Chronic widespread pain and fibromyalgia: What we know, and what we need to know

Best Practice and Research: Clinical Rheumatology

Volumn 17, Issue 4, 2003, Pages 685-701

  Clauw, Daniel J ^a   Crofford, Leslie J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Chronic; Fibromyalgia; Pain; Widespread

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; 5 HYDROXYINDOLEACETIC ACID; AMITRIPTYLINE; ANALGESIC AGENT; ANTIDEPRESSANT AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BIOLOGICAL MARKER; CLONAZEPAM; CORTICOSTEROID DERIVATIVE; CORTICOTROPIN RELEASING FACTOR; CYCLOBENZAPRINE; DOPAMINE; GABAPENTIN; LONG ACTING DRUG; NEFAZODONE; NONSTEROID ANTIINFLAMMATORY AGENT; NORADRENALIN; OPIATE DERIVATIVE; PEPTIDE; SEROTONIN; SEROTONIN RECEPTOR AFFECTING AGENT; SEROTONIN UPTAKE INHIBITOR; SUBSTANCE P; TRAMADOL; TRAZODONE; TRICYCLIC ANTIDEPRESSANT AGENT; TRYPTOPHAN; UNINDEXED DRUG; VENLAFAXINE; ZOLPIDEM; CORTICOSTEROID; OPIATE; SEROTONIN AGONIST;

ACUPUNCTURE; ADRENERGIC ACTIVITY; BEHAVIOR; BEHAVIOR THERAPY; CEREBROSPINAL FLUID; CHRONIC FATIGUE SYNDROME; CHRONIC PAIN; CLINICAL FEATURE; CLINICAL TRIAL; COGNITIVE THERAPY; DISTRESS SYNDROME; DOPAMINERGIC ACTIVITY; DRUG EFFICACY; DRUG TOLERABILITY; ENVIRONMENTAL EXPOSURE; EPIDEMIOLOGICAL DATA; EXERCISE; FATIGUE; FIBROMYALGIA; GENDER; HUMAN; HYPOTENSION; INFLAMMATION; INJURY; INSOMNIA; LOW BACK PAIN; LOW DRUG DOSE; MANIPULATIVE MEDICINE; MULTIPLE CHEMICAL SENSITIVITY; NEUROBIOLOGY; NONHUMAN; PAIN ASSESSMENT; POPULATION; POTASSIUM INTAKE; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; REVIEW; SEROTONIN BLOOD LEVEL; SEROTONIN METABOLISM; SODIUM INTAKE; SOMATOFORM DISORDER; TREATMENT FAILURE; HEALTH CARE ORGANIZATION; OSTEOARTHRITIS; PRESSURE; TENSION HEADACHE;

EID: 0038268869     PISSN: 15216942     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-6942(03)00035-4     Document Type: Review

References (82)

