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Volumn 31, Issue 2, 2003, Pages 109-116

Insulin resistance and polycystic ovary syndrome;Insulinorésistance et syndrome des ovaires polykystiques

Author keywords

Biguanides; Clomiphene citrate; Insulin resistance; Polycystic ovary syndrome

Indexed keywords

ANDROGEN RELEASE; ANOVULATION; ARTICLE; CARDIOVASCULAR RISK; DIABETES MELLITUS; DOSE RESPONSE; DYSLIPIDEMIA; FEMALE; FERTILITY; HUMAN; HYPERANDROGENISM; HYPERTENSION; INSULIN RESISTANCE; OBESITY; OVARY DISEASE; OVARY FUNCTION; OVARY POLYCYSTIC DISEASE; PATIENT CARE; PREGNANCY COMPLICATION; PROTEIN PHOSPHORYLATION; RANDOMIZATION;

EID: 0038637744     PISSN: 12979589     EISSN: 17696682     Source Type: Journal    
DOI: 10.1016/S1297-9589(03)00009-2     Document Type: Article
Times cited : (10)

References (38)
  • 2
    • 0032525901 scopus 로고    scopus 로고
    • Androgens stimulate early stages of follicular growth in the primate ovary
    • Vendola K, Zhou J, Adesanya OO, Weil SJ, Bondy CA. Androgens stimulate early stages of follicular growth in the primate ovary. J Clin Invest 1998;101:2622-9.
    • (1998) J Clin Invest , vol.101 , pp. 2622-2629
    • Vendola, K.1    Zhou, J.2    Adesanya, O.O.3    Weil, S.J.4    Bondy, C.A.5
  • 3
    • 0030832255 scopus 로고    scopus 로고
    • Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome
    • Gilling-Smith C, et al. Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome. Clin. Endo 1997;47:93-9.
    • (1997) Clin Endo , vol.47 , pp. 93-99
    • Gilling-Smith, C.1
  • 4
    • 0035217099 scopus 로고    scopus 로고
    • The biochemical basis for increase testosterone production in thecal cells propagated from patients with polycystic ovary syndrome
    • Nelson V, Qin Kn KN, Rosenfield RL, Wood JR, Penning TM, Legro R, et al. The biochemical basis for increase testosterone production in thecal cells propagated from patients with polycystic ovary syndrome. J Clin Endocrinol Metab 2001;86:5925-33.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5925-5933
    • Nelson, V.1    Qin Kn, K.N.2    Rosenfield, R.L.3    Wood, J.R.4    Penning, T.M.5    Legro, R.6
  • 5
    • 0036313064 scopus 로고    scopus 로고
    • Developmental origin of polycystic ovary syndrome, a hypothesis
    • Abbott D, Dumesic DA, Francks. Developmental origin of polycystic ovary syndrome, a hypothesis. J Endocrinol 2002;174:1-5.
    • (2002) J Endocrinol , vol.174 , pp. 1-5
    • Abbott, D.1    Dumesic, D.A.2    Francks3
  • 6
    • 0036734026 scopus 로고    scopus 로고
    • Molecular progress in infertility: Polycystic ovary syndrome
    • Legro R, Strauss JF. Molecular progress in infertility: polycystic ovary syndrome. Fertil Steril 2002;78:569-76.
    • (2002) Fertil Steril , vol.78 , pp. 569-576
    • Legro, R.1    Strauss, J.F.2
  • 7
    • 0018906734 scopus 로고
    • Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease
    • Burghen G, Givens J, Kitabchi A. Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. J Clin Endocrinol Metab 1980;50:113-6.
    • (1980) J Clin Endocrinol Metab , vol.50 , pp. 113-116
    • Burghen, G.1    Givens, J.2    Kitabchi, A.3
  • 8
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
    • Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 1997;18:774-800.
    • (1997) Endocr Rev , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 9
    • 0024996150 scopus 로고
    • Insulin-like growth factor-1 enhances luteinizing hormone binding to rat ovarian theca-interstitial cells
    • Cara J, et al. Insulin-like growth factor-1 enhances luteinizing hormone binding to rat ovarian theca-interstitial cells. J Clin Invest 1990;86:560-5.
    • (1990) J Clin Invest , vol.86 , pp. 560-565
    • Cara, J.1
  • 10
    • 0028823250 scopus 로고
    • Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by insulin receptor and not the type-1 insulin-like growth factor receptor
