Deuterium NMR tissue perfusion measurements using the tracer uptake approach: II. Comparison with microspheres in tumors

Magnetic Resonance in Medicine

Volumn 42, Issue 2, 1999, Pages 240-247

  Simpson, Nicholas E ^a,c   Evelhoch, Jeffrey L ^a,b,d  

^a WAYNE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY HOSPITAL   (United States)

^d HARPER UNIVERSITY HOSPITAL   (United States)

Author keywords

Deuterium NMR; Microspheres; Perfusion; Tumor blood flow

Indexed keywords

DEUTERIUM; MICROSPHERES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TRACERS; TUMORS;

ARTERIAL INPUT FUNCTION; DEUTERIUM NMR; INTRAVENOUS INJECTIONS; NUCLEAR MAGNETIC RESONANCE(NMR); PERFUSION; QUANTITATIVE MEASUREMENT; STUDENT'S T TESTS; TUMOR BLOOD FLOWS;

NUCLEAR MAGNETIC RESONANCE;

DEUTERIUM OXIDE; MICROSPHERE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; TISSUE PERFUSION; TUMOR; TUMOR BLOOD FLOW;

EID: 0032866249     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1522-2594(199908)42:2<240::AID-MRM5>3.0.CO;2-8     Document Type: Article

References (41)