1. Wolfe F, Ross K, Anderson J et al. The prevalence and characteristics of fibromyalgia in the general population. Arthritis & Rheumatism 1995; 38: 19-28.
2. Croft P, Rigby AS, Boswell R et al. The prevalence of chronic widespread pain in the general population. Journal of Rheumatology 1993; 20: 710-713.
3. Wolfe F, Ross K, Anderson J & Russell IJ. Aspects of fibromyalgia in the general population: Sex, pain, threshold, and fibromyalgia symptoms. Journal of Rheumatology 1995; 22: 151-156.
4. Wolfe F, Smythe HA, Yunus MB et al. The American College of Rheumatology criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis & Rheumatism 1990; 33: 160-172.
5. White KP, Speechley M, Harth M & Ostbye T. The London Fibromyalgia Epidemiology Study: The prevalence of fibromyalgia syndrome in London, Ontario. Journal of Rheumatology 1999; 26: 1570-1576.
6. Wolfe F. The relation between tender points and fibromyalgia symptom variables: Evidence that fibromyalgia is not a discrete disorder in the clinic. Annals of the Rheumatic Diseases 1997; 56: 268-271.
7. White KP, Nielson WR, Harth M et al. Chronic widespread musculoskeletal pain with or without fibromyalgia: Psychological distress in a representative community adult sample. Journal of Rheumatology 2002; 29: 588-594.
8. Croft P, Schollum J & Silman A. Population study of tender point counts and pain as evidence of fibromyalgia. British Medical Journal 1994; 309: 696-699.
9. McBeth J, Macfarlane GJ, Hunt IM & Silman AJ. Risk factors for persistent chronic widespread pain: A community-based study. Rheumatology (Oxford) 2001; 40: 95-101.
10. McBeth J, Macfarlane GJ & Silman AJ. Does chronic pain predict future psychological distress? Pain 2002; 96: 239-245.
11. Nisenbaum R, Reyes M, Mawle AC & Reeves WC. Factor analysis of unexplained severe fatigue and interrelated symptoms: Overlap with criteria for chronic fatigue syndrome. American Journal of Epidemiology 1998; 148: 72-77.
12. Doebbeling BN, Clarke WR, Watson D et al. Is there a Persian Gulf War syndrome? Evidence from a large population-based survey of veterans and nondeployed controls. American Journal of Medicine 2000; 108: 695-704.
13. Fukuda K, Nisenbaum R, Stewart G et al. Chronic multisymptom illness affecting Air Force veterans of the Gulf War. Journal of the American Medical Association 1998; 280: 981-988.
14. Bergman S, Herrstrom P, Jacobsson LT & Petersson IF. Chronic widespread pain: A three year followup of pain distribution and risk factors. Journal of Rheumatology 2002; 29: 818-825.
15. White KP, Harth M, Speechley M & Ostbye T. A general population study of fibromyalgia tender points in noninstitutionalized adults with chronic widespread pain. Journal of Rheumatology 2000; 27: 2677-2682.
16. Croft PR, Papageorgiou AC, Ferry S et al. Psychologic distress and low back pain. Evidence from a prospective study in the general population. Spine 1995; 20: 2731-2737.
17. Nahit ES, Pritchard CM, Cherry NM et al. The influence of work related psychosocial factors and psychological distress on regional musculoskeletal pain: A study of newly employed workers. Journal of Rheumatology 2001; 28: 1378-1384.
18. Papageorgiou AC, Silman AJ & Macfarlane GJ. Chronic widespread pain in the population: A seven year follow up study. Annals of the Rheumatic Diseases 2002; 61: 1071-1074.
19. Felson DT & Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis & Rheumatism 1998; 41: 1343-1355.
20. Frymoyer JW, Newberg A, Pope MH et al. Spine radiographs in patients with low-back pain. An epidemiological study in men. Journal of Bone & Joint Surgery (Am) 1984; 66: 1048-1055.
21. Boden SD, Davis DO, Dina TS et al. Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. Journal of Bone & Joint Surgery (Am) 1990; 72: 403-408.
22. Jensen MC, Brant-Zawadzki MN, Obuchowski N et al. Magnetic resonance imaging of the lumbar spine in people without back pain. New England Journal of Medicine 1994; 331: 69-73.
23. Clauw DJ, Lauerman W, Dahlman M et al. Tenderness as a determinant of outcome in individuals with chronic low back pain (CLBP). Arthritis & Rheumatism 1997; 40(supplement 9): S279.
24. Aaron LA, Bradley LA, Alarcon GS et al. Psychiatric diagnoses in patients with fibromyalgia are related to health care-seeking behavior rather than to illness. Arthritis & Rheumatism 1996; 30: 436-445. See comments.
25. Aaron LA, Burke MM & Buchwald O. Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder. Archives of Internal Medicine 2000; 160: 221-227.
26. Clauw DJ & Chrousos GP. Chronic pain and fatigue syndromes: Overlapping clinical and neuroendocrine features and potential pathogenic mechanisms. Neuroimmunomodulation 1997; 4: 134-153.
27. Fukuda K, Straus SE, Hickie I et al. The chronic fatigue syndrome: A comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Annals of Internal Medicine 1994; 121: 953-959.
