Modulation of respiratory rhythm in vitro: Role of G(i/o) protein- mediated mechanisms

Journal of Applied Physiology

Volumn 80, Issue 6, 1996, Pages 2120-2133

  Johnson, Stephen M ^a,b   Smith, Jeffrey C ^a   Feldman, Jack L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

norepinephrine; opioid; pertussis toxin; pre Botzinger complex; serotonin; substance P; aminobutyric acid

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MU OPIATE RECEPTOR; RECEPTOR SUBTYPE;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; BREATHING RATE; CEREBROSPINAL FLUID; CONTROLLED STUDY; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RESPIRATION CONTROL;

EID: 0030036170     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.80.6.2120     Document Type: Article

References (52)

1. Berger, A. J., D. A. Bayliss, and F. Viana. Modulation of neonatal rat hypoglossal motoneuron excitability by serotonin. Neurosci. Lett. 143: 164-168, 1992.
2. Bianchi, A. L., M. Denavit-Saubié, and J. Champagnat. Neurobiology of the central control of breathing in mammals: neuronal circuitry, membrane properties and neurotransmitters involved. Physiol. Rev. 75: 1-45, 1995.
3. Bolme, P., H. Corrodi, K. Fuxe, T. Hökfelt, P. Lidbrink, and M. Goldstein. Possible involvement of central adrenaline neurons in vasomotor and respiratory control. Studies with clonidine and its interactions with piperoxane and yohimbine. Eur. J. Pharmacol. 28: 89-94, 1974.
4. Champagnat, J., M. Denavit-Saubié, J. L. Henry, and V. Leviel. Catecholaminergic depressant effects on bulbar respiratory mechanisms. Brain Res. 160: 57-68, 1979.
5. Chen, Z., J. Hedner, and T. Hedner. Local effects of substance P on respiratory regulation in the rat medulla oblongata. J. Appl. Physiol. 68: 693-699, 1989.
6. Da Silva, A. M. T., B. Hartley, P. Hamosh, J. A. Quest, and R. A. Gillis. Respiratory depressant effects of GABA α- and β-receptor agonists in the cat. J. Appl. Physiol. 62: 2264-2272, 1987.
7. Denavit-Saubié, M., J. Champagnat, and G. Rondouin. Central effect of adrenergic compounds on cat respiratory mechanisms. In: Central Adrenaline Neurons: Basic Aspects and Their Role in Cardiovascular Functions, edited by K. Fuxe, M. Goldstein, B. Hökfelt, and T. Hökfelt. New York: Pergamon, 1980, p. 277-287.
8. Denavit-Saubié, M., J. Champagnat, and W. Zieglgänsberger. Effects of opiates and methionine-enkephalin on pontine and bulbar respiratory neurones of the cat. Brain Res. 155: 55-67, 1978.
9. Dolphin, A. C. G protein modulation of calcium currents in neurons. Annu. Rev. Physiol. 52: 243-255, 1990.
10. Errchidi, S., G. Hilaire, and R. Monteau. Permanent release of noradrenaline modulates respiratory frequency in the newborn rat: an in vitro study. J. Physiol. Lond. 429: 497-510, 1990.
11. Errichidi, S., R. Monteau, and G. Hilaire. Noradrenergic modulation of the medullary respiratory rhythm generator in the newborn rat: an in vitro study. J. Physiol. Lond. 443: 477-498, 1991.
12. Feldman, J. L., and J. C. Smith. Cellular mechanisms underlying modulation of breathing pattern in mammals. Ann. NY Acad. Sci. 563: 114-130, 1989.
13. Feldman, J. L., and J. C. Smith. Neural control of respiratory pattern in mammals: an overview. In: Regulation of Breathing, edited by J. A. Dempsey and A. I. Pack. New York: Dekker, 1995, vol. 79, p. 39-69. (Lung Biol. Health Dis. Ser.)
