메뉴 건너뛰기




Volumn 12, Issue 3, 2003, Pages 267-272

New insights into the immunopathogenesis and treatment of small vessel vasculitis of the kidney

Author keywords

Antineutrophil cytoplasmic autoantibodies (ANCA); Glomerulonephritis; Microscopic polyangiitis; Vasculitis; Wegener granulomatosis

Indexed keywords

AZATHIOPRINE; CYCLOPHOSPHAMIDE; ETANERCEPT; GLUCOCORTICOID; INFLIXIMAB; METHOTREXATE; MONOCLONAL ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NEUTROPHIL CYTOPLASMIC ANTIBODY; PREDNISOLONE; RITUXIMAB; TUMOR NECROSIS FACTOR;

EID: 0038290336     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-200305000-00007     Document Type: Review
Times cited : (14)

References (40)
  • 1
    • 0036293330 scopus 로고    scopus 로고
    • ANCA-positive vasculitis
    • Kamesh L, Harper L, Savage CO. ANCA-positive vasculitis. J Am Soc Nephrol 2002; 13:1953-1960. An excellent recent update on pathogenetic mechanisms and state of the art of treatment of small vessel vasculitis.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1953-1960
    • Kamesh, L.1    Harper, L.2    Savage, C.O.3
  • 2
    • 0036147344 scopus 로고    scopus 로고
    • Renal histology in ANCA-associated vasculitis: Differences between diagnostic and serologic subgroups
    • Hauer HA, Bajema IM, van Houwelingen HC, et al. Renal histology in ANCA-associated vasculitis: differences between diagnostic and serologic subgroups. Kidney Int 2002; 61:80-89.
    • (2002) Kidney Int , vol.61 , pp. 80-89
    • Hauer, H.A.1    Bajema, I.M.2    Van Houwelingen, H.C.3
  • 3
    • 0033019264 scopus 로고    scopus 로고
    • Wegener granulomatosis. Sensitized cells come of age: A new era in renal immunology with important therapeutic implications
    • Couser WG. Wegener granulomatosis. Sensitized cells come of age: a new era in renal immunology with important therapeutic implications. J Am Soc Nephrol 1999; 10:664-665.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 664-665
    • Couser, W.G.1
  • 4
    • 0344076302 scopus 로고    scopus 로고
    • Prominence of cell-mediated immunity effectors in 'pauci-immune' glomerulonephritis
    • Cunningham MA, Huang XR, Dowling JP, et al. Prominence of cell-mediated immunity effectors in 'pauci-immune' glomerulonephritis. J Am Soc Nephrol 1999; 10:499-506.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 499-506
    • Cunningham, M.A.1    Huang, X.R.2    Dowling, J.P.3
  • 5
    • 0033986121 scopus 로고    scopus 로고
    • Are animal models of vasculitis suitable tools?
    • Specks, U. Are animal models of vasculitis suitable tools? Curr Opin Rheumatol 2000; 12:11-19.
    • (2000) Curr Opin Rheumatol , vol.12 , pp. 11-19
    • Specks, U.1
  • 6
    • 0036182188 scopus 로고    scopus 로고
    • + T cells specific to glomerular basement membrane antigen mediate glomerulonephritis
    • + T cells specific to glomerular basement membrane antigen mediate glomerulonephritis. J Clin Invest 2002; 109:517-524. A sophisticated experimental approach to examining the pathogenic role of T cells in a model of anti-basement membrane disease.
    • (2002) J Clin Invest , vol.109 , pp. 517-524
    • Wu, J.1    Hicks, J.2    Borillo, J.3
  • 7
    • 0000652834 scopus 로고
    • Segmental necrotizing glomerulonephritis with antineutrophil antibody: Possible arbovirus aetiology?
    • Davies DJ, Moran JE, Niall JF, et al. Segmental necrotizing glomerulonephritis with antineutrophil antibody: possible arbovirus aetiology? Br Med J 1982; 288:606.
    • (1982) Br Med J , vol.288 , pp. 606
    • Davies, D.J.1    Moran, J.E.2    Niall, J.F.3
  • 8
    • 85034912621 scopus 로고
    • Autoantibodies against neutrophils and monocytes: Tool for diagnosis and marker of disease activity in Wegener's granulomatosis
    • van der Woude FJ, Rasmussen N, Lobatto S, et al. Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet 1988; 1:425-429.
