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Volumn 40, Issue 2, 2003, Pages 201-205

The Th1-Th2 paradigm and asthma: How far should we go?

Author keywords

Asthma; Hygiene hypothesis; Th1 Th2

Indexed keywords

CYTOKINE;

EID: 0038290674     PISSN: 02770903     EISSN: None     Source Type: Journal    
DOI: 10.1081/JAS-120017991     Document Type: Article
Times cited : (9)

References (49)
  • 1
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136(7):2348-2357.
    • (1986) J Immunol , vol.136 , Issue.7 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 4
    • 0028288179 scopus 로고
    • Lymphokine production by human T cells in disease states
    • Romagnani S. Lymphokine production by human T cells in disease states. Ann Rev Immunol 1994; 12:227-257.
    • (1994) Ann Rev Immunol , vol.12 , pp. 227-257
    • Romagnani, S.1
  • 5
    • 0032968706 scopus 로고    scopus 로고
    • Immunological basis of antigen-induced airway hyperresponsiveness
    • Wills-Karp M. Immunological basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol. 1999; 17:225-281.
    • (1999) Annu Rev Immunol , vol.17 , pp. 225-281
    • Wills-Karp, M.1
  • 6
    • 0028213032 scopus 로고
    • Increase in asthma: A more toxic environment or a more susceptible population?
    • Seaton A, Godden DJ, Brown K. Increase in asthma: a more toxic environment or a more susceptible population? Thorax 1994; 49(2):171-174.
    • (1994) Thorax , vol.49 , Issue.2 , pp. 171-174
    • Seaton, A.1    Godden, D.J.2    Brown, K.3
  • 7
    • 0033966647 scopus 로고    scopus 로고
    • The environmental predictors of allergic disease
    • von Mutius E. The environmental predictors of allergic disease. J Allergy Clin Immunol 2000; 105:9-19.
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 9-19
    • Von Mutius, E.1
  • 8
    • 0024417450 scopus 로고
    • Hay fever, hygiene, and household size
    • Strachan DP. Hay fever, hygiene, and household size. BMJ 1989; 299:1259-1260.
    • (1989) BMJ , vol.299 , pp. 1259-1260
    • Strachan, D.P.1
  • 9
    • 0028607447 scopus 로고
    • Role of viral infections in the inception of asthma and allergies during childhood: Could they be protective?
    • Martinez FD. Role of viral infections in the inception of asthma and allergies during childhood: could they be protective? Thorax 1994; 49(12):1189-1191.
    • (1994) Thorax , vol.49 , Issue.12 , pp. 1189-1191
    • Martinez, F.D.1
  • 10
    • 0028969925 scopus 로고
    • Environmental factors and primary T-cell sensitization to inhalant allergens in infancy: Reappraisal of the role of infections and air pollution
    • Holt PG. Environmental factors and primary T-cell sensitization to inhalant allergens in infancy: reappraisal of the role of infections and air pollution. Pediatr Allergy Immunol 1995; 6(1):1-10.
    • (1995) Pediatr Allergy Immunol , vol.6 , Issue.1 , pp. 1-10
    • Holt, P.G.1
  • 13
    • 0035313297 scopus 로고    scopus 로고
    • Family size, day-care attendance, and breastfeeding in relation to the incidence of childhood asthma
    • Infante-Rivard C, Amre D, Gautrin D, Malo JL. Family size, day-care attendance, and breastfeeding in relation to the incidence of childhood asthma. Am J Epidemiol 2001; 153(7):653-658.
    • (2001) Am J Epidemiol , vol.153 , Issue.7 , pp. 653-658
    • Infante-Rivard, C.1    Amre, D.2    Gautrin, D.3    Malo, J.L.4
  • 14
    • 0033528267 scopus 로고    scopus 로고
    • Age of entry to day nursery and allergy in later childhood
    • Kramer U, Heinrich J, Wjst M, Wichmann HE. Age of entry to day nursery and allergy in later childhood. Lancet 1999; 353(9151):450-454.
    • (1999) Lancet , vol.353 , Issue.9151 , pp. 450-454
    • Kramer, U.1    Heinrich, J.2    Wjst, M.3    Wichmann, H.E.4
  • 15
    • 0032875339 scopus 로고    scopus 로고
    • Frequency of infections and risk of asthma, atopy and airway hyper-responsiveness in children
