Latest aspects in psoriasis pathogenesis;Neueste aspekte in der pathogenese der psoriasis

Hautarzt

Volumn 54, Issue 3, 2003, Pages 209-214

  Prinz, Jörg C ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Pathogenesis; Psoriasis vulgaris; Streptococcus pyogenes; T cells

Indexed keywords

CYTOKINE;

ANTIGEN SPECIFICITY; ARTICLE; ENVIRONMENTAL FACTOR; GENETIC PREDISPOSITION; IMMUNE RESPONSE; PATHOGENESIS; PHENOTYPE; PSORIASIS; T LYMPHOCYTE;

EID: 0038539374     PISSN: 00178470     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00105-003-0490-9     Document Type: Article

References (29)

1. Albert LJ, Inman RD (1999) Molecular mimicry and autoimmunity. N Engl J Med 341:2068-2074
2. Asadullah K, Sterry W, Stephanek K et al. (1998) IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach. J Clin Invest 101:783-794
3. Baker BS, Bolith S, Powles AV et al. (1992) Streptococcal antigen-specific T lymphocytes in skin lesions of guttate psoriasis. J Invest Dermatol 98:535-538
4. Casanova JL, Maryanski JL (1993) Antigen-selected T-cell receptor diversity and self-nonself homology. Immunol Today 14:391-394
5. Chang JCC, Smith LR, Froning KJ et al. (1994) CD8+ T cells in psoriatic lesions preferentially use T-cell receptor Vβ3 and/orVβ13.1 genes. Proc Natl Acad Sci USA 91:9282-9286
6. Ellis CN, Krueger GG (2001) Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N Engl J Med;345:248-255
7. Ghoreschi K, Thomas P, Breit S et al. (in press) Interleukin-4 therapy of psoriasis induces TH2 responses and improves human autoimmune disease. Nature Med
8. Gudmundsdottir AS, Sigmundsdottir H, Sigurgeirsson B et al. (1999) Is an epitope on keratin 17 a major target for autoreactive T lymphocytes in psoriasis? Clin Exp Immunol 117:580-586
9. Guedjonsson JE, Karason A, Antonsdottir AA et al. (2002) HLA-Cw6-positive and HLA-Cw6-negative patients with psoriasis vulgaris have distinct clinical features. J Invest Dermatol 118:362-365
10. Henseler T, Christophers E (1985) Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris. J Am Acad Dermatol 13:450-456
11. Mallon E, Bunce M, Savoie H et al. (2000) HLA-C and guttate psoriasis. Br J Dermatol 143:1177-1182
12. Menssen A, Trommler P, Vollmer S et al. (1995) Evidence for an antigen-specific cellular immune response in skin lesions of patients with psoriasis vulgaris. J Immunol 155:4078-4083
13. Nair RP, Henseler T, Jenisch S et al. (1997) Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genomewide scan. Hum Mol Genet 6:1349-1356
14. Nyfors A, Rasmussen PA, Lemholt K, Eriksen B (1975) Improvement of refractory psoriasis vulgaris after tonsillectomy. Dermatologica 151:216-222
15. Prinz JC (2001) Psoriasis vulgaris - a sterile antibacterial skin reaction mediated by cross-reactive T cells? An immunological view of the pathophysiology of psoriasis. Clin Exp Dermatol 26:326-332
16. Prinz JC (in press) The role of T cells in psoriasis. J Eur Ac Derm Venerol
17. Prinz JC, Braun-Falco O, Meurer M et al. (1991) Chimeric CD4 monoclonal antibody in the treatment of generalized pustular psoriasis. Lancet 338:320-321
18. Prinz JC, Gross B, Vollmer S et al. (1994) T cell clones from psoriasis skin lesions can promote keratinocyte proliferation in vitro. Eur J Immunol 24:593-598
19. Prinz JC, Vollmer S, Boehncke WH et al. (1999) Selection of conserved TCR-VDJ-rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris. Eur J Immunol 29:3360-3368
20. Robinson JH, Kehoe MA (1992) Group A streptococcal M proteins: virulence factors and protective antigens. Immunol Today 13:362-367
21. Said Nahal R, Miceli Richard C et al. (2001) Phenotypic diversity is not determined by independent genetic factors in familial spondylarthropathy. Arthritis Rheum 4S:478-484
22. Schmitt Egenolf M, Eiermann TH et al. (1996) Familial juvenile onset psoriasis is associated with the human leukocyte antigen (HLA) class I side of the extended haplotype Cw6-B57-DRB1*0701-DQA1*0201-DQB1*0303: a population- and family-based study. J Invest Dermatol 106:711-714
23. Sigmundsdottir H, Sigurgeirsson B, Troye Blomberg M et al. (1997) Circulating T cells of patients with active psoriasis respond to streptococcal M-peptides sharing sequences with human epidermal keratins. Scand J Immunol 45:688-697
24. Trembath RC, Clough RL, Rosbotham JL et al. (1997) Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis. Hum Mol Genet 6:813-820
25. Valdimarsson H, Baker BS, Jonsdottir I et al. (1995) Psoriasis: a T-cell-mediated autoimmune disease induced by streptococcal superantigens? Immunol Today 16:145-149
26. Vollmer S, Menssen A, Prinz JC (2001) Dominant lesional T cell receptor rearrangements persist in relapsing psoriasis but are absent from nonlesional skin: evidence for a stable antigen-specific pathogenic T cell response in psoriasis vulgaris. J Invest Dermatol 117:1296-1301
27. Vollmer S, Menssen A, Trommler P et al. (1994) T lymphocytes derived from skin lesions of patients with psoriasis vulgaris express a novel cytokine pattern that is distinct from that of T helper type 1 and T helper type 2 cells. Eur J Immunol 24:2377-2382
28. Weisenseel P, Laumbacher B, Besgen P et al. (2002) Streptococcal infection distinguishes different types of psoriasis. J Med Genet 39:767-768
29. Wrone Smith T, Nickoloff BJ (1996) Dermal injection of immunocytes induces psoriasis. J Clin Invest 98:1878-1887