    • (1988) Lancet , vol.1 , pp. 425-429
    • Van Der Woude, F.J.1    Rasmussen, N.2    Lobatto, S.3
  • 9
    • 0028158243 scopus 로고
    • Nomenclature of systemic vasculitides: The proposal of an International Consensus Conference
    • Jennette JC, Falk RJ, Andrassy K, et al. Nomenclature of systemic vasculitides: the proposal of an International Consensus Conference. Arthritis Rheum 1994; 37:187-192.
    • (1994) Arthritis Rheum , vol.37 , pp. 187-192
    • Jennette, J.C.1    Falk, R.J.2    Andrassy, K.3
  • 10
    • 0025345612 scopus 로고
    • Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro
    • Falk RJ, Terrell RS, Charles LA, et al. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci U S A 1990; 87:4115-4119.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 4115-4119
    • Falk, R.J.1    Terrell, R.S.2    Charles, L.A.3
  • 11
    • 0037452135 scopus 로고    scopus 로고
    • Circulating endothelial cells as markers for ANCA-associated small-vessel vasculitis
    • Woywodt A, Streiber F, deGroot K, et al. Circulating endothelial cells as markers for ANCA-associated small-vessel vasculitis. Lancet 2003; 361:206-210. A provocative study showing markedly increased numbers of necrotic endothelial cells in the circulation of patients with active vasculitis.
    • (2003) Lancet , vol.361 , pp. 206-210
    • Woywodt, A.1    Streiber, F.2    DeGroot, K.3
  • 12
    • 0035987347 scopus 로고    scopus 로고
    • ANCA are pathogenic - Oh yes they are!
    • Falk RJ, Jennette JC. ANCA are pathogenic - Oh yes they are! J Am Soc Nephrol 2002; 13:1977-1979. Authoritative synopsis of the evidence of pathogenicity of ANCA.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1977-1979
    • Falk, R.J.1    Jennette, J.C.2
  • 13
    • 0036790387 scopus 로고    scopus 로고
    • Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice
    • Xiao H, Heeringa P, Hu P, et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 2002; 110:955-963. Major definitive article presenting compelling evidence of the pathogenic role of myeloperoxidase-specific ANCA in an innovative mouse model of small vessel vasculitis.
    • (2002) J Clin Invest , vol.110 , pp. 955-963
    • Xiao, H.1    Heeringa, P.2    Hu, P.3
  • 14
    • 31844443695 scopus 로고
    • The environment and disease: Association or causation?
    • Hill AB. The environment and disease: association or causation? Proc R Soc Med 1965; 58:295-300.
    • (1965) Proc R Soc Med , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 15
    • 0030062483 scopus 로고    scopus 로고
    • Treatment response and relapse in antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis
    • Nachman PH, Hogan SL, Jennette JC, et al. Treatment response and relapse in antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis. J Am Soc Nephrol 1996; 7:33-39.
    • (1996) J Am Soc Nephrol , vol.7 , pp. 33-39
    • Nachman, P.H.1    Hogan, S.L.2    Jennette, J.C.3
  • 16
    • 0035083681 scopus 로고    scopus 로고
    • Long-term followup of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: Analysis of four prospective trials including 278 patients
    • Gayraud M, Guillevin L, le Toumelin P, et al. Long-term followup of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: analysis of four prospective trials including 278 patients. Arthritis Rheum 2001; 44:666-675.
    • (2001) Arthritis Rheum , vol.44 , pp. 666-675
    • Gayraud, M.1    Guillevin, L.2    Le Toumelin, P.3
  • 17
    • 0015764397 scopus 로고
    • Wegener's granulomatosis: Studies in eighteen patients and a review of the literature
    • Fauci A, Wolff S. Wegener's granulomatosis: studies in eighteen patients and a review of the literature. Medicine 1973; 52:535-561.
    • (1973) Medicine , vol.52 , pp. 535-561
    • Fauci, A.1    Wolff, S.2
  • 18
    • 0020656868 scopus 로고
    • Wegener's granulomatosis: Prospective clinical and therapeutic experience with 85 patients for 21 years
    • Fauci A, Haynes B, Katz P, et al. Wegener's granulomatosis: Prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med 1983; 98:76-85.
