Using in silico biology to facilitate drug development

Novartis Foundation Symposium

Volumn 247, Issue , 2002, Pages 222-243

  Levin, Jeremy M ^a   Penland, R Christian ^a   Stamps, Andrew T ^a   Cho, Carolyn R ^a   Winslow, ^b   Subrmaniam, ^b   McCulloch, ^b  

^a Physiome Sciences   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; POTASSIUM;

ANIMAL; BIOLOGICAL MODEL; COMPUTER PROGRAM; DRUG DESIGN; ELECTROPHYSIOLOGY; HUMAN; LONG QT SYNDROME; METABOLISM; PHYSIOLOGY; PROTEIN MOTIF; REVIEW; SIGNAL TRANSDUCTION; TIME;

AMINO ACID MOTIFS; ANIMALS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG DESIGN; ELECTROPHYSIOLOGY; GTP-BINDING PROTEINS; HUMANS; LONG QT SYNDROME; MODELS, BIOLOGICAL; POTASSIUM; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SOFTWARE; TIME FACTORS;

EID: 0038143165     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (27)

1. Asthagiri AR, Lauffenburger DA 2000 Bioengineering models of cell signalling. Annu Rev Biomed Eng 2:31-53
2. Bos JL 2001 Glowing switches. Nature 411:1006-1007
3. Clancy CE, Rudy Y 2001 Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovasc Res 50:301-313
4. + channel by dual pathways. Curr Biol 10:671-674
5. Cui J, Kagan A, Qin D, Mathew J, Melman YF, McDonald TV 2001 Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2. J Biol Chem 276:17244-17251
6. v1.2. Science 293:98-101
7. Delhase M, Hayakawa M, Chen Y, Karin M 1999 Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science 284:309-313
8. Destexhe A, Sejnowski TJ 1995 G protein activation kinetics and spillover of γ-aminobutyric acid may account for differences between inhibitory responses in the hippocampus and thalamus. Proc Natl Acad Sci USA 92:9515-9519
9. Hartwell LH, Hopfield JJ, Leibler S, Murray AW 1999 From molecular to modular cell biology. Nature 402:(Suppl)C47-C52
10. Kenakin T 2002 Drug efficacy at G protein-coupled receptors. Annu Rev Pharmacol Toxicol 42:349-379
11. Kiehn J, Karle C, Thomas D, Yao X, Brachmann J, Kubler W 1998 HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways. J Biol Chem 273:25285-25291
12. Kiehn J, Lacerda AE, Brown AM 1999 Pathways of HERG inactivation. Am J Physiol 277:H199-H210
13. Lauffenburger DA 2000 Cell signaling pathways as control modules: complexity for simplicity? Proc Natl Acad Sci USA 97:5031-5033
14. Luo CH, Rudy Y 1994a A dynamic model of the cardiac ventricular action potential: I. Simulations of ionic currents and concentration changes. Circ Res 74:1071-1096
15. Luo CH, Rudy Y 1994b A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circ Res 74:1097-1113
16. Moller S, Vilo J, Croning MD 2001 Prediction of the coupling specificity of G protein coupled receptors to their G proteins. Bioinformatics 17:S174-S181
17. + channel diversity in the mammalian myocardium. J Physiol 525: 285-298
18. Ks, and length- and tension-dependent processes. Can J Cardiol 14:123-134
19. Pratt CM, Camm AJ, Cooper W 1998 Mortality in the Survival With ORal D-sotalol (SWORD) trial: why did patients die? Am J Cardiol 81:869-876
20. Rao CV, Arkin AP 2001 Control motifs for intracellular regulatory networks. Annu Rev Biomed Eng 3:391-119
21. + currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade. J Physiol 532:143-163
22. Shimizu W, Antzelevitch C 1999 Cellular basis for long QT, transmural dispersion of repolarization, and Torsade de Pointes in the long QT syndrome. J Electrocardiol 32:177-184
23. Tang Y, Othmer HG 1994 A G protein-based model of adaptation in Dictyostelium discoideum. Math Biosci 120:25-76
24. Tang Y, Othmer HG 1995 Excitation, oscillations and wave propagation in a G protein-based model of signal transduction in Dictyostelium discoideum. Philos Trans R Soc Lond B Biol Sci 349:179-195
25. Trudeau MC, Warmke JW, Ganetzky B, Robertson GA 1995 HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 269:92-95
26. Winslow RL, Rice JJ, Jafri MS, Marban E, O'Rourke B 1999 Mechanisms of altered excitation - contraction coupling in canine tachycardia-induced heart failure. II. Model studies. Circ Res 84:571-586
27. + current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circ Res 77:140-152