Influence of lnterleukin-6 on neural activity and transcription of the gene encoding corticotrophin-releasing factor in the rat brain: An effect depending upon the route of administration

European Journal of Neuroscience

Volumn 9, Issue 7, 1997, Pages 1461-1472

  Vallières, Luc ^a   Lacroix, Steve ^a   Rivest, Serge ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

c fos mRNA; HPA axis; Immediate early genes; Immune response; In situ hybridization histochemistry; Intronic probe technology; Neuroendocrinology; Neuroimmune interaction

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; INTERLEUKIN 6; MESSENGER RNA;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA POSTREMA; ARTICLE; BRAIN; GENETIC TRANSCRIPTION; HISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MEDIAN EMINENCE; MEDULLA OBLONGATA; MENINX; NERVE CONDUCTION; NONHUMAN; OLFACTORY BULB; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; SOLITARY TRACT NUCLEUS; STRIA TERMINALIS; SUBFORNICAL ORGAN; THALAMUS MIDLINE NUCLEUS;

ANIMALS; BRAIN; CORTICOTROPIN-RELEASING HORMONE; GENES; INJECTIONS, INTRAVENOUS; INJECTIONS, INTRAVENTRICULAR; INTERLEUKIN-6; MALE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0030751312     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1997.tb01500.x     Document Type: Article

References (29)

