The neonicotinoid electronegative pharmacophore plays the crucial role in the high affinity and selectivity for the Drosophila nicotinic receptor: An anomaly for the nicotinoid cation-π interaction model

Biochemistry

Volumn 42, Issue 25, 2003, Pages 7819-7827

  Tomizawa, Motohiro ^a   Zhang, Nanjing ^a   Durkin, Kathleen A ^a   Olmstead, Marilyn M ^b   Casida, John E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POSITIVE IONS; QUANTUM THEORY; TOPOLOGY; X RAY CRYSTALLOGRAPHY;

ELECTRONEGATIVE PHARMACOPHORES;

BIOCHEMISTRY;

AMIDINE; AMMONIA; ANABASINE DERIVATIVE; ARGININE; CATION; GUANIDINE; IMIDAZOLIDINE DERIVATIVE; IMIDAZOLINE; IMINE; LYSINE; N (TRIFLUOROACETYL)IMINE; N NITROSOIMINE; N TRIFLUOROMETHANESULFONYLIMINE; NEONICOTINOID; NEONICOTINOID N NITROIMINE; NICOTINIC RECEPTOR; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AGONIST; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CONJUGATION; DROSOPHILA; INSECT; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; QUANTUM CHEMISTRY; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA; ELECTROSTATICS; IMINES; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

INSECTA; VERTEBRATA;

EID: 0038338722     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0300130     Document Type: Article

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