Protective effect of Artemisia douglasiana Besser extracts in gastric mucosal injury

Journal of Pharmacy and Pharmacology

Volumn 55, Issue 4, 2003, Pages 551-557

  Repetto, Marisa ^a   María, Alejandra ^b   Guzmán, Jorge ^b   Giordano, Oscar ^b   Llesuy, Susana F ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSIDAD NACIONAL DE SAN LUIS   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ARTEMISIA DOUGLASIANA EXTRACT; CATALASE; DEHYDROLEUCODINE; GLUTATHIONE PEROXIDASE; PLANT EXTRACT; SESQUITERPENE LACTONE DERIVATIVE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTEMISIA; ARTICLE; BIOASSAY; CELL PROTECTION; CHEMOLUMINESCENCE; CONTROLLED STUDY; DISEASE MARKER; DRUG ISOLATION; DRUG SYNTHESIS; ENZYME ACTIVITY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OXIDATIVE STRESS; PEPTIC ULCER; PREMEDICATION; PROTEIN ANALYSIS; RAT; STOMACH; STOMACH ULCER; TISSUE HOMOGENATE; TRADITIONAL MEDICINE;

ANIMALS; ANTI-ULCER AGENTS; ANTIOXIDANTS; ARTEMISIA; CHEMILUMINESCENT MEASUREMENTS; ETHANOL; FEMALE; OXIDATIVE STRESS; PEPTIC ULCER; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR;

EID: 0038399804     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/002235702919     Document Type: Article

References (34)

