Invasion of melanoma cells into dermal connective tissue in vitro: Evidence for an important role of cysteine proteases

International Journal of Cancer

Volumn 106, Issue 3, 2003, Pages 316-323

  Dennhöfer, Ralf ^a   Kurschat, Peter ^a   Zigrino, Paola ^a   Klose, Anke ^a   Bosserhoff, Anja ^b   Van Muijen, Goos ^c   Krieg, Thomas ^a   Mauch, Cornelia ^a   Hunzelmann, Nicolas ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Extracellular matrix; In situ zymography; Proteases; Tumor invasion

Indexed keywords

CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; LEUPEPTIN; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE;

ARTICLE; BASEMENT MEMBRANE; CANCER INVASION; CONNECTIVE TISSUE; CONTROLLED STUDY; DERMIS; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MELANOMA CELL; METASTASIS; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; SKIN; SKIN TUMOR; ZYMOGRAPHY;

CATHEPSINS; CONNECTIVE TISSUE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DERMIS; EXTRACELLULAR MATRIX; HUMANS; LEUCINE; LEUPEPTINS; MATRIX METALLOPROTEINASE 2; MELANOMA; NEOPLASM INVASIVENESS; PROTEASE INHIBITORS; SKIN NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0038505666     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11255     Document Type: Article

References (40)

