423-433
    • Engelhardt, G.1    Homma, D.2    Schlegel, K.3    Utzmann, R.4    Schnitzler, C.5
  • 6
    • 0028590127 scopus 로고
    • Biochemistry and molecular biology of the human CYP2C subfamily
    • GOLSTEIN, J. A. and DE MORAIS, S. M. F., 1994, Biochemistry and molecular biology of the human CYP2C subfamily. Pharmacogenetics, 4, 285-299.
    • (1994) Pharmacogenetics , vol.4 , pp. 285-299
    • Golstein, J.A.1    De Morais, S.M.F.2
  • 7
    • 0022998708 scopus 로고
    • Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
    • GUENGERICH, F. P., MARTIN, M. V., BEAUNE, P. H., KREMERS, P., WOLF, T. and WAXMAN, D. J., 1986, Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. Journal of Biological Chemistry, 261, 5051-5060.
    • (1986) Journal of Biological Chemistry , vol.261 , pp. 5051-5060
    • Guengerich, F.P.1    Martin, M.V.2    Beaune, P.H.3    Kremers, P.4    Wolf, T.5    Waxman, D.J.6
  • 8
    • 0003054992 scopus 로고
    • Methods for preparation of adult and fetal hepatocytes
    • edited by A. Guillouzo and C. Guguen-Guillouzo (Paris and London: INSERM and John Libbey Eurotext)
    • GUGUEN-GUILLOUZO, C. and GUILLOUZO, A., 1986, Methods for preparation of adult and fetal hepatocytes. In Isolated and Cultured Hepatocytes, edited by A. Guillouzo and C. Guguen-Guillouzo (Paris and London: INSERM and John Libbey Eurotext), pp. 1-12.
    • (1986) Isolated and Cultured Hepatocytes , pp. 1-12
    • Guguen-Guillouzo, C.1    Guillouzo, A.2
  • 9
    • 0002636550 scopus 로고    scopus 로고
    • Xenobiotic metabolism in epithelial cell cultures
    • edited by A. J. Shaw (Oxford: IRL)
    • GUILLOUZO, A. and CHESNE, C., 1996, Xenobiotic metabolism in epithelial cell cultures.. In Epithelial Cell Culture: A Practical Approach, edited by A. J. Shaw (Oxford: IRL), pp. 67-85.
    • (1996) Epithelial Cell Culture: A Practical Approach , pp. 67-85
    • Guillouzo, A.1    Chesne, C.2
  • 10
    • 0029868836 scopus 로고    scopus 로고
    • Meloxicam in osteoarthritis: A 6-month double blind comparison with diclofenac sodium
    • HOSIE, J., DISTEL, M. and BLUHMKI, E., 1996, Meloxicam in osteoarthritis: a 6-month double blind comparison with diclofenac sodium. British Journal of Rheumatology, 35 (suppl 1), 39-13.
    • (1996) British Journal of Rheumatology , vol.35 , Issue.1 SUPPL. , pp. 39-113
    • Hosie, J.1    Distel, M.2    Bluhmki, E.3
  • 11
  • 12
    • 0021253492 scopus 로고
    • An alternative 7-ethoxyresorufin O-deethylase activity assay: A continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity
    • KLOTZ, A. V., STEGEMAN, J. J. and WALSH, C., 1984, An alternative 7-ethoxyresorufin O-deethylase activity assay: a continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity. Analytical Biochemistry, 140, 138-145.
    • (1984) Analytical Biochemistry , vol.140 , pp. 138-145
    • Klotz, A.V.1    Stegeman, J.J.2    Walsh, C.3
  • 13
    • 0022494453 scopus 로고
    • Hydroxylation of p-nitrophenol by rabbit ethanol inducible cytochrome P-450 isozyme IIIa
    • KOOP, D. R., 1986, Hydroxylation of p-nitrophenol by rabbit ethanol inducible cytochrome P-450 isozyme IIIa. Molecular Pharmacology, 29, 399-404.
    • (1986) Molecular Pharmacology , vol.29 , pp. 399-404
    • Koop, D.R.1
  • 14
    • 0023258883 scopus 로고
    • High-performance liquid chromatographic assays for bufuralol 1-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver
    • KRONBACH, T., MATHYS, D., GUT, J., CATIN, T. and MEYER, U. A., 1987, High-performance liquid chromatographic assays for bufuralol 1-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver. Analytical Biochemistry, 162, 24-32.
    • (1987) Analytical Biochemistry , vol.162 , pp. 24-32
    • Kronbach, T.1    Mathys, D.2    Gut, J.3    Catin, T.4    Meyer, U.A.5
  • 17
    • 0030056594 scopus 로고    scopus 로고
    • Specificity of substrate and inhibitor probes for cytochromes P450s: Evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes
    • ONO, S., HATANAKA, T., HOTTA, H., SATOH, T., GONAZALEZ, F. J. and TSUTSUI, T., 1996, Specificity of substrate and inhibitor probes for cytochromes P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes. Xenobiotica, 26, 681-693.
