Acute toxicity of stevioside, a natural sweetener, and its metabolite, steviol, in several animal species

Drug and Chemical Toxicology

Volumn 20, Issue 1-2, 1997, Pages 31-44

  Toskulkao, C ^a   Chaturat, L ^a   Temcharoen, P ^a   Glinsukon, T ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b RANGSIT UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

STEVIOL; STEVIOSIDE; SWEETENING AGENT;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEGENERATION; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; INTRAGASTRIC DRUG ADMINISTRATION; LETHALITY; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SYRIAN HAMSTER;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 0030737954     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.3109/01480549709011077     Document Type: Article

References (23)

1. Kinghorn, A.D. and Soejarto, D.D. (1991). Stevioside. In Alternative Sweeteners, Vol. 2 (L.O. Nabors and R.C. Gelardi, Eds.), pp. 157-171. Dekker, New York.
2. Isima, N. and Kakayama, H. (1976). Sensory evaluation of stevioside as a sweetener. Natl. Food Res. Inst. 31, 80-85.
3. Xili, L., Chengjiany, B., Eryi, X., Reiming, S., Yuengming, W., Haodany, and Zhiyian, H. (1992). Chronic oral toxicity and carcinogenicity study of stevioside in rats. Fd. Chem. Toxic. 30, 957-965.
4. Sasaki, K. (1983). Use of stevioside sweeteners in drinks. New Food Ind. 25, 38-43.
5. Fugita, H. and Edahiro, T. (1979). Safety and utilization of Stevia sweetener. Shokuhin Kogyo 22, 65-72.
6. Akashi, H. and Yokoyama, Y. (1975). Dried-leaf extracts of Stevia. Toxicological test. Shokuhin Kogyo 18, 34-43.
7. Wood, H.B., Allerton, R., Dichi, H.W. and Fletcher, H.G. (1955). Stevioside. I: The structure of glucose moieties. J. Org. Chem. 20, 875-879.
8. Mosseting, E. and Wes, W.R.(1955). Stevioside. II: The structure of aglycone. J. Org. Chem. 20, 884-888.
9. Wingard, R.E., Brown, J.P., Enderlin, F.E., Dale, J.A., Hale, R.E. and Seitz, C.T.(1980). Intestinal degradation and absorption of the glycoside sweeteners stevioside and rebaudioside A. Experientia 36, 519-520.
10. Yamamoto, N.S., Bracht, A.M.K., Ishii, E.L., Kemmelmeier, F.S., Alvarez, and Bracht, A. (1985). Effect of steviol and its structural analogues on glucose production and oxygen uptake in rat renal tubules. Experientia 41, 55-57.
11. Toskulkao, C., Sutheerawatananon, M. and Piyachaturawat, P. (1995). Inhibitory effect of steviol, a metabolite of stevioside, on glucose absorption in everted hamster intestine in vitro. Toxicology Lett. 80, 153-159.
12. Pezzuto, J.M., Compadre, C.M., Swanson, S. M., Nanayakkara, N.P.D. and Kinghorn, A.D. (1985). Metabolically activated steviol, the aglycone of stevioside, is mutagenic. Proc. Natl. Acad. Sci. 82, 2478-2482.
13. Adduci, J., Buddhasukh, D. and Ternai, B. (1987). Improved isolation and purification of stevioside. J. Sci. Soc. Thailand 12, 179-183.
14. Ogawa, T., Nozaki, M. and Matsui, M. (1980). Total synthesis of stevioside. Tetrahedron 36, 2641-2648.
15. Litchfield, J.T. and Wilcoxon, F. (1949). A simplified method of evaluating dose-effect experiments. J. Pharmac. Exp. Ther. 69, 99-113.
16. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951). Protein measurement with the folin-phenol reagent. J.Biol. Chem. 193, 265-275.
17. Klaassen, C. and Doull, J.(1986). Evaluation of safety: Toxicological evaluation In Cassarett and Doull's Toxicology, 2nd Edition (J. Doull, C.D. Klaassen and M.O. Amdur, Eds.), pp. 12, Macmillan Publishing Co., New York.
18. Glinsukon, T., Pimbua, J. and Panichkul, T. (1988). Stevioside, a natural sweetener from Stevia rebaudiana Bertoni: Toxicological evaluation. Thai J. Toxicol. 4, 1-22.
19. Toskulkao, C., Deechakawan, W., Leardkamolkarn, V., Glinsukon, T. and Buddhasukh, D. (1994). The low calorie natural sweetener stevioside: Nephrotoxicity and its relation to urinary enzyme excretion in the rat. Phytother. Res. 8, 281-286.
20. Bracht, A.K., Alvarez, M. and Bracht, A. (1985). Effects of Stevia rebaudiana natural products on rat liver mitochondria. Biochem. Pharmacol. 34, 873-882.
21. Yamamoto, N.S., Bracht, A.K., Ishii, E.L., Kemmelmeier, F.S., Alvarez, M. and Bracht, A. (1985). Effect of steviol and its structural analogues on glucose production and oxygen uptake in rat renal tubules. Experientia 41, 55-57.
22. Toskulkao, C., Deechakawan, W., Temcharoen, P., Buddhasukh, D. and Glinsukon, T. (1994). Nephrotoxic effects of Stevioside and steviol in rat renal cortical slices. J.Clin.Biochem.Nutr. 16, 123-131.
23. Comprade, C.M., Hussain, R.A., Nanayakkara, N.P.D., Pezzuto, J.M. and Kinghorn, A.D. (1988). Mass spectral analysis of some derivatives and in vitro metabolites of steviol, the aglycone of the natural sweeteners, stevioside, rebaudioside and rubusoside. Biomed. Environm. Mass Spectro. 15, 211-222.