    • Willis D, Franks S. Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by insulin receptor and not the type-1 insulin-like growth factor receptor. J Clin Endocrinol Metab 1995;80:3788-90.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3788-3790
    • Willis, D.1    Franks, S.2
  • 11
    • 0029796476 scopus 로고    scopus 로고
    • Decreases in ovarian cytochrome P450c17 activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome
    • Nestler J, Jakubowicz D. Decreases in ovarian cytochrome P450c17 activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome. N Engl J Med 1996;335:617-23.
    • (1996) N Engl J Med , vol.335 , pp. 617-623
    • Nestler, J.1    Jakubowicz, D.2
  • 12
    • 0031243858 scopus 로고    scopus 로고
    • Insulin regulation of human ovarian androgens
    • Nestler J. Insulin regulation of human ovarian androgens. Hum Reprod 1997;12:53-62.
    • (1997) Hum Reprod , vol.12 , pp. 53-62
    • Nestler, J.1
  • 13
    • 0031787388 scopus 로고    scopus 로고
    • A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome
    • Legro R, Finegood D, Dunaif A. A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1998;83:2694-9.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2694-2699
    • Legro, R.1    Finegood, D.2    Dunaif, A.3
  • 14
    • 0034977315 scopus 로고    scopus 로고
    • Metabolic and steroidogenic alterations related to increased frequency of polycystic ovaries in women with a history of gestational diabetes
    • Koivunen R, et al. Metabolic and steroidogenic alterations related to increased frequency of polycystic ovaries in women with a history of gestational diabetes. J Clin Endocrinol Metab 2001;86:2591-9.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2591-2599
    • Koivunen, R.1
  • 15
    • 0029142760 scopus 로고
    • Restored insulin sensitivity but persistently increase early insulin secretion after weight loss in obese women with polycystic ovarysyndrome
    • Holte J, Bergh T, Berne C, Wide L, Lithell H. Restored insulin sensitivity but persistently increase early insulin secretion after weight loss in obese women with polycystic ovarysyndrome. J Clin Endocrinol Metab 1995;80:2586-93.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2586-2593
    • Holte, J.1    Bergh, T.2    Berne, C.3    Wide, L.4    Lithell, H.5
  • 16
    • 0033766626 scopus 로고    scopus 로고
    • Metabolic lessons from the study of young adolescents with polycystic ovary syndrome is insulin, indeed, the culprit?
    • Oberfield S. Metabolic lessons from the study of young adolescents with polycystic ovary syndrome is insulin, indeed, the culprit? J Clin Endocrinol Metab 2000;85:3520-5.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3520-3525
    • Oberfield, S.1
  • 17
    • 0034748334 scopus 로고    scopus 로고
    • Increased endothelin-1 levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy
    • Diamanti-Kandarakis E, et al. Increased endothelin-1 levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy. J Clin Endocrinol Metab 2001;86:4666-73.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4666-4673
    • Diamanti-Kandarakis, E.1
  • 18
    • 0034880219 scopus 로고    scopus 로고
    • Sensibilization to insulin induces ovulation in nonobese adolescents with anovulatory hyperandrogenism
    • Ibanez L, et al. Sensibilization to insulin induces ovulation in nonobese adolescents with anovulatory hyperandrogenism. J Clin Endocrinol Metab 2001;86:3595-8.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3595-3598
    • Ibanez, L.1
  • 19
    • 0034880066 scopus 로고    scopus 로고
    • Metformin restore normal menses in oligoamenorrheic teenage girls with polycystic ovary syndrome (PCOS)
