Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1

Pharmacogenetics

Volumn 13, Issue 4, 2003, Pages 225-230

  Risch, Angela ^a   Ramroth, Heribert ^a   Raedts, Vivianne ^a   Rajaee Behbahani, Nahid ^a   Schmezer, Peter ^a   Bartsch, Helmut ^a   Becher, Heiko ^b   Dietz, Andreas ^b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Alcohol dehydrogenase; Genotyping; Glutathione S transferase; Laryngeal carcinoma; Molecular epidemiology; Tobacco and alcohol associated risk

Indexed keywords

ALCOHOL DEHYDROGENASE; GENOMIC DNA; GLUTATHIONE TRANSFERASE;

ADH1B GENE; ADH1C GENE; ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; CANCER RISK; CAUCASIAN; CONTROLLED STUDY; DNA ISOLATION; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; GERMANY; GSTM1 GENE; GSTT1 GENE; HUMAN; LARYNX CANCER; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SMOKING; STATISTICAL ANALYSIS; TOBACCO;

ALCOHOL DEHYDROGENASE; ALCOHOL DRINKING; DNA; DNA, NEOPLASM; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENOTYPE; GERMANY; GLUTATHIONE TRANSFERASE; HUMANS; LARYNGEAL NEOPLASMS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SMOKING;

NICOTIANA TABACUM;

EID: 0038070267     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200304000-00007     Document Type: Article

References (31)