14. Fung, M.-L., W. Wang, and W. M. St. John. Medullary loci critical for expression of gasping in adult rats. J. Physiol. Lond. 480: 597-611, 1994.
15. Funk, G. D., J. C. Smith, and J. L. Feldman. Generation and transmission of respiratory oscillations in medullary slices: role of excitatory amino acids. J. Neurophysiol. 70: 1497-1515, 1993.
16. Funk, G. D., J. C. Smith, and J. L. Feldman. Development of thyrotropin-releasing hormone and norepinephrine potentiation of inspiratory-related hypoglossal motoneuron discharge in neonatal and juvenile mice in vitro. J. Neurophysiol. 72: 2538-2541, 1994.
17. A receptors on cardiorespiratory function. J. Pharmacol. Exp. Ther. 248: 851-857, 1989.
18. Greer, J. J., J. E. Carter, and Z. Al-Zubaidy. Opioid depression of respiration in perinatal rats. J. Physiol. Lond. 485: 845-855, 1995.
19. Hassen, A. H., G. Feuerstein, and A. I. Faden. Selective cardiorespiratory effects mediated by mu opioid receptors in the nucleus ambiguus. Neuropharmacology 23: 407-415, 1984.
20. 1A agonist act synergistically to produce vasodepressor responses in the rat. Eur. J. Pharmacol. 204: 87-95, 1991.
21. Hedner, T., J. Hedner, J. Jonason, and D. Lundberg. Evidence suggesting a role for substance P in central respiratory regulation in the rat. Acta Physiol. Scand. 112: 487-489, 1981.
22. Hille, B. Ionic Channels of Excitable Membranes. Sunderland, MA: Sinauer, 1992.
23. 1A receptors at the ventral medulla on phrenic nerve activity. Eur. J. Pharmacol. 253: 307-310, 1994.
24. + conductance? (Abstract). Physiologist 36: A12, 1993.
25. Johnson, S. M., J. C. Smith, and J. L. Feldman. Pacemaker behavior of respiratory neurons in medullary slices from neonatal rat. J. Neurophysiol. 72: 2598-2608, 1994.
26. Lalley, P. M. Effects of baclofen and γ-aminobutyric acid on different types of medullary respiratory neurons. Brain Res. 376: 392-395, 1986.
27. McCrimmon, D. R., G. S. Mitchell, and M. S. Dekin. Glutamate, GABA, and serotonin in ventilatory control. In: Regulation of Breathing, edited by J. A. Dempsey and A. I. Pack. New York: Dekker, 1995, vol. 79, p. 151-218. (Lung Biol. Health Dis. Ser.)
28. Monteau, R., E. Di Pasquale, and G. Hilaire. Further evidence that various 5-HT receptor subtypes modulate central respiratory activity: in vitro studies with SR 46349B. Eur. J. Pharmacol. 259: 71-74, 1994.
29. Morin-Surun, M. P., E. Boudinot, M. C. Fournie-Zaluski, J. Champagnat, B. P. Roques, and M. Denavit-Saubié. Control of breathing by endogenous opioid peptides: possible involvement in sudden infant death syndrome. Neurochem. Int. 20: 103-107, 1992.
30. Morin-Surun, M. P., G. Gacel, J. Champagnat, M. Denavit-Saubié, and B. P. Roques. Pharmacological identification of δ and μ opiate receptors on bulbar respiratory neurons. Eur. J. Pharmacol. 98: 241-247, 1984.
31. Murakoshi, T., T. Suzue, and S. Tamai. A pharmacological study on respiratory rhythm in the isolated brainstem-spinal cord preparation of the newborn rat. Br. J. Pharmacol. 86: 95-104, 1985.
32. Nakajima, Y., S. Nakajima, and M. Inoue. Pertussis toxin-insensitive G protein mediates substance P-induced inhibition of potassium channels in brain neurons. Proc. Natl. Acad. Sci. USA 85: 3643-3647, 1988.
33. Nicholson, C. Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity. Brain Res. 333: 325-329, 1985.