    • von Mutius E, Illi S, Hirsch T, Leupold W, Keil U, Weiland SK. Frequency of infections and risk of asthma, atopy and airway hyper-responsiveness in children. Eur Respir J 1999; 14(1):4-11.
    • (1999) Eur Respir J , vol.14 , Issue.1 , pp. 4-11
    • Von Mutius, E.1    Illi, S.2    Hirsch, T.3    Leupold, W.4    Keil, U.5    Weiland, S.K.6
  • 16
    • 0035901102 scopus 로고    scopus 로고
    • Early childhood infectious diseases and the development of asthma up to school age: A birth cohort study
    • Illi S, von Mutius E, Lau S, Bergmann R, Niggemann B, Sommerfeld C, Wahn U. Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. BMJ 2001; 322(7283):390-395.
    • (2001) BMJ , vol.322 , Issue.7283 , pp. 390-395
    • Illi, S.1    Von Mutius, E.2    Lau, S.3    Bergmann, R.4    Niggemann, B.5    Sommerfeld, C.6    Wahn, U.7
  • 17
    • 17144432975 scopus 로고    scopus 로고
    • Early respiratory infections and childhood asthma
    • Nafstad P, Magnus P, Jaakkola JJ. Early respiratory infections and childhood asthma. Pediatrics 2000; 106(3):E38.
    • (2000) Pediatrics , vol.106 , Issue.3
    • Nafstad, P.1    Magnus, P.2    Jaakkola, J.J.3
  • 18
    • 0032745436 scopus 로고    scopus 로고
    • Day care attendance, recurrent respiratory tract infections and asthma
    • Nystad W, Skrondal A, Magnus P. Day care attendance, recurrent respiratory tract infections and asthma. Int J Epidemiol 1999; 28(5):882-887.
    • (1999) Int J Epidemiol , vol.28 , Issue.5 , pp. 882-887
    • Nystad, W.1    Skrondal, A.2    Magnus, P.3
  • 19
    • 0034053750 scopus 로고    scopus 로고
    • Childhood exposure to infection and risk of adult onset wheeze and atopy
    • Bodner C, Anderson WJ, Reid TS, Godden DJ. Childhood exposure to infection and risk of adult onset wheeze and atopy. Thorax 2000; 55(5):383-387.
    • (2000) Thorax , vol.55 , Issue.5 , pp. 383-387
    • Bodner, C.1    Anderson, W.J.2    Reid, T.S.3    Godden, D.J.4
  • 21
    • 0035127143 scopus 로고    scopus 로고
    • Relation of two different subtypes of croup before age three to wheezing, atopy, and pulmonary function during childhood: A prospective study
    • Castro-Rodriguez JA, Holberg CJ, Morgan WJ, Wright AL, Halonen M, Taussig LM, Martinez FD. Relation of two different subtypes of croup before age three to wheezing, atopy, and pulmonary function during childhood: a prospective study. Pediatrics 2001; 107(3):512-518.
    • (2001) Pediatrics , vol.107 , Issue.3 , pp. 512-518
    • Castro-Rodriguez, J.A.1    Holberg, C.J.2    Morgan, W.J.3    Wright, A.L.4    Halonen, M.5    Taussig, L.M.6    Martinez, F.D.7
  • 22
    • 0034241683 scopus 로고    scopus 로고
    • Family size, infection and atopy: The first decade of the "hygiene hypothesis."
    • Strachan DP. Family size, infection and atopy: the first decade of the "hygiene hypothesis." Thorax 2000; 55(suppl 1):S2-S10.
    • (2000) Thorax , vol.55 , Issue.SUPPL. 1
    • Strachan, D.P.1
  • 23
    • 0028100444 scopus 로고
    • Respiratory symptoms, bronchial responsiveness, and atopy in Fijian and Indian children
    • Flynn MG. Respiratory symptoms, bronchial responsiveness, and atopy in Fijian and Indian children. Am J Respir Crit Care Med 1994; 150:415-420.
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 415-420
    • Flynn, M.G.1
  • 24
    • 0016808137 scopus 로고
    • Asthma and IgE levels in rural and urban communities in the Gambia
    • Godfrey RC. Asthma and IgE levels in rural and urban communities in the Gambia. Clin Allergy 1975; 5:201-207.
    • (1975) Clin Allergy , vol.5 , pp. 201-207
    • Godfrey, R.C.1
  • 25
    • 0030769394 scopus 로고    scopus 로고
    • Prevalence of wheeze and asthma and relation to atopy in urban and rural Ethiopia
    • Yemaneberhan H, Bekele Z, Venn A, Lewis S, Parry E, Britton J. Prevalence of wheeze and asthma and relation to atopy in urban and rural Ethiopia. Lancet 1997; 350:85-90.
    • (1997) Lancet , vol.350 , pp. 85-90
    • Yemaneberhan, H.1    Bekele, Z.2    Venn, A.3    Lewis, S.4    Parry, E.5    Britton, J.6
  • 26
    • 0033386392 scopus 로고    scopus 로고
