Effects of insulin-like growth factor-I deficiency and replacement therapy on the hematopoietic system in patients with Laron syndrome (primary growth hormone insensitivity)

Journal of Pediatric Endocrinology and Metabolism

Volumn 16, Issue 4, 2003, Pages 509-520

  Sivan, Bezalel ^a,b   Lilos, Pearl ^a,b   Laron, Zvi ^a,b  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Growth hormone insensitivity; Growth hormone resistance; Hematopoiesis; IGF I; Laron syndrome; Monocytes

Indexed keywords

FK 780; GROWTH HORMONE; HEMOGLOBIN; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN C;

ADULT; ADULTHOOD; ANALYSIS OF VARIANCE; ARTICLE; BLOOD CELL COUNT; BLOOD SAMPLING; CHILD; CHILDHOOD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG RESPONSE; ERYTHROCYTE COUNT; ERYTHROPOIESIS; FEMALE; FOLLOW UP; HEMATOCRIT; HEMATOPOIETIC SYSTEM; HEMOGLOBIN DETERMINATION; HUMAN; LARON SYNDROME; MALE; MEAN CORPUSCULAR VOLUME; MEDICAL RECORD; MONOCYTE; PERIPHERAL CIRCULATION; PROTEIN DEFICIENCY; RETROSPECTIVE STUDY; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; SUBSTITUTION THERAPY; THROMBOCYTE COUNT; BLOOD; CYTOLOGY; DRUG EFFECT; GROWTH DISORDER; HEMATOPOIESIS; INFANT; LYMPHOCYTE COUNT; METABOLISM; MIDDLE AGED; PRESCHOOL CHILD;

ADULT; CHILD; CHILD, PRESCHOOL; ERYTHROCYTE COUNT; FEMALE; GROWTH DISORDERS; HEMATOCRIT; HEMATOPOIESIS; HEMOGLOBINS; HUMANS; INFANT; INSULIN-LIKE GROWTH FACTOR I; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; MONOCYTES; PLATELET COUNT; RETROSPECTIVE STUDIES;

EID: 0038266175     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2003.16.4.509     Document Type: Article

References (35)

