Characteristic dysmetabolic hepatosiderosis in 51 patients;Hépatosideroses dysmétaboliques, caracteristiques chez 51 patients

Presse Medicale

Volumn 32, Issue 9, 2003, Pages 400-405

  Venat L ^a,b   Loustaud Ratti, V ^a   Liozon, E ^a   Soria, P ^a   Nadalon, S ^a   Gissot, V ^a   Labrousse, F ^a   Vidal, E ^a  

^a DUPUYTREN UNIVERSITY HOSPITAL   (France)

^b NONE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; LIVER ENZYME; TRANSFERRIN;

ADULT; AGED; ARTICLE; CLINICAL FEATURE; CONSULTATION; CONTROLLED STUDY; DYSLIPIDEMIA; DYSMETABOLIC HEPATOSIDEROSIS; ECHOGRAPHY; FATTY LIVER; FEMALE; GENE MUTATION; HOSPITALIZATION; HUMAN; HYPERFERRITINEMIA; IRON OVERLOAD; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; OBESITY; RETROSPECTIVE STUDY; SCREENING; SEX RATIO; CASE REPORT; HEPATITIS; MIDDLE AGED; ONSET AGE; PATHOLOGY; SEX DIFFERENCE; SYNDROME;

ADULT; AGE OF ONSET; AGED; FEMALE; HEPATITIS; HUMANS; IRON OVERLOAD; MALE; METABOLIC DISEASES; MIDDLE AGED; RETROSPECTIVE STUDIES; SEX FACTORS; SYNDROME;

EID: 0038528219     PISSN: 07554982     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Feder J, Gnirke A, Thomas W et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nature Genet 1996; 13: 399-408.
2. Deugnier Y, Moirand R, Guyader D, Jouanolle AM, Brissot P. Surcharge en fer et gène HFE. Gastroenterol Clin Biol 1999; 23: 122-31.
3. Deugnier Y, Moirand R, Brissot P, David V. Le fer à l'âge de la biologie moléculaire. Ann Endocrinol (Paris) 1999; 60: 197-203.
4. Deugnier Y, Mendler MH, Moirand R. Une nouvelle entité, l'hépatosidérose dysmétabolique, Presse Med 2000; 26: 949-51.
5. Deugnier Y, Mendler MH, Turlin B, Guillygomar'ch A, Moirand R. Metabolic hepatosiderosis. Gastroenterol Clin Biol 2000 (5pt2) B79, 81.
6. Piperno A. Classification and diagnosis of iron overload. Haematologica 1998; 83: 447-55.
7. Pietrangelo A, Montosi G, Totaro A et al. Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene. N Engl Med 1999; 341: 725-32.
8. Deugnier Y, Moirand R, Jouanolle A, Le gall J, Brissot P, David V. HLA-H mutations in patients with iron overload and normal transferrin saturation. Hepatology 1997; 26: 199A.
9. Mendler M, Turlin B, Moirand R et al. The dysmetabolic iron overload syndrome: a concept which unites hepatic iron overload associated with polymetabolic disorders, steatosis and NASH, Hepatology 1998; 28: 134A.
10. Moirand R, Mortaji A, Loreal O, Paillard F, Brissot P, Deugnier Y. A new syndrome of iron overload with normal transferrin saturation. Lancet 1997; 349: 95-8
11. Fargion S. Dysmetabolic iron overload syndrome. Haematologica 1999; 84 (2): 97-8.
12. Mendler M, Guyader D, Turlin B, Moirand R, Brissot P, Deugnier Y. Prediction of fibrosis and indication for liver biopsy in insulin resistance associated liver siderosis. Hepatology 1999; 886: 382A.
13. Nilssen O, Forde OH. Seven-year longitudinal population study of change in gammaglutamyltransferase: the Tromso Study. Am J Epidemiol 1994; 139: 787-92.
14. Moirand R, Adams PC, Bicheler V, Brissot P, Deugnier Y. Clinical features of genetic hemochromatosis in women compared with men. Ann Intern Med 1997; 127: 105-10.
15. Deugnier Y, Turlin B, Powell L et al. Differentiation between heterozygotes and homozygotes in genetic hemochromatosis by means of a histological hepatic iron index: a study of 192 cases. Hepatology 1993; 17 (1): 30-4.
16. Guillygomarc'h A, Mendler M, Moirand R et al. HFE mutations in insulin resistance associated liver siderosis. Hepatology 1999; 889: 383A.
17. Kwan T, Leber B, Ahuja S, Carter R, Gerstein HC. Patients with type 2 diabetes have a high frequency of the C282Y mutation of the hemochromatosis gene. Clin Invest Med 1998; 21 (6): 251-7.
18. Halimi G, Chiavérini C, Halfon P, Ortonne JP, Lacour JP, Ouzan D. Distribution de la mutation H63D du gène HFE dans la porphyrie cutanée tardive et dans les hyperferritinémies associées à une surcharge hépatique en fer sans hémochromatose. Gastroenterology 2000; 24: pages ?
19. Halimi G, Gerolami V, Halfon P, Ouzan D. Prévalence de la mutation H63D du gène HFE chez les patients présentant une hyperferritinémie et une surcharge hépatique en fer sans hémochromatose. Gastroenterology 2000; 24: A14.
20. Moirand R, Jouanolle AM, Brissot P, Le gall JY, David V, Deugnier Y. Phenotypic expression of HFE mutations: a french study of 1110 unrelated iron-overload patients and relatives. Gastroenterology 1999; 116: 372-7.
21. Orlandi E, Arbustini E, Lazzarino M. Isolated hyperferritinemia with normal transferrin saturation and dysmetabolism, in the absence of the two known mutations in the HFE gene of hereditary hemochromatosis. Haematologica 1999; 84: 181-2.
22. Rovati A, Bergamaschi G, Casula S, Cerani P, Grasso M, Cazzola M. The dysmetabolic iron overload syndrome is clinically and genetically distinct from HFE - related genetic hemochromatosis. Haematologica 1999; 84: 182-3.
23. Deugnier Y, Charalambous P, Le Quilleuc D et al. Preneoplastic signifiance of hepatic iron-free-foci in genetic hemochromatosis: a study of 185 patients. Hepatology 1993; 18: 1363-9.
24. Guyader D, Jacquelinet C, Moirand R et al. Non invasive prediction of fibrosis in C282Y homozygous hemochromatosis. Gastroenterology 1998; 115 (4): 929-36.
25. Angulo P, Keach JC, Batts KP, Lindor KD. Independant predictors of liver fibrosis in patients with non alcoholic steatohepatitis. Hepatology 1999; 30: 1356-62
26. Georges DK, Goldwurm S, Macdonald GA et al. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology 1998; 114: 311-18.
27. Nelson RL, Davis FG, Persky V, Becker E. Risk of neoplastic and other diseases among people with heterozygosity for hereditary hemochromatosis. Cancer 1995; 76: 875-9.
28. Kiechl S, Willeit J, Egger G, Poewe W, Oberhollenzer F. Body iron store and the risk of carotid atherosclerosis. Circulation 1997; 96: 3300-7.
29. Guillygomarc'h A, Moirand R, Mendler MH et al. Veresection therapy of insulin resistance associated hepatic iron overload. J Hepatol 2001; 35: 344-9.
30. Facchini FS, Hua NW, Stoohs RA. Effect of iron depletion in carbohydrate intolerant patients with clinical evidence of non alcoholic fatty liver disease. Gastroenterology 2002; 122: 931-9.