New selenyl linker for solid-phase synthesis of dehydropeptides

Tetrahedron Letters

Volumn 44, Issue 29, 2003, Pages 5445-5448

  Nakamura, Kazuhiko ^a   Ohnishi, Yuki ^a,c   Horikawa, Eiji ^a,b   Konakahara, Takeo ^b   Kodaka, Masato ^a   Okuno, Hiroaki ^a,d  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c JAPAN ATOMIC ENERGY AGENCY   (Japan)

^d TOHO UNIVERSITY   (Japan)

Author keywords

Dehydropeptide; RGD conjugate; Selenyl linker; Solid phase synthesis

Indexed keywords

CARBOXYLIC ACID; CYANIC ACID DERIVATIVE; PEPTIDE DERIVATIVE; SELENIUM DERIVATIVE; SELENOCYANIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CONJUGATION; SOLID; SYNTHESIS;

EID: 0038539560     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)01309-1     Document Type: Article

References (22)

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16. The detailed reaction mechanism and selectivity will be discussed elsewhere.
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20. 17 indicated very low concentration of remaining reactive amino groups (2.8 μmol/g). Thus, the authors did not carry out any capping reaction, and the following reactions were carried out using this loading amount.
21. The peptide elongation was carried out at 0.03 mmol scale.
22. Using 'extended cycle', Fmoc deprotection 5 min, coupling 60 min.