Response surface methodology as a predictive tool for determining the effects of preparation conditions on the physicochemical properties of poly(isobutylcyanoacrylate) nanoparticles

International Journal of Pharmaceutics

Volumn 193, Issue 1, 1999, Pages 37-47

  McCarron, Paul A ^a   Woolfson, A David ^a   Keating, Siobhán M ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Nanoparticles; Poly(isobutylcyanoacrylate); Response surface methodology; Synperonic; Zeta potential

Indexed keywords

MONOMER; NANOPARTICLE; POLY(ISOBUTYL 2 CYANOACRYLATE);

ARTICLE; DRUG FORMULATION; FACTORIAL ANALYSIS; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SURFACE PROPERTY; ZETA POTENTIAL;

BUCRYLATE; CHEMISTRY, PHARMACEUTICAL; DIFFUSION; HYDROGEN-ION CONCENTRATION; MICROSPHERES; MOLECULAR WEIGHT; PARTICLE SIZE; POLYMERS; REPRODUCIBILITY OF RESULTS; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS;

EID: 0032743871     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00311-7     Document Type: Article

References (17)

1. Armstrong N.A., James K.C. Understanding Experimental Design and Interpretation in Pharmaceutics. 1990;Ellis Horwood, Chichester, UK.
2. Blunk T., Müller R.H. Uptake of charged serum components as selection criterion for i.v. drug carriers avoiding liver/spleen uptake. Arch. Pharm. 322:1989;755.
3. Box G.E.P., Wilson K.B. On the experimental attainment of optimum conditions. J. R. Statist. Soc. 13:1951;1-38.
4. Couvreur P., Dubernet C., Puisieux F. Controlled drug delivery with nanoparticles: current possibilities and future trends. Eur. J. Pharm Biopharm. 41:1995;2-13.
5. Couvreur P., Roblot-Treupel L., Poupon M.F., Brsseur F., Puisieux F. Nanoparticles as microcarriers for anticancer drugs. Adv. Drug Del. Rev. 5:1990;209-230.
6. Douglas S.J., Davis S.S., Illum L. Nanoparticles in drug delivery. Crit. Rev. Ther. Drug Carrier Syst. 3:1987;233-261.
7. Fessi H., Puisieux F., Devissaguet J.P., Ammoury N., Benita S. Nanocapsule formation by interfacial deposition following solvent displacement. Int. J. Pharm. 55:1989;R1-R4.
8. Illum L., Davis S.S. The targeting of drugs parenterally by use of microspheres. J. Parent. Sci. Tech. 36:1982;242.
9. Juliano R.L., Stamp D. The effect of particle size and charge on the clearance rate of liposomes and liposome encapsulated drugs. Biochem. Biophys. Res. Commun. 63:1975;651.
10. Khuri A.I., Cornell J.A. Response Surfaces; Designs and Analyses. 1987;Marcel Dekker, New York.
11. Krause H.J., Schwarz A., Rohdewald P. Interfacial polymerization, a useful method for the preparation of polymethylcyanoacrylate nanoparticles. Drug Dev. Ind. Pharm. 12:1986;527-552.
12. Lescure F., Zimmer C., Roy R., Couveur P. Optimization of poly(alkylcyanoacrylate) nanoparticles: influence of sulphur dioxide and pH on nanoparticles characteristics. J. Colloid Interf. Sci. 154:1992;77-86.
13. Müller R.H., Wallis K.H., Tröster S.D., Kreuter J. In vitro characterization of poly(methyl-methacrylate) nanoparticles and correlation to their in vivo fate. J. Cont. Rel. 20:1992;237-246.
14. Puglisi G., Giammona G., Fresta M., Carlisi B., Micali N., Villari A. Evaluation of polyalkylcyanoacrylate nanoparticles as a potential drug carrier: preparation, morphological characterization and loading capacity. J. Microencapsulation. 10:1993;353-366.
15. Seijo B., Fattal E., Roblot-Treupel L., Couveur P. Design of nanoparticles of less than 50 nm diameter: preparation, characterization and drug loading. Int. J. Pharm. 62:1990;1-7.
16. Vansnick L., Couvreur P., Christiaens-Leyh D., Roland M. Molecular weights of free and drug-loaded nanoparticles. Pharm. Res. 1:1984;36-41.
17. Wilkins D.J., Meyers P.A. Studies on the relationship between the electrophoretic properties of colloids and their blood clearance and organ distribution in the rat. Br. J. Exp. Path. 47:1966;568-571.