28. Hudson JI, Goldenberg DL, Pope HGJ et al. Comorbidity of fibromyalgia with medical and psychiatric disorders. American Journal of Medicine 1993; 92: 363-367.
29. Buskila D, Neumann L, Vaisberg G et al. Increased rates of fibromyalgia following cervical spine injury. A controlled study of 161 cases of traumatic injury. Arthritis & Rheumatism 1997; 40: 446-452. See comments.
30. Buskila D, Shnaider A, Neumann L et al. Fibromyalgia in hepatitis C virus infection. Another infectious disease relationships. Archives of Internal Medicine 1997; 157: 2497-2500.
31. White PD, Thomas JM, Amess J et al. The existence of a fatigue syndrome after glandular fever. Psychological Medicine 1995; 25: 907-916.
32. Bourdette DN, McCauley LA, Barkhuizen A et al. Symptom factor analysis, clinical findings, and functional status in a population-based case control study of Gulf War unexplained illness. Journal of Occupational & Environmental Medicine 2001; 43: 1026-1040.
33. Unwin C, Blatchley N, Coker W et al. Health of UK servicemen who served in Persian Gulf War. Lancet 1999; 353: 169-178.
34. Clauw DJ & Katz P. The overlap between fibromyalgia and inflammatory rheumatic diseases: When and why does it occur? Journal of Clinical Rheumatology 1995; 1: 335-341.
35. Bates DW, Buchwald D, Lee J et al. Clinical laboratory test findings in patients with chronic fatigue syndrome. Archives of Internal Medicine 1995; 155: 97-103.
36. Pincus T. A pragmatic approach to cost-effective use of laboratory tests and imaging procedures in patients with musculoskeletal symptoms. Primary Care 1993; 20: 795-814.
37. Romero LM, Plotsky PM & Sapolsky RM. Patterns of adrenocorticotropin secretagog release with hypoglycemia, novelty, and restraint after colchicine blockade of axonal transport. Endocrinology 1993; 132: 199-204.
38. Lautenbacher S & Rollman GB. Possible deficiencies of pain modulation in fibromyalgia. Clinical Journal of Pain 1997; 13: 189-196.
39. Raphael KG, Natelson BH, Janal MN & Nayak S. A community-based survey of fibromyalgia-like pain complaints following the World Trade Center terrorist attacks. Pain 2002; 100: 131-139.
40. Pillow DR, Zautra AJ & Sandler I. Major life events and minor stressors: Identifying mediational links in the stress process. Journal of Personality and Social Psychology 1996; 70: 381-394.
41. Sapolsky RM. Why stress is bad for your brain. Science 1996; 273: 749-750.
42. Crofford LJ, Pillemer SR, Kalogeras KT et al. Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. Arthritis & Rheumatism 1994; 37: 1583-1592.
43. Crofford LJ. The hypothalamic-pituitary-adrenal stress axis in fibromyalgia and chronic fatigue syndrome. Zeitschrift für Rheumatologie 1998; 57(supplement 2): 67-71.
44. Adler GK, Kinsley BT, Hurwitz S et al. Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome. American Journal of Medicine 1999; 106: 534-543.
45. Petzke F & Clauw DJ. Sympathetic nervous system function in fibromyalgia. Current Rheumatology Reports 2000; 2: 116-123.
46. Martinez-Lavin M, Hermosillo AG, Rosas M & Soto ME. Circadian studies of autonomic nervous balance in patients with fibromyalgia: A heart rate variability analysis. Arthritis & Rheumatism 1998; 41: 1966-1971.
47. Granges G & Littlejohn GO. A comparative study of clinical signs in fibromyalgia/fibrositis syndrome, healthy and exercising subjects. Journal of Rheumatology 1993; 20: 344-351.
48. Lautenbacher S, Rollman GB & McCain GA. Multi-method assessment of experimental and clinical pain in patients with fibromryalgia. Pain 1994; 49: 45-53.
49. Petzke F, Gracely RH, Khine A & Clauw DJ. Pain sensitivity in patients in fibromyalgia (FM): Expectancy effects on pain measurements. Arthritis & Rheumtism 1999; 42(supplement 9): S342.
50. Kosek E & Ekholm J. Modulatio of pressure pain thresholds during and following isometric contraction. Pain 1995; 61: 481-486.
51. Price DD, Staud R, Robinson ME et al. Enhanced temporal summation and second pain and its central modulation in fibromyalgia patients. Pain 2002; 99: 49-59.
52. Staud R, Vierck CJ, Cannon RL et al. Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome. Pain 2001; 91: 165-175.
53. Price DD. Psychological and neural mechanism of the affective dimension of pain. Science 2000; 288: 1769-1772.
54. Lorenz J, Grasedyck K & Bromm B. Middle and long latency somatosensory evoked potentials after painful laser stimulation in patients with fibromyalgia syndrome. Electroencephalograhy and Clinical Neurophysiology 1996; 100: 165-168.
55. Mountz JM, Bradley LA, Modell JG et al. Fibromyalgia in women. Abnormalities of regional cerebral blood flow in the thalamus and the caudate nucleus are associated with low pain threshold levels. Arthritis & Rheumatism 1995; 38: 926-938.