34. Nicholl, R. A. The coupling of neurotransmitter receptors to ion channels in the brain. Science Wash. DC 241: 545-551, 1988.
35. Nicholl, R., A., R. C. Malenka, and J. A. Kauer. Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system. Physiol Rev. 70: 513-565, 1990.
36. Onimaru, H., A. Arata, and I. Homma. Localization of respiratory rhythm-generating neurons in the medulla of brainstem-spinal cord preparations from newborn rats. Neurosci. Lett. 78: 151-155, 1987.
37. Otsuka, M., and K. Yoshioka. Neurotransmitter functions of mammalian tachykinins. Physiol. Rev. 73: 229-308, 1993.
38. Pennington, N. J., J. S. Kelly, and A. P. Fox. Unitary properties of potassium channels activated by 5-HT in acutely isolated rat dorsal raphe neurones. J. Physiol. Lond. 469: 407-426, 1993.
39. B receptor agonists and antagonists on the bulbar respiratory network in cat. Brain Res. 605: 77-84, 1993.
40. Rondouin, G., E. Boudinot, J. Champagnat, and M. Denavit-Saubié. Effects of sulfonated Leu-enkephalin applied iontophoretically to cat respiratory neurones. Neuropharmacology 20: 963-967, 1981.
41. B receptor mediated effects on central respiratory system and their antagonism by phaclofen. Neurosci. Lett. 99: 305-310, 1989.
42. Schultz, G., W. Rosenthal, J. Hescheler, and W. Trautwein. Role of G proteins in calcium channel modulation. Annu. Rev. Physiol. 52: 275-292, 1990.
43. Smith, J. C., H. H. Ellenberger, K. Ballanyi, D. W. Richter, and J. L. Feldman. Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science Wash. DC 254: 726-729, 1991.
44. Smith, J. C., G. D. Funk, S. M. Johnson, and J. L. Feldman. Cellular and synaptic mechanisms generating respiratory rhythm: insights from in vitro and computational studies. In: Ventral Brainstem Mechanisms and Control of Breathing and Blood Pressure, edited by O. Trouth, R. Millis, H. Kiwull-Schone, and M. Schlafke. New York: Dekker, 1995, vol. 82, pp. 463-496. (Lung Biol. Health Dis. Ser.)
45. Smith, J. C., J. J. Greer, G. Liu, and J. L. Feldman. Neural mechanisms generating respiratory pattern in mammalian brainstem-spinal cord in vitro. I. Spatiotemporal patterns of motor and medullary neuron activity. J. Neurophysiol. 64: 1149-1169, 1990.
46. 2-adrenoceptors. Proc. R. Soc. Lond. Ser. B Biol. Sci. 234: 85-114, 1988.
47. B receptors are coupled to a barium-insensitive outward rectifying potassium conductance in premotor respiratory neurons. J. Neurophysiol. 69: 286-289, 1993.
48. Williams, J. T., W. F. Colmers, and Z. Z. Pan. Voltage- and ligand-activated inwardly rectifying currents in dorsal raphe neurons in vitro. J. Neurosci. 8: 3499-3506, 1988.
49. Williams, J. T., R. A. North, and T. Tokimasa. Inward rectification of resting and opiate-activated potassium currents in rat locus coeruleus neurons. J. Neurosci. 8: 4299-4306, 1988.
50. Wimpey, T. L., and C. Chavkin. Opioids activate both an inward rectifier and a novel voltage-gated potassium conductance in the hippocampal formation. Neuron 6: 281-289, 1991.
51. Yamamoto, Y., H. Lagercrantz, and C. von Euler. Effects of substance P and TRH on ventilation and pattern of breathing in newborn rabbits. Acta Physiol. Scand. 113: 541-543, 1981.
52. Yamamoto, Y., H. Onimaru, and I. Homma. Effect of substance P on respiratory rhythm and pre-inspiratory neurons in the ventrolateral structure of rostral medulla oblongata: an in vitro study. Brain Res. 599: 272-276, 1992.