    • (1983) Ann Intern Med , vol.98 , pp. 76-85
    • Fauci, A.1    Haynes, B.2    Katz, P.3
  • 19
    • 0026505235 scopus 로고
    • Wegener granulomatosis: An analysis of 158 patients
    • Hoffman GS, Kerr GS, Leavitt RY, et al. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med 1992; 116:488-494.
    • (1992) Ann Intern Med , vol.116 , pp. 488-494
    • Hoffman, G.S.1    Kerr, G.S.2    Leavitt, R.Y.3
  • 20
    • 0034044534 scopus 로고    scopus 로고
    • An interdisciplinary approach to the care of patients with Wegener's granulomatosis: Long-term outcome in 155 patients
    • Reinhold-Keller E, Beuge N, Latza U, et al. An interdisciplinary approach to the care of patients with Wegener's granulomatosis: long-term outcome in 155 patients. Arthritis Rheum 2000; 43:1021-1032.
    • (2000) Arthritis Rheum , vol.43 , pp. 1021-1032
    • Reinhold-Keller, E.1    Beuge, N.2    Latza, U.3
  • 21
    • 0026564405 scopus 로고
    • The treatment of Wegener's granulomatosis with glucocorticoids and methotrexate
    • Hoffman GS, Leavitt RY, Kerr GS, et al. The treatment of Wegener's granulomatosis with glucocorticoids and methotrexate. Arthritis Rheum 1992; 35:6112-6118.
    • (1992) Arthritis Rheum , vol.35 , pp. 6112-6118
    • Hoffman, G.S.1    Leavitt, R.Y.2    Kerr, G.S.3
  • 22
    • 0028969403 scopus 로고
    • An analysis of forty-two Wegener's granulomatosis patients treated with methotrexate and prednisone
    • Sneller MC, Hoffman GS, Talar-Williams C, et al. An analysis of forty-two Wegener's granulomatosis patients treated with methotrexate and prednisone. Arthritis Rheum 1995; 38:608-613.
    • (1995) Arthritis Rheum , vol.38 , pp. 608-613
    • Sneller, M.C.1    Hoffman, G.S.2    Talar-Williams, C.3
  • 23
    • 2642671151 scopus 로고    scopus 로고
    • Induction of remission in Wegener's granulomatosis with low dose methotrexate
    • de Groot K, Muhler M, Reinhold-Keller E, et al. Induction of remission in Wegener's granulomatosis with low dose methotrexate. J Rheumatol 1998; 25:492-495.
    • (1998) J Rheumatol , vol.25 , pp. 492-495
    • De Groot, K.1    Muhler, M.2    Reinhold-Keller, E.3
  • 24
    • 0032962071 scopus 로고    scopus 로고
    • Treatment of non-life threatening Wegener's granulomatosis with methotrexate and daily prednisone as the initial therapy of choice
    • Stone JH, Tun W, Hellman DB. Treatment of non-life threatening Wegener's granulomatosis with methotrexate and daily prednisone as the initial therapy of choice. J Rheumatol 1999; 26:1134-1139.
    • (1999) J Rheumatol , vol.26 , pp. 1134-1139
    • Stone, J.H.1    Tun, W.2    Hellman, D.B.3
  • 25
    • 0033869129 scopus 로고    scopus 로고
    • Use of methotrexate and glucocorticoids in the treatment of Wegener's granulomatosis. Long-term renal outcome in patients with glomerulonephritis
    • Langford CA, Talar-Williams C, Sneller MC. Use of methotrexate and glucocorticoids in the treatment of Wegener's granulomatosis. Long-term renal outcome in patients with glomerulonephritis. Arthritis Rheum 2000; 43:1836-1840.
    • (2000) Arthritis Rheum , vol.43 , pp. 1836-1840
    • Langford, C.A.1    Talar-Williams, C.2    Sneller, M.C.3
  • 26
    • 0033499210 scopus 로고    scopus 로고
    • A staged approach to the treatment of Wegener's granulomatosis: Induction of remission with glucocorticoids and daily cyclophosphamide switching to methotrexate for remission maintenance
    • Langford CA, Talar-Williams C, Barron KS, et al. A staged approach to the treatment of Wegener's granulomatosis: induction of remission with glucocorticoids and daily cyclophosphamide switching to methotrexate for remission maintenance. Arthritis Rheum 1999; 42:2666-2673. A prospective, standardized open-label trial examining the use of a staged therapeutic regimen utilizing cyclophosphamide for remission induction followed by methotrexate for remission maintenance.