1. Liotta LA, Rao CN, Wewer UM. Biochemical interactions of tumor cells with the basement membrane. Annu Rev Biochem 1986;55:1037-57.
2. Friedl P, Bröcker EB. The biology of cell locomotion within three-dimensional extracellular matrix. Cell Mol Life Sci 2000;57:41-64.
3. Mareel M, Kint J, Meyvisch C. Methods of study of the invasion of malignant C3H-mouse fibroblasts into embryonic chick heart in vitro. Virchows Arch B Cell Pathol 1979;30:95-111.
4. Ossowski L. Invasion of connective tissue by human carcinoma cell lines: requirement for urokinase, urokinase receptor, and interstitial collagenase. Cancer Res 1992;52:6754-60.
5. Mignatti P, Robbins E, Rifkin DB. Tumor invasion through human amniotic membrane: requirement for a proteinase cascade. Cell 1986;47:487-98.
6. Buck CA, Horwitz AF. Cell surface receptors for extracellular matrix molecules. Annu Rev Cell Biol 1987;3:179-205.
7. Kurschat P, Zigrino P, Nischt R, Breitkopf K, Steurer P, Klein CE, Krieg T, Mauch C. Tissue inhibitor of matrix metalloproteinase 2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type I matrix metalloproteinase activity in high and low invasive melanoma cell lines. J Biol Chem 1999;274:21056-62.
8. Nduwimana J, Guenet L, Dorval I, Blayau M, LeGall JY, LeTreut A. Proteases. Ann Biol Clin 1995;53:251-64.
9. Ferrier CM, van Muijen GNP, Ruiter DJ. Proteases in cutaneous melanoma. Ann Med 1998;30:431-42.
10. Yan S, Sameni M, Sloane BF. Cathepsin B and human tumor progression. Biol Chem 1998;379:113-23.
11. Lah TT, Kos J. Cysteine proteinases in cancer progression and their clinical relevance for prognosis. Biol Chem 1998;379:125-30.
12. Fröhlich E, Schlagenhauff B, Möhrle M, Weber E, Klessen C, Rassner G. Activity, expression and transcription rate of cathepsins B, D, H, and L in cutaneous malignant melanoma. Cancer 2001;91:972-82.
13. van Mujen GNP, Cornelissen IMHA, Jansen KFJ, Figdor CG, Johnson JP, Broecker EB, Ruiter DJ. Antigen expression of metastasizing and non-metastasizing human melanoma cell lines xenografted into nude mice. Clin Exp Metast 1991;9:259-72.
14. Kolles H, Förderer W, Bock R, Feiden W. Combined Ki-67 and feulgen stain for morphometric determination of the Ki-67 labeling index. Histochemistry 1993;100:293-6.
15. Kurschat P, Wickenhauser C, Groth W, Krieg T, Mauch C. Activated matrix metalloproteinase-2 (MMP-2) as the main gelatinolytic enzyme at the invasive front of malignant melanoma as shown by in situ zymography. J Pathol 2002;197:179-87.
16. Schaumburg-Lever G. The alkaline phosphatase anti alkaline phosphatase technique in dermatopathology. J Cutan Pathol 1987;14:6-9.
17. Meier F, Nesbit M, Hsu MY, Martin B, van Belle P, Elder DE, Schaumburg-Lever G, Garbe C, Walz TM. Donatien P, Crombleholme TM, Herlyn M. Human melanoma progression in skin reconstructs - biological significance of bFGF. Am J Pathol 2000;156:193-200.
18. Eves P, Layton C, Hedley S, Dawson RA, Wagner M, Morandini R, Ghanem G, MacNeil S. Characterisation of an in vitro model of human melanoma invasion based on reconstructed human skin. Br J Dermatol 2000;142:210-22.
19. Regnier M, Desbas C, Bailly C, Darmon M. Differentiation of normal and tumoral human keratinocytes cultured on dermis: reconstruction of either normal or tumoral architecture. In vitro Cell Dev Biol 1988;24:625-32.
20. Ceilley E, Watnabe N, Shapiro D. Labeling of fractured skin with antibodies to BM600/nicein, epilegrin, kalinin, and other matrix components. J Derm Sci 1993;5:97-103.
21. Allen J, Schomburg K, Wojnarowska F. Physicochemical characterisation and differentiation of the components of the cutaneous basement membrane zone. Br J Derm 1997;137:907-15.
22. Kronick PL, Maleeff B, Carroll R. The location of collagens with different thermal stabilities in fibrils of bovine reticular dermis. Connect Tissue Res 1988;18:123-34.
23. Hambleton J, Shakespeare PG. Thermal damage to skin collagen. Bums 1997;17:209-12.
24. Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, deCarlo A, Engler JA. Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 1993;4:197-250.
25. Kähäri VM, Saarialho-Kere U. Matrix metalloproteinases and their inhibitors in tumor growth and invasion. Ann Med 1999;31:34-45.
26. Hoffmann UB, Westphal JR, Waas ET, Zendmann AJW, Cornelissen IMHA, Ruiter DJ, van Muijen GNP. Matrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 correlates with melanoma progression. Br J Cancer 1999;81:774-82.
27. Butler GS, Butler MJ, Atkinson SJ, Will H, Tamura T, van Westrum SS, Crabe T, Clements J, d'Ortho MP, Murphy G. The TIMP2 membrane type metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. J Biol Chem 1998; 273:871-80.
28. Mueller BM. Different roles for plasminogen activators and metalloproteinases in melanoma metastasis. Curr Top Microbiol Immunol 1996;213:65-80.
29. Fröhlich E, Schaumburg-Lever G, Klessen C. Immunocytochemical and immunoelectron microscopic demonstration of cathepsin B in human malignant melanoma. Br J Derm 1995;132:867-75.
30. Buck MR, Karustis DG, Day NA, Honn KV, Sloane BF. Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumor tissues. Biochem J 1992;282:273-8.
31. Kirschke H, Barrett AJ, Rawlings ND. Proteinases I: lysosomal cysteine proteases. Protein Profile 1995;2:1587-1693.
32. Turk B, Dolenc I, Zerovnik E, Turk D, Gubansek F, Turk V. Human cathepsin B is a metastable enzyme stabilized by specific ionic interactions associated with the active site. Biochemistry 1994; 33:14800-6.
33. Dehrmann FM, Elliott E, Dennison C. Reductive activation markedly increase the stability of cathepsin B and L to extracellular ionic conditions. Biol Chem 1996;377:391-4.
34. Werle B, Julke B, Lah T, Spiess E, Ebert W. Cathepsin B fraction active at physiological pH of 7.5 is of prognostic significance in squamous cell carcinoma of human lung. Br J Cancer 1997;75:1137-43.
35. Almeida PC, Nantes IL, Chagas JR, Rizzi CCA, Faljoni A, Carmona E, Juliano L, Nader HB, Tersariol ILS. Cathepsin B activity regulation heparin-like glycosaminoglycans protect human cathepsin B from alkaline pH-induced inactivation. J Biol Chem 2001;276:944-51.
36. Illy C, Quraishi O, Wang J, Purisima E, Vernet T, Mort JS. Role of occluding loop in cathepsin B activity. J Biol Chem 1997;272:1197-1202.
37. Thistlethwaite AJ, Leeper DB, Moylen DJ, Nerlinger BS. pH distribution in human tumors. Int J Radiation Oncology Biol Phys 1985; 11:1647-52.
38. Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989;49:6449-65.
39. Tepel C, Bromme D, Herzog V, Brix K. Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin. J Cell Sci 2000;113:4487-98.
40. Maquoi E, Munaut C, Colige A, Lambert C, Frankenne F, Noel A, Krell HW, Foidart JM. Stimulation of matrix metalloproteinase-9 expression in human fibrosarcoma cells by synthetic matrix metalloproteinase inhibitors. Exp Cell Res 2002;275:110-21.