The genetic basis of severe osteoarthritis

Annals of the Royal College of Surgeons of England

Volumn 85, Issue 4, 2003, Pages 263-268

  Carr, Andrew J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGED; ALLELE; AUTOSOMAL DOMINANT DISORDER; CHROMOSOME 11; CHROMOSOME MARKER; CLINICAL RESEARCH; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE SEVERITY; ENVIRONMENTAL FACTOR; FEMALE; GENETIC ANALYSIS; GENETIC CODE; GENOME; HEREDITY; HERITABILITY; HUMAN; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; MALE; MOLECULAR BIOLOGY; MORBIDITY; MORTALITY; MULTIFACTORIAL GENETIC DISORDER; OSTEOARTHRITIS; PREVALENCE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; SIBLING; TOTAL HIP PROSTHESIS;

AGED; CHROMOSOMES, HUMAN, PAIR 11; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE (GENETICS); LOSS OF HETEROZYGOSITY; MALE; OSTEOARTHRITIS, HIP; OSTEOARTHRITIS, KNEE; PEDIGREE; RISK FACTORS;

EID: 0038298244     PISSN: 00358843     EISSN: None     Source Type: Journal    
DOI: 10.1308/003588403766274999     Document Type: Conference Paper

References (19)

1. Cunningham LS, Kelsey JL. Epidemiology of musculoskeletal impairments and associated disability. Am J Public Health 1984; 74: 574-9.
2. Petersson I, Jacobsson L, Silman A, Croft P. The epidemiology of osteoarthritis in the peripheral joints. EULAR Standing Committee for Epidemiology; Orenas, Sweden. Ann Rheum Dis 1996; 55: 585-688.
3. Stecher R. Heberden's nodes: Hereditary in hypertrophic arthritis of the finger joints. Am J Med Sci 1941; 201: 801-9.
4. Kellgren JH, Lawrence JS. Rheumatism in Populations. London: Heinemann, 1977.
5. Spector TD, Cicuttini F, Baker J, Loughlin J, Hart D. Genetic influences on osteoarthritis in women: A twin study. BMJ 1996; 312: 940-3.
6. Falconer DS. Introduction to Quantitative Genetics, 3rd Edition. Harlow: Longman, 1989.
7. Chitnavis J, Sinsheimer JS, Clipsham K, Loughlin J, Sykes B et al. Genetic influences in end stage osteoarthritis. J Bone Joint Surg Br 1997; 79: 660-4.
8. Weiss KM, Chakraborty R, Majumder PP, Smouse PE. Problems in the assessment of relative risk of chronic disease among biological relatives of affected individuals. J Chronic Dis 1982; 35: 539-51.
9. Vikkula M, Palotie A, Ritvaniemi P, Ott J, Ala-Kokko L, Sievers U et al. Early onset osteoarthritis linked to the type 11 collagen gene. Arthritis Rheum 1993; 36: 401-9.
10. Loughlin J, Irven C, Fergusson C, Sykes B. Sibling pair analysis shows no linkage of generalised osteoarthritis to the loci encoding type II collagen, cartilage link protein or cartilage matrix protein. Br J Rheumatol 1994; 33: 1103-6.
11. Holmans P, Craddock N. Efficient strategies for genome scanning using maximum-likelihood affected-sib-pair analysis. Am J Hum Genet 1997; 60: 657-60.
12. Reed PW, Davies JL, Copeman JB, Bennett ST, Palmer SM, Pritchard LE et al. Chromosome-specific microsatellite sets for fluorescene-based, semi-automated genome mapping. Nat Genet 1994; 7: 390-5.
13. Kaprio J, Kujala UM, Peltonen L, Koskenvuo M. Genetic liability to osteoarthritis may be greater in women than men. BMJ 1996; 313: 232.
14. Felson DT, Couropmitree NN, Chaisson CE, Hannan MT, Khang Y, McAlindon TE et al. Evidence for a Mendelian gene in a segregation analysis of generalised radiographic osteoarthritis. Arthritis Rheum 1998; 41: 1064-71.
15. Chapman K, Mustafa Z, Irven C, Carr AJ, Clipsham K, Smith A et al. Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage. Am J Hum Genet 1999; 65: 167-74.
16. Loughlin J, Mustafa Z, Smith A, Irven C, Carr AJ, Clipsham K et al. Linkage analysis of chromosome 2q in osteoarthritis. Rheumatology 2000; 39: 377-81.
17. Loughlin J, Mustafa Z, Irven C, Smith A, Carr AJ, Sykes B et al. Stratification analysis of an osteoarthritis genome screen suggestive linkage to chromosomes 4, 6, and 16. Am J Hum Genet 1999; 65: 1795-8.
18. Murray CJL, Lopez AD. The Global Burden of Disease. Geneva: World Health Organization, 1997.
19. Dieppe PA. Osteoarthritis: Time to shift the paradigm. BMJ 1999; 318: 1299-30.