-
2
-
-
0035128439
-
New anticoagulant drugs
-
Weitz JI, Hirsh J. New anticoagulant drugs. Chest 2001; 119: 95S-107S.
-
(2001)
Chest
, vol.119
-
-
Weitz, J.I.1
Hirsh, J.2
-
3
-
-
0029835392
-
A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes
-
The global use of strategies to open occluded coronary arteries (GUSTO) IIb investigators
-
The global use of strategies to open occluded coronary arteries (GUSTO) IIb investigators. A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. N Engl J Med 1996; 335: 775-82.
-
(1996)
N Engl J Med
, vol.335
, pp. 775-782
-
-
-
4
-
-
0033528281
-
Effects of recombinant hirudin (lepirudin) compared with heparin on death, myocardial infarction, refractory angina, and revascularisation procedures in patients with acute myocardial ischaemia without ST elevation: a randomised trial
-
Organization to Assess Strategies for Ischemic Syndromes (OASIS-2) Investigators
-
Organization to Assess Strategies for Ischemic Syndromes (OASIS-2) Investigators. Effects of recombinant hirudin (lepirudin) compared with heparin on death, myocardial infarction, refractory angina, and revascularisation procedures in patients with acute myocardial ischaemia without ST elevation: a randomised trial. Lancet 1999; 353: 429-38.
-
(1999)
Lancet
, vol.353
, pp. 429-438
-
-
-
5
-
-
0033818487
-
In vivo thrombin generation and activity during and after intravenous infusion of heparin or recombinant hirudin in patients with unstable angina pectoris
-
Merlini PA, Ardissino D, Rosenberg RD, Colombi E, Agricola P, Oltrona L, Ottani F, Galvani M, Bauer KA, Bottasso B, Bertocchi F, Mannucci PM. In vivo thrombin generation and activity during and after intravenous infusion of heparin or recombinant hirudin in patients with unstable angina pectoris. Arterioscler Thromb Vasc Biol 2000; 20: 2162-6.
-
(2000)
Arterioscler Thromb Vasc Biol
, vol.20
, pp. 2162-2166
-
-
Merlini, P.A.1
Ardissino, D.2
Rosenberg, R.D.3
Colombi, E.4
Agricola, P.5
Oltrona, L.6
Ottani, F.7
Galvani, M.8
Bauer, K.A.9
Bottasso, B.10
Bertocchi, F.11
Mannucci, P.M.12
-
6
-
-
0037176525
-
Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data
-
The Direct Thrombin Inhibitor Trialists' Collaborative Group
-
The Direct Thrombin Inhibitor Trialists' Collaborative Group. Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data. Lancet 2002; 359: 294-302.
-
(2002)
Lancet
, vol.359
, pp. 294-302
-
-
-
7
-
-
0035251672
-
The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects
-
Gustafsson D, Nyström J-E, Carlsson S, Bredberg U, Eriksson U, Gyzander E, Elg M, Antonsson T, Hoffmann K, Ungell A, Sorensen H, Någard S, Abrahamsson A, Bylund R. The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects. Thromb Res 2001; 101: 171-81.
-
(2001)
Thromb Res
, vol.101
, pp. 171-181
-
-
Gustafsson, D.1
Nyström, J.-E.2
Carlsson, S.3
Bredberg, U.4
Eriksson, U.5
Gyzander, E.6
Elg, M.7
Antonsson, T.8
Hoffmann, K.9
Ungell, A.10
Sorensen, H.11
Någard, S.12
Abrahamsson, A.13
Bylund, R.14
-
8
-
-
0013432360
-
Pharmacokinetics and pharmacodynamics of ximelagatran, a novel oreal direct thrombin inhibitor, in young healthy male subjects
-
in press
-
Eriksson UG, Bredberg U, Gislen K, Johansson LC, Frison L, AhnoffM, Gustafsson D. Pharmacokinetics and pharmacodynamics of ximelagatran, a novel oreal direct thrombin inhibitor, in young healthy male subjects. Eur J Clin Pharmacol 2003; in press.
-
(2003)
Eur J Clin Pharmacol
-
-
Eriksson, U.G.1
Bredberg, U.2
Gislen, K.3
Johansson, L.C.4
Frison, L.5
Ahnoff, M.6
Gustafsson, D.7
-
9
-
-
0031984477
-
Effects of melagatran, a new low-molecular-weight thrombin inhibitor, on thrombin and fibrinolytic enzymes
-
Gustafsson D, Antonsson T, Bylund R, Eriksson U, Gyzander E, Nilsson I, Elg M, Mattsson C, Deinum J, Pehrsson S, Karlsson O, Nilsson A, Sorensen H. Effects of melagatran, a new low-molecular-weight thrombin inhibitor, on thrombin and fibrinolytic enzymes. Thromb Haemost 1998; 79: 110-8.
