Tachykinins in the control of breathing by hypoxia: Pre- and post-genomic era

Respiratory Physiology and Neurobiology

Volumn 135, Issue 2-3, 2003, Pages 145-154

  Kumar, Ganesh K ^a   Prabhakar, Nanduri R ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Carotid body, hypoxia, tachykinins; Control of breathing, chemoafferents; Hypoxia, carotid body; Mediators, substance P; Mediators, tachykinins; Pattern of breathing, hypoxia

Indexed keywords

NEUROKININ A; NEUROKININ B; NEUROPEPTIDE GAMMA; NEUROPEPTIDE K; PROTEINASE; SUBSTANCE P; TACHYKININ;

AMINO ACID SEQUENCE; CAROTID BODY; GENE DELETION; GENE TARGETING; GENETIC CODE; GENOMICS; HUMAN; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; RESPIRATION CONTROL; RESPIRATORY SYSTEM; REVIEW;

EID: 0038384629     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1569-9048(03)00033-8     Document Type: Review

References (59)

1. Bianchi A.L., Denavit-Saubie M., Champagnat J. Central control of breathing in mammals: neuronal circuitary, membrane properties, and neurotransmitters. Physiol. Rev. 75:1995;1-45.
2. Bonham A.C. Neurotransmitters in the CNS control of breathing. Respir. Physiol. 101:1995;219-230.
3. Burton M.D., Kazemi H. Neurotransmitters in central respiratory control. Respir. Physiol. 122:2000;111-121.
4. Chen I.I., Yates R.D., Hansen J.T. Substance P-like immunoreactivity in rat and cat carotid bodies: light and electron microscopic studies. Histol. Histopathol. 1:1986;203-212.
5. Cragg P.A., Runold M., Kou Y.R., Prabhakar N.R. Tachykinin antagonists in carotid body responses to hypoxia and substance P in the rat. Respir. Physiol. 95:1994;295-310.
6. De Sanctis G.T., Green F.H., Remmers J.E. Ventilatory responses to hypoxia and hypercapnia in awake rats pretreated with capsaicin. J. Appl. Physiol. 70:1991;1168-1174.
7. De Sanctis G.T., Green F.H., Jiang X., King M., Remmers J.E. Ventilatory responses to hypoxia in rats pretreated with nonpeptide NK1 receptor antagonist CP-96345. J. Appl. Physiol. 76:1994;1528-1532.
8. Gallagher P.J., Paxinos G., White S.W. The role of substance P in arterial chemoreflex control of ventilation. J. Auton. Nerv. Syst. 12:1985;195-210.
9. Gauda E.B., Bamford O.S., Northington F.J. Lack of induction of substance P gene expression by hypoxia and absence of neurokinin 1-receptor mRNAs in the rat carotid body. J. Auton. Nerv. Syst. 74:1998;100-108.
10. Grasemann H., Lu B., Jiao A., Boudreau J., Gerard N.P., De Sanctis G.T. Targeted deletion of the neutral endopeptidase gene alters ventilatory responses to acute hypoxia in mice. J. Appl. Physiol. 87:1999;1266-1271.
11. Gray P.A., Rekling J.C., Bocchiaro C.M., Feldman J.L. Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the pre-Botzinger complex. Science. 286:1999;1566-1568.
12. Gray P.A., Janczewski W.A., Mellen N., McCrimmon D.R., Feldman J.L. Normal breathing requires pre Botzinger complex neurokinin-1 receptor-expressing neurons. Nat. Neurosci. 4:2001;927-930.
13. Guyenet P.G., Sevigny C.P., Weston M.C., Stornetta R.L. Neurokinin-1 receptor-expressing cells of the ventral respiratory group are functionally heterogeneous and predominantly glutamatergic. J. Neurosci. 22:2002;3806-3816.
14. Hanson G., Jones L., Fidone S. Physiological chemoreceptor stimulation decreases enkephalin and substance P in the carotid body. Peptides. 7:1986;767-769.
15. Heath D., Quinzanini M., Rodella A., Albertini A., Ferrari R., Harris P. Immunoreactivity to various peptides in the human carotid body. Res. Commun. Chem. Pathol. Pharmacol. 62:1988;289-293.
16. Hedner J., Hedner T., Wessberg P., Jonason J. Interaction of substance P with the respiratory control system in the rat. J. Pharmacol. Exp. Ther. 228:1984;196-201.
17. Hedner J., Hedner T., Jonason J. Capsaicin and regulation of respiration: interaction with central substance P mechanisms. J. Neural. Transm. 61:1985;239-252.
