Activated and mature CD83-positive dendritic cells and interferon-γ-positive cells in skin eruptions of secondary syphilis

Acta Dermato-Venereologica

Volumn 83, Issue 3, 2003, Pages 214-217

  Koga, Tetsuya ^a   Duan, Hong ^a   Moroi, Yoichi ^a   Urabe, Kazunori ^a   Furue, Masutaka ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

CD83; Dendritic cell; Interferon ; Syphilis

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CD83 ANTIGEN; FORMALDEHYDE; GAMMA INTERFERON; PARAFFIN;

ADULT; ANTIGEN DETECTION; ANTIGEN PRESENTING CELL; ARTICLE; CELL ACTIVATION; CELL CONTACT; CELL FUNCTION; CELL INFILTRATION; CELL INTERACTION; CELL MATURATION; CELL SUBPOPULATION; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; DENDRITIC CELL; DERMIS; ECZEMA; FEMALE; HELPER CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LYMPHOCYTE; LYMPHOID CELL; MACROPHAGE; MALE; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RASH; SECONDARY SYPHILIS; SKIN BIOPSY; TISSUE DISTRIBUTION; TISSUE SECTION; TREPONEMA PALLIDUM;

ANTIGENS, CD; DENDRITIC CELLS; HUMANS; IMMUNOGLOBULINS; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; SKIN; SYPHILIS, CUTANEOUS;

EID: 0038578300     PISSN: 00015555     EISSN: None     Source Type: Journal    
DOI: 10.1080/00015550310007247     Document Type: Article

References (21)

1. Engelkens HJH, ten Kate FJW, Judanarso J, Vuzevski VD, van Lier JBHJ, Godschalk JCJ, et al. The localisation of treponemes and characterisation of the inflammatory infiltrate in skin biopsies from patients with primary or secondary syphilis, or early infectious yaws. Genitourin Med 1993; 69: 102-107.
2. Bjerke JR, Krogh HK, Matre R. In situ identification of mononuclear cells in cutaneous infiltrates in discoid lupus erythematosus, sarcoidosis and secondary syphilis. Acta Derm Venereol 1981; 61: 371-380.
3. Van Voorhis WC, Barrett LK, Nasio JM, Plummer FA, Lukehart SA. Lesions of primary and secondary syphilis contain activated cytolytic T cells. Infect Immun 1996; 64: 1048-1050.
4. Zoechling N, Schluepen EM, Soyer HP, Kerl H, Volkenandt M. Molecular detection of Treponema pallidum in secondary and tertiary syphilis. Br J Dermatol 1997; 136: 683-686.
5. Hart DNJ. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 1997; 90: 3245-3287.
6. Zhou LJ, Tedder TF. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J Immunol 1995; 154: 3821-3835.
7. Reis e Sousa C, Sher A, Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr Opin Immunol 1999; 11: 392-399.
8. Bouis DA, Popova TG, Takashima A, Norgard MV. Dendritic cells phagocytose and are activated by Treponema pallidum. Infect Immun 2001; 69: 518-528.
9. Sellati TJ, Waldrop SL, Salazar JC, Bergstresser PR, Picker LJ, Radolf JD. The cutaneous response in humans to Treponema pallidum lipoprotein analogues involves cellular elements of both innate and adaptive immunity. J Immunol 2001; 166: 4131-4140.
10. Van Voorhis WC, Barrett LK, Koelle DM, Nasio JM, Plummer FA, Lukehart SA. Primary and secondary syphilis lesions contain mRNA for Th1 cytokines. J Infect Dis 1996; 173: 491-495.
11. Arroll TW, Centurion-Lara A, Lukehart SA, Van Voorhis WC. T-cell responses to Treponema pallidum subsp. pallidum antigens during the course of experimental syphilis infection. Infect Immun 1999; 67: 4757-4763.
12. + dendritic cells in granulomas of sporotrichosis. Eur J Dermatol 2001; 11: 527-529.
13. Koga T, Duan H, Urabe K, Furue M. In situ localization of CD83-positive dendritic cells in psoriatic lesions. Dermatology 2002; 204: 100-103.
14. Koga T, Duan H, Urabe K, Furue M. Immunohistochemical detection of interferon-γ-producing cells in dermatophytosis. Eur J Dermatol 2001; 11: 105-107.
15. Kolb-Maurer A, Gentschev I, Fries HW, Fiedler F, Brocker EB, Kampgen E, et al. Listeria monocytogenes-infected human dendritic cells: uptake and host cell response. Infect Immun 2000; 68: 3680-3688.
16. Marovich MA, McDowell MA, Thomas EK, Nutman TB. IL-12p70 production by Leishmania major-harboring human dendritic cells is a CD40/CD40 ligand-dependent process. J Immunol 2000; 164: 5858-5865.
17. McBroom RL, Styles AR, Chiu MJ, Clegg C, Cockerell CJ, Radolf JD. Secondary syphilis in persons infected with and not infected with HIV-1: a comparative immunohistologic study. Am J Dermatopathol 1999; 21: 432-441.
18. Sieling PA, Jullien D, Dahlem M, Tedder TF, Rea TH, Modlin RL, Porcelli SA. CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity. J Immunol 1999; 162: 1851-1858.
19. Radolf JD, Arndt LL, Akins DR, Curetty LL, Levi ME, Shen Y, et al. Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytes/macrophages. J Immunol 1995; 154: 2866-2877.
20. Underhill DM, Ozinsky A, Hajjar AM, Stevens A, Wilson CB, Bassetti M, et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 1999; 401: 811-815.
21. Hertz CJ, Kiertscher SM, Godowski PJ, Bouis DA, Norgard MV, Roth MD, et al. Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2. J Immunol 2001; 166: 2444-2450.