    • Race, socioeconomic factors, and area of residence are associated with asthma prevalence
    • Litonjua AA, Carey VJ, Weiss ST, Gold DR. Race, socioeconomic factors, and area of residence are associated with asthma prevalence. Pediatr Pulmonol 1999; 28:394-401.
    • (1999) Pediatr Pulmonol , vol.28 , pp. 394-401
    • Litonjua, A.A.1    Carey, V.J.2    Weiss, S.T.3    Gold, D.R.4
  • 27
    • 0030922388 scopus 로고    scopus 로고
    • Sensitization to inhaled allergens as a risk factor for asthma and allergic diseases in Chinese population
    • Leung R, Ho P, Lam CW, Lai CK. Sensitization to inhaled allergens as a risk factor for asthma and allergic diseases in Chinese population. J Allergy Clin Immunol 1997; 99(5):594-599.
    • (1997) J Allergy Clin Immunol , vol.99 , Issue.5 , pp. 594-599
    • Leung, R.1    Ho, P.2    Lam, C.W.3    Lai, C.K.4
  • 28
    • 0035832508 scopus 로고    scopus 로고
    • Are all wheezing disorders in very young (preschool) children increasing in prevalence?
    • Kuehni CE, Davis A, Brooke AM, Silverman M. Are all wheezing disorders in very young (preschool) children increasing in prevalence? Lancet 2001; 357(9271):1821-1825.
    • (2001) Lancet , vol.357 , Issue.9271 , pp. 1821-1825
    • Kuehni, C.E.1    Davis, A.2    Brooke, A.M.3    Silverman, M.4
  • 29
    • 0032848050 scopus 로고    scopus 로고
    • The magnitude of the effect of smaller family sizes on the increase in the prevalence of asthma and hay fever in the United Kingdom and New Zealand
    • Wickens K, Crane J, Pearce N, Beasley R. The magnitude of the effect of smaller family sizes on the increase in the prevalence of asthma and hay fever in the United Kingdom and New Zealand. J Allergy Clin Immunol 1999; 104(3 Pt 1):554-558.
    • (1999) J Allergy Clin Immunol , vol.104 , Issue.3 PART 1 , pp. 554-558
    • Wickens, K.1    Crane, J.2    Pearce, N.3    Beasley, R.4
  • 30
    • 0035901129 scopus 로고    scopus 로고
    • The protective effect of childhood infections
    • Johnston SL, Openshaw PJM. The protective effect of childhood infections [editorial]. BMJ 2001; 322:376-377.
    • (2001) BMJ , vol.322 , pp. 376-377
    • Johnston, S.L.1    Openshaw, P.J.M.2
  • 31
    • 0034128220 scopus 로고    scopus 로고
    • Could the risk of asthma and atopy be reduced by a vaccine that induces a strong T-helper type 1 response?
    • von Hertzen LC, Haahtela T. Could the risk of asthma and atopy be reduced by a vaccine that induces a strong T-helper type 1 response? Am J Respir Cell Mol Biol 2000; 22(2):139-142.
    • (2000) Am J Respir Cell Mol Biol , vol.22 , Issue.2 , pp. 139-142
    • Von Hertzen, L.C.1    Haahtela, T.2
  • 32
    • 0033060552 scopus 로고    scopus 로고
    • How much asthma is really attributable to atopy?
    • Pearce N, Pekkanen J, Beasley R. How much asthma is really attributable to atopy? Thorax 1999; 54(3):268-272.
    • (1999) Thorax , vol.54 , Issue.3 , pp. 268-272
    • Pearce, N.1    Pekkanen, J.2    Beasley, R.3
  • 33
    • 0032927086 scopus 로고    scopus 로고
    • Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. SCARPOL team. Swiss Study on Childhood Allergy and Respiratory Symptoms with respect to air pollution
    • Braun-Fahrlander C, Gassner M, Grize L, Neu U, Sennhauser FH, Varonier HS, Vuille JC, Wuthrich B. Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. SCARPOL team. Swiss Study on Childhood Allergy and Respiratory Symptoms with respect to air pollution. Clin Exp Allergy 1999; 29(1):28-34.
    • (1999) Clin Exp Allergy , vol.29 , Issue.1 , pp. 28-34
    • Braun-Fahrlander, C.1    Gassner, M.2    Grize, L.3    Neu, U.4    Sennhauser, F.H.5    Varonier, H.S.6    Vuille, J.C.7    Wuthrich, B.8
  • 34
    • 0033962806 scopus 로고    scopus 로고
    • Austrian children living on a farm have less hay fever, asthma and allergic sensitization
    • Riedler J, Eder W, Oberfeld G, Schreuer M. Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clin Exp Allergy 2000; 30(2):194-200.
