Prediction of in vivo tissue distribution from in vitro data. 2. Influence of albumin diffusion from tissue pieces during an in vitro incubation on estimated tissue-to-unbound plasma partition coefficients (Kpu)

Pharmaceutical Research

Volumn 20, Issue 6, 2003, Pages 857-863

  Ballard, Peter ^a   Arundel, Philip A ^a   Leahy, David E ^b   Rowland, Malcolm ^c  

^a ASTRAZENECA   (United Kingdom)

^b CYPROTEX DISCOVERY LTD   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Albumin; Diffusion; In vitro in vivo; Protein binding; Tissue distribution

Indexed keywords

ALBUMIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DIFFUSION; IN VITRO STUDY; IN VIVO STUDY; MALE; MATHEMATICAL MODEL; NONHUMAN; PARTITION COEFFICIENT; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; RAT; TISSUE DISTRIBUTION;

ALBUMINS; ALGORITHMS; ANIMALS; CHEMISTRY, PHYSICAL; CULTURE TECHNIQUES; DIFFUSION; EXTRACELLULAR SPACE; INDICATORS AND REAGENTS; KIDNEY; LIVER; MALE; MODELS, STATISTICAL; PROTEIN BINDING; RATS; RATS, WISTAR; SERUM ALBUMIN, RADIO-IODINATED;

EID: 0037986156     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023879001294     Document Type: Article

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