18. Henry J.L., Sessle B.J. Effects of glutamate, substance P and eledoisin-related peptide on solitary tract neurones involved in respiration and respiratory reflexes. Neuroscience. 14:1985;863-873.
19. Johnson S.M., Smith J.C., Feldman J.L. Modulation of respiratory rhythm in vitro: role of Gi/o protein-mediated mechanisms. J. Appl. Physiol. 80:1996;2120-2133.
20. Kim D.K., Oh E.K., Summers B.A., Prabhakar N.R., Kumar G.K. Release of substance P by low oxygen in the rabbit carotid body: evidence for the involvement of calcium channels. Brain. Res. 892:2001;359-369.
21. Kumar G.K. Neuropeptide processing enzymes of the carotid body: biochemical and immunological characterization of carboxypeptidase activity. Adv. Exp. Med. Biol. 410:1996;319-323.
22. Kumar G.K. Peptidases of the peripheral chemoreceptors: biochemical, immunological, in vitro hydrolytic studies and electron microscopic analysis of neutral endopeptidase-like activity of the carotid body. Brain Res. 748:1997;39-50.
23. Kumar G.K., Runold M., Ghai R.D., Cherniack N.S., Prabhakar N.R. Occurrence of neutral endopeptidase activity in the cat carotid body and its significance in chemoreception. Brain res. 517:1990;341-343.
24. Kumar G.K., Kou Y.R., Overholt J.L., Prabhakar N.R. Involvement of substance P in neutral endopeptidase modulation of carotid body sensory responses to hypoxia. J. Appl. Physiol. 88:2000;195-202.
25. Kusakabe T., Kawakami T., Tanabe Y., Fujii S., Takenaka T. Distribution of substance P-containing and catecholaminergic nerve fibers in the rabbit carotid body: an immunohistochemical study in combination with catecholamine fluorescent histochemistry. Arch. Histol. Cytol. 57:1994;193-199.
26. Lieske S.P., Thoby-Brisson M., Telgkamp P., Ramirez J.M. Reconfiguration of the neural network controlling multiple breathing patterns: eupnea, sighs and gasps. Nat. Neurosci. 3:2000;531-532.
27. Liu Y.Y., Ju G., Wong-Riley M.T. Distribution and colocalization of neurotransmitters and receptors in the pre-Botzinger complex of rats. J. Appl. Physiol. 91:2001;1387-1395.
28. Maggi C.A. The mammalian tachykinin receptors. Gen. Pharmacol. 26:1995;911-944.
29. Maxwell D.L., Fuller R.W., Dixon C.M., Cuss F.M., Barnes P.J. Ventilatory effects of substance P, vasoactive intestinal peptide, and nitroprusside in humans. J. Appl. Physiol. 68:1990;295-301.
30. Mazzone S.B., Geraghty D.P. Respiratory actions of tachykinins in the nucleus of the solitary tract: characterization of receptors using selective agonists and antagonists. Br. J. Pharmacol. 129:2000;1121-1131.
31. McQueen D.S. Effects of substance P on carotid chemoreceptor activity in the cat. J. Physiol. London. 302:1980;31-47.
32. Monteau R., Ptak K., Broquere N., Hilaire G. Tachykinins and central respiratory activity: an in vitro study on the newborn rat. Eur. J. Pharmacol. 314:1996;41-50.
33. Monti-Bloch L., Eyzaguirre C. Effects of methionine-enkephalin and substance P on the chemosensory discharge of the cat carotid body. Brain Res. 338:1985;297-307.
34. Oh E.K., Kline D.D., Lu B., Gerard N.P., Prabhakar N.R., Kumar G.K. Ventilatory responses to hypoxia and hypercapnia in neurokinin-1 receptor knock-out mice. FASEB J. 14:2000;A641.
35. Oh E.K., Prabhakar N.R., Basbaum A.I., Kumar G.K. Blunted ventilatory responses to hypoxia in preprotachykinin-A knock-out mice. FASEB J. 15:2001;A423.
36. Pizarro J., Ryan M.L., Hedrick M.S., Xue D.H., Keith I.M., Bisgard G.E. Intracarotid substance P infusion inhibits ventilation in the goat. Respir. Physiol. 101:1995;11-22.
37. Prabhakar N.R. Neurotransmitters in the carotid body. Adv. Exp.Med. Biol. 360:1994;57-69.
38. Prabhakar N.R. Oxygen sensing by the carotid body chemoreceptors. J. Appl. Physiol. 88:2000;2287-2295.
