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Grabowski EF. The hemolytic-uremic syndrome-toxin, thrombin, and thrombosis. N Engl J Med 2002; 346:58-61. This is an excellent editorial summarizing current opinion regarding the coagulopathy of HUS.
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N Engl J Med
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Grabowski, E.F.1
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51
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Prothrombotic coagulation abnormalities preceding the hemolytic-uremic syndrome
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Chandler WL, Jelacic S, Boster DR, et al. Prothrombotic coagulation abnormalities preceding the hemolytic-uremic syndrome. N Engl J Med 2002; 346:23-32. Although the definition of HUS used is problematic (it is likely to include children who do not actually have HUS), the main findings in this prospective study are critically important to our understanding of pathogenesis. Both impaired fibrinolysis and thrombin generation precede development of HUS.
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(2002)
N Engl J Med
, vol.346
, pp. 23-32
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Chandler, W.L.1
Jelacic, S.2
Boster, D.R.3
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52
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0035035397
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Von Willebrand factor and von Willebrand factor-cleaving metalloprotease activity in Escherichia coli O157:H7-associated hemolytic uremic syndrome
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Tsai HM, Chandler WL, Sarode R, et al. von Willebrand factor and von Willebrand factor-cleaving metalloprotease activity in Escherichia coli O157:HT-associated hemolytic uremic syndrome. Pediatr Res 2001; 49:653-659.
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Pediatr Res
, vol.49
, pp. 653-659
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Tsai, H.M.1
Chandler, W.L.2
Sarode, R.3
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53
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0034972253
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Von Willebrand factor-cleaving protease in childhood diarrhoea-associated haemolytic uraemic syndrome
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Hunt BJ, Lammle B, Nevard CH, et al. von Willebrand factor-cleaving protease in childhood diarrhoea-associated haemolytic uraemic syndrome. Thromb Haemost 2001; 85:975-978.
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Thromb Haemost
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Hunt, B.J.1
Lammle, B.2
Nevard, C.H.3
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54
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0036185829
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Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome
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Ray P, Acheson D, Chitrakar R, et al. Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome. J Am Soc Nephrol 2002; 13:699-707.
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J Am Soc Nephrol
, vol.13
, pp. 699-707
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Ray, P.1
Acheson, D.2
Chitrakar, R.3
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55
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0036708369
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Importance of testing stool specimens for shiga toxins
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Park CH, Kim HJ, Hixon DL. Importance of testing stool specimens for shiga toxins. J Clin Microbiol 2002; 40:3542-3543.
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(2002)
J Clin Microbiol
, vol.40
, pp. 3542-3543
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Park, C.H.1
Kim, H.J.2
Hixon, D.L.3
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56
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0036702018
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Role of the laboratory in the diagnosis of enterohemorrhagic Escherichia coli infections
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Kehl SC. Role of the laboratory in the diagnosis of enterohemorrhagic Escherichia coli Infections. J Clin Microbiol 2002; 40:2711-2715. This excellent review summarizes both the history of development of diagnostic tests and the current state of the art. The rationale for testing as well as the data supporting use of each method are presented.
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(2002)
J Clin Microbiol
, vol.40
, pp. 2711-2715
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Kehl, S.C.1
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57
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0036302102
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Real-time fluorescence PCR assays for detection and characterization of Shiga toxin, intimin, and enterohemolysin genes from Shiga toxin-producing Escherichia coli
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Reischl U, Youssef MT, Kilwinski J, et al. Real-time fluorescence PCR assays for detection and characterization of Shiga toxin, intimin, and enterohemolysin genes from Shiga toxin-producing Escherichia coli. J Clin Microbiol 2002; 40:2555-2565.
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J Clin Microbiol
, vol.40
, pp. 2555-2565
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Reischl, U.1
Youssef, M.T.2
Kilwinski, J.3
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58
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0037209273
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Methods for detection of STEC in humans. An overview
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Paton JC, Paton AW. Methods for detection of STEC in humans. An overview. Methods Mol Med 2003; 73:9-26.
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(2003)
Methods Mol Med
, vol.73
, pp. 9-26
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Paton, J.C.1
Paton, A.W.2
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59
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Detection and characterization of STEC in stool samples using PCR
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Paton AW, Paton JC. Detection and characterization of STEC in stool samples using PCR. Methods Mol Med 2003; 73:45-54.
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Methods Mol Med
, vol.73
, pp. 45-54
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Paton, A.W.1
Paton, J.C.2
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60
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Escherichia coli O157:H7 infections: Discordance between filterable fecal shiga toxin and disease outcome
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Cornick NA, Jelacic S, Ciol MA, Tarr PI. Escherichia coli O157:H7 infections: discordance between filterable fecal shiga toxin and disease outcome. J Infect Dis 2002; 186:57-63. This paper suggests that therapeutic strategies aimed at removal of toxin from gut may be futile.
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(2002)
J Infect Dis
, vol.186
, pp. 57-63
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Cornick, N.A.1
Jelacic, S.2
Ciol, M.A.3
Tarr, P.I.4
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61
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The risk of the hemolytic-uremic syndrome after antibiotic treatment of Escherichla coli O157:H7 infections
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Wong CS, Jelacic S, Habeeb RL, et al. The risk of the hemolytic-uremic syndrome after antibiotic treatment of Escherichla coli O157:H7 infections. N Engl J Med 2000; 342:1930-1936.
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N Engl J Med
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Wong, C.S.1
Jelacic, S.2
Habeeb, R.L.3
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62
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Effects of azithromycin on shiga toxin production by Escherichia coli and subsequent host inflammatory response
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Ohara T, Kojio S, Taneike I, et al. Effects of azithromycin on shiga toxin production by Escherichia coli and subsequent host inflammatory response. Antimicrob Agents Chemother 2002; 46:3478-3483. This report raises the possibility that antibiotic therapy might both decrease toxin production and inflammatory cytokine responses. Unfortunately there are no data in humans to confirm this phenomenon where it is most relevant.
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(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 3478-3483
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Ohara, T.1
Kojio, S.2
Taneike, I.3
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63
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Risk of hemolytic uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 enteritis: A meta-analysis
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Safdar N, Said A, Gangnon RE, Maki DG. Risk of hemolytic uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 enteritis: a meta-analysis. JAMA 2002; 288:996-1001.
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(2002)
JAMA
, vol.288
, pp. 996-1001
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Safdar, N.1
Said, A.2
Gangnon, R.E.3
Maki, D.G.4
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