Sustained complete remission of CLL associated with the use of a Chinese herbal extract: Case report and mechanistic analysis

Leukemia Research

Volumn 27, Issue 9, 2003, Pages 859-863

  Battle, Traci E ^a,b   Castro Malaspina, Hugo ^c   Gribben, John G ^a,b   Frank, David A ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Apoptosis; Complementary therapy; Kinase; Non Hodgkin's lymphoma; Protein phosphorylation; Signal transduction

Indexed keywords

HERBACEOUS AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SERINE;

ADULT; ARTICLE; CANCER CELL CULTURE; CANCER SURVIVAL; CASE REPORT; CHINESE HERB; CHRONIC LYMPHATIC LEUKEMIA; DISEASE ASSOCIATION; ENZYME INHIBITION; HUMAN; LEUKEMIA REMISSION; LYMPHADENOPATHY; LYMPHOCYTOSIS; MALE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0038203179     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(03)00009-2     Document Type: Article

References (14)

1. Arbiser J.L., Moses M.A., Fernandez C.A., Ghiso N., Cao Y., Klauber N.et al. Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc. Natl. Acad. Sci. 94:1997;861-866.
2. Frank D.A., Mahajan S., Ritz J. B lymphocytes from patients with chronic lymphocytic leukemia contain STAT1 and STAT3 constitutively phosphorylated on serine residues. J. Clin. Invest. 100:1997;3140-3148.
3. Chung J.Y., Huang C., Meng X., Dong Z., Yang C.S. Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. Cancer Res. 59:1999;4610-4617.
4. Yang G.Y., Chen L., Lee M.J., Landau J.M. Inhibition of growth and induction of apoptosis in human cancer cells by tea polyphenols. Carcinogenesis. 19:1998;611-616.
5. Lin T.S., Mahajan S., Frank D.A. STAT signaling in the pathogenesis and treatment of leukemias. Oncogene. 19:2000;2496-2504.
6. Battle T.E., Frank D.A. The role of STATs in apoptosis. Curr. Mol. Med. 2:2002;381-392.
7. Frank D.A., Mahajan S., Ritz J. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nature Med. 5:1999;444-447.
8. Sun M., Wang G., Paciga J.E., Feldman R.I., Yuan Z.-Q., Ma X.-L.et al. AKT1/PKBa kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am. J. Pathol. 159:2001;431-437.
9. Ballif B.A., Blenis J. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Diff. 12:2001;397-408.
10. Ribera J.M., Vinolas N., Urbano-Ipizua A., Gallart T., Montserrat E., Rozman C. "Spontaneous" complete remissions in chronic lymphocytic leukemia: report of three cases and review of the literature. Blood Cells. 12:1987;471-479.
11. Wierda W.G., Cantwell M.J., Woods S.J., Rassenti L.Z., Prussak C.E., Kipps T.J. CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia. Blood. 96:2000;2917-2924.
12. Collins R.H.J., Shpilberg O., Drobyski W.R., Porter D.L., Giralt S., Champlin R.et al. Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. J. Clin. Oncol. 15:1997;433-444.
13. Berchem G.J., Bosseler M., Mine N., Avalosse B. Nanomolar range docetaxel treatment sensitizes MCF-7 cells to chemotherapy induced apoptosis, induces G2M arrest and phosphorylates bcl-2. Anticancer Res. 19:1999;535-540.
14. Kolfschoten G.M., Hulscher T.M., Duyndam M.C., Pinedo H.M., Boven E. Variation in the kinetics of caspase-3 activation, Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian cancer cell lines as a response to docetaxel. Biochem. Pharmacol. 63:2002;733-743.