Generation of highly selective VPAC2 receptor agonists by high throughput mutagenesis of vasoactive intestinal peptide and pituitary adenylate cyclase-activating peptide

Journal of Biological Chemistry

Volumn 278, Issue 12, 2003, Pages 10273-10281

  Yung, Stephanie L ^a   Dela Cruz, Fernando ^b   Hamren, Sarah ^a   Zhu, Jian ^b   Tsutsumi, Manami ^b   Bloom, James W ^b   Caudle, Margaret ^b   Roczniak, Steve ^a   Todd, Tracey ^a   Lemoine, Lynn ^b   MacDougall, Margit ^b   Shanafelt, Armen B ^c   Pan, Clark Q ^a  

^a Department of Molecular Technology ^*  (United States)

^b BAYER CORPORATION   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST SELECTIVITY; CHEMICAL MODIFICATION; DISEASE CONTROL; ENZYMES; GLUCOSE; INSULIN; MUTAGENESIS;

RECOMBINANT PEPTIDES;

BIOCHEMISTRY;

G PROTEIN COUPLED RECEPTOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR; NEUROPEPTIDE; RECOMBINANT PROTEIN; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2;

AMIDATION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL MODIFICATION; ENZYME ACTIVATION; INSULIN RELEASE; MUTAGENESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CHO CELL; DRUG POTENTIATION; HAMSTER; MOLECULAR GENETICS; SITE DIRECTED MUTAGENESIS;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEUROPEPTIDES; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE, TYPE II; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0038532265     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211945200     Document Type: Article

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