X-chromosome inactivation in healthy females: Incidence of excessive lyonization with age and comparison of assays involving DNA methylation and transcript polymorphisms

Clinical Chemistry

Volumn 44, Issue 1, 1998, Pages 61-67

  El Kassar, Nahed ^a   Hetet, Gilles ^a   Brière, Jean ^a   Grandchamp, Bernard ^a  

^a BICHAT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; DNA; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; IDURONATE 2 SULFATASE; PROTEIN P53; RNA;

ADULT; AGED; ARTICLE; DNA METHYLATION; DNA POLYMORPHISM; FEMALE; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; INCIDENCE; MOLECULAR CLONING; NEWBORN; NORMAL HUMAN; THROMBOCYTHEMIA; UMBILICAL CORD BLOOD; X CHROMOSOME INACTIVATION;

EID: 0031972966     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/44.1.61     Document Type: Article

References (25)

1. Lyon MF. Gene action in the X chromosome of the mouse. Nature 1961;190:372-3.
2. Vogelstein B, Fearon ER, Hamilton SR, Feinberg AP. Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors. Science 1985;227:642-5.
3. Fialkow PJ. Primordial cell pool size and lineage relationships of five human cell types. Ann Hum Genet 1973;37:39-48.
4. Fialkow PJ, Faguet GB, Jacobson RJ, Vaidya K, Murphy S. Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell. Blood 1981;58:916-9.
5. Mediterranean subject. Blood 1982;59:76-9.
6. Gilliland DG, Blanchard KL, Levy J, Perrin S, Bunn HF. Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction. Proc Natl Acad Sci U S A 1991;88:6848-52.
7. Fey MF, Peter HJ, Hinds HL, Zimmermann A, Liechti-Gallati S, et al. Clonal analysis of human tumors with M27β, a highly informative polymorphic X chromosomal probe. J Clin Invest 1992;89:1438-44.
8. Tsukamoto N, Morita K, Maehara T, Okamoto K, Sakai H. Clonality in chronic myeloproliferative disorders defined by X-chromosome linked probes: demonstration of heterogeneity in lineage involvement. Br J Haematol 1994;86:253-8.
9. Allen RC, Zoghbi HY, Moseley AB, Rosenblatt HM, Belmont JW. Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. Am J Hum Genet 1992;51:1229-39.
10. Prchal JT, Guan YL. A novel clonality assay based on transcriptional analysis of the active X-chromosome. Stem Cells 1993;11: 62-5.
11. El Kassar N, Hetet GLY, Brière J, Grandchamp B. Clonal analysis of haematopoietic cells in essential thrombocythaemia. Br J Haematol 1995;90:131-7.
12. El Kassar N, Hetet G, Brière J, Grandchamp B. Clonality analysis of hematopoiesis in essential thrombocythemia: advantages of studying T-lymphocytes and platelets. Blood 1997;89:128-4.
13. Busque L, Gilliland DG. Clonal evolution in acute myeloid leukemia. Blood 1993;82:337-42.
14. Young NS. The problem of clonality in aplastic anemia: Dr Dameshek's riddle, restated. Blood 1992;79:1385-92.
15. Tan SS, Williams EA, Tam PPL. X-chromosome inactivation occurs at different times in different tissues of the post-implantation mouse embryon. Nature Genet 1993;3:170-4.
16. Luzzatto L, Usanga EA, Bienzle U, Esan GFJ, Fusuan FA. Imbalance in X-chromosome expression: evidence for a human X-linked gene affecting growth of hemopoietic cells. Science 1979;205:1418-20.
17. Gale RE, Wheadon H, Boulos P, Linch DC. Tissue specificity of X chromosome inactivation patterns. Blood 1994;83:2899-905.
18. Busque L, Mio R, Mattioli J, Brais E, Blais N, Lalonde Y, et al. Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age. Blood 1996;88:59-65.
19. Prchal JT, Liu Y, Prchal JF, Hoffman R, Tushinski R. Are normal stem cells present in myeloproliferative syndrome? [Abstract]. Blood 1994;84:207.
20. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
21. Lee JS, Anvret M. Identification of the most common mutation within the porphobilinogen deaminase gene in Swedish patients with acute intermittent porphyria. Proc Natl Acad Sci U S A 1991;88:10912-5.
22. Porcher C, Malinge MC, Picat C, Grandchamp B. A simplified method for determination of specific DNA or RNA copy number using quantitative PCR and an automatic DNA sequencer. Biotechniques 1992;13:106-13.
23. Gouya L, Deybach JC, Lamoril J, Da Silva V, Beaumont C, Grandchamp B, Nordmann Y. Modulation of the phenotype in dominant erythropoietic protoporphyria by a low expression of the normal ferrochelatase allele. Am J Hum Genet 1996;58:292-9.
24. Busque L, Zhu J, DeHart D, Griiffith B, Willman C, Carroll R, et al. An expression based clonality assay at the human androgen receptor locus (HUMARA) on chromosome X. Nucleic Acids Res 1994;22:697-8.
25. Simmler MC. L'inactivation du chromosome X chez les mammifères. Med Sci 1992;8:972-8.