56. Gracely RH, Petzke K, Wolf J & Clauw DJ. Functional MRI evidence of augmented pain processing in fibromyalgia. Arthritis & Rheumatism 2002; 46: 1333-1343.
57. Welin M, Bragee B, Nyberg F & Kristiansson M. Elevated substance P levels are contrasted by a decrease in met-enkephalin-arg-phe levels in CSF from fibromyalgia patients. Journal of Musculoskeletal Pain 1995; 3: 4.
58. Vaeroy H, Helle R, Forre O et al. Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: New features for diagnosis. Pain 1988; 32: 21-26.
59. Russell IJ, Orr MD, Littman B et al. Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis & Rheumatism 1994; 37: 1593-1601.
60. Evengard B, Nilsson CG, Lindh G et al. Chronic fatigue syndrome differs from fibromyalgia. No evidence for elevated substance P levels in cerebrospinal fluid of patients with chronic fatigue syndrome. Pain 1998; 78: 153-155.
61. Russell IJ, Vaeroy H, Javors M & Nyberg F. Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis. Arthritis & Rheumatism 1992; 35: 550-556.
62. Yunus MB, Dailey JW, Aldag JC et al. Plasma tryptophan and other amino acids in primary fibromyalgia: A controlled study. Journal of Rheumatology 1992; 19: 90-94.
63. Boissevain MD & McCain GA. Toward an integrated understanding of fibromyalgia syndrome. I. Medical and pathophysiological aspects. Pain 1991; 45: 227-238.
64. Hudson JI, Hudson MS, Pliner LF et al. Fibromyalgia and major affective disorder: A controlled phenomenology and family story study. American Journal of Psychiatry 1985; 142: 441-446.
65. White KP, Nielson WR, Harth M et al. Does the label 'fibromyalgia' alter health status, function, and health service utilization? A prospective, within-group comparison in a community cohort of adults with chronic widespread pain. Arthritis & Rheumatism 2002; 47: 260-265.
66. Hadler NM. If you have to prove you are ill, you can't get well. The object lesson of fibromyalgia. Spine 1996; 21: 2397-2400.
67. Hawley DJ & Wolfe F. Pain, disability, and pain/disability relationships in seven rheumatic disorders: A study of 1522 patients. Journal of Rheumatology 1991; 18: 1552-1557.
68. Callahan LF, Smith WJ & Pincus T. Self-report questionnaires in five rheumatic diseases: Comparisons of health status constructs and associations with formal education level. Arthritisi Care Research 1989; 2: 122-131.
69. Hadler NM. Fibromyalgia, chronic fatigue, and other iatrogenic diagnostic algorithms. Do some labels escalate illness in vulnerable patients. Postgraduate Medicine 1997; 102: 161-166. See comments, see also p. 171.
70. White KP & Harth M. Classification, epidemiology, and natural history of fibromyalgia. Current Pain and Headache Reports 2001; 5: 320-329.
71. O'Malley PG, Balden E, Tomkins G et al. Treatment of fibromyalgia with antidepressants. A meta-analysis (in process citation). Journal of General Internal Medicine 2000; 16: 659-666.
72. Goldenberg D, Mayskiy M, Mossey C et al. A randomized, double-blind crossover trial of fluoxetine and imitriptyline in the treatment of fibromylalgia. Arthritis & Rheumatism 1996; 39: 1852-1859.
73. Wolfe F, Cathey MA & Hawley DJ. A double-blind placebo controlled trial of fluoxetine in fibromyalgia. Scandinavian Journal of Rheumatology 1994; 23: 255-259.
74. Arnold LM, Hess EV, Hudson JI et al. A randomized, placebo-controlled, double-blind, flexible-doses study of fluoxetine in the treatment of women with fibromyalgia. American Journal of Medicine 2002; 112: 191-197.
75. Guymer EK & Clauw DJ. Treatment of fatigue of fatigue in fibromyalgia. Rheumatic Diseases Clinics of North America 2002; 28: 367-378.
76. Park DC, Glass JM, Minear M & Crofford LJ. Cognitive function in fibromyalgia patients. Arthritis & Rheumatism 2001; 44: 2125-2133.
77. Wiliams DA, Cary MA, Glazer LJ et al. Randomized controlled trial of CBT to improve functional status in fibromyalgia. American College of Rheumatology 2000; 43: S210.
78. N.I.H. Integration of behavioral and relaxation approaches into the treatment of chronic pain and isomnia. NIH Technology Assessment Panel on Integration of Behavioral and Relaxation Approaches into the Treatment of Chronic Pain and Insomnia. Journal of the American Medical Association 1996; 275:313-318.
79. Keefe FJ, Gil KM & Ross SC. Behavioral approaches in the multidisciplinnary management of chronic pain: Program and issues. Clinical Psychology Review 1986; 6: 870-113.
80. Janal MN. Pain sensitivity, exercise and stoicism. Journal of the Royal Society of Medicine 1996; 89: 376-381.
81. Crofford LJ & Appleton BE. Complementary and alternative therapies by fibromyalgia. Current Rheumatology Reports 2001; 3: 147-156.
82. Harris RE & Clauw DJ. The use of complementary medical therapies in the management of myofascial pain disorders. Current Pain and Headache Reports 2000; 6:370-374.