    • Glueck C, et al. Metformin restore normal menses in oligoamenorrheic teenage girls with polycystic ovary syndrome (PCOS). J Adolesc Health 2001;29:160-9.
    • (2001) J Adolesc Health , vol.29 , pp. 160-169
    • Glueck, C.1
  • 20
    • 0034458234 scopus 로고    scopus 로고
    • Metformin effects on clinical features, endocrine and metabolic profiles and insulin sensitivity in polycystic ovary syndrome: A randomized, double blind, placebo-controlled 6 months trial, followed by open, long-term clinical evaluation
    • Moghetti P, et al. Metformin effects on clinical features, endocrine and metabolic profiles and insulin sensitivity in polycystic ovary syndrome: a randomized, double blind, placebo-controlled 6 months trial, followed by open, long-term clinical evaluation. J Clin Endocrinol Metab 2000;85:139-46.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 139-146
    • Moghetti, P.1
  • 21
    • 0036170744 scopus 로고    scopus 로고
    • Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial
    • Fleming R, et al. Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial. J Clin Endocrinol Metab 2002;87:569-74.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 569-574
    • Fleming, R.1
  • 22
    • 0032565971 scopus 로고    scopus 로고
    • Effects of metformin on spontaneous and clomipheneinduced ovulation in the polycystic ovary syndrome
    • Nestler J, et al. Effects of metformin on spontaneous and clomipheneinduced ovulation in the polycystic ovary syndrome. N Engl J Med 1998;338:1876-80.
    • (1998) N Engl J Med , vol.338 , pp. 1876-1880
    • Nestler, J.1
  • 23
    • 0036153384 scopus 로고    scopus 로고
    • Metformin therapy improves ovulatory rates, cervical score and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome
    • Kocak M, et al. Metformin therapy improves ovulatory rates, cervical score and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome. Fertil Steril 2002;77:101-6.
    • (2002) Fertil Steril , vol.77 , pp. 101-106
    • Kocak, M.1
  • 24
    • 0034888296 scopus 로고    scopus 로고
    • Metformin improves ovulation and pregnancy rates in patients with polycystic ovary syndrome
    • Batukan C, Baysal BBB. Metformin improves ovulation and pregnancy rates in patients with polycystic ovary syndrome. Arch Gynecol Obstet 2001;265:124-7.
    • (2001) Arch Gynecol Obstet , vol.265 , pp. 124-127
    • Batukan, C.1    Baysal, B.B.B.2
  • 25
    • 0035708055 scopus 로고    scopus 로고
    • Insulin resistance in clomiphene responders and non responders with polycystic ovarian disease and therapeutic effects of metformin
    • Parsanezhad M, Alborzi S, Zarei A, Dehbashi S, Omrani G. Insulin resistance in clomiphene responders and non responders with polycystic ovarian disease and therapeutic effects of metformin. Int J Gyn Obstet 2001;75:43-50.
    • (2001) Int J Gyn Obstet , vol.75 , pp. 43-50
    • Parsanezhad, M.1    Alborzi, S.2    Zarei, A.3    Dehbashi, S.4    Omrani, G.5
  • 26
    • 0035145624 scopus 로고    scopus 로고
    • Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone
    • Vandermolen D, Ratts VS, Evans WS, Stovall DW, Kauma SW, Nestler JE. Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. Fertil Steril 2001;75:310-5.
    • (2001) Fertil Steril , vol.75 , pp. 310-315
    • Vandermolen, D.1    Ratts, V.S.2    Evans, W.S.3    Stovall, D.W.4    Kauma, S.W.5    Nestler, J.E.6
  • 27
    • 0035999635 scopus 로고    scopus 로고
    • Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice
    • Sturrock N, Lannon B, Fay TN. Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice. Br J Clin Pharmacol 2002;53:469-73.
    • (2002) Br J Clin Pharmacol , vol.53 , pp. 469-473
    • Sturrock, N.1    Lannon, B.2    Fay, T.N.3
  • 28
    • 0034886493 scopus 로고    scopus 로고
    • Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: A randomized, double-blinded placebo-controlled trial
