Aminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible to Salmonella typhimurium infection

FEMS Microbiology Letters

Volumn 206, Issue 1, 2002, Pages 93-98

  Zhou, Xin ^a,c   Potoka, Douglas A ^a   Boyle, Patricia ^a   Nadler, Evan P ^a   McGinnis, Kathleen ^b   Ford, Henri R ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c University of Maryland School of Medicine Center for Vaccine Development   (United States)

Author keywords

Aminoguinidine; iNOS knockout mouse; Salmonella typhimurium

Indexed keywords

AMINOGUANIDINE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME INHIBITION; HOST RESISTANCE; INFECTION SENSITIVITY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; SALMONELLOSIS; WEIGHT REDUCTION;

SALMONELLA TYPHIMURIUM;

EID: 0037005876     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(01)00539-0     Document Type: Article

References (16)

1. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro
2. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosi. II. Effects on microbial proliferation and host survival in vivo
3. Apoptosis of human intestinal epithelial cells after bacterial invasion
4. Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice
5. Nitric oxide and macrophage function
6. In vivo blockage of nitric oxide with aminoguanidine inhibits immunosuppression induced by an attenuated strain of Salmonella typhimurium, potentiates Salmonella infection, and inhibits macrophage and polymorphonuclear leukocyte influx into the spleen
7. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase
8. Homocysteine antagonism of nitric oxide-related cytostasis in Salmonella typhimurium
9. Clearance of Shigella flexneri infection occurs through a nitric oxide- independent mechanism
10. Chlamydial infection in inducible nitric oxide synthase knockout mice
11. Immunosuppression and nitric oxide production induced by parenteral live Salmonella vaccines do not correlate with protective capacity: A phoP::Tn10 mutant does not suppress but does protect
12. Production and use of monoclonal IgA antibodies complexed with recombinant secretory component for passive mucosal protection
13. Trypanosoma cruzi affects nitric oxide production by murine peritoneal macrophages
14. Molecular mechanism of T-cell control of Chlamydia in mice: Role of nitric oxide in vivo
15. A dichotomous role for nitric oxide during acute Toxoplasma gondii infection in mice
16. Effect of aminoguanidine on the generation of superoxide anion and nitric oxide by peripheral blood granulocytes of rats with streptozotocin-induced diabetes