Increased HLA-DR and decreased CD3 on human intestinal intraepithelial lymphocytes: Evidence of activation?

Gut

Volumn 39, Issue 3, 1996, Pages 396-400

  Abuzakouk, M ^a   Kelleher, D ^a   Feighery, C ^a   O'Farrelly, C ^b  

^a ST JAMES S HOSPITAL   (Ireland)

^b ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Activation markers; Intraepithelial lymphocytes; Major histocompatibility complex; Mean fluorescence intensity; Peripheral blood

Indexed keywords

CD3 ANTIGEN; HLA DR ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; DUODENUM BIOPSY; FLOW CYTOMETRY; HLA SYSTEM; HUMAN; HUMAN TISSUE; INTESTINE; INTESTINE LYMPHATIC TISSUE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0029842799     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.39.3.396     Document Type: Article

References (33)

1. Brandtzaeg P, Bosnes V, Halstensen TS, Scott H, Sollid LM, Valnes KN. T lymphocytes in human gut epithelium preferentially express the αβ antigen receptor and are often CD45/UCHL-1 positive. Scand J Immunol 1989; 30: 123-30.
2. Jarry A, Cerf-Bensussan N, Brousse N, Selz F, Guy-Grand D. Subsets of CD3+ (T-cell receptor αβ or γδ) and CD3 lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur J Immunol 1990; 20: 1097-103.
3. Cerf-Bensussan N, Guy-Grand D, Griscelli C. Intraepithelial lymphocytes of human gut: isolation, characterisation and study of natural killer activity. Gut 1985; 26: 81-8.
4. Taunk J, Roberts AI, Ebert EC. Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumours. Gastroenterology 1992; 102: 69-75.
5. Arnaud-Battandier F, Bundy BM, C'Neill M, Bienenstock J, Nelson DL. Cytotoxic activities of gut mucosal lymphoid cells in guinea pigs. J Immunol 1978; 121: 1059-65.
6. Tagliabue A, Luini W, Soldateschi D, Boraschi D. Natural killer activity of gut mucosal lymphoid cells in mice. Eur J Immunol 1981; 11: 919-26.
7. Ebert EC. Intraepithelial lymphocytes: interferon-gamma production and suppressor/cytotoxic activities, Clin Exp Immunol 1990; 82: 81-5.
8. Sanders ME, Makgoba MW, Shaw S. Human naive and memory T cells: reinterpretation of helper-inducer and suppresser-inducer subsets. Immunol Today 1988; 9: 195-9.
9. Kelly J, O'Farrelly C, O'Mahony C, Weir DG, Feighery C. Immunoperoxidase demonstration of the cellular composition of the normal and coeliac small bowel. Clin Exp Immunol 1987; 68: 177-88.
10. Malizia G, Trejdosiewicz LK, Wood GM, Howdle PD, Janossy G, Losowsky MS. The microenvironment of coeliac disease: T cell phenotypes and expression of the T2'T blast' antigen by small bowel lymphocytes. Clin Exp Immunol 1985; 60: 437-46.
11. Scott H, Sollid LM, Fausa O, Brandtzaeg P, Thorsby E. Expression of major histocompatibility complex class II subregion products by jejunal epithelium in patients with coeliac disease. Scand J Immunol 1987; 26: 563-71.
12. Spencer J, MacDonald TT, Diss TC, Walker-Smith JA, Ciclitira PJ, Isaacson PG. Changes in intraepithelial lymphocyte subpopulations in coeliac disease and enteropathy associated T cell lymphoma (malignant histiocytosis of the intestine). Gut 1989; 30: 339-46.
13. Holm K, Savilahti E, Koskimies S, Lipsanen V, Maki M. Immunohistochemical changes in the jejunum in first degree relatives of patients with coeliac disease and the coeliac disease marker DQ genes. HLA class II antigen expression, Interleukine-2 receptor positive cells and dividing crypt cells, Gut 1994; 35: 55-60.