    • (1999) Arthritis Rheum , vol.42 , pp. 2666-2673
    • Langford, C.A.1    Talar-Williams, C.2    Barron, K.S.3
  • 27
    • 0037097601 scopus 로고    scopus 로고
    • High rate of renal relapse in 71 patients with Wegener's granulomatosis under maintenance of remission with low-dose methotrexate
    • Reinhold-Keller E, Fink CO, Herlyn K, et al. High rate of renal relapse in 71 patients with Wegener's granulomatosis under maintenance of remission with low-dose methotrexate. Arthritis Rheum 2002; 47:326-332. This trial examines the use of methotrexate for maintenance of remission achieved with cyclophosphamide. This study found glomerulonephritis to be a feature of disease relapse in 16 patients, 14 of whom exhibited a rise in serum creatinine.
    • (2002) Arthritis Rheum , vol.47 , pp. 326-332
    • Reinhold-Keller, E.1    Fink, C.O.2    Herlyn, K.3
  • 28
    • 0035170339 scopus 로고    scopus 로고
    • Update on the European Vasculitis Study Group trials
    • Jayne D. Update on the European Vasculitis Study Group trials. Curr Opin Rheumatol 2001; 13:48-55.
    • (2001) Curr Opin Rheumatol , vol.13 , pp. 48-55
    • Jayne, D.1
  • 29
    • 0344549857 scopus 로고    scopus 로고
    • Mycophenolate mofetil for maintenance therapy of Wegener's granulomatosis and microscopic polyangiitis: A pilot study in 11 patients with renal involvement
    • Nowack R, Göbel U, Klooker P, et al. Mycophenolate mofetil for maintenance therapy of Wegener's granulomatosis and microscopic polyangiitis: a pilot study in 11 patients with renal involvement. J Am Soc Nephrol 1999; 10:1965-1971. This study reports the first prospective open-label data on the use of the mycophenolate mofetil in patients with Wegener's granulomatosis and microscopic polyangiitis.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 1965-1971
    • Nowack, R.1    Göbel, U.2    Klooker, P.3
  • 30
    • 0343472033 scopus 로고    scopus 로고
    • Mycophenolate mofetil for systemic vasculitis and IgA nephropathy
    • Nowack R, Birck R, van der Woude FJ. Mycophenolate mofetil for systemic vasculitis and IgA nephropathy. Lancet 1997; 349:774.
    • (1997) Lancet , vol.349 , pp. 774
    • Nowack, R.1    Birck, R.2    Van Der Woude, F.J.3
  • 31
    • 4243327845 scopus 로고    scopus 로고
    • Treatment of acute c-ANCA-positive vasculitis with mycophenolate mofetil
    • Waiser J, Budde K, Braasch E, et al. Treatment of acute c-ANCA-positive vasculitis with mycophenolate mofetil. Am J Kidney Dis 1999; 34:e9.
    • (1999) Am J Kidney Dis , vol.34
    • Waiser, J.1    Budde, K.2    Braasch, E.3
  • 32
    • 0036116244 scopus 로고    scopus 로고
    • Pyoderma gangrenosum associated with Wegener's granulomatosis: Partial response to mycophenolate mofetil
    • Le Hello C, Bonte I, Mora JJ, et al. Pyoderma gangrenosum associated with Wegener's granulomatosis: partial response to mycophenolate mofetil. Rheumatology (Oxford) 2002; 41:236-237.
    • (2002) Rheumatology (Oxford) , vol.41 , pp. 236-237
    • Le Hello, C.1    Bonte, I.2    Mora, J.J.3
  • 33
    • 0035985414 scopus 로고    scopus 로고
    • Tolerance of mycophenolate mofetil in end-stage renal disease patients with ANCA-associated vasculitis
    • Haubitz M, de Groot K. Tolerance of mycophenolate mofetil in end-stage renal disease patients with ANCA-associated vasculitis. Clin Nephrol 2002; 57:421-424.