    • (2000) Clin Exp Allergy , vol.30 , Issue.2 , pp. 194-200
    • Riedler, J.1    Eder, W.2    Oberfeld, G.3    Schreuer, M.4
  • 35
    • 0033963118 scopus 로고    scopus 로고
    • Farm environment in childhood prevents the development of allergy
    • Kilpelainen M, Terho EO, Helenius H, Koskenvuo M. Farm environment in childhood prevents the development of allergy. Clin Exp Allergy 2000; 30(2):201-208.
    • (2000) Clin Exp Allergy , vol.30 , Issue.2 , pp. 201-208
    • Kilpelainen, M.1    Terho, E.O.2    Helenius, H.3    Koskenvuo, M.4
  • 36
    • 0034110846 scopus 로고    scopus 로고
    • Relative scarcity of asthma and atopy among rural adolescents raised on a farm
    • Ernst P, Cormier Y. Relative scarcity of asthma and atopy among rural adolescents raised on a farm. Am J Respir Crit Care Med 2000; 161(5):1563-1566.
    • (2000) Am J Respir Crit Care Med , vol.161 , Issue.5 , pp. 1563-1566
    • Ernst, P.1    Cormier, Y.2
  • 39
    • 0021836202 scopus 로고
    • Distinct functional phenotypes of cloned Ia-restricted helper T cells
    • Kim J, Woods A, Becker-Dunn E, Bottomly K. Distinct functional phenotypes of cloned Ia-restricted helper T cells. J Exp Med 1985; 162(1):188-201
    • (1985) J Exp Med , vol.162 , Issue.1 , pp. 188-201
    • Kim, J.1    Woods, A.2    Becker-Dunn, E.3    Bottomly, K.4
  • 40
    • 0030746897 scopus 로고    scopus 로고
    • Th1-Th2: Reliable paradigm or dangerous dogma
    • Allen JE, Maizels RM. Th1-Th2: reliable paradigm or dangerous dogma. Immunol Today 1997; 18:38792.
    • (1997) Immunol Today , vol.18 , pp. 38792
    • Allen, J.E.1    Maizels, R.M.2
  • 42
    • 0035005238 scopus 로고    scopus 로고
    • The other side of the coin: The protective role of the Th2 cytokines
    • Finkelman FD, Urban JF Jr. The other side of the coin: the protective role of the Th2 cytokines. J Allergy Clin Immunol 2001; 107(5):772-780.
    • (2001) J Allergy Clin Immunol , vol.107 , Issue.5 , pp. 772-780
    • Finkelman, F.D.1    Urban J.F., Jr.2
  • 43
    • 0034076847 scopus 로고    scopus 로고
    • Could asthma be worsened by stimulating the T-helper type 1 immune response?
    • Castro M, Chaplin DD, Walter MJ, Holtzman MJ. Could asthma be worsened by stimulating the T-helper type 1 immune response? Am J Respir Cell Mol Biol 2000; 22(2):143-146.
    • (2000) Am J Respir Cell Mol Biol , vol.22 , Issue.2 , pp. 143-146
    • Castro, M.1    Chaplin, D.D.2    Walter, M.J.3    Holtzman, M.J.4
  • 44
    • 0035835981 scopus 로고    scopus 로고
    • Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: A population-based cross-sectional study
    • Platts-Mills T, Vaughan J, Squillace S, Woodfolk J, Sporik R. Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet 2001; 357(9258):752-756.
    • (2001) Lancet , vol.357 , Issue.9258 , pp. 752-756
    • Platts-Mills, T.1    Vaughan, J.2    Squillace, S.3    Woodfolk, J.4    Sporik, R.5
  • 47
    • 0034210009 scopus 로고    scopus 로고
    • Danger: The view from the bottom of the cliff
    • discussion 257-344
    • Anderson CC, Matzinger P. Danger: the view from the bottom of the cliff. Semin Immunol. 2000; 12(3):231-238; discussion 257-344.
    • (2000) Semin Immunol , vol.12 , Issue.3 , pp. 231-238
    • Anderson, C.C.1    Matzinger, P.2
  • 48
    • 0033012903 scopus 로고    scopus 로고
    • The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy
    • Kapsenberg ML, Hilkens CM, Wierenga EA, Kalinski P. The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy. Clin Exp Allergy 1999; 29(suppl 2):33-36.
    • (1999) Clin Exp Allergy , vol.29 , Issue.SUPPL. 2 , pp. 33-36
    • Kapsenberg, M.L.1    Hilkens, C.M.2    Wierenga, E.A.3    Kalinski, P.4
  • 49
    • 0028201726 scopus 로고
    • Acquisition of lymphokine-producing phenotype by CD4+ T cells
    • Seder RA, Paul WE. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 1994; 12:635-673.
    • (1994) Annu Rev Immunol , vol.12 , pp. 635-673
    • Seder, R.A.1    Paul, W.E.2


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