Signal transducer and activator of transcription-3 activation is mediated by N-methyl-D-aspartate receptor and L-type voltage-gated Ca2+ channel during cerebral ischemia in rat hippocampus

Neuroscience Letters

Volumn 345, Issue 1, 2003, Pages 61-64

  Li, Hongchun ^a   Zhang, Quanguang ^a   Zhang, Guangyi ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cerebral ischemia; L Type voltage gated Ca2+ channel; N Methyl D aspartate receptor; Rat; Signal transducer and activator of transcription 3

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NIFEDIPINE; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN ISCHEMIA; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DNA BINDING; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RAT STRAIN; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

EID: 0038180779     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(03)00504-4     Document Type: Article

References (14)

1. Acrrin L., Gonzalez B., Castellano B. STAT3 and NFkappaB activation precedes glial reactivity in the excitotoxically injured young cortex but in the corresponding distal thalamic nuclei. J. Neuropathol. Exp. Neurol. 59:2000;151-163.
2. Jenab S., Morris P.L. Testicular leukemia inhibitory factor (LIF) and LIF receptor mediate phosphorylation of signal transducers and activators of transcription (STAT)-3 and STAT-1 and induce c-fos transcription and activator protein-1 activation in rat Sertoli but not germ cells. Endocrinology. 139:1998;1883-1890.
3. Justicia C., Gabriel C., Planas A.M. Activation of the JAK/STAT pathway following transient focal cerebral ischemia: signaling through Jak1 and Stat3 in astrocytes. Glia. 30:2000;253-270.
4. Lavine S.D., Hofman F.M., Zlokovic B.V. Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury. J. Cereb. Blood Flow Metab. 18:1998;52-58.
5. Liu Y., Zhang G.Y., Gao C., Hou X.Y. NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion. Brain Res. 909:2001;51-58.
6. Loddick S.A., Turnbull A.V., Rothwell N.J. Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat. J. Cereb. Blood Flow Metab. 18:1998;176-179.
7. Negoro S., Kunisada K., Fujio Y., Funamoto M., Darville M.I., Eizirik D.L., Osugi T., Izumi M., Oshima Y., Nakaoka Y., Hirota H., Kishimoto T., Yamauchi-Takihara K. Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase. Circulation. 104:2001;979-981.
8. Ogita K., Yoneda Y. Selective potentiation of DNA binding activities of both activator protein 1 and cyclic AMP response element binding protein though in vivo activation of N-methyl-D-aspartate receptor complex in mouse brain. J. Neurochem. 63:1994;525-534.
9. Schuringa J.J., Dekker L.V., Vellenga E., Kruijer W. Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation. J. Biol. Chem. 276:2001;27709-27715.
10. Shen W., Zhang C., Zhang G. Nuclear factor kappaB activation is mediated by NMDA and non-NMDA receptor and L-type voltage-gated Ca (2+) channel following severe global ischemia in rat hippocampus. Brain Res. 12:2002;23-30.
11. Stromberg H., Svensson S.P., Hermanson O. Distribution of the transcription factor signal transducer and activator of transcription 3 in the rat central nervous system and dorsal root ganglia. Brain Res. 853:2000;105-114.
12. Suzuki S., Tanaka K., Nogawa S., Dembo T., Kosakai A., Fukuuchi Y. Phosphorylation of signal transducer and activator of transcription-3 (Stat3) after focal cerebral ischemia in rats. Exp. Neurol. 170:2001;63-71.
13. Wen T.C., Peng H., Hata R., Desaki J., Sakanaka M. Induction of phosphorylated-Stat3 following focal cerebral ischemia in mice. Neurosci. Lett. 303:2001;153-156.
14. Yokogami K., Wakisaka S., Avruch J., Reeves S.A. Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr. Biol. 10:2000;47-50.