Differences between rat primary cortical neurons and astrocytes in purine release evoked by ischemic conditions

Neuropharmacology

Volumn 43, Issue 5, 2002, Pages 836-846

  Parkinson, F E ^a   Sinclair, C J D ^a   Othman, T ^b   Haughey, N J ^c   Geiger, J D ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Adenine nucleotides; Adenosine; Adenosine deaminase; Adenosine kinase; Hypoxanthine; Inosine; Nucleoside transport; Purine nucleoside phosphorylase

Indexed keywords

9 (2 HYDROXY 3 NONYL)ADENINE; ADENINE; ADENINE NUCLEOTIDE; ADENOSINE; ADENOSINE DEAMINASE INHIBITOR; ADENOSINE KINASE INHIBITOR; ADENOSINE TRIPHOSPHATE; BUFFER; DIPYRIDAMOLE; GLUCOSE; INOSINE; IODOACETIC ACID; IODOTUBERCIDIN; OXYGEN; PELDESINE; PURINE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; SODIUM CYANIDE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN CELL; CELL TYPE; CONTROLLED STUDY; DRUG EFFECT; INCUBATION TIME; ISCHEMIA; ISOTOPE LABELING; NONHUMAN; NUCLEOSIDE TRANSPORT; PRIORITY JOURNAL; PURINE METABOLISM; RAT;

ADENINE NUCLEOTIDES; ADENOSINE DEAMINASE; ADENOSINE KINASE; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIMETABOLITES; ASTROCYTES; BRAIN ISCHEMIA; CELLS, CULTURED; CEREBRAL CORTEX; CHROMATOGRAPHY, THIN LAYER; ENZYME INHIBITORS; EXTRACELLULAR SPACE; GLUCOSE; HYPOXANTHINE; HYPOXIA-ISCHEMIA, BRAIN; INOSINE; IODOACETATES; NEURONS; PURINES; RATS; SODIUM CYANIDE;

EID: 0036801703     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00083-7     Document Type: Article

References (44)

