Targeting Cells that Overexpress the Epidermal Growth Factor Receptor with Polyethylene Glycolated BPD Verteporfin Photosensitizer Immunoconjugates

Photochemistry and Photobiology

Volumn 77, Issue 4, 2003, Pages 431-439

  Savellano, Mark D ^a,b   Hasan, Tayyaba ^c  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^b DARTMOUTH COLLEGE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; BENZOPORPHYRIN DERIVATIVE; DODECYL SULFATE SODIUM; EPIDERMAL GROWTH FACTOR RECEPTOR; PHOTOSENSITIZING AGENT; POLYETHYLENE; MACROGOL DERIVATIVE; PORPHYRIN;

ANTIGEN BINDING; ARTICLE; CELL INTERACTION; CELL KILLING; COVALENT BOND; GENE OVEREXPRESSION; GLYCOSYLATION; HUMAN; HUMAN CELL; IMMUNOTHERAPY; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SOLUBILITY; TARGET CELL; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECT; METABOLISM; MOUSE;

ANIMALIA;

ANIMALS; CELL LINE; HUMANS; IMMUNOCONJUGATES; MICE; PHOTOSENSITIZING AGENTS; POLYETHYLENE GLYCOLS; PORPHYRINS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 0038206602     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/0031-8655(2003)077<0431:TCTOTE>2.0.CO;2     Document Type: Article

References (46)

