Activation of human intraepithelial lymphocytes reduces CD3 expression

Clinical and Experimental Immunology

Volumn 132, Issue 3, 2003, Pages 424-429

  Ebert, Ellen C ^a,b  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b NONE   (United States)

Author keywords

Calcium influx; CD2; CD3; IL 2; Intraepithelial lymphocytes; Lamina propria lymphocytes

Indexed keywords

CALCIUM ION; CD3 ANTIGEN; CD8 ANTIGEN; FURA 2; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; PHYTOHEMAGGLUTININ;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; ISOTOPE LABELING; JEJUNUM MUCOSA; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; MORBID OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; STOMACH BYPASS; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADULT; ANTIGENS, CD3; APOPTOSIS; CALCIUM; CD8-POSITIVE T-LYMPHOCYTES; HUMANS; IMMUNITY, MUCOSAL; INTERLEUKIN-2; INTESTINAL MUCOSA; JEJUNUM; LYMPHOCYTE ACTIVATION; MIDDLE AGED; PHYTOHEMAGGLUTININS; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTE SUBSETS;

EID: 0038133396     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2003.02156.x     Document Type: Article

References (31)

1. Kim S-K, Reed DS, Heath WR et al. Activation and migration of CD8 T cells in the intestinal mucosa. J Immunol 1997; 159:4295-306.
2. Ebert EC. Human intestinal intraepithelial lymphocytes have potent chemotactic activity. Gastroenterology 1995; 109:1154-9.
3. Kunkel EJ, Campbell JJ, Haraldsen G et al. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: epithelial expression of tissue-specific chemokines as an organizing principal in regional immunity. J Exp Med 2000; 192:761-8.
4. Roberts AI, O'Connell SM, Ebert EC. Intestinal intraepithelial lymphocytes bind to colon cancer cells by HML-1 and CD11a. Cancer Res 1993; 53:1608-11.
5. 7 mediates adhesion of T lymphocytes to epithelial cells. J Immunol 1993; 150:3459-70.
6. Roberts AI, Brolin RE, Ebert EC. VLA1 mediates adhesion of activated intraepithelial lymphocytes to collagen. Immunology 1999; 97:679-85.
7. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ['celiac sprue']. Gastroenterology 1992; 102:330-54.
8. Ebert EC. Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli. Gastroenterology 1989; 97:1372-81.
9. Sydora BC, Mixter PF, Holcombe HR et al. Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals. J Immunol 1993; 150:2179-91.
10. Sanchez-Garcia FJ, Aller WW, McCormack WT. Impaired calcium mobilization and differential tyrosine phosphorylation in intestinal intraepithelial lymphocytes. Immunol 1997; 91:81-7.
11. Lundqvist C, Melgar S, Yeung MM-W et al. Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggests T helper 1 and cytotoxic functions. J Immunol 1996; 157:1926-34.
12. + via T cell receptor-CD3 complex results in interferon-γ and interleukin-5 production, while low density T cells undergo DNA fragmentation. Eur J Immunol 1994; 24:1301-6.
13. Olaussen RW, Johansen FE, Lundin KEA, Jahnsen J, Brandtzaeg P, Farstad IN. Interferon-ā-secreting T cells localize to the epithelium in coeliac disease. Scand J Immunol 2002; 56:652-64.
14. Reinecker H, MacDermott RP, Mirau S, Dignass A, Podolsky DK. Intestinal epithelial cells both express and respond to interleukin 15. Gastroenterology 1996; 111:1706-13.
15. Mayer L, Panja A, Li Y et al. Unique features of antigen presentation in the intestine. Ann NY Acad Sci 1992; 664:39-46.
16. Bloom S, Simmons D, Jewell DP. Adhesion molecules intercellular adhesion molecules-1 (ICAM-1), ICAM-3, and B7 are not expressed by epithelium in normal or inflamed colon. Clin Exp Immunol 1995; 101:157-63.
17. Framson PE, Cho DH, Lee LY et al. Polarized expression and function of the costimulatory molecule CD58 on human intestinal epithelial cells. Gastroenterology 1999; 116:1054-62.
18. Yamamoto M, Fujihashi K, Kawabata K et al. A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. J Immunol 1998; 160:2188-96.
19. Lundqvist C, Baranov V, Hammarstrom S, Athlin L, Hammarstrom ML. Intra-epithelial lymphocytes, evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium. Int Immunol 1995; 7:1473-87.
20. Hoang P, Dalton HR, Jewell DP. Human colonic intra-epithelial lymphocytes are suppressor cells. Clin Exp Immunol 1991; 85:498-503.
21. Meuer SC, Hussey RE, Fabbi M et al. An alternative pathway of T cell activation: a functional role for the 50 Kd T11 sheep erythrocyte receptor protein. Cell 1984; 36:897-906.
22. Abuzakouk M, Kelleher D, Feighery C et al. Increased HLA-DR and decreased CD3 on human intestinal intraepithelial lymphocytes: evidence of activation? Gut 1996; 39:396-400.
23. Esser MT, Krishnamurthy B, Braciale VL. Distinct T cell receptor signaling requirements for perforin- or FasL-mediated cytotoxicity. J Exp Med 1996; 183:1697-706.
24. DeMaria R, Fais S, Silvestri M et al. Continous in vivo activation and transient hyporesponsiveness to TCR/CD3 triggering of human gut lamina propria lymphocytes. Eur J Immunol 1993; 23:3104-8.
25. Qiao L, Schurmann G, Betzler M et al. Activation and signaling status of human lamina propria T lymphocytes. Gastroenterology 1991; 101:1529-36.
26. ++. J Immunol 1993; 150:5338-49.
27. Lissy NA, Van Dyk LF, Becker-Hapak M et al. TCR antigen-induced cell death occurs from a late G1 phase cell cycle check point. Immunity 1998; 8:57-65.
28. - T lymphocytes. Antigenic and functional properties. J Immunol 1993; 150:1147-59.
29. - T cells: certainties and uncertainties of a prevalent human T-cell subset. Immunol Cell Biol 2002; 80:1-13.
30. Liu H, Rhodes M, Wiest DL et al. On the dynamics of TCR-CD3 complex cell surface expression and downmodulation. Immunity 2000; 13:665-75.
31. Dietrich J, Menne C, Lauritsen JPH et al. Ligand-induced TCR down-regulation is not dependent on constitutive TCR cycling. J Immunol 2002; 168:5434-40.