-
(1998)
Thromb Haemost
, vol.79
, pp. 110-118
-
-
Gustafsson, D.1
Antonsson, T.2
Bylund, R.3
Eriksson, U.4
Gyzander, E.5
Nilsson, I.6
Elg, M.7
Mattsson, C.8
Deinum, J.9
Pehrsson, S.10
Karlsson, O.11
Nilsson, A.12
Sorensen, H.13
-
10
-
-
0036007936
-
Inhibition of thrombin generation by the oral direct thrombin inhibitor ximelagatran in shed blood from healthy male subjects
-
Sarich TC, Eriksson UG, Mattsson C, Wolzt M, Frison L, Fager G, Gustafsson D. Inhibition of thrombin generation by the oral direct thrombin inhibitor ximelagatran in shed blood from healthy male subjects. Thromb Haemost 2002; 87: 300-5.
-
(2002)
Thromb Haemost
, vol.87
, pp. 300-305
-
-
Sarich, T.C.1
Eriksson, U.G.2
Mattsson, C.3
Wolzt, M.4
Frison, L.5
Fager, G.6
Gustafsson, D.7
-
11
-
-
0037454036
-
Effects of ximelagatran, an oral direct thrombin inhibitor, r-hirudin and enoxaparin on thrombin generation and platelet activation in healthy male subjects
-
Sarich TC, Wolzt M, Eriksson UG, Mattsson C, Schmidt A, Elg S, Andersson M, Wollbratt M, Fager G, Gustafsson D. Effects of ximelagatran, an oral direct thrombin inhibitor, r-hirudin and enoxaparin on thrombin generation and platelet activation in healthy male subjects. J Am Coll Cardiol 2003; 41: 557-64.
-
(2003)
J Am Coll Cardiol
, vol.41
, pp. 557-564
-
-
Sarich, T.C.1
Wolzt, M.2
Eriksson, U.G.3
Mattsson, C.4
Schmidt, A.5
Elg, S.6
Andersson, M.7
Wollbratt, M.8
Fager, G.9
Gustafsson, D.10
-
12
-
-
0031936090
-
Thrombin binds to soluble fibrin degradation products where it is protected from inhibition by heparin-antithrombin but susceptible to inactivation by antithrombin-independent inhibitors
-
Weitz JI, Leslie B, Hudoba M. Thrombin binds to soluble fibrin degradation products where it is protected from inhibition by heparin-antithrombin but susceptible to inactivation by antithrombin-independent inhibitors. Circulation 1998; 97: 544-52.
-
(1998)
Circulation
, vol.97
, pp. 544-552
-
-
Weitz, J.I.1
Leslie, B.2
Hudoba, M.3
-
13
-
-
0031729548
-
Direct thrombin inhibitors for treatment of arterial thrombosis: potential differences between bivalirudin and hirudin
-
Bates SM, Weitz JI. Direct thrombin inhibitors for treatment of arterial thrombosis: potential differences between bivalirudin and hirudin. Am J Cardiol 1998; 82: 12P-18P.
-
(1998)
Am J Cardiol
, vol.82
-
-
Bates, S.M.1
Weitz, J.I.2
-
14
-
-
0642372601
-
The benefit-to-risk profile of melagatran is superior to that of hirudin in rabbit arterial thrombosis prevention and bleeding models
-
Klement P, Carlsson S, Liao P, Vlasin M, Stafford A, Johnston M, Rak J, Weitz JI. The benefit-to-risk profile of melagatran is superior to that of hirudin in rabbit arterial thrombosis prevention and bleeding models. J Thromb Haemost 2003; 1: 587-94.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 587-594
-
-
Klement, P.1
Carlsson, S.2
Liao, P.3
Vlasin, M.4
Stafford, A.5
Johnston, M.6
Rak, J.7
Weitz, J.I.8
-
15
-
-
0038436878
-
Comparison of the pharmacokinetics of ximelagatran, an oral direct thrombin inhibitor, in patients with nonvalvular atrial fibrillation and elderly healthy subjects
-
(Abstract)
-
Eriksson UG, Wollbratt M, Wolzt M, Svensson M, Grind M. Comparison of the pharmacokinetics of ximelagatran, an oral direct thrombin inhibitor, in patients with nonvalvular atrial fibrillation and elderly healthy subjects. Clin Pharmacol Therapeut 2002; 71: 95(Abstract).
-
(2002)
Clin Pharmacol Therapeut
, vol.71
, pp. 95
-
-
Eriksson, U.G.1
Wollbratt, M.2
Wolzt, M.3
Svensson, M.4
Grind, M.5
-
16
-
-
0035829034
-
Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement: a phase 2 dose-finding study
-
Heit JA, ColwellCW, FrancisCW, Ginsberg JS, Berkowitz SD, Whipple J, Peters G. Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement: a phase 2 dose-finding study. Arch Intern Med 2001; 161: 2215-21.
