The Danish PET/depression project: Poor verbal fluency performance despite normal prefrontal activation in patients with major depression

Psychiatry Research - Neuroimaging

Volumn 123, Issue 1, 2003, Pages 49-63

  Videbech, Poul ^a   Ravnkilde, Barbara ^a   Kristensen, Salomeh ^a   Egander, Annette ^a   Clemmensen, Karin ^a   Rasmussen, Niels Anton ^a   Gjedde, Albert ^a   Rosenberg, Raben ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Cerebral blood flow; Cingulate cortex; Cognitive activation; Depressive disorder; Positron emission tomography; Verbal fluency test

Indexed keywords

ADULT; ARTICLE; BRAIN PERFUSION; CEREBELLUM CORTEX; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EVOKED CORTICAL RESPONSE; FEMALE; FUNCTION TEST; HUMAN; HYPOTHESIS; MAJOR DEPRESSION; MALE; MENTAL TASK; OCCIPITAL CORTEX; PHOTON EMISSION TOMOGRAPHY; PREDICTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; RIGHT HEMISPHERE; TASK PERFORMANCE; TEMPORAL CORTEX; VERBAL BEHAVIOR;

ADULT; BASAL GANGLIA; BRAIN STEM; CEREBELLUM; DEPRESSIVE DISORDER, MAJOR; FEMALE; GYRUS CINGULI; HEMODYNAMIC PROCESSES; HUMANS; HYPOTHALAMUS; MALE; PREFRONTAL CORTEX; SEVERITY OF ILLNESS INDEX; TEMPORAL LOBE; THALAMUS; TOMOGRAPHY, EMISSION-COMPUTED; VERBAL BEHAVIOR;

EID: 0038399770     PISSN: 09254927     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4927(03)00002-7     Document Type: Article

References (79)