1. Denekamp J. The current status of targeting tumour vasculature as a means of cancer therapy: an overview. Int J Radiat Biol 1991;60:401-408.
2. Malik AB, Kaplan JE, Saba TM. Reference sample method for cardiac output and regional blood flow determinations in the rat. J Appl Physiol 1976;40:472-475.
3. Jirtle R, Clifton KH, Rankin JH. Measurement of mammary tumor blood flow in unanesthetized rats. J Natl Cancer Inst 1978;60:881-886.
4. Jirtle RL. Blood flow to lymphatic metastases in conscious rats. Eur J Cancer 1981;17:53-60.
5. Panther LA, Baumbach GL, Bigner DD, Piegors D, Groothuis DR, Heistad DD. Vasoactive drugs produce selective changes in flow to experimental brain tumors. Ann Neurol 1985;18:712-715.
6. Hasegawa T, Song CW. Effect of hydralazine on the blood flow in tumors and normal tissues in rats. Int J Radiat Oncol Biol Phys 1991;20:1001-1007.
7. Nah BS, Choi IB, Oh WY, Osborn JL, Song CW. Vascular thermal adaptation in tumors and normal tissue in rats. Int J Radiat Oncol Biol Phys 1996;35:95-101.
8. 2O as a freely diffusible tracer. Proc Natl Acad Sci USA 1987;84:4099-4102.
9. Mattiello J, Evelhoch JL. Relative volume-average murine tumor blood flow measurement via deuterium nuclear magnetic resonance spectroscopy. Magn Reson Med 1991;18:320-334.
10. Kety SS. Measurement of regional circulation by the local clearance of radioactive sodium. Am Heart J 1949;38:321-328.
11. Kety SS. Theory and application of the exchange of inert gas at the lungs and tissues. Pharmacol Rev 1951:3:1-41.
12. 31P NMR in vivo. II. Validation of the deuterium NMR washout method for measuring organ perfusion. Magn Reson Med 1992;25:56-66.
13. 2O clearance measurements of tumor blood flow in mice. Cancer Res 1990;50:363-369.
14. Less JR, Skalak TC, Sevick EM, Jain RK. Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. Cancer Res 1991;51:265-273.
15. Konderding MA, Steinberg F, Budach V. The vascular system of xenotransplanted tumors - scanning electron and light microscopic studies. Scanning Microsc 1989;3:327-335; discussion 335-326.
16. Jain RK. Determinants of tumor blood flow: a review. Cancer Res 1988;48:2641-2658.
17. Mattson J, Appelgren L, Hamberger B, Peterson H-I. Tumor vessel innervation and influence of vasoactive drugs on tumor blood flow. In: Peterson HI, editor. Tumor blood circulation. Boca Raton, FL: CRC Press; 1979. p 129-135.
18. Simpson NE, He Z, Evelhoch JL. Deuterium NMR tissue perfusion measurements using the tracer uptake approach: I. Optimization of methods. Mag Reson Med 1999;42:42-52.
19. Schmidek HH, Nielsen SL, Schiller AL, Messer J. Morphological studies of rat brain tumors induced by N-nitrosomethylurea. J Neurosurg 1971;34:335-340.
20. Ng TC, Glickson JD. Shielded solenoidal probe for in vivo NMR studies of solid tumors. Magn Reson Med 1985;2:169-175.
21. 1H NMR signals with receiver coils tuned for other nuclides. J Magn Reson 1981;42:498-500.
22. Thulborn KR, Ackerman JJH. Absolute molar concentrations by NMR in inhomogeneous B1: a scheme for analysis of in vivo metabolites. J Magn Reson 1983;55:357-371.
23. Simpson NE. Absolute tumor perfusion determined by nuclear magnetic resonance spectroscopy: optimization and comparison of a deuterium uptake method. Ph.D. dissertation, Wayne State University, 1997.
24. Evelhoch JL, McDouall JB, Mattiello J, Simpson NE. Measurement of relative regional tumor blood flow in mice by deuterium NMR imaging. Magn Reson Med 1992;24:42-52.
25. Tuma RF, Vasthare US, Irion GL, Wiedeman MP. Considerations in use of microspheres for flow measurements in anesthetized rat. Am J Physiol 1986;250:H137-143.
26. Levine BA, Sirinek KR, Gaskill HVd. The radiolabeled microsphere technique in gut blood flow measurement - current practice. J Surg Res 1984;37:241-255.
27. Heymann MA, Payne BD, Hoffman JI, Rudolph AM. Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis 1977;20:55-79.
28. Glenny RW, Bernard S, Brinkley M. Validation of fluorescent-labeled microspheres for measurement of regional organ perfusion. J Appl Physiol 1993;74:2585-2597.
29. Abel FL, Cooper RH, Beck RR. Use of fluorescent latex microspheres to measure coronary blood flow distribution. Circ Shock 1993;41:156-161.
30. Mimran A, Casellas D. Microsphere size and determination of intrarenal blood flow distribution in the rat. Pflugers Arch Eur J Physiol 1979;382:233-240.
31. Sabto J, Bankir L, Grunfeld JP. The measurement of glomerular blood flow in the rat kidney: influence of microsphere size. Clin Exp Pharmacol Physiol 1978;5:559-565.
32. Buckberg GD, Luck JC, Payne DB, Hoffman JI, Archie JP, Fixler DE. Some sources of error in measuring regional blood flow with radioactive microspheres. J Appl Physiol 1971;31:598-604.
33. Zar JH. Simple linear correlation. In: Biostatistical analysis. Englewood Cliffs, NJ: Prentice Hall; 1984. p 306-327.
34. Song CW, Rhee JG, Levitt SH. Blood flow in normal tissues and tumors during hyperthermia.J Natl Cancer Inst 1980;64:119-124.
35. Wilke AV, Ausmus PL, Frazier DL. Reduced Adriamycin concentration in rat mammary tumors treated previously with hyperthermia. Radiat Res 1993;135:278-280.
36. Trevor AJ, Miller RD. General anesthetics. In: Katzung, BG, editor. Basic and clinical pharmacology. San Mateo, CA: Appleton & Lange; 1989. p 304-314.
37. Ikeda K, Nara Y, Yamori Y. Indirect systolic and mean blood pressure determination by a new tail cuff method in spontaneously hypertensive rats. Lab Anim 1991;25:26-29.
38. Steen RG, Kromhout-Schiro S, Graham MM. Relationship of perfusion to edema in the 9L gliosarcoma. J Neurooncol 1993;16:81-87.
39. Larcombe-McDouall JB, Mattiello J, McCoy CL, Simpson NE, Seyedsadr M, Evelhoch JL. Size dependence of regional blood flow in murine tumours using deuterium magnetic resonance imaging. Int J Radiat Biol 1991;60:109-113.
40. 125I washout. J Appl Physiol 1971;31:38-47.
41. Brown BW, Hales JR, Mattner PE. Capillary blood flow in sheep ovaries, measured by iodoantipyrine and microsphere techniques. Experientia 1974;30:914-915.