    • Ng E HPC. Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial. Hum Reprod 2001;16:1625-31.
    • (2001) Hum Reprod , vol.16 , pp. 1625-1631
    • Ng, E.H.P.C.1
  • 29
    • 0033179753 scopus 로고    scopus 로고
    • Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome
    • De Leo V, et al. Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome. Fertil Steril 1999;72.
    • (1999) Fertil Steril , pp. 72
    • De Leo, V.1
  • 30
    • 0036177496 scopus 로고    scopus 로고
    • Co-administration of metformin during rFSH treatment in patients with clomiphene citrate-resistant polycystic ovarian syndrome: A prospective randomized trial
    • Yarali H, et al. Co-administration of metformin during rFSH treatment in patients with clomiphene citrate-resistant polycystic ovarian syndrome: a prospective randomized trial. Hum Reprod 2002;17:289-94.
    • (2002) Hum Reprod , vol.17 , pp. 289-294
    • Yarali, H.1
  • 31
    • 0035112663 scopus 로고    scopus 로고
    • Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-growth factors
    • Stadtmauer L, et al. Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-growth factors. Fertil Steril 2001;75:505-9.
    • (2001) Fertil Steril , vol.75 , pp. 505-509
    • Stadtmauer, L.1
  • 32
    • 0035044332 scopus 로고    scopus 로고
    • Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovarysyndrome
    • Jakubowicz D, et al. Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor- binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovarysyndrome. J Clin Endocrinol Metab 2001;86:1126-33.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1126-1133
    • Jakubowicz, D.1
  • 33
    • 0035168622 scopus 로고    scopus 로고
    • Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: A pilot study
    • Glueck C, et al. Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study. Fertil Steril 2001;75:46-52.
    • (2001) Fertil Steril , vol.75 , pp. 46-52
    • Glueck, C.1
  • 34
    • 0036171653 scopus 로고    scopus 로고
    • Effects of metformin on early pregnancy loss in the polycystic ovarysyndrome
    • Jakubowicz D, et al. Effects of metformin on early pregnancy loss in the polycystic ovarysyndrome. J Clin Endocrinol Metab 2002;87:524-9.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 524-529
    • Jakubowicz, D.1
  • 35
    • 0036851165 scopus 로고    scopus 로고
    • Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin
    • Glueck C, Wang P, Goldenberg N, Sieve-Smith L. Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin. Hum Reprod 2002;17:2858-64.
    • (2002) Hum Reprod , vol.17 , pp. 2858-2864
    • Glueck, C.1    Wang, P.2    Goldenberg, N.3    Sieve-Smith, L.4
  • 36
    • 17744400090 scopus 로고    scopus 로고
    • Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome
    • Pasquali R, et al. Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome. J Clin Endocrinol Metab 2000;85:2767-74.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2767-2774
    • Pasquali, R.1
  • 37
    • 0035041906 scopus 로고    scopus 로고
    • Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: A multicenter, double blind, placebocontrolled trial
    • Azziz R, et al. Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebocontrolled trial. J Clin Endocrinol Metab 2001;86:1232-626.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1232-1626
    • Azziz, R.1
  • 38
    • 0032708106 scopus 로고    scopus 로고
    • High ovulatory rates use of troglitazone in clomiphene-resistant women with polycystic ovary syndrome
    • Mitwally M, Kuscu N, Yalcinkaya T. High ovulatory rates use of troglitazone in clomiphene-resistant women with polycystic ovary syndrome. Hum Reprod 1999;14:2700-3.
    • (1999) Hum Reprod , vol.14 , pp. 2700-2703
    • Mitwally, M.1    Kuscu, N.2    Yalcinkaya, T.3


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