1. Abrams R., Taylor M.A. Cognitive dysfunction in melancholia. Psychological Medicine. 17:1987;359-362.
2. Ali S.O., Denicoff K.D., Altshuler L.L., Hauser P., Li X., Conrad A.J., Mirsky A.F., Smith-Jackson E.E., Post R.M. A preliminary study of the relation of neuropsychological performance to neuroanatomic structures in bipolar disorder. Neuropsychiatry, Neuropsychology and Behavioural Neurology. 13:2000;20-28.
3. Audenaert K., Brans B., Van Laere K., Lahorte P., Versijpt J., van Heeringen K., Dierckx R. Verbal fluency as a prefrontal activation probe: a validation study using 99mTc-ECD brain SPET. European Journal of Nuclear Medicine. 27:2000;1800-1808.
4. Austin M.P., Mitchell P., Goodwin G.M. Cognitive deficits in depression: possible implications for functional neuropathology. British Journal of Psychiatry. 178:2001;200-206.
5. Austin M.P., Ross M., Murray C., O'Carroll R.E., Ebmeier K.P., Goodwin G.M. Cognitive function in major depression. Journal of Affective Disorders. 25:1992;21-29.
6. Baker S.C., Frith C.D., Dolan R.J. The interaction between mood and cognitive function studied with PET. Psychological Medicine. 27:1997;565-578.
7. Bech P., Kastrup M., Rafaelsen O.J. Mini-compendium of rating scales for states of anxiety, depression, mania and schizophrenia with corresponding DSM-III syndromes. Acta Psychiatrica Scandinavica Supplementum. 326:1986;1-37.
8. Bench C.J., Friston K.J., Brown R.G., Frackowiak R.S., Dolan R.J. Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions. Psychological Medicine. 23:1993;579-590.
9. Berman K.F., Doran A.R., Pickar D., Weinberger D.R. Is the mechanism of prefrontal hypofunction in depression the same as in schizophrenia? Regional cerebral blood flow during cognitive activation. British Journal of Psychiatry. 162:1993;183-192.
10. Berman K.F., Schmidt P.J., Rubinow D.R., Danaceau M.A., Van H.J., Esposito G., Ostrem J.L., Weinberger D.R. Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women. Proceedings of the National Academy of Sciences of the USA. 94:1997;8836-8841.
11. Boivin M.J., Giordani B., Berent S., Amato D.A., Lehtinen S., Koeppe R.A., Buchtel H.A., Foster N.L., Kuhl D.E. Verbal fluency and positron emission tomographic mapping of regional cerebral glucose metabolism. Cortex. 28:1992;231-239.
12. Bonne O., Krausz Y., Aharon Y., Gelfin Y., Chisin R., Lerer B. Clinical doses of fluoxetine and cerebral blood flow in healthy volunteers. Psychopharmacology (Berlin). 143:1999;24-28.
13. Brown R.G., Scott L.C., Bench C.J., Dolan R.J. Cognitive function in depression: its relationship to the presence and severity of intellectual decline. Psychological Medicine. 24:1994;829-847.
14. Cabeza R., Nyberg L. Imaging cognition: an empirical review of PET studies with normal subjects. Journal of Cognitive Neuroscience. 9:1997;1-26.
15. Cabeza R., Nyberg L. Imaging cognition II: an empirical review of 275 PET and fMRI studies. Journal of Cognitive Neuroscience. 12:2000;1-47.
16. Campbell J.J.I., Coffey C.E. Neuropsychiatric significance of subcortical hyperintensity. Journal of Neuropsychiatry and Clinical Neuroscience. 13:2001;261-288.
17. Clark L., Iversen S.D., Goodwin G.M. The influence of positive and negative mood states on risk taking, verbal fluency, and salivary cortisol. Journal of Affective Disorders. 63:2001;179-187.
18. Collins D.L., Neelin P., Peters T.M., Evans A.C. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. Journal of Computer Assisted Tomography. 18:1994;192-205.
19. Cuenod C.A., Bookheimer S.Y., Hertz-Pannier L., Zeffiro T.A., Theodore W.H., Le Bihan D. Functional MRI during word generation, using conventional equipment: a potential tool for language localization in the clinical environment. Neurology. 45:1995;1821-1827.
20. Curtis V.A., Dixon T.A., Morris R.G., Bullmore E.T., Brammer M.J., Williams S.C., Sharma T., Murray R.M., McGuire P.K. Differential frontal activation in schizophrenia and bipolar illness during verbal fluency. Journal of Affective Disorders. 66:2001;111-121.
21. Degl'Innocenti A., Ågren H., Backman L. Executive deficits in major depression. Acta Psychiatrica Scandinavica. 97:1998;182-188.
22. Duara, R., Chang, J., Barker, W., Yoshii, F., Apicella, A., 1986. Correlation of regional cerebral metabolic activation to performance in activation tasks. Neurology 36(Suppl. 1), 349.
23. Dye S.M., Spence S.A., Bench C.J., Hirsch S.R., Stefan M.D., Sharma T., Grasby P.M. No evidence for left superior temporal dysfunction in asymptomatic schizophrenia and bipolar disorder. PET study of verbal fluency. British Journal of Psychiatry. 175:1999;367-374.
24. Elliott R., Baker S.C., Rogers R.D., O'Leary D.A., Paykel E.S., Frith C.D., Dolan R.J., Sahakian B.J. Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography. Psychological Medicine. 27:1997;931-942.
25. Elliott R., Sahakian B.J., McKay A.P., Herrod J.J., Robbins T.W., Paykel E.S. Neuropsychological impairments in unipolar depression: the influence of perceived failure on subsequent performance. Psychological Medicine. 26:1996;975-989.