1. Anonymous (1995) Manual de Técnicas de Investigación. Programa Iberoamericano de Ciencias y Tecnología para el desarrollo (CYTED), Madrid, Spain
2. 2 in rat stomach. Aliment. Pharmacol. Ther. 14: 116-124
3. Boveris, A., Ilesuy, S., Fraga, C. (1985) Increased liver chemiluminescence in tumor-bearing mice. Free Rad. Biol. Med. 1: 131-138
4. Cao, G., Sofic, E., Prior, R. (1997) Antioxidant and prooxidant behavior of flavonoids: Structure-activity relationships. Free Rad. Biol. Med. 22: 749-760
5. Chance, B. (1954) Special methods: Catalase. In: Glick, D (ed.) Methods of Biochem Analysis. Interscience Publishers, New York, pp. 408-424
6. Drake, I., Mapstone, N., Schorah, C., White, K., Chalmers, D., Dixon, M., Axon, A. (1998) Reactive oxygen species activity and lipid peroxidation in Helicobacter pylori associated gastritis: Relation to gastric mucosal ascorbic acid concentrations and effect of H pylori eradication. Gut 42: 768-771
7. Evelson, P., Ordoñez, C., Llesuy, S., Boveris, A. (1997) Oxidative stress and in vivo chemiluminescence in mouse skin exposed to UVA radiation. J. Photochem. Photobiol. Biol. 38: 215-219
8. Giordano, O., Guerreiro, E., Pestchanker, M., Guzmán, J., Pastor, D., Guardia, T. (1990) The gastric cytoprotective effect of several sesquiterpene lactones. J. Nat. Prod. 53: 803-809
9. Giordano, O., Pestchanker, M., Guerreiro, E., Saad, J., Enriz, R., Rodriguez, A., Jáuregui, E., Guzmán, J., María, A., Wendel, G. (1992) Structure-activity relationship in the gastric cytoprotective effect of several sesquiterpene lactones. J. Med. Chem. 335: 2452-2458
10. Gonzalez Flecha, B., Llesuy, S., Boveris, A. (1991) Hydroperoxide-initiated chemiluminescence: An assay for oxidative stress in biopsies of heart, liver and muscle. Free Rad. Biol. Med. 10: 93-100
11. Guardia, T., Guzmán, J., Pestchanker, M., Guerreiro, E., Giordano, O. (1994) Mucus synthesis and sulfhydryl groups in cytoprotection mediated by dehydroleucodine, a sesquiterpene lactone. J. Nat. Prod. 57: 507-509
12. Hanasaki, Y., Ogawa, S., Fukui, S. (1994) The correlation between active oxygen scavenging and antioxidative effects of flavonoids. Free Rad. Biol. Med. 16: 845-850
13. Hirokawa, M., Miura, S., Yoshida, H., Kurose, I., Shigematsu, T., Hokari, R., Higuchi, H., Watanabe, N., Yokoyama, Y., Kimura, H., Kato, S., Ishii, H (1998) Oxidative stress and mitochondrial damage precedes gastric mucosal cell death induced by ethanol administration. Alcohol Clin. Exp. Res. 22: 111-114
14. Keck, D. (1946) A revision of the Artemisia vulgaris complex in North America. Proc. Calif. Acad. Sci. 25: 421-468
15. Lissi, E., Pascual, C., Del Castillo, M. (1992) Luminol luminescence induced by 2,2′-azo-bis (2-amidinopropane) thermolysis. Free Rad. Res. Comm. 17: 299-311
16. Llesuy, S., Milei, J., Gonzalez Flecha, B., Boveris, A. (1990) Myocardial damage induced by doxorubicins: Hydroperoxide initiated chemiluminescence and morphology. Free Rad. Biol. Med. 8: 259-264
17. Lowry, O., Rosebrough, A., Farr, A., Randall, R. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275
18. María, A., Franchi, G., Gimmeno, M., Guzmán, J., Giordano, O., Guerreiro, E. (1998) Gastric cytoprotective activity of dehydroleucodine in rats. Role of prostaglandins. Biol. Pharm. Bull. 21: 335-338
19. María, A. O., Repetto, M., Llesuy, S., Giordano, O., Guzmán, J., Guerreiro, E. (2000) Antioxidant activity of Artemisia douglasiana Besser extract and dehydroleucodine. Phytother. Res. 14: 558-560
20. Marotta, F., Tajiri, H., Safran, P., Fesce, E., Ideo, G. (1999) Ethanol-related gastric mucosal damage: Evidence of a free radical-mediated mechanism and beneficial effect of oral supplementation with bionormalizer, a novel natural antioxidant. Digestion 60: 538-543
21. Misra, H., Fridovich, I. (1972) The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 247: 3170-3175
22. Mutoh, H., Hirahishi, H., Ota, S., Ivey, K., Terano, A., Sugimoto, T. (1990) Role of oxygen radicals in ethanol-induced damaged to cultured gastric mucosal cells. Am. J. Physiol. 258: 603-609
23. Piezzi, R., Guzmán, J., Guardia, T., Pestchanker, M., Guerreiro, E., Giordano, O. (1992) Dehydroleucodine prevents ethanol-induced necrosis in the rat gastric mucosa. A histological study. Mic. Electr. Biol. Cell 16: 45-56
24. Piezzi, R., Guzmán, J., Guardia, T., Pestchanker, M., Guerreiro, E., Giordano, O. (1995) Dehydroleucodine prevents ethanol-induced necrosis in the mice duodenal mucosa. A histological study. Biocell 19: 27-33
25. Repetto, M., Reides, C., Evelson, P., Kohan, S., Sacerdote De Lustig, E., Llesuy, S. (1999) Peripheral markers of oxidative stress in probable Alzheimer patients. Eur. J. Clin. Invest. 29: 643-649
26. Robert, A., Nezamis, J., Lancaster, C., Hanchar, A. (1979) Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 71: 433-443
27. Romay, C., Del Castillo, M., Pascual, C., Campos, A., Escobar, J., Lissi, E. (1996) Evaluation of the total content of antioxidants in complex mixtures. J. Braz. Assoc. Adv. Sci. 48: 86-95
28. Saeki, T., Ohmo, T., Boku, K., Saiigengi, K., Katori, M., Majima, M. (2000) Mechanism of prevention by capsaicin of ethanol-induced gastric mucosal injury. A study in the rat using intravital microscopy. Aliment. Pharmacol. Ther. 14: 135-144
29. Seno, K., Joh, T., Yokoyama, Y., Itoh, M. (1995) Role of mucus in gastric mucosal injury induced by local ischemia/reperfusion. J. Lab. Clin. Med. 126: 287-293
30. Sies, H. (1985) Oxidative stress: Introductory remarks. In: Sies, H. (ed.) Oxidative Stress. Academic Press, San Diego, pp. 1-7
31. Szabo, S., Trier, J., Frankel, P. (1984) Role of sulfhydryls and early vascular lesions in gastric mucosal injury. In: Mozsik, G., Part, A., Bertelli, A. (eds) Recent Advances in Gastrointestinal Cytoprotection. Akademial Kiodo, Budapest, pp. 17-28
32. Vaya, J., Belinky, P., Aviram, M. (1997) Antioxidant constituents from licorice roots: Isolation, structure elucidation and antioxidative capacity toward LDL oxidation. Free Rad. Biol. Med. 23: 303-313
33. Wendel, A. (1981) Glutathione peroxidase. In: Packer, L. (ed.) Methods in Enzymology. Academic Press, New York, pp. 325-333
34. Wingsle, G., Karpinski, S. (1996) Differential redox regulation by glutathione of glutathione reductase and CuZn-superoxide dismutase gene expression in Pinus sylvestris needles. Planta 198: 151-157