1. Jepson JH, McGarry EE. Haemopoiesis in pituitary dwarfs treated with human growth hormone and testosterone. Blood 1972; 39: 229-248.
2. Christ ER, Cummings MH, Westwood NB, Sawyer BM, Pearson TC, Sonksen PH, Russell-Jones DL. The importance of growth hormone in the regulation of erythropoiesis, red cell mass, and plasma volume in adults with growth hormone deficiency. J Clin Endocrinol Metab 1997; 82: 2985-2990.
3. Ten Have SMTH, van der Lely AJ, Lamberts SWJ. Increase in haemoglobin concentrations in growth hormone deficient adults during human recombinant growth hormone replacement therapy. Clin Endocrinol 1997; 47: 565-570.
4. Sohmiya M, Kato Y. Effect of long-term administration of recombinant human growth hormone (rhGH) on plasma erythropoietin (EPO) and haemoglobin levels in anaemic patients with adult GH deficiency. Clin Endocrinol 2001; 55: 749-754.
5. Vihervuori E, Virtanen M, Koistinen H, Koistinen R, Seppala M, Simes MA. Hemoglobin level is linked to growth hormone-dependent proteins in short children. Blood 1996; 87: 2075-2081.
6. Golde DW, Cline MJ. Hormonal interactions with haematopoietic cells in vitro. Transpl Proc 1978; 10: 95-97.
7. Merchav S, Tatarsky I, Hochberg Z. Enhancement of erythropoiesis in vitro by human growth hormone is mediated by insulin-like growth factor I. Br J Haematol 1988; 70: 267-271.
8. Merchav S. The haematopoietic effects of growth hormone and insulin-like growth factor-I. J Pediatr Endocrinol Metab 1998; 11: 677-685.
9. Laron Z, Pertzelan A, Mannheimer S. Genetic pituitary dwarfism with high serum concentration of growth hormone. A new inborn error of metabolism? Isr J Med Scis 1966; 2: 152-155.
10. Laron Z, Pertzelan A, Karp M. Pituitary dwarfism with high serum levels of growth hormone. Isr J Med Sci 1968; 4: 883-894.
11. Laron Z. Natural history of the classical form of primary growth hormone (GH) resistance (Laron syndrome). J Pediatr Endocrinol Metab 1999; 12: 231-249.
12. Godowski PJ, Leung DW, Meacham LR, Galagani JP, Hellmiss R, Keret R, Rotwein PS, Parks JS, Laron Z, Wood WI. Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron type dwarfism. Proc Natl Acad Sci USA 1989; 86: 8083-8087.
13. Amselem S, Duquesnoy P, Duriez B, Dastot F, Sobrier ML, Valleix S. Spectrum of growth hormone receptor mutations and associated haplotypes in Laron syndrome. Hum Mol Genet 1993; 2: 355-359.
14. Laron Z, Klinger B, Eshet R, Kaneti H, Karasik A, Silbergeld A. Laron syndrome due to a post-receptor defect: response to IGF-I treatment. Isr J Med Sci 1993; 29: 757-763.
15. Laron Z. Growth hormone resistance (Laron syndrome). In: Chrousos G, ed. Hormone Resistance and Hypersensitivity States. New York: Lippincott Williams & Wilkins, 2002; 251-267.
16. Laron Z. Prismatic cases: Laron syndrome (primary growth hormone resistance). From patient to laboratory to patient. J Clin Endocrinol Metab 1995; 80: 1526-1573.
17. Laron Z, Klinger B. IGF-I treatment of adult patients with Laron syndrome. Clin Endocrinol (Oxf) 1994; 41: 631-638.
18. Klinger B, Laron Z. Three year IGF-I treatment of children with Laron syndrome. J Pediatr Endocrinol Metab 1995; 8: 149-158.
19. Laron Z, Pertzelan A, Karp M, Kowadlo-Silbergeld A, Daughaday WH. Administration of growth hormone to patients with familial dwarfism with high plasma immunoreactive growth hormone. Measurement of sulfation factor, metabolic and linear growth responses. J Clin Endocrinol Metab 1971; 33: 332-342.
20. Dixon WJ. BMDP Statistical Software. Los Angeles, CA: University of California Press, 1992.
21. Pertzelan A, Lazar L, Klinger B, Laron Z. Puberty in 15 patients with Laron syndrome: a longitudinal study. In: Laron Z, Parks JS, eds. Lessons from Laron Syndrome (LS) 1966-1992. Pediatric and Adolescent Endocrinology, vol. 24. Basel: Karger, 1993; 27-33.
22. Laron Z, Klinger B, Silbergeld A. Serum insulin-like growth factor-I (IGF-I) levels during long-term IGF-I treatment of children and adults with primary GH resistance (Laron syndrome). J Pediatr Endocrinol Metab 1999; 12: 145-152.
23. Golde DW, Bershch N, Li CH. Growth hormone: species-specific stimulation of erythropoiesis in vitro. Science 1977; 196: 1112-1113.
24. Claustres M, Chatelain P, Sultan C. Insulin-like growth factor I stimulates human erythroid colony formation in vitro. J Clin Endocrinol Metab 1987; 65: 78-82.
25. Kurtz A, Zapf J, Eckardt K-U, Clemons G, Froesch ER, Bauer C. Insulin-like growth factor I stimulates erythropoiesis in hypophysectomized rats. Proc Natl Acad Sci USA 1988; 85: 7825-7829.
26. Murphy WJ, Tsarfaty G, Longo DL. Growth hormone exerts haematopoietic growth-promoting effects in vivo and partially counteracts the myelosuppressive effects of azidothymidine. Blood 1992; 80: 1443-1447.
27. Tsarfaty G, Longo DL, Murphy WJ. Human insulin-like growth factor I exerts haemopoietic growth-promoting effects after in vivo administration. Exp Haemotol 1994; 22: 1273-1277.
28. Valerio G, Di Maio S, Salerno M, Argenziano A, Badolato R, Tenore A. Assessment of red blood cell indices in growth-hormone-treated children. Horm Res 1997; 47: 62-66.
29. Eshet R, Dux Z, Silbergeld A, Koren R, Klinger B, Laron Z. Erythrocytes from patients with low serum concentrations of IGF-I have an increase in receptor sites for IGF-I. Acta Endocrinol (Copenh) 1991; 125: 354-358.
30. Merchav S, Tatarsky I. Hochberg Z. Enhancement of human granulopoiesis in vitro by biosynthetic insulin-like growth factor I/somatomedin C and human growth hormone. J Clin Invest 1988; 81: 791-797.
31. Kotzmann H, Riedl M, Clodi M, Barnas U, Kaider A, Hocker P, Luger A. The influence of growth hormone substitution therapy on erythoid and myeloid progenitor cells and on peripheral blood cells in adult patients with growth hormone deficiency. Eur J Clin Invest 1996; 26: 1175-1181.
32. Serri O, St-Jacques P, Sartippour M, Renier G. Alterations of monocyte function in patients with growth hormone (GH) deficiency: effect of substitutive GH therapy. J Clin Endocrinol Metab 1999; 84: 58-63.
33. Wiedermann CJ, Reinisch N, Braunsteiner H. Stimulation of monocyte chemotaxis by human growth hormone and its deactivation by somatostatin. Blood 1993; 82: 954-960.
34. LeRoith D, Yanowski J, Kaldjian EP, Jaffe ES, LeRoith T, Purdue K, Cooper BD, Pyle R Adler W. The effects of growth hormone and insulin-like growth factor I on the immune system of aged female monkeys. Endocrinology 1996; 137: 1071-1079.
35. Backeljauw PF, Underwood LE, GHIS Collaborative Group. Prolonged treatment with recombinant insulin-like growth factor-I in children with growth hormone insensitivity syndrome - a clinical Research Center study. J Clin Endocrinol Metab 1996; 81: 3312-3317.