Hyperoxia and nitric oxide reduce surfactant components (DSPC and surfactant proteins) and increase apoptosis in adult and fetal rat type II pneumocytes

Lung

Volumn 180, Issue 6, 2002, Pages 301-317

  Bhandari, V ^a,e   Johnson, L ^a   Smith Kirwin, S ^b   Vigliotta, G ^c   Funanage, V ^b,c   Chander, A ^c,d  

^a ALBERT EINSTEIN MEDICAL CENTER   (United States)

^b NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^c THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^d STONY BROOK UNIVERSITY   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; NOS; Surfactant; Surfactant proteins

Indexed keywords

3 NITROTYROSINE; CATALASE; CHOLINE; DISATURATED PHOSPHATIDYLCHOLINE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN; PEROXYNITRITE; PHOSPHATIDYLCHOLINE; SUPEROXIDE DISMUTASE; SURFACTANT; SURFACTANT PROTEIN A; SURFACTANT PROTEIN B; SURFACTANT PROTEIN C; UNCLASSIFIED DRUG; INDUCIBLE NITRIC OXIDE SYNTHASE; LUNG SURFACTANT; NOS2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; FEMALE; HYPEROXIA; HYPOTHESIS; LUNG; LUNG ALVEOLUS CELL TYPE 2; MALE; NONHUMAN; PREMATURITY; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; METABOLISM; PATHOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CELLS, CULTURED; FEMALE; LUNG; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OXYGEN; PREGNANCY; PULMONARY SURFACTANTS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0038204406     PISSN: 03412040     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00408-002-0102-y     Document Type: Article

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