1. Brugere J, Guenel P, Leclerc A, Rodriguez J. Differential effects of tobacco and alcohol in cancer of the larynx, pharynx, and mouth. Cancer 1986; 57:391-395.
2. Duester G, Farres J, Felder MR, Holmes RS, Hoog JO, Pares X, et al. Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family. Biochem Pharmacol 1999; 58:389-395.
3. IARC. Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide (part two), 319-335. IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans (71). Lyon, IARC, 1999.
4. Yin SJ, Bosron WF, Magnes LJ, Li TK. Human liver alcohol dehydrogenase: purification and kinetic characterization of the beta 2 beta 2, beta 2 beta 1, alpha beta 2, and beta 2 gamma 1 'Oriental' isoenzymes, Biochemistry 1984', 23:5847-5853.
5. Yokoyama A, Muramatsu T, Omori T, Yokoyama T, Matsushita S, Higuchi S, et al. Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. Carcinogenesis 2001; 22:433-439.
6. Coutelle C, Ward PJ, Fleury B, Quattrocchi P, Chambrin H, Iron A, et al. Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms. Hum Genet 1997; 99:319-325.
7. Olshan AF, Weissler MC, Watson MA, Bell DA. Risk of head and neck cancer and the alcohol dehydrogenase 3 genotype. Carcinogenesis 2001; 22:57-61.
8. Bouchardy C, Hirvonen A, Coutelle C, Ward PJ, Dayer P, Benhamou S. Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract. Int J Cancer 2001; 87:734-740.
9. Sturgis EM, Dahlstrom KR, Guan Y, Eicher SA, Strom SS, Spitz MR, et al. Alcohol dehydrogenase 3 genotype is not associated with risk of squamous cell carcinoma of the oral cavity and pharynx. Cancer Epidemiol Biomarkers Prev 2001; 10:273-275.
10. Li JJ, Benesova M, Goette K, Fiehn W, Conradt C, Hoermann K, et al. Enhanced risk of upper alimentary tract cancer in patients with the alcohol dehydrogenase 3* 1 allele due to increased salivary acetaldehyde following ethanol ingestion. Gastroenterology 2001; 120:A160.
11. Osier MV, Pakstis AJ, Soodyall H, Comas D, Goldman D, Odunsi A, et al. A Global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet 2002; 71:84-99.
12. Borras E, Coutelle C, Rosell A, Fernandez Muixi F, Broch M, Crosas B, et al. Genetic polymorphism of alcohol dehydrogenase in Europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. Hepatology 2000; 31:984-989.
13. Geisler SA, Olshan AF. GSTM1, GSTT1, and the risk of squamous cell carcinoma of the head and neck: a mini-HuGE review. Am J Epidemiol 2001; 154:95-105.
14. Ramroth H, Altenburg H-P, Becher H. Auswahl von Populationskontrollen für epidemiologische Fall-Kontroll-Studien unter Verwendung regienaler Stichproben. Informatik, Biometrie und Epidemiologie in Medizin und Biologie 2001; 32:60-70.
15. Groppi A, Begueret J, Iron A. Improved methods for genotype determination of human alcohol dehydrogenase (ADH) at ADH 2 and ADH 3 loci by using polymerase chain reaction-directed mutagenesis. Clin Chem 1990; 36:1765-1768.
16. Hirvonen A, Saarikoski ST, Linnainmaa K, Koskinen K, Husgafvel Pursiainen K, Mattson K, et al. Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders. J Natl Cancer Inst 1996; 88:1853-1856.
17. Neuhauser M, Becher H. Improved odds ratio estimation by post hoc stratification of case-control data. Stat Med 1997; 16:993-1004.
18. Ryberg D, Skaug V, Hewer A, Phillips DH, Harries LW, Wolf CR, et al. Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk. Carcinogenesis 1997; 18:1285-1289.
19. Saarikoski ST, Voho A, Reinikainen M, Anttila S, Karjalainen A, Malaveille C, et al. Combined effect of polymorphic GST genes on individual susceptibility to lung cancer. Int J Cancer 1998; 77:516-521.
20. Harty LC, Caporaso NE, Hayes RB, Winn DM, Bravo-Otero E, Blot WJ, et al. Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers. J Natl Cancer Inst 1997; 89:1698-1705.
21. Schwartz SM, Doody DR, Fitzgibbons ED, Ricks S, Porter PL, Chen C. Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypes. Cancer Epidemiol Biomarkers Prev 2001; 10:1137-1144.
22. Chao YC, Lieu SR, Chung YY, Tang HS, Hsu CT, Li TK, et al. Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients. Hepatology 1994; 19:360-366.
23. Chao YC, Young TH, Tang HS, Hsu CT. Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients. Hepatology 1997; 25:112-117.
24. Trizna Z, Clayman GL, Spitz MR, Briggs KL, Goepfert H. Glutathione s-transferase genotypes as risk factors for head and neck cancer. Am J Surg 1995; 170:499-501.
25. Kihara M, Kubota A, Furukawa M, Kimura H. GSTM1 gene polymorphism as a possible marker for susceptibility to head and neck cancers among Japanese smokers. Cancer Lett 1997; 112:257-262.
26. Matthias C, Bockmuhl U, Jahnke V, Jones PW, Hayes JD, Alldersea J, et al. Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers. Pharmacogenetics 1998; 8:91-100.
27. Jourenkova N, Reinikainen M, Bouchardy C, Dayer P, Benhamou S, Hirvonen A. Larynx cancer risk in relation to glutathione S-transferase M1 and T1 genotypes and tobacco smoking. Cancer Epidemiol Biomarkers Prev 1998; 7:19-23.
28. Oude Ophuis MB, van Lieshout EM, Roelofs HM, Peters WH, Manni JJ. Glutathione S-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions. Cancer 1998; 82:936-9]43.
29. Thier R, Pemble SE, Kramer H, Taylor JB, Guengerich FP, Ketterer B. Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium. Carcinogenesis 1996; 17:163-166.
30. Osier M, Pakstis AJ, Kidd JR, Lee JF, Yin SJ, Ko HC, et al. Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. Am J Hum Genet 1999; 64:1147-1157.
31. Ko Y, Abel J, Harth V, Brode P, Antony C, Donat S, et al. Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue. Cancer Res 2001; 61:4398-4404.