Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 285, Issue 1 48-1, 2003, Pages

  Phillipson, Mia ^a   Henriksnäs, Johanna ^a   Holstad, Maria ^a   Sandler, Stellan ^a   Holm, Lena ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Gastric mucosal blood flow; In vivo; L N6 (1 iminoethyl)lysine; Laser Doppler flowmetry; Neuronal nitric oxide synthase; S methyl L thiocitrulline

Indexed keywords

CITRULLINE; EDETATE CHROMIUM; HYDROCHLORIC ACID; ISOFLURANE; LYSINE DERIVATIVE; MESSENGER RNA; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; THIOBUTABARBITAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HYPEREMIA; LASER DOPPLER FLOWMETRY; MALE; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH BLOOD FLOW; STOMACH MUCOSA; STOMACH PROTECTION; WILD TYPE;

EID: 0038339448     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00432.2002     Document Type: Article

References (37)

1. Ahn H, Lindhagen J, Nilsson GE, Salerud EG, Jodal M, and Lundgren O. Evaluation of laser Doppler flowmetry in the assessment of intestinal blood flow in cat. Gastroenterology 88: 951-957, 1985.
2. Barreto JC, Smith GS, Russell DH, and Miller TA. Gastric damage caused by acidified ethanol: role of molecular HCl. Am J Physiol Gastrointest Liver Physiol 265: G133-G137, 1993.
3. 51Cr-EDTA in rats with experimental induced enteropathy. Gut 26: 579-585, 1985.
4. Brown JF, Tepperman BL, Hanson PJ, Whittle BJ, and Moncada S. Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa. Biochem Biophys Res Commun 184: 680-685, 1992.
5. Byrne CR, Price KJ, Williams JM, Brown JF, Hanson PJ, and Whittle BJR. Nitric oxide synthase and arginase in cells isolated from the rat gastric mucosa. Biochim Biophys Acta 1356: 131-139, 1997.
6. Casselbrant A, Pettersson A, Ruth M, Bove M, Lundell L, and Fändriks L. Sources of intra-oesophagal nitric oxide production following intraluminal acid exposure. Scand J Gastroenterol 37: 631-637, 2002.
7. Crissinger KD, Kvietys PR, and Granger DN. Pathophysiology of gastrointestnal mucosal permeability. J Int Med 228, Suppl 1: 145-154, 1990.
8. Flodström M, Niemann A, Bedoya FJ, Morris SM Jr, and Eizirik DL. Expression of the citrulline-NO cycle in rodent and human pancreatic β-cells: induction of argininosuccinate synthetase by cytokines. Endocrinology 136: 3200-3206, 1997.
9. Furfine ES, Harmon MF, Paith JE, Knowles RG, Salter M, Kiff RJ, Duffy C, Hazelwood JA, Oplinger JA, and Garvey EP. Potent and selective inhibition of human nitric oxide synthases. J Biol Chem 269: 26677-26683, 1994.
10. Gibson UE, Heid CA, and Williams PM. A novel method for real time quantitative RT-PCR. Genome Res 6: 995-1001, 1996.
11. Gozal D, Torres JE, Gozal YM, and Littwin SM. Effect of nitric oxide synthase inhibition on cardiorespiratory responses in the conscious rat. J Appl Physiol 81: 2068-2077, 1996.
12. Guo FH, De Raeve HR, Rice TW, Stuehr DJ, Thunnissen FBJM, and Erzurum SC. Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc Natl Acad Sci USA 92: 7809-7813, 1995.
13. 51Cr-labelled ethylenediaminetetraacetate. Am J Vet Res 50: 2069-2074, 1989.
14. Heid CA, Stevens J, Livak KJ, and Williams PM. Real time quantitative PCR. Genome Res 6: 986-994, 1996.
15. Henriksnäs J, Johansson M, Atuma C, and Holm L. The mouse in functional gastrointestinal studies in vivo (Abstract). Pflügers Arch Suppl 441: R184, 2001.
16. Hoffman RA, Zhang G, Nüssler NC, Gleixner SL, Ford HR, Simmons RL, and Watkins SC. Constitutive expression of inducible nitric oxide synthase in the mouse ileal mucosa. Am J Physiol Gastrointest Liver Physiol 272: G383-G392, 1997.