1. Hamblin, M. R., J. L. Miller and T. Hasan (1996) Effects of charge on the interaction of site-specific photoimmunoconjugates with human ovarian cancer cells. Cancer Res. 56, 5205-5210.
2. DeLaney, T. F., W. F. Sindelar, Z. Tochner, P. D. Smith, W. S. Friauf, G. Thomas, L. Dachowski, J. W. Cole, S. M. Steinberg and E. Glatstein (1993) Phase I study of debulking surgery and photodynamic therapy for disseminated intraperitoneal tumors. Int. J. Radiat. Oncol. Biol. Phys. 25, 445-457.
3. Duska, L. R., M. R. Hamblin, J. L. Miller and T. Hasan (1999) Combination photoimmunotherapy and cisplatin: effects on human ovarian cancer ex vivo. JNCI 91, 1557-1563.
4. Mew, D., C. K. Wat, G. H. N. Towers and J. G. Levy (1983) Photoimmunotherapy: treatment of animal tumors with tumor-specific monoclonal antibody-hematoporphyrin conjugates. J. Immunol. 130, 1473-1477.
5. Hasan, T. (1992) Photosensitizer delivery mediated by macromolecular carrier systems. In Photodynamic Therapy: Basic Principles and Clinical Applications (Edited by B. W. Henderson and T. J. Dougherty), pp. 187-200. Marcel Dekker, Inc., New York.
6. Sternberg, E. D., D. Dolphin and C. Brückner (1998) Porphyrin-based photosensitizers for use in photodynamic therapy. Tetrahedron 54, 4151-4202.
7. Yarmush, M. L., W. P. Thorpe, L. Strong, S. L. Rakestraw, M. Toner and R. G. Tompkins (1993) Antibody targeted photolysis. Crit. Rev. Ther. Drug Carrier Syst. 10, 197-252.
8. Savellano, M. D. (2000) Photodynamic Targeting with Photosensitizer Immunoconjugates. Ph.D. Thesis, University of Michigan, Ann Arbor, MI. [Available online from UMI Dissertations Publishing]
9. Richter, A. M., B. Kelly, J. Chow, D. J. Liu, G. H. N. Towers, D. Dolphin and J. G. Levy (1987) Preliminary studies on a more effective phototoxic agent than hematoporphyrin. JNCI 79, 1327-1331.
10. Aveline, B., T. Hasan and R. W. Redmond (1994) Photophysical and photosensitizing properties of benzoporphyrin derivative monoacid ring A (BPD-MA). Photochem. Photobiol. 59, 328-335.
11. Schmidt-Erfurth, U. and T. Hasan (2000) Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degeneration. Surv. Ophthalmol. 45, 195-214.
12. Fan, Z. and J. Mendelsohn (1998) Therapeutic application of anti-growth factor receptor antibodies. Curr. Opin. Oncol. 10, 67-73.
13. Harari, P. M. and S. M. Huang (2000) Modulation of molecular targets to enhance radiation. Clin. Cancer Res. 6, 323-325.
14. Mendelsohn, J. and Z. Fan (1997) Epidermal growth factor receptor family and chemosensitization. JNCI 89, 341-343.
15. Huang, S. M., J. M. Bock and P. M. Harari (1999) Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res. 59, 1935-1940.
16. Harari, P. M. and S. M. Huang (2001) Head and neck cancer as a clinical model for molecular targeting of therapy: combining EGFR blockade with radiation. Int. J. Radiat. Oncol. Biol. Phys. 49, 427-433.
17. Mendelsohn, J. (2000) Jeremiah Metzger lecture: targeted cancer therapy. Trans. Am. Clin. Climatol. Assoc. 111, 95-111.
18. de Bono, J. S. and E. K. Rowinsky (2002) The ErbB receptor family: a therapeutic target for cancer. Trends Mol. Med. 8S, S19-S26.
19. Perkins, A. S. and D. F. Stern (1997). In Cancer: Principles and Practice of Oncology, V (Edited by T. DeVita, S. Hellman and S. A. Rosenberg), pp. 79-102. Lippincott-Raven, Philadelphia, PA.
20. Garber, K. (2000) New discoveries still abundant in monoclonal antibody research. JNCI 92, 1462-1464.
21. Levy, J. G., D. Dolphin and J. K. Chow (1989) Wavelength-specific cytotoxic agents. U.S. patent 4,883,790.
22. Jiang, F. N., S. Jiang, D. Liu, A. Richter and J. G. Levy (1990) Development of technology for linking photosensitizers to a model monoclonal antibody. J. Immunol. Methods 134, 139-149.
23. Jiang, F. N., D. J. Liu, H. Neyndorff, M. Chester, S. Jiang and J. G. Levy (1991) Photodynamic killing of human squamous cell carcinoma cells using a monoclonal antibody-photosensitizer conjugate. JNCI 83, 1218-1225.
24. Jiang, F. N., B. Allison, D. Liu and J. G. Levy (1992) Enhanced photodynamic killing of target cells by either monoclonal antibody or low density lipoprotein mediated delivery systems. J. Control. Release 19, 41-58.
25. Jiang, F. N., A. M. Richter, A. K. Jain, J. G. Levy and C. Smits (1993) Biodistribution of a benzoporphyrin derivative-monoclonal antibody conjugate in A549-tumor-bearing nude mice. Biotechnol. Ther. 4, 43-61.
26. Molpus, K. L., M. R. Hamblin, I. Rizvi and T. Hasan (2000) Intraperitoneal photoimmunotherapy of ovarian carcinoma xenografts in nude mice using charged photoimmunoconjugates. Gynecol. Oncol. 76, 397-404.
27. Pruss, R. M. and H. R. Herschman (1977) Variants of 3T3 cells lacking mitogenic response to epidermal growth factor. Proc. Natl. Acad. Sci. USA 74, 3918-3921.
28. Bodanszky, M. (1993) Side reactions due to overactivation. In Principles of Peptide Synthesis, 2nd revised ed., pp. 195, 196. Springer-Verlag, New York.
29. Bauminger, S. and M. Wilchek (1980) The use of carbodiimides in the preparation of immunizing conjugates. Methods Enzymol. 70, 151-159.
30. Sambrook, J., E. F. Fritsch and T. Maniatis (1989) Spun-column chromatography. In Molecular Cloning: A Laboratory Manual, 2nd ed., pp. E.37, E.38. Cold Spring Harbor Laboratory Press, New York.
31. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.) 227, 680-685.
32. Hames, B. D. and D. Rickwood (eds.) (1996) Gel Electrophoresis of Proteins: A Practical Approach, pp. 46, 113-114. Oxford University Press Inc., New York.
33. (1994) TimeMaster Fluorescence Lifetime Spectrometer Reference Manual. Photon Technology International, Inc., South Brunswick, NJ.
34. (1998) Fluorescence System User's Manual, Version 1.2x/TimeMaster Pro Software User's Manual. Photon Technology International, Inc., Monmouth Junction, NJ.
35. Bevington, P. R. (1969) Data Reduction and Error Analysis for the Physical Sciences. McGraw-Hill, New York.
36. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
37. Aveline, B. M., T. Hasan and R. W. Redmond (1995) The effects of aggregation, protein binding, and cellular incorporation on the photophysical properties of benzoporphyrin derivative monoacid ring A (BPDMA). J. Photochem. Photobiol. B: Biol. 30, 161-169.
38. Friedman, M. (1967) Solvent effects of amino groups in amino acids, peptides, and proteins with α, β-unsaturated compounds. J. Am. Chem. Soc. 89, 4709-4713.
39. Mew, D., C. K. Wat, C. K. Lum, G. H. N. Towers, C. H. C. Sun, R. T. Walter, M. W. Berns and J. G. Levy (1985) Ability of specific monoclonal antibodies and conventional antisera conjugated to hematoporphyrin to label and kill selected cell lines subsequent to light activation. Cancer Res. 45, 4380-4386.
40. Steele, K. J., D. Liu, A. T. Stammers, H. Deal, S. Whitney and J. G. Levy (1988) Suppressor deletion therapy: selective elimination of T suppressor cells using a hematoporphyrin conjugated monoclonal antibody. In Antibody-mediated Delivery Systems, pp. 157-189. Marcel Dekker, Inc., New York.
41. Gross, S., A. Brandis, L. Chen, V. Rosenbach-Belkin, S. Roehrs, A. Scherz and Y. Salomon (1997) Protein-A-mediated targeting of bacteriochlorophyll-IgG to Staphylococcus aureus: a model for enhanced site-specific photocytotoxicity. Photochem. Photobiol. 66, 872-878.
42. Hamblin, M. R., J. L. Miller and B. Ortel (2000) Scavenger-receptor targeted photodynamic therapy. Photochem. Photobiol. 72, 533-540.
43. Suppan, P. (1994) Chemistry and Light, pp. 70-72. The Royal Society of Chemistry, Cambridge, UK.
44. Goldstein, N. I., M. Prewett, K. Zuklys, P. Rockwell and J. Mendelsohn (1995) Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin. Cancer Res. 1, 1311-1318.
45. Moan, J. (1986) Porphyrin photosensitization and phototherapy. Photochem. Photobiol. 43, 681-690.
46. Dougherty, T. J. (1996) A brief history of clinical photodynamic therapy development at Roswell Park Cancer Institute. J. Clin. Laser Med. 14, 219-221.