Sex differences in the rate dependence of the T wave descending limb

Cardiovascular Research

Volumn 58, Issue 3, 2003, Pages 549-554

  Smetana, Peter ^a   Batchvarov, Velislav ^a   Hnatkova, Katerina ^a   Camm, A John ^a   Malik, Marek ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Arrhythmia (mechanisms); ECG; Electrophysiology; Gender; Heart rate; Repolarisation

Indexed keywords

ACTION POTENTIAL; ADULT; ARTICLE; AUTOMATION; AVERAGING; CALCULATION; COMPUTER PROGRAM; CONTROLLED STUDY; ELECTROCARDIOGRAM; ELECTROPHYSIOLOGY; FEMALE; HEART CYCLE; HEART RATE; HEART REPOLARIZATION; HEART VENTRICLE WALL; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; MALE; NORMAL HUMAN; OBSERVATION; PRIORITY JOURNAL; QT INTERVAL; RECORDER; RR INTERVAL; SEX DIFFERENCE; T WAVE; TIME;

ADULT; ARRHYTHMIA; ELECTROCARDIOGRAPHY, AMBULATORY; ELECTROPHYSIOLOGY; FEMALE; GENDER IDENTITY; HEART; HEART RATE; HUMANS; MALE; STATISTICS, NONPARAMETRIC;

EID: 0038545664     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(03)00319-5     Document Type: Article

References (30)

1. O'Donnell J., Knoebel S.B., Lovelace D.E., McHenry P.L. Computer quantitation of Q-T and terminal T wave (aT-eT) intervals during exercise: methodology and results in normal men. Am J Cardiol. 47:1981;1168-1172.
2. O'Donnell J., Lovelace D.E., Knoebel S.B., McHenry P.L. Behavior of the terminal T wave during exercise in normal subjects, patients with symptomatic coronary artery disease and apparently healthy subjects with abnormal ST segment depression. J Am Coll Cardiol. 5:1985;78-84.
3. Sicouri S., Antzelevitch C. A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell. Circ Res. 68:1991;1729-1741.
4. Yan G.X., Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation. 98:1998;1928-1936.
5. Anyukhovsky E.P., Sosunov E.A., Rosen M.R. Regional differences in electrophysiological properties of epicardium, midmyocardium, and endocardium. In vitro and in vivo correlations. Circulation. 94:1996;1981-1988.
6. Taggart P., Sutton P.M., Opthof T., et al. Transmural repolarisation in the left ventricle in humans during normoxia and ischaemia. Cardiovasc Res. 50:2001;454-462.
7. Savelieva I., Yap Y.G., Yi G., et al. Relation of ventricular repolarization to cardiac cycle length in normal subjects, hypertrophic cardiomyopathy, and patients with myocardial infarction. Clin Cardiol. 22:1999;649-654.
8. Lubinski A., Kornacewicz-Jach Z., Wnuk-Wojnar A.M., et al. The terminal portion of the T wave: a new electrocardiographic marker of risk of ventricular arrhythmias. Pacing Clin Electrophysiol. 23:2000;1957-1959.
9. Wolk R., Stec S., Kulakowski P. Extrasystolic beats affect transmural electrical dispersion during programmed electrical stimulation. Eur J Clin Invest. 31:2001;293-301.
10. Lubinski A., Lewicka-Nowak E., Kempa M., et al. New insight into repolarization abnormalities in patients with congenital long QT syndrome: the increased transmural dispersion of repolarization. Pacing Clin Electrophysiol. 21:1998;172-175.
11. Merri M., Benhorin J., Alberti M., Locati E., Moss A.J. Electrocardiographic quantitation of ventricular repolarization. Circulation. 80:1989;1301-1308.
12. Antzelevitch C., Shimizu W., Yan G.X., et al. The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart. J Cardiovasc Electrophysiol. 10:1999;1124-1152.
13. Batchvarov V., Yi G., Guo X., et al. QT interval and QT dispersion measured with the threshold method depend on threshold level. Pacing Clin Electrophysiol. 21:1998;2372-2375.
14. Batchvarov V.N., Ghuran A., Smetana P., et al. QT-RR relationship in healthy subjects exhibits substantial intersubject variability and high intrasubject stability. Am J Physiol Heart Circ Physiol. 282:2002;H2356-2363.
15. Bazett H. An analysis of the time-relations of electrocardiograms. Heart. vii:1920;353-370.
16. Stramba-Badiale M., Locati E.H., Martinelli A., Courville J., Schwartz P.J. Gender and the relationship between ventricular repolarization and cardiac cycle length during 24-h Holter recordings. Eur Heart J. 18:1997;1000-1006.
17. Simonson E., Blackburn H., Puchner T.C., Ribeiro F., Meja M. Sex differences in the electrocardiograms. Circulation. 22:1960;598-601.
18. Michaelides A., Ryan J.M., VanFossen D., Pozderac R., Boudoulas H. Exercise-induced QRS prolongation in patients with coronary artery disease: a marker of myocardial ischemia. Am Heart J. 126:1993;1320-1325.
19. Drouin E., Charpentier F., Gauthier C., Laurent K., Le Marec H. Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: evidence for presence of M cells. J Am Coll Cardiol. 26:1995;185-192.
20. Anyukhovsky E.P., Sosunov E.A., Gainullin R.Z., Rosen M.R. The controversial M cell. J Cardiovasc Electrophysiol. 10:1999;244-260.
21. Schatzkin A., Cupples L.A., Heeren T., Morelock S., Kannel W.B. Sudden death in the Framingham Heart Study. Differences in incidence and risk factors by sex and coronary disease status. Am J Epidemiol. 120:1984;888-899.
22. Kawasaki R., Machado C., Reinoehl J., et al. Increased propensity of women to develop torsades de pointes during complete heart block. J Cardiovasc Electrophysiol. 6:1995;1032-1038.
23. Smetana P., Batchvarov V.N., Hnatkova K., Camm A.J., Malik M. Sex differences in repolarization homogeneity and its circadian pattern. Am J Physiol Heart Circ Physiol. 282:2002;H1889-1897.
24. Katz A.M. Cardiac ion channels. New Engl J Med. 328:1993;1244-1251.
25. Drici M.D., Burklow T.R., Haridasse V., Glazer R.I., Woosley R.L. Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart. Circulation. 94:1996;1471-1474.
26. Liu X.K., Katchman A., Drici M.D., et al. Gender difference in the cycle length-dependent QT and potassium currents in rabbits. J Pharmacol Exp Ther. 285:1998;672-679.
27. Pham T.V., Sosunov E.A., Gainullin R.Z., Danilo P. Jr., Rosen M.R. Impact of sex and gonadal steroids on prolongation of ventricular repolarization and arrhythmias induced by I(k)-blocking drugs. Circulation. 103:2001;2207-2212.
28. Trepanier-Boulay V., St-Michel C., Tremblay A., Fiset C. Gender-based differences in cardiac repolarization in mouse ventricle. Circ Res. 89:2001;437-444.
29. Pham T.V., Robinson R.B., Danilo P. Jr., Rosen M.R. Effects of gonadal steroids on gender-related differences in transmural dispersion of L-type calcium current. Cardiovasc Res. 53:2002;752-762.
30. Savelieva I., Yap Y.G., Yi G., et al. Comparative reproducibility of QT, QT peak, and T peak-T end intervals and dispersion in normal subjects, patients with myocardial infarction, and patients with hypertrophic cardiomyopathy. Pacing Clin Electrophysiol. 21:1998;2376-2381.