-
(2001)
Arch Intern Med
, vol.161
, pp. 2215-2221
-
-
Heit, J.A.1
Colwell, C.W.2
Francis, C.W.3
Ginsberg, J.S.4
Berkowitz, S.D.5
Whipple, J.6
Peters, G.7
-
17
-
-
0037048939
-
Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial
-
Eriksson BI, Bergqvist D, Kalebo P, Dahl OE, Lindbratt S, Bylock A, Frison L, Eriksson UG, Welin L, Gustafsson D. Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial. Lancet 2002; 360: 1441-7.
-
(2002)
Lancet
, vol.360
, pp. 1441-1447
-
-
Eriksson, B.I.1
Bergqvist, D.2
Kalebo, P.3
Dahl, O.E.4
Lindbratt, S.5
Bylock, A.6
Frison, L.7
Eriksson, U.G.8
Welin, L.9
Gustafsson, D.10
-
18
-
-
0037108825
-
A randomized, double-blind, comparative study of ximelagatran and warfarin for the prevention of venous thromboembolism after total knee arthroplasty
-
Francis CW, Davidson BL, Berkowitz SD, Lotke PA, Ginsberg JS, Lieberman JR, Webster AK, Whipple JP, Peters GR, Colwell CW. A randomized, double-blind, comparative study of ximelagatran and warfarin for the prevention of venous thromboembolism after total knee arthroplasty. Ann Intern Med 2002; 137: 648-55.
-
(2002)
Ann Intern Med
, vol.137
, pp. 648-655
-
-
Francis, C.W.1
Davidson, B.L.2
Berkowitz, S.D.3
Lotke, P.A.4
Ginsberg, J.S.5
Lieberman, J.R.6
Webster, A.K.7
Whipple, J.P.8
Peters, G.R.9
Colwell, C.W.10
-
19
-
-
0033786342
-
Statins and cardiovascular diseases: multiple effects of lipid-lowering therapy by statins
-
Rauch U, Osende JI, Chesebro JH, Fuster V, Vorchheimer DA, Harris K, Harris P, Sandler DA, Fallon JT, Jayaraman S, Badimon JJ. Statins and cardiovascular diseases: multiple effects of lipid-lowering therapy by statins. Atherosclerosis 2000; 153: 181-9.
-
(2000)
Atherosclerosis
, vol.153
, pp. 181-189
-
-
Rauch, U.1
Osende, J.I.2
Chesebro, J.H.3
Fuster, V.4
Vorchheimer, D.A.5
Harris, K.6
Harris, P.7
Sandler, D.A.8
Fallon, J.T.9
Jayaraman, S.10
Badimon, J.J.11
-
20
-
-
0035281821
-
Administration of abciximab to patients receiving tirofiban or eptifibatide: effect on platelet function
-
Lev EI, Osende JI, Richard M, Robbins JA, Delfin JA, Rodriguez O, Sharma SK, Jayasundera T, Badimon JJ, Marmur JD. Administration of abciximab to patients receiving tirofiban or eptifibatide: effect on platelet function. J Am Coll Cardiol 2001; 37: 847-55.
-
(2001)
J Am Coll Cardiol
, vol.37
, pp. 847-855
-
-
Lev, E.I.1
Osende, J.I.2
Richard, M.3
Robbins, J.A.4
Delfin, J.A.5
Rodriguez, O.6
Sharma, S.K.7
Jayasundera, T.8
Badimon, J.J.9
Marmur, J.D.10
-
21
-
-
0035499206
-
Blood thrombogenicity in type 2 diabetes mellitus patients is associated with glycemic control
-
Osende J, Badimon JJ, Fuster V, Herson P, Rabito P, Vidhun R, Zaman A, Rodriguez OJ, Lev EI, Rauch U, Heflt G, Fallon JT, Crandall JP. Blood thrombogenicity in type 2 diabetes mellitus patients is associated with glycemic control. J Am Coll Cardiol 2001; 38: 1307-12.
-
(2001)
J Am Coll Cardiol
, vol.38
, pp. 1307-1312
-
-
Osende, J.1
Badimon, J.J.2
Fuster, V.3
Herson, P.4
Rabito, P.5
Vidhun, R.6
Zaman, A.7
Rodriguez, O.J.8
Lev, E.I.9
Rauch, U.10
Heflt, G.11
Fallon, J.T.12
Crandall, J.P.13
-
22
-
-
0036165984
-
Determination of melagatran, a novel direct thrombin inhibitor, in human plasma and urine by liquid chromatography-mass spectrometry
-
Larsson M, Logren U, Ahnoff M, Lindmark B, Abrahamsson P, Svennberg H, Persson BA. Determination of melagatran, a novel direct thrombin inhibitor, in human plasma and urine by liquid chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl 2002; 766: 47-55.
-
(2002)
J Chromatogr B Biomed Sci Appl
, vol.766
, pp. 47-55
-
-
Larsson, M.1
Logren, U.2
Ahnoff, M.3
Lindmark, B.4
Abrahamsson, P.5
Svennberg, H.6
Persson, B.A.7
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