1. Akira, S., Hirano, T., Taga, T. and Kishimoto, T. (1990) Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J., 4, 2860-2867.
2. Andersson, J., Nagy, S., Björk, L., Abrams, J., Holm, S. and Andersson, U. (1992) Bacterial toxin-induced cytokine production studied at the single-cell level. Immunol. Rev., 127, 69-96.
3. Bellinger, D. L., Lorton, D., Felten, S. Y. and Felten, D. L. (1992) Innervation of lymphoid organs and implications in development, aging, and autoimmunity. Int. J. Immunopharmacol., 14, 329-344.
4. Berkenbosch, F., Wolvers, D. A. W. and De Rijk, R. (1991) Neuroendocrine and immunological mechanisms in stress-induced immunomodulation. J. Steroid Biochem. Biol., 40, 639-647.
5. Besedovsky, H. O., Delrey, A., Klusman, I., Furukawa, H., Arditi, G. M. and Kabiersch, A. (1991) Cytokines as modulators of the hypothalamus-pituitary-adrenal axis. J. Steroid Biochem. Mol. Biol., 40, 613-618.
6. Campbell, I. L., Abraham, C. R., Masliah, E., Kemper, P., Inglis, J. D., Oldstone, M. B. and Mucke, L. (1993) Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natl Acad. Sci. USA, 90, 10061-10065.
7. Chai, Z., Gatti, S., Toniatti, C., Poli, V. and Bartfai, T. (1996) Interleukin (IL) 6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice. J.Exp. Med., 183, 311-316.
8. Chiang, C. S., Stalder, A., Samimi, A. and Campbell, I. L. (1994) Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice. Dev. Neurosci., 16, 212-221.
9. Conti, P., Bartle, L., Barbacane, R. C., Reale, M., Placido, F. C. and Sipe, J. (1995) Synergistic activation of serum amyloid A (SAA) by IL-6 and IL-1 in combination on human Hep 3B hepatoma cell line. Role of PGE2 and IL-1 receptor antagonist. Immunol. Invest., 24, 523-535.
10. Dinarello, C. A., Cannon, J. G., Mancilla, J., Bishai, I., Lees, J. and Coceani, F. (1991) Interleukin-6 as an endogenous pyrogen: induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells. Brain Res., 562, 199-206.
11. Ericsson, A., Kovacs, K. J. and Sawchenko, P. E. (1994) A functional anatomical analysis of central pathways subserving the effects of interleukin1 on stress-related neuroendocrine neurons. J. Neurosci., 14, 897-913.
12. Frei, K., Malipiero, U. V., Leist, T. P., Zinkernagel, R. M., Schwab, M. E. and Fontana, A. (1989) On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases. Ear. J. Immunol., 19, 689-694.
13. Fukata, J., Usui, T., Naitoh, Y., Nakay, Y. and Imura, H. (1989) Effects of recombinant human interleukin-1 alpha, -1 beta, 2 and 6 on ACTH synthesis and release in the mouse pituitary tumour cell line AtT-20. J. Endocrinol., 122, 33-39.
14. Gadient, H. and Otten, U. (1993) Differential expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat hypothalamus. Neurosci. Lett., 153, 13-16.
15. Gadient, R. A. and Otten, U. (1994) Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development. Brain Res., 637, 10-14.
16. Hama, T., Kushima, Y., Miyamoto, M., Kubota, M., Takei, N. and Hatanaka, H. (1991) Interleukin-6 improves the survival of mesencephalic' catecholaminergic and septal cholinergic neurons from postnatal, two-weekold rats in cultures. Neuroscience, 40, 445-452.
17. Harbuz, M. S., Rees, R. G., Eckland, D., Jessop, D. S., Brewerton, D. and Lightman, S. L. (1992a) Paradoxical responses of hypothalamic corticotrophin-releasing factor (CRF) messenger ribonucleic acid (mRNA) and CRF-41 peptide and adenohypophysial pro-opiomelanocortin mRNA during chronic inflammatory stress. Endocrinology, 130, 1394-1400.
18. Harbuz, M. S., Stephanou, A., Sarlis, N. and Lightman, S. L. (1992b) The effects of recombinant human interleukin (IL) 1 alpha, IL-1 beta or IL-6 on hypothalamo-pituitary-adrenal axis activation. J. Endocrinol., 133, 349-355.
19. Klir, J.J., Roth, J. and Kluger, M. J. (1992) Interleukin-6 (IL6) and tumor - necrosis factor (TNF) in hypothalamus of rats during lipopolysaccharide (LPS) induced fever. FASEB J., 6, 1522.
20. Klir, J.J., Roth, J., Szelenyi, Z., McClellan, J. L. and Kluger, M. J.(1993) Role of hypothalamic interleukin-6 and tumor necrosis factor-a in LPS fever in rat. Am. J. Physiol., 265, R512-R517.
21. Klir, J. J., McClellan, J. L. and Kluger, M. J. (1994) Interleukin-1 beta causes the increase in anterior hypothalamic interleukin-6 during LPS-induced fever in rats. Am. J. Physiol., 266, R1845-R1848.
22. LeMay, L. G., Vander, A. J. and Kluger, M. J. (1990) Role of interleukin 6 in fever in rats. Am. J. Physiol., 258, R798-R803.
23. Lieberman, A. P., Pitha, P. M., Shin, H. S. and Shin, M. L. (1989) Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc. Natl Acad. Sci. USA, 86, 6348-6352.
24. Lyson, K. and McCann, S. M. (1992) Involvement of arachidonic acid cascade pathways in interleukin-6-stimulated corticotrophin-releasing factor release m vitro. Neuroendocrinology, 55, 708-713.
25. Masek, K., Petrovicky, P. and Seifert, J. (1992) An introduction to the possible role of central nervous system structures in neuroendocrine-immune systems interaction. Int. J. Imimmophannacol., 14, 317-322.
26. Malta, S. G., Weatherbee, J. and Sharp, B. M. (1992) A central mechanism is involved in the secretion of ACTH in response to IL-6 in rats: comparison to and interaction with IL-1 beta. Neuroendocrinology, 56, 516-525.
27. McCabe, J. T. and Pfaff, D. W. (1989) In situ hybridization: a methodological guide. Meth. Neurosci., 1, 98-117.
28. Muramami, N., Fukata, J., Tsukada, T., Kobayashi, H., Ibisui, O., Segawa, H., Muro, S., Imura, H. and Nakao, K. (1993) Bacterial lipopolysaccharideinduced expression of interleukin-6 messenger rinonucleic acid in the rat hypothalamus, pituitary, adrenal gland, and spleen. Endocrinology, 133, 2574-2578.
29. Naitoh, Y., Fukata, J., Tominaga, T., Nakai, Y., Sunao, T., Kenjiro, M. and Imura, H. (1988) Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats. Biochem. Biophys. Res. Commun., 155, 1459-1463.