A randomized controlled trial for chemoprevention of gastric cancer in high-risk Japanese population; Study design, feasibility and protocol modification

Japanese Journal of Cancer Research

Volumn 88, Issue 4, 1997, Pages 344-349

  Tsubono, Yoshitaka ^a,b   Okubo, Shunji ^c   Hayashi, Masato ^c   Kakizoe, Tadao ^d   Tsugane, Shoichiro ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Hiraka General Hospital   (Japan)

^d NATIONAL CANCER CENTER HOSPITAL   (Japan)

Author keywords

Ascorbic acid; Atrophic gastritis; Beta carotene; Gastric cancer; Randomized controlled trial

Indexed keywords

ASCORBIC ACID; BETA CAROTENE; PEPSINOGEN;

ADULT; ARTICLE; ATROPHIC GASTRITIS; CANCER INCIDENCE; CANCER PREVENTION; CANCER RISK; CHEMOPROPHYLAXIS; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; HIGH RISK POPULATION; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MALE; MASS SCREENING; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH CANCER;

EID: 0030979464     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1997.tb00387.x     Document Type: Article

References (17)

1. Blot, W. J., Li, J. Y., Taylor, P. R., Guo, W., Dawsey, S., Wang, G., Yang, C. S., Zheng, S., Gail, M., Li, G., Yu, Y., Liu, B., Tangrea, J., Sun, Y., Liu, F., Fraumeni, J. F., Zhang, Y. and Li, B. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/ mineral combinations, cancer incidence, and disease specific mortality in the general population. J. Natl. Cancer Inst., 85, 1483-1492 (1993).
2. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group: The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med., 330, 1029-1035 (1994).
3. Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H. Jr., Barnhart, S. and Hammar, S. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N. Engl. J. Med., 334, 1150-1155 (1996).
4. Hennekens, C. H., Burning, J. E., Manson, J. E., Stampfer, M., Rosner, B., Cook, N. R., Belanger, C., LaMotte, F., Gaziano, J. M., Ridker, P. M., Willett, W. and Peto, R. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N. Engl. J. Med., 334, 1145-1149 (1996).
5. Tsugane, S., Tsubono, Y., Okubo, S., Hayashi, M. and Kakizoe, T. A pilot study for a randomized controlled trial to prevent gastric cancer in high-risk Japanese population: study design and feasibility evaluation. Jpn. J. Cancer Res., 87, 676-679 (1996).
6. Anonymous. Beta carotene and vitamin A halted in lung cancer prevention trial. National Cancer Institute Press Release, Jan. 18, 1996.
7. Ishikawa, H., Akedo, I., Suzuki, T., Otani, T. and Sobue, T. Intervention trial for colorectal cancer prevention in Osaka: an introduction to the protocol. Jpn. J. Cancer Res., 86, 707-710 (1995).
8. Kato, I., Tominaga, S., Ito, Y., Kobayashi, S., Yoshii, Y., Matsumura, A., Kameya, A., Kano, T. and Ikari, A. A prospective study of atrophic gastritis and stomach cancer risk. Jpn. J. Cancer Res., 83, 1137-1142 (1992).
9. Samloff, M. I., Varis, K., Ihamaki, T., Siurala, M. and Rotter, J. I. Relationships among serum pepsinogen I, serum pepsinogen II, and gastric mucosal histology. Gastroenterology, 83, 204-209 (1982).
10. Tannenbaum, S. R., Wishnok, J. S. and Leaf, C. D. Inhibition of nitrosamine formation by ascorbic acid. Am. J. Clin. Nutr., 53, 247S-250S (1991).
11. Ministry of Health and Welfare: "Report of the National Nutrition Survey in 1994" (1996). Daiichi-Shuppan, Tokyo, in Japanese.
12. O'Toole, P. and Lombard, M. Vitamin C and gastric cancer: supplements for some or fruit for all? Gut, 39, 345-347 (1996).
13. Tsugane, S., Kabuto, M., Imai, H., Gey, F., Tei, Y., Hanaoka, T., Sugano, K. and Watanabe, S. Helicobacter pylori, dietary factors, and atrophic gastritis in five Japanese populations with different gastric cancer mortality. Cancer Causes Control 4, 297-305 (1993).
14. Kabuto, M., Imai, H., Tsugane, S. and Watanabe, S. Correlation between atrophic gastritis prevalence and gastric cancer mortality among middle-aged men in 5 areas in Japan. J. Epidemiol., 3, 35-39 (1993).
15. Tsubono, Y., Kobayashi, M. and Tsugane, S. Food consumption and gastric cancer mortality in five regions of Japan. Nutr. Cancer. 27, 60-64 (1997).
16. Tsugane, S., Tsuda, M., Gey, F. and Watanabe, S. Cross-sectional study with multiple measurements of biological markers for assessing stomach cancer risks at the population level. Environ. Health Perspect., 98, 207-210 (1992).
17. Law, C. and Ra'ad, D. CARET, PHS findings have inconsistent impact on other beta carotene trials. J. Natl. Cancer Inst., 88, 236 (1996).