    • (1996) Xenobiotica , vol.26 , pp. 681-693
    • Ono, S.1    Hatanaka, T.2    Hotta, H.3    Satoh, T.4    Gonazalez, F.J.5    Tsutsui, T.6
  • 18
    • 0029870733 scopus 로고    scopus 로고
    • A double blind three-week study to compare the efficacy and safety of meloxicam 7.5 mg and meloxicam 15 mg in patients with rheumatoid arthritis
    • REGINSTER, J. Y., DISTEL, M. and BLUHMKI, E., 1996, A double blind three-week study to compare the efficacy and safety of meloxicam 7.5 mg and meloxicam 15 mg in patients with rheumatoid arthritis. British Journal of Rheumatology, 35 (Suppl 1), 17-21.
    • (1996) British Journal of Rheumatology , vol.35 , Issue.1 SUPPL. , pp. 17-21
    • Reginster, J.Y.1    Distel, M.2    Bluhmki, E.3
  • 20
    • 0025763625 scopus 로고
    • Cloning and expression of complementary DNAs for multiple members of the human cytochrome P-450IIC
    • ROMKES, M., FALETTO, M. B., BLAISDELL, J. A., RAUCY, J. L. and GOLDSTEIN, J. A., 1991, Cloning and expression of complementary DNAs for multiple members of the human cytochrome P-450IIC. Biochemistry, 30, 3247-3255.
    • (1991) Biochemistry , vol.30 , pp. 3247-3255
    • Romkes, M.1    Faletto, M.B.2    Blaisdell, J.A.3    Raucy, J.L.4    Goldstein, J.A.5
  • 21
    • 0028805121 scopus 로고
    • Meloxicam: Metabolic profile and biotransformation products in the rat
    • SCHMID, J., BUSCH., U., TRUMMLITZ, G., PROX, A., KASCHKE, S. and WACHSMUTH, H., 1995a, Meloxicam: metabolic profile and biotransformation products in the rat. Xenobiotica, 25, 1219-1236.
    • (1995) Xenobiotica , vol.25 , pp. 1219-1236
    • Schmid, J.1    Busch, U.2    Trummlitz, G.3    Prox, A.4    Kaschke, S.5    Wachsmuth, H.6
  • 22
    • 0029397306 scopus 로고
    • Meloxicam: Pharmacokinetics and metabolic pattern after intravenous infusion and oral administration to healthy subjects
    • SCHMID, J., BUSCH, U., HEINZEL, G., BOZLER, G., KASCHKE, S. and KUMMER, M., 1995b, Meloxicam: pharmacokinetics and metabolic pattern after intravenous infusion and oral administration to healthy subjects. Drug Metabolism and Disposition, 23, 1206-1213.
    • (1995) Drug Metabolism and Disposition , vol.23 , pp. 1206-1213
    • Schmid, J.1    Busch, U.2    Heinzel, G.3    Bozler, G.4    Kaschke, S.5    Kummer, M.6
  • 23
    • 0344778346 scopus 로고
    • HPLC-procedure for drug metabolism studies: The potential of column switching
    • edited by D. J. Benford, J. W. Bridges and C. G. Gibson (London: Taylor & Francis)
    • SCHMID, J. and ROTH, W., 1987, HPLC-procedure for drug metabolism studies: the potential of column switching. In Drug Metabolism, From Molecules to Man, edited by D. J. Benford, J. W. Bridges and C. G. Gibson (London: Taylor & Francis), pp. 213-216.
    • (1987) Drug Metabolism, from Molecules to Man , pp. 213-216
    • Schmid, J.1    Roth, W.2
  • 25
    • 0022574425 scopus 로고
    • Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism
    • SHIMADA, T., MISONO, S. K. and GUENGERICH, F. P., 1986. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Journal of Biological Chemistry, 261, 909-921.
    • (1986) Journal of Biological Chemistry , vol.261 , pp. 909-921
    • Shimada, T.1    Misono, S.K.2    Guengerich, F.P.3
  • 29
    • 0026696993 scopus 로고
    • In vitro oxidation of oxicam NSAIDs by a human liver cytochrome P-450
    • ZHAO, J., LEEMANN, T. and DAYER, P., 1992, In vitro oxidation of oxicam NSAIDs by a human liver cytochrome P-450. Life Sciences, 51, 575-581.
    • (1992) Life Sciences , vol.51 , pp. 575-581
    • Zhao, J.1    Leemann, T.2    Dayer, P.3


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