14. Selby WS, Janossy G, Bofill M, Jewell DP. Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa and in the mucosa of patients with adult coeliac disease. Clin Exp Immunol 1983; 52: 219-28.
15. Lynch S, Kelleher D, Feighery C, Weir DG, O'Farrelly C. Flow cytometric analysis of intraepithelial lymphocytes from small intestinal biopsies reveals populations of CD4+CD8+ and CD8αα+ cells. Eur J Gastroenterol Hepatol 1993; 5: 907-12.
16. Cantrell DA, Smith KA. Transient expression of interleukin 2 receptor. Consequences for T cell growth. J Exp Med 1983; 158: 1895-911.
17. Cotner T, Williams JM, Christenson L, Shapiro HM, Strom TB, Strominger J. Simultaneous flow cytometric analysis of human T cell activation antigen expression and DNA content. J Exp Med 1983; 157:461-72.
18. Matsui Y. Increased density of class I major histocompatibility complex antigens and decreased density of T cell differentiation antigens in the early stages of T-cell activation. Hum Immunol 1987; 18: 123-33.
19. Weyand CM, Goronzy J, Fathman CG. Modulation of CD4 by antigenic activation. J Immunol 1987; 138: 1351-4.
20. Omary MB, Kelleher D, Kagnoff MF. An 80 to 85 kilodalton human phosphoglyeoprotein associated with cell activation. J Immunol 1988; 141: 3492-7.
21. Omary MB, DeGrandpre L, Varki NM, Kagnoff MF. A tyrosine sulfated human glycoprotein with an unusual cell distribution. Mol Immunol 1992; 29: 9-19.
22. Abuzakouk M, Feighery C, O'Farrelly C. Collagenase and dispase enzymes disrupt lymphocyte surface molecules. J Immunol Methods 1996; 194: 211-6.
23. Trejdosiewicz LK, Badr-el-Din S, Smart CJ, Malizia G, Oakes DJ, Heatley RV, Losowsky MS. Colonic mucosal T lymphocytes in ulcerative colitis: expression of CD7 antigen in relation to MHC class II (HLA-D) antigens. Dig Dis Sci 1989; 34: 1449-56.
24. Trejdosiewicz LK. Intestinal intraepithelial lymphocytes and lymphoepithelial interactions in the human gastrointestinal mucosa. Immunol Lett 1992; 32: 13-20.
25. Ebert EC. Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli. Gastroenterology 1989; 97: 1372-81.
26. Kelleher D, Murphy A, Lynch S, O'Farrelly C. Adhesion molecules utilized in binding of intraepithelial lymphocytes to human enterocytes. Eur J Immunol 1994; 24: 1013-6.
27. Ebert EC. Sheep red blood cells enhance T-lymphocyte proliferation. Clin Immuol Immunopathol 1985; 37: 203-12.
28. Halstensen TS, Brandtzaeg P. Activated T lymphocytes in the celiac lesion:non-proliferative activation (CD25) of CD4+ α/β cells in the lamina propria but proliferation (Ki-67) of α/β and γ/δ cells in the epithelium. Eur J Immunol 1993; 23: 505-10.
29. Dutia BM, MacConnell I, Bird K, Keating P, Hopkins J. Patterns of major histocompatibility complex class II expression on T cell subsets in different immunological compartments 1. Expression on resting T cells. Eur J Immunol 1993; 23: 2882-8.
30. Cush JJ, Lipsky PE. Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum 1988; 31: 1230-8.
31. Russo C, Indiveri F, Quaranta V, Molinaro GA, Pellegrino MA, Ferrone S. Stimulation of human T lymphocytes by PHA-activated autologous T lymphocytes: Analysis of the role of Ia-like antigen with monoclonal antibodies. Immunogenetics 1981; 12: 267-74.
32. Brown MF, Cook RG, Van M, Rich RR. Cloned human T cells synthesise Ia molecules and can function as antigen presenting cells. Hum Immunol 1984; 11: 219-28.
33. Triebel F, De Roquefeuil S, Blanc C, Charron DJ, Debre P. Expression of MHC class II and Tac antigens on IL2-activaied human T cell clones that can stimulate in MLR, AMLR, PLT and can present antigen. Hum Immunol 1986; 15: 302-15.