1. Ames A. CNS energy metabolism as related to function. Brain Research Review. 34:2000;42.
2. Ballarin M., Fredholm B.B., Ambrosio S., Mahy N. Extracellular levels of adenosine and its metabolites in the striatum of awake rats: inhibition of uptake and metabolism. Acta Physiologica Scandinavica. 142:1991;97.
3. Cass C.E., Young J.D., Baldwin S.A. Recent advances in the molecular biology of nucleoside transporters of mammalian cells. Biochemical and Cell Biology. 76:1998;761.
4. Castellano B., Gonzalez B., Finsen B.R., Zimmer J. Histochemical demonstration of purine nucleoside phosphorylase (PNPase) in microglial and astroglial cells of adult rat brain. Journal of Histochemistry and Cytochemistry. 38:1990;1535.
5. Ceballos G., Rubio R. Coculture of astroglial and vascular endothelial cells as apposing layers enhances the transcellular transport of hypoxanthine. Journal of Neurochemistry. 64:1995;991.
6. Chang C.H., Brockman R.W., Bennett L.L. Jr. Adenosine kinase from L1210 cells. Purification and some properties of the enzyme. Journal of Biolical Chemistry. 255:1980;2366.
7. Chen Y., Graham D.I., Stone T.W. Release of endogenous adenosine and its metabolites by the activation of NMDA receptors in the rat hippocampus in vivo. British Journal of Pharmacology. 106:1992;632.
8. Ciccarelli R., Di Iorio P., Giuliani P., D'Alimonte I., Ballerini P., Caciagli F., Rathbone M.P. Rat cultured astrocytes release guanine-based purines in basal conditions and after hypoxia/hypoglycemia. Glia. 25:1999;93.
9. Cotrina M.L., Lin J.H., Alves-Rodrigues A., Liu S., Li J., Azmi-Ghadimi H., Kang J., Naus C.C., Nedergaard M. Connexins regulate calcium signaling by controlling ATP release. Proceedings of the National Academy of Science USA. 95:1998;15735.
10. Cotrina M.L., Lin J.H., Nedergaard M. Cytoskeletal assembly and ATP release regulate astrocytic calcium signaling. Journal of Neuroscience. 18:1998;8794.
11. Decking U.K., Schlieper G., Kroll K., Schrader J. Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine release. Circulation Research. 81:1997;154.
12. Fillenz M., Lowry J.P., Boutelle M.G., Fray A.E. The role of astrocytes and noradrenaline in neuronal glucose metabolism. Acta Physiologica Scandinavia. 167:1999;275.
13. Fredholm B.B. Adenosine and neuroprotection. International Review of Neurobiology. 40:1997;259.
14. 3H]Nitrobenzylthioinosine as markers of adenosine metabolism and transport in central purinergic systems. Williams M., Adenosine and Adenosine Receptors. 1990;225 Humana Press.
15. Geiger J.D., Parkinson F.E., Kowaluk E.A. Regulators of endogenous adenosine levels as therapeutic targets. Jacobson K.A., Jarvis M.F., Purinergic Approaches in Experimental Therapeutics. 1997;55 Wiley-Liss Inc, New York.
16. Golembiowska K., White T.D., Sawynok J. Adenosine kinase inhibitors augment release of adenosine from spinal cord slices. European Journal of Pharmacology. 307:1996;157.
17. Griffith D.A., Jarvis S.M. Nucleoside and nucleobase transport systems of mammalian cells. Biochimia Biophysica Acta. 1286:1996;153.
18. Gu J.G., Nath A., Geiger J.D. Characterization of inhibitor-sensitive and -resistant adenosine transporters in cultured human fetal astrocytes. Journal of Neurochemistry. 67:1996;972.
19. Hagberg H., Andersson P., Lacarewicz J., Jacobson I., Butcher S., Sandberg M. Extracellular adenosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia. Journal of Neurochemistry. 49:1987;227.
20. Hebb M.O., White T.D. Co-administration of adenosine kinase and deaminase inhibitors produces supra-additive potentiation of N-methyl-D-aspartate-evoked adenosine formation in cortex. European Journal of Pharmacology. 344:1998;121.
21. Kowaluk E., Jarvis M. Therapeutic potential of adenosine kinase inhibitors. Exp. Opin. Invest. Drugs. 9:2000;551.
22. Lee C.W., Jarvis S.M. Nucleoside transport in rat cerebral-cortical synaptosomes. Evidence for two types of nucleoside transporters. Biochemical Journal. 249:1988;557.
23. Litsky M.L., Hohl C.M., Lucas J.H., Jurkowitz M.S. Inosine and guanosine preserve neuronal and glial cell viability in mouse spinal cord cultures during chemical hypoxia. Brain Research. 821:1999;426.
24. Lloyd H.G., Fredholm B.B. Involvement of adenosine deaminase and adenosine kinase in regulating extracellular adenosine concentration in rat hippocadenine nucleotideal slices. Neurochemistry International. 26:1995;387.
25. Lynch J.J. 3rd, Alexander K.M., Jarvis M.F., Kowaluk E.A. Inhibition of adenosine kinase during oxygen-glucose deprivation in rat cortical neuronal cultures. Neuroscience Letters. 252:1998;207.
26. Matz H., Hertz L. Adenosine metabolism in neurons and astrocytes in primary cultures. Journal of Neuroscience Research. 24:1989;260.
27. Meno J.R., Ngai A.C., Ibayashi S., Winn H.R. Adenosine release and changes in pial arteriolar diameter during transient cerebral ischemia and reperfusion. Journal of Cerebral Blood Flow and Metabolism. 11:1991;986.
28. Pak M.A., Haas H.L., Decking U.K., Schrader J. Inhibition of adenosine kinase increases endogenous adenosine and depresses neuronal activity in hippocampa slices. Neuropharmacology. 33:1994;1049.
29. Parkinson F.E., Zhang J.W., Shepel P.N., Greenway S.C., Peeling J., Geiger J.D. Effects of nitrobenzylthioinosine on neuronal injury, adenosine levels and adenosine receptor activity in rat forebrain ischemia. Journal of Neurochemistry. 75:2000;795.
30. Phillis J.W., Walter G.A., O'Regan M.H., Stair R.E. Increases in cerebral cortical perfusate adenosine and inosine concentrations during hypoxia and ischemia. Journal of Cerebral Blood Flow and Metabolism. 7:1987;679.
31. Rudolphi K.A., Schubert P., Parkinson F.E., Fredholm B.B. Neuroprotective role of adenosine in cerebral ischaemia. Trends in Pharmacolical Science. 13:1992;439.
32. Schrader J., Gerlach E. Compartmentation of cardiac adenine nucleotides and formation of adenosine. Pflugers Archive European Journal of Physiology. 367:1976;129.
33. Shulman R.G., Hyder F., Rothman D.L. Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging. Proceedings of the National Academy of Science. 98:2001;6417.
34. Sinclair C.J.D., Powell A., Xiong W., LaRivière C.G., Baldwin S.A., Cass C.E., Young J.D., Parkinson F.E. Nucleoside transporter subtype expression: Effects on potency of adenosine kinase inhibitors. British Journal of Pharmacology. 134:2001;1037.
35. Sinclair C., Shepel N.P., Geiger J.D., Parkinson F.E. Stimulation of nucleoside efflux and inhibition of adenosine kinase by Al adenosine receptor activation. Biochemical Pharmacology. 59:2000a;477.
36. Sinclair C.J., LaRiviere C.G., Young J.D., Cass C.E., Baldwin S.A., Parkinson F.E. Purine uptake and release in rat C6 glioma cells: nucleoside transport and purine metabolism under ATP-depleting conditions. Journal of Neurochemistry. 75:2000b;1528.
37. Van Reempts J., Van Deuren B., Haseldonckx M., Van de Ven M., Thone F., Borgers M. Purine nucleoside phosphorylase: a histochemical marker for glial cells. Brain Research. 462:1988;142.
38. Van Wylen D.G., Park T.S., Rubio R., Berne R.M. Increases in cerebral interstitial fluid adenosine concentration during hypoxia, local potassium infusion, and ischemia. Journal of Cerebral Blood Flow and Metabolism. 6:1986;522.
39. Von Lubitz D.K. Adenosine and cerebral ischemia: therapeutic future or death of a brave concept? European Journal of Pharmacology. 365:1999;9.
40. Whittingham T.S. Aspects of brain energy metabolism and cerebral metabolism. Schurr A., Rigor B.M., Cerebral Ischemia and Resuscitation. 1990;101 CRC Press, Boca Raton, FL.
41. Zimmermann H. 5'-Nucleotidase: molecular structure and functional aspects. Biochemical Journal. 285:1992;345.
42. Zimmermann H. Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system. Progress in Neurobiology. 49:1996;589.
43. Zimmermann H. Extracellular metabolism of ATP and other nucleotides. Naunyn Schmiedebergs Archives of Pharmacology. 362:2000;299.
44. Zoref-Shani E., Bromberg Y., Lilling G., Gozes I., Brosh S., Sidi Y., Sperling O. Developmental changes in purine nucleotide metabolism in cultured rat astroglia. International Journal of Developmental Neuroscience. 13:1995;887.