39. Prabhakar N.R., Cherniack N.S. Importance of tachykinin peptides in hypoxic ventilatory drive. Lahiri S., Forster R.E. II, Davies R.O., Pack A.I. Chemoreceptors and Reflexes in Breathing: Cellular and Molecular Aspects. 1989;99-112 Oxford university press, New York.
40. Prabhakar N.R., Runold M., Yamamoto Y., Lagercrantz H., von Euler C. Effect of substance P antagonist on the hypoxia-induced carotid chemoreceptor activity. Acta Physiol. Scand. 121:1984;301-303.
41. Prabhakar N.R., Kumar G.K., Mitra J., von Euler C., Cherniack N.S. Comparison of presence and chemoreceptive function of different tachykinins in the carotid body. Neurosci. Abstracts. 1:1986;494.
42. Prabhakar N.R., Runold M., Yamamoto Y., Lagercrantz H., Cherniack N.S., von Euler C. Role of the vagal afferents in substance P-induced respiratory responses in anaesthetized rabbits. Acta Physiol. Scand. 131:1987;63-71.
43. Prabhakar N.R., Mitra J., Cherniack N.S. Role of substance P in hypercapnic excitation of carotid chemoreceptors. J. Appl. Physiol. 63:1987;2418-2425.
44. O2. Brain Res. 481:1989;205-214.
45. Prabhakar N.R., Runold M., Kumar G.K., Cherniack N.S., Scarpa A. Substance P and mitochondrial oxygen consumption: evidence for a direct intracellular role for the peptide. Peptides. 10:1989;1003-1006.
46. Prabhakar N.R., Kou Yu R., Runold M. Chemoreceptor responses to substance P, physalaemin and eledoisin: evidence for neurokinin-1 receptors in the cat carotid body. Neurosci. Lett. 120:1990;183-186.
47. Prabhakar N.R., Snider R.M., Lowe J.A. 3rd, Cao H. Selective blockade of sensory response of the carotid body to hypoxia by NK-1 receptor antagonist CP-96345. Regul. Pept. 46:1993;266-268.
48. Prabhakar N.R., Gouda E., Kumar G.K., Kou Y.R. Analysis of carotid chemoreceptor responses to substance P analogue in anaesthetized cats. J. Auton. Nerv. Syst. 52:1995;43-50.
49. Ptak K., Di Pasquale E., Monteau R. Substance P and central respiratory activity: a comparative in vitro study on foetal and newborn rat. Brain Res. Dev. Brain Res. 114:1999;217-227.
50. Ptak K., Hunt S.P., Monteau R. Substance P and central respiratory activity: a comparative in vitro study in NK1 receptor knockout and wild-type mice. Pflügers Arch. 440:2000;446-451.
51. Scheibner T., Read D.J., Sullivan C.E. Distribution of substance P-immunoreactive structures in the developing cat carotid body. Brain Res. 453:1988;72-78.
52. Solomon I.C., Edelman N.H., Neubauer J.A. Pre-Botzinger complex functions as ac central hypoxia chemosensor for respiration in vivo. J. Neurophysiol. 83:2000;2854-2868.
53. Srinivasan M., Goiny M., Pantaleo T., Lagercrantz H., Brodin E., Runold M., Yamamoto Y. Enhanced in vivo release of substance P in the nucleus tractus solitarii during hypoxia in the rabbit: role of peripheral input. Brain Res. 546:1991;211-216.
54. Telgkamp P., Cao Y.Q., Basbaum A.I., Ramirez J.M. Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network. J. Neurophysiol. 88:2002;206-213.
55. Thoby-Brisson M., Ramirez J.M. Identification of two types of inspiratory pacemaker neurons in the isolated respiratory neural network of mice. J. Neurophysiol. 86:2001;104-112.
56. von Euler U.S., Pernow B. Neurotrophic effects of substance P. Acta Physiol. Scand. 36:1956;265-274.
57. Wang Z.Z., Stensaas L.J., Dinger B., Fidone S.J. The co-existence of biogenic amines and neuropeptides in the type I cells of the cat carotid body. Neuroscience. 47:1992;473-480.
58. Wharton J., Polak J.M., Pearse A.G., McGregor G.P., Bryant M.G., Bloom S.R., Emson P.C., Bisgard G.E., Will J.A. Enkephalin-, VIP- and substance P-like immunoreactivity in the carotid body. Nature. 284:1980;269-271.
59. Yamamoto Y., Lagercrantz H. Some effects of substance P on central respiratory control in rabbit pups. Acta Physiol. Scand. 124:1985;449-455.