26. Franke P., Maier W., Hardt J., Frieboes R., Lichtermann D., Hain C. Assessment of frontal lobe functioning in schizophrenia and unipolar major depression. Psychopathology. 26:1993;76-84.
27. Frith C.D., Friston K.J., Liddle P.F., Frackowiak R.S. A PET study of word finding. Neuropsychologia. 29:1991;1137-1148.
28. Gjedde A. Brain energy metabolism and the physiological basis of the hemodynamic response. Jezzard P., Matthews P.M., Smith S. Functional Magnetic Resonance Imaging. Methods for Neuroscience. 2001;Oxford University Press, Oxford.
29. Goodwin G.M. Neuropsychological and neuroimaging evidence for the involvement of the frontal lobes in depression. Journal of Psychopharmacology. 11:1997;115-122.
30. Hertel P.T., Rude S.S. Depressive deficits in memory: focusing attention improves subsequent recall. Journal of Experimental Psychology (General). 120:1991;301-309.
31. Kessing L.V. Cognitive impairment in the euthymic phase of affective disorder. Psychological Medicine. 28:1998;1027-1038.
32. Landrø N.I., Stiles T.C., Sletvold H. Neuropsychological function in nonpsychotic unipolar major depression. Neuropsychiatry, Neuropsychology and Behavioural Neurology. 14:2001;233-240.
33. Leggio M.G., Silveri M.C., Petrosini L., Molinari M. Phonological grouping is specifically affected in cerebellar patients: a verbal fluency study. Journal of Neurology, Neurosurgery and Psychiatry. 69:2000;102-106.
34. Leiner H.C., Leiner A.L., Dow R.S. The human cerebro-cerebellar system: its computing, cognitive, and language skills. Behavioural Brain Research. 44:1991;113-128.
35. Lezak M.D. Neuropsychological Assessment. third ed:1995;Oxford University Press, New York.
36. 15O PET. Neuroimage. 3:1996;127-142.
37. Maes M., Dierckx R., Meltzer H.Y., Ingels M., Schotte C., Vandewoude M., Calabrese J., Cosyns P. Regional cerebral blood flow in unipolar depression measured with Tc-99m-HMPAO single photon emission computed tomography: negative findings. Psychiatry Research: Neuroimagining. 50:1993;77-88.
38. Marien P., Engelborghs S., Fabbro F., De Deyn P.P. The lateralized linguistic cerebellum: a review and a new hypothesis. Brain and Language. 79:2001;580-600.
39. Mazziotta J.C. Time and space. Toga A.W., Mazziotta J.C. Brain Mapping: The Methods. 1996;389-406 Academic Press, San Diego.
40. McGuffin P., Farmer A., Harvey I. A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Archives of General Psychiatry. 48:1991;764-770.
41. Moore C.J., Price C.J. Three distinct ventral occipitotemporal regions for reading and object naming. Neuroimage. 10:1999;181-192.
42. Mummery C.J., Patterson K., Hodges J.R., Wise R.J. Generating 'tiger' as an animal name or a word beginning with T: differences in brain activation. Proceedings of the Royal Society of London. Biological Sciences. 263:1996;989-995.
43. Munk-Jørgensen P., Mortensen P.B. The Danish Psychiatric Central Register. Danish Medical Bulletin. 44:1997;82-84.
44. Neau J.P., Arroyo-Anllo E., Bonnaud V., Ingrand P., Gil R. Neuropsychological disturbances in cerebellar infarcts. Acta Neurologica Scandinavica. 102:2000;363-370.
45. Neelin P., Crossman J., Hawkes D.J., Ma Y., Evans A.C. Validation of an MRI/PET landmark registration method using 3D simulated PET images and point simulations. Computerized Medical Imaging and Graphics. 17:1993;351-356.
46. Oldfield R.C. The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia. 9:1971;97-113.
47. Parks R.W., Loewenstein D.A., Dodrill K.L., Barker W.W., Yoshii F., Chang J.Y., Emran A., Apicella A., Sheramata W.A., Duara R. Cerebral metabolic effects of a verbal fluency test: a PET scan study. Journal of Clinical and Experimental Neuropsychology. 10:1988;565-575.
48. Phelps E.A., Hyder F., Blamire A.M., Shulman R.G. fMRI of the prefrontal cortex during overt verbal fluency. Neuroreport. 8:1997;561-565.
49. Philpot M.P., Banerjee S., Needham Bennett H., Costa D.C., Ell P.J. 99mTc-HMPAO single photon emission tomography in late life depression: a pilot study of regional cerebral blood flow at rest and during a verbal fluency task. Journal of Affective Disorders. 28:1993;233-240.
50. Pujol J., Vendrell P., Deus J., Kulisevsky J., Marti-Vilalta J.L., Garcia C., Junque C., Capdevila A. Frontal lobe activation during word generation studied by functional MRI. Acta Neurologica Scandinavica. 93:1996;403-410.
51. Ravnkilde, B., Videbech, P., Clemmensen, K., Egander, A., Rasmussen, N.A., Gjedde, A., Rosenberg, R., Gade, A., 2000a. The Danish PET/depression project: neuropsychological function and regional cerebral blood flow. Acta Psychiatrica Scandinavica, in press.
52. Ravnkilde B., Videbech P., Clemmensen K., Egander A., Rasmussen N.A., Rosenberg R. Cognitive deficits in major depression. Scandinavian Journal of Psychology. 43:2002b;239-251.
53. Ravnkilde B., Videbech P., Rosenberg R., Gjedde A., Gade A. Putative tests of frontal lobe function: a PET-study of brain activation during Stroop's Test and verbal fluency. Journal of Clinical and Experimental Neuropsychology. 24:2002c;534-547.
