8OH-DPAT-induced ocular hypotension: Sites and mechanisms of action

Experimental Eye Research

Volumn 69, Issue 2, 1999, Pages 227-238

  Chu, Teh Ching ^a   Ogidigben, Miller J ^a   Potter, David E ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

5 HT(1A); 8 OH DPAT; cAMP; Central administration; Intraocular pressure; Receptors

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ALPHA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; CYTOKINE; NORADRENALIN; RAUWOLSCINE; SEROTONIN 1A RECEPTOR; SPIROXATRINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CILIARY BODY; CONTROLLED STUDY; CYTOKINE RELEASE; INTRAOCULAR HYPOTENSION; INTRAOCULAR PRESSURE; IRIS; NONHUMAN; NORADRENALIN BLOOD LEVEL; PATHOGENESIS; PRIORITY JOURNAL; RABBIT; SYMPATHECTOMY; TOPICAL DRUG ADMINISTRATION;

EID: 0032775497     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.1999.0694     Document Type: Article

References (25)

1. Arvidsson L. E., Hacksell U., Nilsson J. L., Hjorth S., Carlsson A., Lindberg P., Sanchez D., Wikstrom H. 8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist. J. Med. Chem. 24:1981;921-923.
2. 1) receptors negatively coupled to adenylate cyclase in rabbit and human iris-ciliary processes. Exp. Eye Res. 57:1993;209-216.
3. Campbell W. R., Potter D. E. Centrally mediated ocular hypotension: Potential role of imidazoline receptors. Ann. N.Y. Acad. Sci. 763:1995;463-485.
4. Chang F. W., Burke J. A., Potter D. E. Mechanism of the ocular hypotensive action of ketanserin. J. Ocular Pharmacol. 1:1985;137-147.
5. Chidlow G., Le Corre S., Osborne N. N. Localization of 5-hydroxytryptamine1A and 5-hydroxytryptamine7 receptors in rabbit ocular and brain tissues. Neuroscience. 87:1998;675-689.
6. Chiou G. C. Y., Byron N. P. Ocular hypotensive actions of serotonin antagonist-ketanserin analogs. J. Ocular Pharmacol. 8:1992;11-21.
7. 1A) agonist, 8-hydroxy-DPAT. Invest. Ophthalmol. Vis. Sci. 37:1996a;S837.
8. Chu T. C., Ogidigben M. J., Potter D. E. Oxymetazoline: potential mechanisms of inhibitory effects on aqueous humor dynamics. Pharmacology. 53:1996b;259-270.
9. 2receptors. Curr. Eye Res. 15:1996c;943-950.
10. Costaglioda C., Iuliano G., Rinaldi M., Russo V., Scibelli G., Mastropasqua L. Effect of topical ketanserin administration on intraocular pressure. Br. J. Ophthalmol. 77:1993;344-348.
11. Hof R. P., Fozard J. R. 8-OH-DPAT, flesinoxan and guanfacine: systemic and regional haemodynamic effects of centrally acting antihypertensive agents in anaesthetized rabbits. Br. J. Pharmacol. 96:1989;864-871.
12. Hoyer D., Clarke D. E., Fozard J. R., Hartig P. R., Martin G. R., Mylecharane E. J., Saxena P. R., Humphrey P. P. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46:1994;157-203.
13. Krootila K., Palkama A., Uusitalo H. Effect of serotonin and its antagonist (ketanserin) on intraocular pressure in the rabbit. J. Ocular Pharmacol. 3:1987;279-290.
14. Mallorga P., Sugrue M. F. Characterization of serotonin receptors in the iris-ciliary body of the albino rabbit. Curr. Eye Res. 6:1987;527-532.
15. Martin X. D., Brennan M. C., Lichter P. R. Serotonin in human aqueous humor. Ophthalmology. 95:1988;1221-1226.
16. Matsumoto M., Yoshioka M., Togasi H., Tochihara M., Ikeda T., Saito H. Modulation of norepinephrine release by serotonergic receptors in the rat hippocampus as measured by in vivo microdialysis. J. Pharmacol. Exp. Ther. 272:1995;1044-1051.
17. Metwally K. A., Dukat M., Egan C. T., Smith C., Dupre A., Gauthier C. B., Herrick-Davis K., Teitler M., Glennon R. A. Spiperone: Influence of spiro ring substituents on 5-HT2A serotonin receptor binding. J. Med. Chem. 41:1998;5084-5093.
18. Middlemiss D. N., Fozard J. R. 8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site. Eur. J. Pharmacol. 90:1983;151-153.
19. Nelson D. L., Taylor E. W. Spiroxatrine: serotonin1A receptor antagonist. Eur. J. Pharmacol. 124:1986;207-208.
20. Ogidigben M., Chu T. C., Potter D. E. Ocular actions of moxonidine: a possible role for imidazoline receptors. J. Pharmacol. Exp. Ther. 269:1994;897-904.
21. 1A, receptors have similar functions in the control of intraocular pressure in the rabbit?, Ophthalmologica, 210, 308-14.
22. Rowland J. M., Potter D. E., Reiter R. J. Circadian rhythm in an intraocular pressure model. Curr. Eye Res. 1:1981;169-173.
23. Tobin A. B., Osborne N. N. Evidence for the presence of serotonin receptors negatively coupled to adenylate cyclase in the rabbit iris-ciliary body. J. Neurochem. 53:1989;686-691.
24. Tobin A. B., Unger W., Osborne N. N. Evidence for the presence of serotonergic nerves and receptors in the iris-ciliary body complex of the rabbit. J. Neurosci. 10:1988;3713-3721.
25. Uhlen S., Muceniece R., Rangel N., Tiger G., Wikberg J. E. Comparison of the binding activities of some drugs on alpha 2A, alpha 2B and alpha 2C-adrenoceptors and non-adrenergic imidazoline sites in the guinea pig. Pharmacol. Toxicol. 76:1995;353-364.