17. Holm M, Powell T, Casselbrant A, Johansson B, and Fändriks L. Dynamic involvement of the inducible type of nitric oxide synthase in acid-induced duodenal mucosal alkaline secretion in the rat. Dig Dis Sci 46: 1765-1771, 2001.
18. Holm-Rutili L and Öbrink KJ. Rat gastric mucosal microcirculation in vivo. Am J Physiol Gastrointest Liver Physiol 248: G741-G746, 1985.
19. Holzer P. Neural emergency system in the stomach. Gastroenterology 114:823-839, 1998.
20. Huang PL, Dawson TM, Bredt DS, Snyder SH, and Fishman MC. Targeted disruption of the neuronal nitric oxide synthase gene. Cell 75: 1273-1286, 1993.
21. Jain B, Rubinstein I, Robbins RA, Leise KL, and Sisson JH. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. J Biochem Biophys Res Commun 191: 83-88, 1993.
22. Knowles RG and Moncada S. Nitric oxide synthases in mammals. Biochem J 298: 249-258, 1994.
23. Konturek PC, Brzozowski T, Sliwowski Z, Pajdo R, Stachura J, Hahn EG, and Konturek SJ. Involvement of nitric oxide and prostaglandins in gastroprotection induced by bacterial lipopolysaccharide. Scand J Gastroenterol 33: 691-700, 1998.
24. Kriegsfeld LJ, Eliasson MJL, Demas GE, Blackshaw S, Dawson TM, Nelson RJ, and Snyder SH. Nocturnal motor coordination deficits in neuronal nitric oxide synthase knock-out mice. Neuroscience 89: 311-315, 1999.
25. Li DS, Raybould HE, Quintero E, and Guth PH. Calcitonin gene-related peptide mediates the gastric hyperemic response to acid back-diffusion. Gastroenterology 102: 1124-1128, 1992.
26. Lippe IT and Holzer P. Participation of endothelium-derived nitric oxide but not prostacyclin in the gastric mucosal hyperaemia due to acid back-diffusion. Br J Pharmacol 105: 708-714, 1992.
27. Lundberg JO, Farkas-Szallasi T, Weitzberg E, Rinder J, Lidholm J, Änggård A, Hökfält T, Lundberg JM, and Alving K. High nitric oxide production in human paranasal sinuses. Nat Med 1: 370-373, 1995.
28. MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, Xie QW, Sokol K, and Hutchinson N. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81: 641-650, 1995.
29. McCafferty DM, Miampamba M, Sihota E, Sharkey KA, and Kubes P. Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice. Gut 45: 864-873, 1999.
30. Moore PK, Babbedge RC, Wallace P, Gaffen ZA, and Hart SL. 7-Nitro indazole, an inhibitor of nitric oxide synthase in kidney macula densa cells. Kidney Int 42: 1017-1019, 1992.
31. Morris SM, Nakayama DK, Nussler AK, Liu ZZ, Davies P, Pitt BR, Simmons RL, and Billiar TR. Coinduction of nitric oxide synthase and argininosuccinate synthetase gene expression: implications for regulation of nitric oxide synthesis. In: The Biology of Nitric Oxide: Enzymology, Biochemestry and Immunology, edited by Moncada S, Freelish M, Busse R, and Higgis EA. London: Portland, 1994, vol. 4, p. 301-303.
32. Phillipson M, Atuma C, Henriksnäs J, and Holm L. The importance of mucus layers and bicarbonate transport in preservation of gastric juxtamucosal pH. Am J Physiol Gastrointest Liver Physiol 282: G211-G219, 2002.
33. Price KJ, Hanson PJ, and Whittle BJR. Localization of constitutive isoforms of nitric oxide synthase in the gastric glandular mucosa of the rat. Cell Tissue Res 285: 157-163, 1996.
34. Schmidt HHHW and Walter U. NO at work. Cell 78: 919-925, 1994.
35. Shimizu S, Ishii M, Momose K, and Yamamoto T. Role of tetrahydrobiopterin in the function of nitric oxide synthase, and its cytoprotective effect. Int J Mol Med 2: 533-540, 1998.
36. Synnerstad I, Johansson M, Nylander O, and Holm L. Intraluminal acid and gastric mucosal integrity: the importance of blood-borne bicarbonate. Am J Physiol Gastrointest Liver Physiol 280: G138-G146, 2001.
37. Wallace JL and Miller MJS. Nitric oxide in mucosal defense: a little goes a long way. Gastroenterology 119: 512-520, 2000.