54. Reischies F.M., Neu P. Comorbidity of mild cognitive disorder and depression - a neuropsychological analysis. European Archives of Psychiatry and Clinical Neurosciences. 250:2000;186-193.
55. Robertson G., Taylor P.J. Some cognitive correlates of affective disorders. Psychological Medicine. 15:1985;297-309.
56. Rogers M.A., Bradshaw J.L., Pantelis C., Phillips J.G. Frontostriatal deficits in unipolar major depression. Brain Research Bulletin. 47:1998;297-310.
57. Rubin P., Holm S., Friberg L., Videbech P., Andersen H.S., Bendsen B.B., Stromso N., Larsen J.K., Lassen N.A., Hemmingsen R. Altered modulation of prefrontal and subcortical brain activity in newly diagnosed schizophrenia and schizophreniform disorder: a regional cerebral blood flow study. Archives of General Psychiatry. 48:1991;987-995.
58. Rubinsztein J.S., Michael A., Paykel E.S., Sahakian B.J. Cognitive impairment in remission in bipolar affective disorder. Psychological Medicine. 30:2000;1025-1036.
59. Ruff R.M., Light R.H., Parker S.B., Levin H.S. The psychological construct of word fluency. Brain and Language. 57:1997;394-405.
60. Sackeim H.A., Steif B.L. Neuropsychology of depression and mania. Georgotas A., Cancro R. Depression and Mania. 1988;265-289 Elsevier, New York.
61. Schapiro M.B., Berman K.F., Alexander G.E., Weinberger D.R., Rapoport S.I. Regional cerebral blood flow in Down syndrome adults during the Wisconsin Card Sorting Test: exploring cognitive activation in the context of poor performance. Biological Psychiatry. 45:1999;1190-1196.
62. Schlösser R., Hutchinson M., Joseffer S., Rusinek H., Saarimaki A., Stevenson J., Dewey S.L., Brodie J.D. Functional magnetic resonance imaging of human brain activity in a verbal fluency task. Journal of Neurology, Neurosurgery and Psychiatry. 64:1998;492-498.
63. Sergent J. Brain-imaging studies of cognitive functions. Trends in Neuroscience. 17:1994;221-227.
64. Spitzer R.L., Williams J.B., Gibbon M., First M.B. The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description. Archives of General Psychiatry. 49:1992;624-629.
65. Spitzer R.L., Williams J.B., Miriam G., First M.B. The Structured Clinical Interview for DSM-III-R. (SCID-P, version 1.0). Patient Edition:1990;American Psychiatric Press, Washington, DC.
66. Talairach J., Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain. 1988;Georg Thieme Verlag, Stuttgart.
67. Trichard C., Martinot J.L., Alagille M., Masure M.C., Hardy P., Ginestet D., Feline A. Time course of prefrontal lobe dysfunction in severely depressed in-patients: a longitudinal neuropsychological study. Psychological Medicine. 25:1995;79-85.
68. Tsourtos G., Thompson J.C., Stough C. Evidence of an early information processing speed deficit in unipolar major depression. Psychological Medicine. 32:2002;259-265.
69. Veiel H.O. A preliminary profile of neuropsychological deficits associated with major depression. Journal of Clinical and Experimental Neuropsychology. 19:1997;587-603.
70. Videbech P. MRI findings in patients with affective disorder: a meta-analysis. Acta Psychiatrica Scandinavica. 96:1997;157-168.
71. Videbech P. PET measurements of brain glucose metabolism and blood flow in major depressive disorder: a critical review. Acta Psychiatrica Scandinavica. 101:2000;11-20.
72. Videbech P., Ravnkilde B., Fiirgaard B., Clemmensen K., Egander A., Rasmussen N.A., Christensen T., Sangill R., Rosenberg R. Structural brain abnormalities in unselected in-patients with major depression. Acta Psychiatrica Scandinavica. 103:2001a;282-286.
73. Videbech P., Ravnkilde B., Pedersen A.R., Egander A., Landbo B., Rasmussen N.A., Andersen F., Stødkilde-Jørgensen H., Gjedde A., Rosenberg R. The Danish PET/depression project: PET findings in patients with major depression. Psychological Medicine. 31:2001b;1147-1158.
74. Videbech P., Ravnkilde B., Pedersen T.H., Hartvig H., Egander A., Clemmensen K., Rasmussen N.A., Andersen F., Gjedde A., Rosenberg R. The Danish PET/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis. Acta Psychiatrica Scandinavica. 106:2002;35-44.
75. Weinberger D.R., Berman K.F. Prefrontal function in schizophrenia: confounds and controversies. Philosophical Transactions of the Royal Society of London. Biological Sciences. 351:1996;1495-1503.
76. Widlöcher D.J. Psychomotor retardation: clinical, theoretical, and psychometric aspects. Psychiatric Clinics of North America. 6:1983;27-40.
77. Wolfe J., Granholm E., Butters N., Saunders E., Janowsky D. Verbal memory deficits associated with major affective disorders: a comparison of unipolar and bipolar patients. Journal of Affective Disorders. 13:1987;83-92.
78. Worsley K.J., Evans A.C., Marrett S., Neelin P. A three-dimensional statistical analysis for CBF activation studies in human brain. Journal of Cerebral Blood Flow and Metabolism. 12:1992;900-918.
79. Worsley K.J., Evans A.C., Marrett S., Neelin P. Detecting and estimating the regions of activation in CBF activation studies in human brain. Quantification of Brain Function. Tracer Kinetics and Image Analysis in Brain PET. 1993;535-575 Elsevier Science Publishers, Amsterdam.