    • (2002) Clin Nephrol , vol.57 , pp. 421-424
    • Haubitz, M.1    De Groot, K.2
  • 34
    • 0036097334 scopus 로고    scopus 로고
    • A new acute inflammatory syndrome related to the introduction of mycophenolate mofetil in patients with Wegener's granulomatosis
    • Maes B, Oellerich M, Ceuppens JL, et al. A new acute inflammatory syndrome related to the introduction of mycophenolate mofetil in patients with Wegener's granulomatosis. Nephrol Dial Transplant 2002; 17:923-926.
    • (2002) Nephrol Dial Transplant , vol.17 , pp. 923-926
    • Maes, B.1    Oellerich, M.2    Ceuppens, J.L.3
  • 35
    • 0034526461 scopus 로고    scopus 로고
    • Cytomegalovirus colitis during mycophenolate mofetil therapy for Wegener's granulomatosis
    • Woywodt A, Choi M, Schneider W, et al. Cytomegalovirus colitis during mycophenolate mofetil therapy for Wegener's granulomatosis. Am J Nephrol 2000; 20:468-472.
    • (2000) Am J Nephrol , vol.20 , pp. 468-472
    • Woywodt, A.1    Choi, M.2    Schneider, W.3
  • 36
    • 0035033807 scopus 로고    scopus 로고
    • Etanercept combined with conventional treatment in Wegener's granulomatosis: A six-month open-label trial to evaluate safety
    • Stone JH, Uhlfelder ML, Hellmann DB, et al. Etanercept combined with conventional treatment in Wegener's granulomatosis: a six-month open-label trial to evaluate safety. Arthritis Rheum 2001; 44:1149-1154. Open-label phase I safety study of etanercept combined with standard therapies in Wegener's granulomatosis.
    • (2001) Arthritis Rheum , vol.44 , pp. 1149-1154
    • Stone, J.H.1    Uhlfelder, M.L.2    Hellmann, D.B.3
  • 37
    • 0036092632 scopus 로고    scopus 로고
    • Safety and efficacy of TNF-alpha blockade in relapsing vasculitis
    • Booth AD, Jefferson HJ, Ayliffe W, et al. Safety and efficacy of TNF-alpha blockade in relapsing vasculitis. Ann Rheum Dis 2002; 61:559.
    • (2002) Ann Rheum Dis , vol.61 , pp. 559
    • Booth, A.D.1    Jefferson, H.J.2    Ayliffe, W.3
  • 38
    • 0036796830 scopus 로고    scopus 로고
    • Efficacy of the anti-TNF-alpha antibody infliximab against refractory systemic vasculitides: An open pilot study on 10 patients
    • Bartolucci P, Ramanoelina J, Cohen P, et al. Efficacy of the anti-TNF-alpha antibody infliximab against refractory systemic vasculitides: an open pilot study on 10 patients. Rheumatology (Oxford) 2002; 41:1126-1132.
    • (2002) Rheumatology (Oxford) , vol.41 , pp. 1126-1132
    • Bartolucci, P.1    Ramanoelina, J.2    Cohen, P.3
  • 39
    • 0036853090 scopus 로고    scopus 로고
    • Effectiveness of TNF-alpha blockade with infliximab in refractory Wegener's granulomatosis
    • Lamprecht P, Voswinkel J, Lilienthal T, et al. Effectiveness of TNF-alpha blockade with infliximab in refractory Wegener's granulomatosis. Rheumatology (Oxford) 2002; 41:1303-1307.
    • (2002) Rheumatology (Oxford) , vol.41 , pp. 1303-1307
    • Lamprecht, P.1    Voswinkel, J.2    Lilienthal, T.3
  • 40
    • 0035674612 scopus 로고    scopus 로고
    • Response of Wegener's granulomatosis to anti-CD20 chimeric monoclonal antibody therapy
    • Specks U, Fervenza FC, McDonald TJ, et al. Response of Wegener's granulomatosis to anti-CD20 chimeric monoclonal antibody therapy. Arthritis Rheum 2001; 44:2836-2840. An interesting case report of a patient with PR-3 ANCA positive Wegener's granulomatosis treated with rituximab.
    • (2001) Arthritis Rheum , vol.44 , pp. 2836-2840
    • Specks, U.1    Fervenza, F.C.2    McDonald, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.