The influence of physico-chemical and process conditions on the physical stability of plasmid DNA complexes using response surface methodology

Biotechnology and Applied Biochemistry

Volumn 37, Issue 3, 2003, Pages 225-234

  Mount, Clare N ^a   Lee, Li K ^a   Yasin, Ahmad ^b   Scott, Andrew ^b   Fearn, Tom ^a   Shamlou, Parviz Ayazi ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Factorial design; Plasmid DNA condensation; Response surface methodology; Therapeutic gene processing

Indexed keywords

DNA; GENES; IONIC STRENGTH; PH EFFECTS; PROTEINS;

MATERIAL FACTORS;

BIOTECHNOLOGY;

PLASMID DNA;

ARTICLE; COMPLEX FORMATION; DNA VECTOR; DRUG CONJUGATION; DRUG MANUFACTURE; DRUG RESEARCH; DRUG SAFETY; DRUG STABILITY; GENE THERAPY; GENETIC DISORDER; GENETIC ENGINEERING; HUMAN; IONIC STRENGTH; NONVIRAL GENE DELIVERY SYSTEM; PH; PHYSICAL CHEMISTRY; SURFACE PROPERTY;

COLLOIDS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DELIVERY SYSTEMS; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; LIPOSOMES; MATERIALS TESTING; PARTICLE SIZE; PLASMIDS; POLYLYSINE; SALTS; STATISTICS;

EID: 0038614932     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20030012     Document Type: Article

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